[Modern view on the mechanism of traffic injury in collision of moving vehicle and pedestrian].

The article considers the main phases of traffic injury (TI) described by A.A. Solokhin in 1968 and their modern application in forensic medical and automotive examination.

[Organ and species identification of liver microparticles using forensic cytology and quantitative enzyme-linked immunosorbent assay methods].

Objective: To establish organ affiliation of liver microparticles using forensic cytological method based on hepatocytes' morphological characteristics and to determine their species belonging according to the human IgG using a quantitative enzyme-linked immunosorbent assay (ELISA).

Material And Methods: Previously dried microparticles (from 0.2×0.

[Forensic medical expertise in the cases of sexual crimes: dynamics of indicators and regional features].

Unlabelled: Crimes against the sexual integrity of the individual represent one of the most serious forms of violence.

Objective: To perform a retrospective epidemiological analysis with the systematization of analytical data on the performed forensic medical examinations (FMEs) of survivors of sexual abuse in order to increase the effectiveness of the system of preventive measures against such crimes.

Material And Methods: The data from the industry statistical report №42 were analyzed.

Tuning the Electrical Property and Electronic Band Structures of Organic Semiconductors via Surface Tension.

Stress engineering is an effective way to tune the performance of semiconductors, which has been verified in the work of inorganic and organic single-crystal semiconductors. However, due to the limitations of the vapor-phase growth preparation conditions, the deposited polycrystalline organic semiconductors are more susceptible to residual stress. Therefore, it is of great research significance to develop a low-cost stress engineering applicable to vapor-deposited semiconductors.

Multienzyme Cascade Coimmobilization on ZIF-8-Coated Magnetic Nanoparticles for Efficient d-Allulose Synthesis.

This study develops a multienzyme coimmobilization strategy on NTA-functionalized ZIF-8-coated magnetic nanoparticles (NZMNPs) for efficient d-allulose synthesis. Under optimized immobilization conditions (enzyme-to-carrier ratio: 1:50 w/w, 30 min immobilization), the system achieved an immobilization efficiency of 93.7% along with 107.

Systemic Delivery of an mRNA-Encoding, Tumor-Activated Interleukin-12 Lock to Eliminate Tumors and Avoid Immune-Related Adverse Events.

Interleukin-12 (IL-12) is a robust proinflammatory cytokine that activates immune cells, such as T cells and natural killer cells, to induce antitumor immunity. However, the clinical application of recombinant IL-12 has been limited by systemic immune-related adverse events (irAEs) and rapid degradation. To address these challenges, we employed mRNA technology to encode a tumor-activated IL-12 "lock" fusion protein that offers both therapeutic efficacy and systemic safety.

Brain-wide activation and deactivation maps during smooth and saccadic tracking in humans.

This study aimed to identify brain activity modulations associated with different types of visual tracking using advanced functional magnetic resonance imaging techniques developed by the Human Connectome Project (HCP) consortium. Magnetic resonance imaging data were collected from 27 healthy volunteers using a 3-T scanner. During a single run, participants either fixated on a stationary visual target (fixation block) or tracked a smoothly moving or jumping target (smooth or saccadic tracking blocks), alternating across blocks.

Neural alpha oscillations and auditory steady-state responses during adaptation to a cochlear implant.

The human auditory system must distinguish relevant sounds from noise. Severe hearing loss can be treated with cochlear implants (CIs), but how the brain adapts to electrical hearing remains unclear. This study examined adaptation to unilateral CI use in the first and seventh months after CI activation using speech comprehension measures and electroencephalography recordings, both during passive listening and an active spatial listening task.

Novel Prognostic Scoring Systems for Severe CRS after Anti-CD19 CAR-T-Cells in Acute B-Lymphoblastic Leukemia.

Objective: To develop a novel prognostic scoring system for severe cytokine release syndrome (CRS) in patients with B-cell acute lymphoblastic leukemia (B-ALL) treated with anti-CD19 chimeric antigen receptor (CAR)-T-cell therapy, aiming to optimize risk mitigation strategies and improve clinical management.

Methods: This single-center retrospective cohort study included 125 B-ALL patients who received anti-CD19 CAR-T-cell therapy from January 2017 to October 2023. These cases were selected from a cohort of over 500 treated patients on the basis of the availability of comprehensive baseline data, documented CRS grading, and at least 3 months of follow-up.

Decoding binocular color differences via EEG signals: linking ERP dynamics to chromatic disparity in CIELAB space.

This study explores how differences in colors presented separately to each eye (binocular color differences) can be identified through EEG signals, a method of recording electrical activity from the brain. Four distinct levels of green-red color differences, defined in the CIELAB color space with constant luminance and chroma, are investigated in this study. Analysis of Event-Related Potentials (ERPs) revealed a significant decrease in the amplitude of the P300 component as binocular color differences increased, suggesting a measurable brain response to these differences.

Expanding the frontier of CAR therapy: comparative insights into CAR-T, CAR-NK, CAR-M, and CAR-DC approaches.

Chimeric antigen receptor (CAR) therapies have demonstrated remarkable clinical efficacy in hematological malignancies, validating their therapeutic potential. However, challenges such as therapeutic resistance and limited accessibility hinder their broader application. To overcome these limitations, alternative CAR-based cell therapies, including CAR-Natural Killer (CAR-NK), CAR-macrophage (CAR-M), and CAR-dendritic cell (CAR-DC) therapies, have been proposed.

Photodynamic inactivation of bacterial biofilms on absorbable collagen membranes using indocyanine green in aqueous and hydrogen peroxide solutions.

Microbial contamination of absorbable collagen membranes used in guided bone regeneration (GBR) may compromise healing outcomes. This study aimed to investigate whether the minimum inhibitory concentration (MIC) of hydrogen peroxide (HO) can improve the antibacterial effect of indocyanine green (ICG)-mediated antimicrobial photodynamic therapy (PDT) on absorbable collagen membranes while reducing the need for high HO concentrations. A laboratory-based model was developed using Streptococcus sanguinis and Staphylococcus aureus.

External root resorption of second molars caused by impacted third molars: CBCT characteristics.

Objectives: This study aims to describe the cone-beam computed tomography (CBCT) characteristics of external root resorption (ERR) in second molars associated with impacted third molars.

Methods: This study analyzed 69 s molars diagnosed with ERR caused by impacted third molars in 52 patients (age range: 22-59 years; mean age = 31.2 ± 7.

Jasmine tea: unveiling the secrets of processing, flavor characteristics, and potential health benefits.

Jasmine tea, a further processing tea made by scenting green, black, oolong, or other tea with jasmine flowers, is widely appreciated worldwide for its fragrant aroma, refreshing taste, and beneficial health effects. The production of jasmine tea is a meticulous and complex process that involves chemical reactions, physical adsorption, and flavor interaction effects at the sensory level between jasmine and tea. This paper provides a comprehensive review of the research on the processing technology, characteristic aroma formation, nonvolatile compounds, and health benefits of jasmine tea.

The effects of acidifying agents on the growth, antimicrobial resistance, and plasmid genome of Salmonella enterica serovar Infantis.

This study evaluated if acidifying agents used for ammonia control and pathogen reduction in poultry houses have a deleterious effect on the survival and growth of Salmonella Infantis. Changes in antimicrobial resistance (AMR) and pESI plasmid gene composition were also investigated. When S.

Biomineralized Electroactive Microbe as the Whole-Cell Electrical Transducer for Electrochemically Online Monitoring of Lactic Acid Fermentation.

Electroactive bacteria (EAB) hold great promise for the development of electrochemical biosensors given their unique ability to transfer electrons extracellularly via specialized pathways, a process termed extracellular electron transfer (EET). Ongoing research aims to overcome current limitations and fully harness the potential of EABs for high-performance biosensing applications. Herein, we report the fabrication of an electrochemical microsensor based on biomineralized electroactive bacteria, specifically MR-1.

Expert consensus regarding the clinical application of liver contrast-enhanced US with Sonazoid (Sonazoid CEUS).

Sonazoid, a combined blood pool and Kupffer-cell agent, can be specifically phagocytosed by Kupffer cells in the liver, allowing lesion detection and characterization of focal liver lesions (FLLs) at the post-vascular phase apart from the vascular phase which is similar to that of other second-generation US contrast agents. Sonazoid CEUS is currently approved for use in some Asian countries. With the increasing use of Sonazoid CEUS for FLLs in clinical practice, developing consensus or guidelines to help standardize its use is required.

Causes of Death After Surgery Among Cancer Patients: A Population-based Cohort Study.

Introduction: Recent advancements in surgical techniques and perioperative care have improved cancer survival rates, yet postoperative comorbidity and mortality remain a critical concern. Despite progress in cancer control, systematic analyses of long-term mortality trends and competing risks in surgery-intervened cancer populations are lacking. This study aimed to quantify temporal patterns of postoperative mortality causes across 21 solid cancers and identify dominant non-cancer risk factors to inform survivorship care strategies.

Correction: Distinct autophagy-inducing abilities of similar-sized nanoparticles in cell culture and live .

Correction for 'Distinct autophagy-inducing abilities of similar-sized nanoparticles in cell culture and live ' by Qin Wang , , 2018, , 23059-23069, https://doi.org/10.1039/C8NR05851B.

subsp. B-53 Alleviated Abnormalities of Glycolipid Metabolism and Oxidative Stress in T2DM Mice Through Regulating Gut Microbiota and GLP-1 Secretion.

Creating effective treatments for type 2 diabetes mellitus (T2DM) remains a critical global health challenge. This study investigates the antidiabetic mechanisms of subsp. B-53 ( B-53) in T2DM mice.

Efficient Fully-Solution-Processed Inverted Red Quantum Dot Light-Emitting Diodes Enabled by Charge-Exciton Regulation.

Inverted quantum dot light-emitting diodes (QLEDs) show great promise for next-generation displays due to their compatibility with integrated circuit architectures. However, their development has been hindered by inefficient exciton utilization and charge transport imbalance. Here, we present a strategy for regulating charge-exciton dynamics through the rational design of a multifunctional hole transport layer (HTL), incorporating polyethylenimine ethoxylated (PEIE) as a protective interlayer in fully-solution-processed inverted red QLEDs.

Development of Cyclooctyne-Nitrone Based Click Release Chemistry for Bioorthogonal Prodrug Activation both and .

The advancement of bioorthogonal cleavage platforms has emerged as a critical frontier in chemical biology, offering precise molecular liberation through physiologically compatible activation mechanisms. Despite its significant potential, ensuring efficacy typically requires rapid reaction kinetics, high-efficiency payload release, and stable reactants; however, relevant reports remain sparse. Herein, we developed a strain-promoted alkyne-nitrone cycloaddition (SPANC)-based click-release chemistry through installation of a carbamate-linked release moiety at the propargyl position of cyclooctyne, triggering a spontaneous elimination following click cycloaddition to achieve efficient payload liberation.

Burden of Disease Attributable to High Systolic Blood Pressure in Young Adults: An Analysis From the Global Burden of Disease Study 2021.

This study aims to fill this gap by leveraging Global Burden of Disease 2021 (GBD 2021) data to conduct a comprehensive assessment of the disease burden attributable to high systolic blood pressure (SBP) in young adults. Data from the Global Health Data Exchange were utilized to estimate the disease burden attributable to high SBP in young adults, stratified by overall disease, sex, socio-demographic index (SDI) level, GBD region, nation, and specific disease. In 2021, the overall disease attributable to high SBP in young adults was substantial, with approximately 24,626,362 disability-adjusted life years (DALYs) and 477,992 deaths, and the DALYs and mortality rates were 623.