Indobufen Versus Aspirin Plus Clopidogrel in Patients After Coronary Stenting in Patients With Diabetes: A Post Hoc Analysis of the OPTION Trial.

Background: Despite increased risk of ischemic events in diabetes, the optimal anti-thrombotic strategy for secondary prevention has not been defined. We aimed to assess the efficacy and safety of optimal antiplatelet agents such as indobufen-based dual antiplatelet therapy (DAPT) in patients with diabetes after coronary stenting.

Methods: OPTION trial was a randomized, open-label, noninferiority, and multicentric study in China.

Fetuin-A increases thrombosis risk in non-alcoholic fatty liver disease by binding to TLR-4 on platelets.

Aims: Fetuin-A, a liver-derived heterodimeric plasma glycoprotein, exhibits abnormal elevation in non-alcoholic fatty liver disease (NAFLD). Plasma fetuin-A levels correlate closely with both morbidity and mortality associated with cardiovascular diseases. However, the precise influence of fetuin-A on NAFLD-related platelet activation and thrombosis remains to be elucidated.

Endoplasmic Reticulum Stress-Induced triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Downregulation Exacerbates Platelet Activation and Myocardial Infarction in Patients With Coronary Artery Disease.

Background: Coronary artery disease is characterized by chronic immune-inflammation, excessive endoplasmic reticulum (ER) stress, and platelet hyperactivity; however, whether there is a signaling hub linking these events remains unclear. Here, we identified that TREM2 (triggering receptor expressed on myeloid cells 2), an important pattern recognition receptor of the innate immune system, may serve as one such hub.

Methods: TREM2 expression and ER stress were assessed in platelets.

Nitrogen Immobilization by Wood Fiber Substrates Strongly Affects the Photosynthetic Performance of Lettuce.

Wood fiber substrates are widely used as peat substitutes in horticulture, but the impact of their high carbon-to-nitrogen ratio on nitrogen immobilization and crop photosynthetic performance remains unclear. This study systematically examined the effects of wood fiber substrates on lettuce photosynthetic performance and underlying physiological mechanisms using pot experiments. Two substrate treatments-peat (control) and wood fiber-were combined with three nitrogen levels: low, medium, and high (63, 127, and 210 mg N·L).

The soluble guanylate cyclase (sGC) stimulator vericiguat inhibits platelet activation and thrombosis.

Background: Vericiguat, a soluble guanylate cyclase (sGC) stimulator, is used to treat chronic heart failure. Vericiguat can directly bind to the sGC in the absence of NO or stabilize the binding of NO to sGC, thereby stimulating cGMP production. Vericiguat correlates closely with the platelet activation.

The gut microbiota-bile acid-TGR5 axis orchestrates platelet activation and atherothrombosis.

Gut microbiota-derived bile acids are crucial in the pathogenesis and treatment of metabolic diseases. However, their impact on platelet activation and thrombosis in coronary artery disease (CAD) remains poorly understood. In this study, we observed reduced serum deoxycholic acid (DCA) in patients with CAD and an underrepresentation of Bacteroides vulgatus in the gut microbiota of patients with CAD, affecting DCA metabolism.

Intermittent fasting inhibits platelet activation and thrombosis through the intestinal metabolite indole-3-propionate.

Platelet hyperreactivity contributes significantly to thrombosis in acute myocardial infarction and stroke. While antiplatelet drugs are used, residual ischemic risk remains. Intermittent fasting (IF), a dietary pattern characterized by alternating periods of eating and fasting, has shown cardiovascular benefits, but its effect on platelet activation is unclear.

Research on the Modification Process of Jute Fiber as a Strengthening Material for the Structure of Solidification Substrate.

Substrate is the key material of soilless culture. The physical and chemical properties of the solidified cultivation medium are good and relatively stable, and there is no need to use plastic cultivation containers in the cultivation process, which has a broad application prospect in three-dimensional greening and fruit and vegetable planting. We have developed a novel substrate solidified process with high-frequency electromagnetic heating, which significantly reduces energy consumption compared to the traditional curing process with steam heating.

Indobufen-based dual antiplatelet therapy in patients with multivessel coronary disease undergoing drug-eluting stent implantation insight from the OPTION trial.

Background: It remains unclear whether indobufen-based dual antiplatelet therapy (DAPT) preserves ischemic protection while limiting bleeding risk in patients with multivessel coronary disease (MVD). This study aimed to investigate the efficacy and safety of indobufen-based DAPT in patients with MVD.

Methods: Patients in the OPTION trial were stratified based on the presence of MVD.

Double-stranded DNA enhances platelet activation, thrombosis, and myocardial injury via cyclic GMP-AMP synthase.

Aims: Elevated dsDNA levels in ST-elevated myocardial infarction (STEMI) patients are associated with increased infarct size and worse clinical outcomes. However, the direct effect of dsDNA on platelet activation remains unclear. This study aims to investigate the direct influence of dsDNA on platelet activation, thrombosis, and the underlying mechanisms.

Rapid Reduction of Phytotoxicity in Green Waste for Use as Peat Substitute: Optimization of Ammonium Incubation Process.

The rapid growth of the horticultural industry has increased demand for soilless cultivation substrates. Peat, valued for its physical and chemical properties, is widely used in soilless cultivation. However, peat is non-renewable, and over-extraction poses serious ecological risks.

The fate of organic compounds in organic waste during torrefaction and implications for its valorization.

Torrefaction is commonly used to improve biomass properties, applications, and economy. The characteristics and subsequent applications of torrefied biomass are largely contingent on the organic compounds in parent biomass and their evolution during torrefaction. Yet, the evolution of organic compounds in biomass particularly minor components (e.

Carboxymethylcellulose sodium-derived carbon aerogels for solar-driven water purification.

Recycling polluted water via different techniques has become one of the most feasible ways to solve the freshwater crisis. We describe a novel method to prepare reusable and efficient photothermal energy conversion materials for water purification. Using crosslinked xerogels as precursor, the porous and interconnected carboxymethylcellulose sodium-derived carbon aerogels (abbreviated as CCAs) with good hydrophilic performance and strong light absorption capability are firstly fabricated through pyrolysis.

Research Progress on Hygroscopic Agents for Atmospheric Water Harvesting Systems.

Adsorptive atmospheric water harvesting systems (AWHs) represent an innovative approach to collecting freshwater resources from the atmosphere, with a hygroscopic agent at their core. This method has garnered significant attention due to its broad applicability, strong recycling capacity, and sustainability. It is being positioned as a key technology to address global freshwater scarcity.

Microbial mechanism of biochar addition to reduce NO emissions from soilless substrate systems.

The soilless peat-based substrate partially solves the global soil problem in greenhouse vegetable production. However, it still produces serious NO emissions due to the application of nutrient solutions. The pyrolysis biochar is regarded as an effective measure to reduce soil NO emissions.

Nitrogen transformation and its microbial mechanism under co-composting of biogas slurry with garden waste.

Large amount of garden waste is consecutively produced in China every year. The composting with urea and microbial inoculum makes it possible to dispose garden waste in large quantities. However, composting accompanies with serious nitrogen loss and environmental problems.

Insights into production and consumption processes of nitrous oxide emitted from soilless culture systems by dual isotopocule plot and functional genes.

Soilless culture systems (SCS) play an increasing role in greenhouse vegetable production. In the SCS, soilless substrates serve as the major substitute for soil, supplying nutrients to plants but releasing greenhouse gases into the atmosphere. Remarkably, there is a serious problem of NO emission due to excessive input of N fertilizer.

Phytotoxicity of Chemical Compounds from Pruning Waste in Germination and Plant Cultivation.

Much previous research has indicated most composts of pruning waste are characterized by potential phytotoxicity, it is highly correlated with the chemical compounds of raw materials. a common kind of pruning waste in Southeast Asia and East Asia, is characterized by intense bioactivities due to complex chemical components. This study investigated the potential phytotoxicity of pruning waste in light of germination and higher plant growth.

Steam-Exploded Pruning Waste as Peat Substitute: Physiochemical Properties, Phytotoxicity and Their Implications for Plant Cultivation.

Peat is a nonrenewable resource that we are using at alarming rates. Development of peat alternative from pruning waste (PW) could be a cost- and environment-friendly way of disposal. Steam explosion (SE) is a commonly used pretreatment of lignocellulosic biomass, but its impact on the properties of PW as a growing substrate is largely unknown.

Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: a translational study.

Aims: Galectin-3, a β-galactoside-binding lectin, is abnormally increased in cardiovascular disease. Plasma Galectin-3 receives a Class II recommendation for heart failure management and has been extensively studied for multiple cellular functions. The direct effects of Galectin-3 on platelet activation remain unclear.

NOD2-mediated P2Y upregulation increases platelet activation and thrombosis in sepsis.

Background: Platelets from septic patients exhibit increased reactivity. However, the underlying mechanism of sepsis-induced platelet hyperactivity is still not completely understood.

Objective: P2Y is a central receptor for platelet activation.