Natural Polyphenol-Functionalized Schwann Cell-Derived Exosomes as a Temporal Neuromodulation Strategy for Diabetic Periodontitis Therapy.

An interactive bidirectional relationship between periodontitis and diabetes poses great challenges for the treatment of diabetic periodontitis in clinical practice. The hyperglycemic inflammatory periodontal microenvironment is characterized by oxidative damage, chronic invasive infection, excessive inflammation, unbalanced immunomodulation, progressive neuropathy, diabetic vasculopathy, and uncoupled bone resorption and formation responses. The neuromodulation strategy holds great potential to mediate and coordinate temporally the complex microenvironment for diabetic periodontal regeneration.

From Virtual Maxillomandibular Relationship Determination to Clinical Implementation for Digital Functional-Esthetic Rehabilitation in Severe Generalised Tooth Surface Loss.

Objective: The purpose of this article is to present a digital workflow to resolve functional-esthetic conflicts in severe generalised tooth surface loss (TSL).

Clinical Considerations: Key challenges in TSL involved compromised structural integrity of the dentition, necessitating precise occlusal rehabilitation to achieve a stable mandibular position and occlusion. The virtual patient-derived protocol introduced two technical advancements: (1) maxillomandibular relationship (MMR) determination through jaw kinematics capture, and (2) dynamic anterior guidance optimization via jaw motion tracking and dynamic articulation simulation.

The undescribed alkaloids from (less.) E. Wiebe and their anti-inflammatory activities.

From the whole herb of (Less.) E. Wiebe, one new alkaloid named cannabliold E (), one new natural alkaloid derivative named methyl 4-(2-oxo-1-pyrrolidinyl) benzene acetate () along with seven known alkaloids () were successfully isolated.

A Comparative Research of the Flavonoid Metabolites From Viscum coloratum in Normal and RA Rats by an Integrated Analytical Strategy.

Viscum coloratum (Kom.) Nakai has been demonstrated to be an effective treatment for rheumatoid arthritis (RA), but the pharmacodynamic substances are still unclear. In this study, a four-step strategy integrated nontargeted metabolomics, multivariate statistical analysis, and UNIFI software.

Steroidal saponins from the bulbs of Lilium lancifolium Thunb. and their antioxidant effects.

Nine previously undescribed compounds (1-9) and one known compound (10) are isolated from the bulbs of Lilium lancifolium Thunb. Of these compounds 1 and 2 feature unique structures based on the known polyoxypregnane skeleton. All the compounds are characterized via nuclear magnetic resonance and high-resolution mass spectrometry, and their cytotoxicity on rat adrenal pheochromocytoma cells (PC12 cells) and their antioxidant effects against hydrogen peroxide (HO)-induced oxidative damage in PC12 cells are evaluated.

Exploring risk and protective factors for anxiety in older adults living with chronic conditions: A longitudinal analysis.

Objective: This longitudinal study aims to explore risk and protective factors associated with anxiety to tailor supportive services for older adults according to their changing needs.

Methods: Utilizing rounds 5-9 of the National Health and Aging Trends Study (NHATS), 3541 older adults were studied. The Transactional Theory of Stress and Coping (TTSC) model was utilized to select predictors.

Saponins from (Fisch.) Bge Alleviated Neuronal Ferroptosis in Alzheimer's Disease by Regulating the NOX4/Nrf2 Signaling Pathway.

Alzheimer's disease (AD) is a chronic neurodegenerative disease of the central nervous system caused by loss of neuronal or myelin function, accompanied by ferroptosis. (Fisch.) Bge.

An integrated analysis strategy for characterization of chromones and coumarins from Saposhnikovia divaricata (Turcz.) Schischk. by UHPLC-QTOF-MS.

This study aimed to employ a comprehensive data screening strategy to identify the chromones and coumarins present in Saposhnikovia divaricata (SD). Initially, the five-point mass defect filter (MDF) method was utilized to screen the respective three subclasses of chromones and coumarins for MS. In comparison to the traditional MDF method, the number of interference peaks was reduced from 3462 to 1053, representing a decrease of 69.

Dictamnus dasycarpus turcz. Attenuates collagen-induced rheumatoid arthritis in DBA/1J mice through inhibiting IL-17 signaling pathway.

Ethnopharmacological Relevance: Rheumatoid Arthritis (RA), a chronic inflammatory autoimmune condition, presents a substantial challenge to public health. Dictamnus dasycarpus Turcz. (D.

Two new compounds from the roots of Pall. and their anti-inflammatory effects.

Two new compounds (-), together with six known ones (), were isolated from the roots of Pall. The structures of two new compounds were elucidated based on HR-ESI-MS, UV, and NMR spectroscopic data analysis. Moreover, the anti-inflammatory activities of compounds were determined using LPS-induced RAW 264.

Lignans from Schisandra chinensis (Turcz.) Baill ameliorates cognitive impairment in Alzheimer's disease and alleviates ferroptosis by activating the Nrf2/FPN1 signaling pathway and regulating iron levels.

Ethnopharmacological Relevance: Schisandra chinensis (Turcz.) Baill (S. chinensis), first recorded in Shennong's Classic of the Materia Medica, is described as a "top grade medicine".

New cytotoxic compounds from (Kom.) Nakai.

Twenty-one compounds were isolated and identified from the ethanol extract of (Kom.) Nakai, including two new compounds ( and ), a new artificial product () and eighteen known compounds (). Compounds and were isolated from for the first time.

Panax quinquefolium saponins protects neuronal activity by promoting mitophagy in both in vitro and in vivo models of Alzheimer's disease.

Ethnopharmacological Relevance: In the realm of traditional Chinese medicine, Panax quinquefolius L. has garnered significant attention for its potential to treat various ailments associated with deficiencies, including qi, blood, and kidneys. As its primary bioactive constituent, Panax quinquefolius saponins (PQS) have the potential therapeutic role of Alzheimer's disease (AD) treatment, but with unclear mechanisms of action.

Saikosaponins from Bupleurum scorzonerifolium Willd. alleviates microglial pyroptosis in depression by binding and inhibiting P2X7 expression.

Background: The major depressive disorder (MDD) is a heterogeneous condition and characterized by a high recurrence rate, with neuroinflammation playing a significant role in its various potential pathologies. In recent years, neuronal pyroptosis induced by neuroinflammation has garnered increasing attention in depression research. Bupleurum scorzonerifolium Willd.

Phytohormonal dynamics in the abscission zone of Korla fragrant pear during calyx abscission: a visual study.

Introduction: Phytohormones play a crucial role in regulating the abscission of plant organs and tissues.

Methods: In this study, the ultrastructure of the sepals of Korla fragrant pears was observed using a transmission electron microscope, and high-performance liquid and gas chromatography were used to analyze the dynamic changes of phytohormones in the abscission zone during the calyx abscission process of Korla fragrant pears, and mass spectrometry imaging was applied to ascertain the spatial distribution of phytohormones.

Results: The results revealed that the mitochondria in the abscission zone of the decalyx fruits were regularly distributed around the cell wall, and the chloroplasts were moderately present.

Three undescribed isosteroidal alkaloids from the bulbs of Fritillaria ussuriensis maxim: Anti-inflammatory activities, docking studies and molecular dynamic.

Three undescribed isosteroidal alkaloids (1-3), along with two known ones (4, 5) were isolated from the bulbs of Fritillaria ussuriensis Maxim, their structures were established by comprehensive analyses of the 1D, 2D-NMR and HR-ESI-MS data. Meanwhile, LPS-activated RAW 264.7 macrophages were used to determine the potential anti-inflammatory activity of all the alkaloids in vitro.

Taurochenodeoxycholic acid ameliorates the Staphylococcus aureus infection-induced acute lung injury through toll-like receptor 2 in mice.

Acute lung injury (ALI) is a significant clinical problem associated with high morbidity and mortality. Inflammation induced by gram-positive bacterial pathogens, specifically Staphylococcus aureus (S. aureus), plays a major role in ALI development and other infectious diseases.

Digitally driven tooth reduction guide combined with chairside tooth preparation monitoring tool for veneer preparation: A dental technique.

This article describes a completely digital workflow for ceramic veneer preparation with computer-aided design and computer-aided manufacturing technology. A simplified 3-dimensionally printed tooth reduction guide for accurate intraoral trial restorations is manufactured to indicate the range of the unprepared tooth surfaces erupted beyond the digital esthetic waxing. By using the Medit Design software program, chairside tooth preparation is monitored by accurate measurement of the amount of tooth reduction relative to the required restorative contours.

Extracellular vesicles meet mitochondria: Potential roles in regenerative medicine.

Extracellular vesicles (EVs), secreted by most cells, act as natural cell-derived carriers for delivering proteins, nucleic acids, and organelles between cells. Mitochondria are highly dynamic organelles responsible for energy production and cellular physiological processes. Recent evidence has highlighted the pivotal role of EVs in intercellular mitochondrial content transfer, including mitochondrial DNA (mtDNA), proteins, and intact mitochondria.

Triterpenoids from the leaves of Eleutherococcus sessiliflorus, and their antiproliferative activities in TNF-α induced HFLS-RA cells.

Five undescribed elesesterpenes L-U, along with nine known 3,4-seco-lupane-type triterpenoids were isolated from the leaves of Eleutherococcus sessiliflorus (Rupr. & Maxim.) S.

A new triterpenoid saponin and a new natural saponin from the roots of willd.

Sixteen triterpenoid saponins were isolated from the roots of Willd., including a new triterpenoid saponin and new natural saponin that was characterised by NMR for the first time, along with 14 known triterpenoid saponins. The structures of the compounds were established by 1D and 2D NMR spectroscopy, HR-ESI-MS, and comparison with the literature.