Natural Polyphenol-Functionalized Schwann Cell-Derived Exosomes as a Temporal Neuromodulation Strategy for Diabetic Periodontitis Therapy.

An interactive bidirectional relationship between periodontitis and diabetes poses great challenges for the treatment of diabetic periodontitis in clinical practice. The hyperglycemic inflammatory periodontal microenvironment is characterized by oxidative damage, chronic invasive infection, excessive inflammation, unbalanced immunomodulation, progressive neuropathy, diabetic vasculopathy, and uncoupled bone resorption and formation responses. The neuromodulation strategy holds great potential to mediate and coordinate temporally the complex microenvironment for diabetic periodontal regeneration.

Effectiveness of sirolimus for early on-set autoimmune cytopenias of autoimmune lymphoproliferative immunodeficiencies.

Background: Pediatric patients with autoimmune lymphoproliferative immunodeficiencies (ALPIDs) who exhibit autoimmune cytopenias are frequently diagnosed with immune thrombocytopenia (ITP), autoimmune hemolytic anemia (AIHA), or Evans syndrome (ES). These conditions generally necessitate long-term immunosuppressive therapy using medications that are often ineffective and highly toxic before the diagnosis of ALPIDs. A less harmful treatment strategy is needed.

CAR-T cell therapy in china: innovations, challenges, and strategic pathways.

Cancer immunotherapy has transformed oncology, with CAR-T cell therapy emerging as a cornerstone of personalized treatment for hematologic malignancies. In China, rapid advancements in domestically developed CAR-T therapies have achieved clinical outcomes comparable to global benchmarks, with overall response rates (ORR) of 79-89% in B-cell malignancies and 64% 12-month progression-free survival in multiple myeloma. Despite these successes, CAR-T application in solid tumors remains hindered by antigen heterogeneity, immunosuppressive microenvironments, and on-target/off-tumor toxicity.

Detecting infrared UAVs on edge devices through lightweight instance segmentation.

Motivation: Infrared unmanned aerial vehicle (UAV) detection for surveillance applications faces three conflicting requirements: accurate detection of pixel-level thermal signatures, real-time processing capabilities, and deployment feasibility on resource-constrained edge devices. Current deep learning approaches typically optimize for one or two of these objectives while compromising the third.

Method: This paper presents YOLO11-AU-IR, a lightweight instance segmentation framework that addresses these challenges through three architectural innovations.

Melanin-like nanofibers with highly ordered structures achieve ultrahigh specific electromagnetic interference shielding efficiency.

Lightweight, high-performance electromagnetic shielding materials rely on the precise design of electromagnetic response structures. Conventional shielding materials often involve complex fabrication of conjugated composites or graphitization of organic materials, facing challenges in balancing their performance and processability. As such, seeking and designing intrinsically conjugated materials with superior processability is crucial.

Singular jets with beads-on-a-string structures during the impact of elasto-viscoplastic droplets on superhydrophobic surfaces.

Hypothesis: A singular jet, as a phenomenon caused by flow singularity, is an important process for the transport of liquid in an extensive range of applications. New singular jet dynamics are expected during the impact of droplets of different non-Newtonian fluids.

Experiments: We study the impact of elasto-viscoplastic (EVP) droplets on super-hydrophobic surfaces via high-speed imaging, digital image processing, and theoretical analysis, focusing on the singular jet.

Regulation of the Light Absorption and Photothermal Performance of Melanin-Like Polymers.

ConspectusMelanin-like polymers have attracted significant attention for their excellent light absorption and photothermal conversion properties. Unlike sequence-controlled biomacromolecules such as proteins and DNA, natural melanin and its analogues derive their broadband light absorption and photothermal performance from heterogeneous polymerization of 5,6-dihydroxyindole (DHI), indolequinone (IQ), and uncycled dopamine derivatives, as well as simultaneous progressive assembly between different monomeric species or oligomers. A key challenge in this field lies in establishing their structure-property relationships as well as precisely regulating the light absorption and photothermal performance of these bioinspired polymers to meet specific application requirements.

The role of endoplasmic reticulum stress in Atrazine-induced hepatic lipid accumulation.

Atrazine (ATR) is an extensively applied triazine herbicide which belongs to the persistent environmental endocrine disruptors. ATR is capable of penetrating the body and disrupting lipid metabolism, but its underlying mechanism is still unclear. L02 hepatocytes were exposed to ATR (0 (Con), 10, 50, 100 μM) and 0.

SARS-CoV-2 encoded ORF3a interacts with YY1 to promote latent HCMV reactivation.

Human Cytomegalovirus (HCMV) is a commonly infected double-stranded DNA virus of the β-herpesviridae subfamily that typically establishes lifelong latency or persistent infection following primary infection. The regulation of HCMV latency and reactivation is governed by the chromatin structure at the viral major immediate early promoter (MIEP) within myeloid cells. Both cellular and viral factors play a role in regulating the reactivation of latent HCMV.

Self-Reported Resilience During the COVID-19 Pandemic.

Importance: Identifying factors associated with resilience during the COVID-19 pandemic can inform targeted interventions and resource allocation for groups disproportionately affected by systemic inequities.

Objective: To examine factors associated with self-reported resilience during the COVID-19 pandemic in racially and ethnically diverse, community-dwelling US adults.

Design, Setting, And Participants: This cross-sectional study was conducted as part of the Collaborative Cohort of Cohorts for COVID-19 Research (C4R) study, which assessed the associations of the pandemic with self-reported resilience of participants from 14 established US prospective cohorts since January 2021.

Efficacy and safety of ruxolitinib-based regimen in the treatment of paediatric Epstein-Barr virus-associated haemophagocytic lymphohistiocytosis.

Ruxolitinib (RUX) has demonstrated efficacy in haemophagocytic lymphohistiocytosis (HLH) patients, but large cohort studies regarding its clinical application in children with Epstein-Barr virus-associated HLH (EBV-HLH) remain scarce. This retrospective study analysed the efficacy and safety of RUX-based regimen (n = 53) and compared it with adjusted HLH-94 chemotherapy (n = 42) in the treatment of paediatric EBV-HLH. The patients treated with the RUX-based regimen received RUX monotherapy as front-line therapy.

CD4 T cells correlate with better prognosis in medulloblastoma.

Objective: T cells and tumor-associated macrophages (TAMs) are critical immune components within the brain tumor microenvironment (TME), yet their precise roles in medulloblastoma remains unclear. In this study, we examined the infiltration characteristics of T cells in medulloblastoma tissues and analyzed the correlation between T cells and the clinical outcomes of medulloblastoma patients. Additionally, we further investigated the relationship between T cells and TAMs.

Effects of miR-200b-3p and miR-424-5p regulating notch signaling pathway on atherosclerosis induced by PMin vitro.

Atmospheric particulate matter (PM) is one of the main pollutants of air pollution, which adsorbs several harmful organic substances, heavy metals, bacteria, and viruses. Epidemiological research has demonstrated that PM exposure might alter subclinical markers of atherosclerosis while the mechanism is unclear. In the current study, macrophages and foam cells that were differentiated from THP-1 cells were exposed to PM (0, 25, 50, and 100 μg/mL).

Innovative applications of silicon dioxide nanoparticles for targeted liver cancer treatment.

Liver cancer remains a major global health challenge, characterized by high mortality and limited treatment efficacy. Conventional therapies, including chemotherapy, immunotherapy, and viral vectors, are hindered by systemic toxicity, drug resistance, and high costs. Silica nanoparticles (SiONPs) have emerged as promising platforms for liver cancer therapy, offering precise drug delivery, stimuli-responsive release, and integrated diagnostic-therapeutic capabilities.

Intrathecal rituximab in pediatric CD20-positive central nervous system limited lymphoproliferative disease: report of two cases and literature review.

Isolated central nervous system (CNS) involvement due to posttransplantation proliferative disorder (PTLD) is even rarer, with only a few cases reported in the literature. CNS involvement in patients with mature B-cell non-Hodgkin's (NHL) and PTLD confers a significantly worse prognosis as compared to patients without CNS lymphoma disease. Treatment of CNS lymphoma (CNSL) is challenging due to resistance to conventional cytotoxic and intrathecal chemotherapy.

Smart polydopamine nanodot-knotted hydrogels for photodynamic tumor therapy.

Integrating nature-derived polyphenolic nanodots (PDs) with polymeric matrices presents a sustainable strategy for developing multifunctional nanocomposite hydrogels with enhanced biological performance. However, conventional PDs-knotted hydrogel fabrication methods still face significant challenges in regulating PDs properties and seamlessly incorporating them into hydrogel systems. Herein, we reported a facile and eco-friendly approach to construct polydopamine (PDA) nanodots polyethyleneimine (PEI)-mediated oxidative polymerization under mild aqueous conditions.

Tumor-associated macrophages correlate with better outcome in SHH medulloblastoma.

Objective: Tumor-associated macrophages (TAMs) constitute a significant proportion of the immune cell population within brain tumors. The polarization of macrophages exerts an important influence on the tumor microenvironment (TME). Nevertheless, the specific role of TAMs in sonic hedgehog (SHH) medulloblastoma remains unclear.

A natural polyphenolic nanoparticle--knotted hydrogel scavenger for osteoarthritis therapy.

Exploring highly efficient and cost-effective biomaterials for osteoarthritis (OA) treatment remains challenging, as current therapeutic strategies are difficult to eradicate the excessive reactive oxygen species (ROS) and nitric oxide (NO) at damaged sites. Tea polyphenol (TP) nanoparticles (NPs), a nature-inspired antioxidant in combination with 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO), a NO scavenger, could provide maximized positive therapeutic effects on OA by eradicating both ROS and NO. Notably, this combination not only improves the half-life of the TP monomer and the drug loading efficiency of carboxy-PTIO but also prevents nitrite from being harmful to tissue.

Genome-wide analysis of sugar transporter gene family in and , expression profiling and identification of transcription factors.

Sugar, the primary product of photosynthesis, is a vital requirement for cell activities. Allocation of sugar from source to sink tissues is facilitated by sugar transporters (ST). These STs belong to the Major Facilitator Superfamily (MFS), the largest family of STs in plants.

Idiopathic multicentric Castleman disease in children: a single-center retrospective analysis.

Objective: To investigate the clinical features, pathological phenotype, treatment and prognosis of idiopathic multicenter Castleman disease (iMCD)in children.

Methods: From January 2017 to September 2023, basic information, laboratory tests, treatment and prognosis of children diagnosed with iMCD who attended Beijing Children's Hospital of Capital Medical University were collected.

Results: A total of 9 children were enrolled, with a median age of onset of median 11 (2-15) years, 6 males and 3 female.

Single-cell RNA sequencing highlights the unique tumor microenvironment of small cell neuroendocrine cervical carcinoma.

Small cell neuroendocrine cervical carcinoma is a highly aggressive tumor characterized by early metastasis, a high recurrence rate, and poor prognosis. This study represents the first instance of single-cell sequencing conducted on small cell neuroendocrine carcinoma of the cervix worldwide. Analysis of gene expression regulatory networks revealed that the transcription factor TFF3 drived up-regulation of ELF3.

The highly allo-autopolyploid modern sugarcane genome and very recent allopolyploidization in Saccharum.

Modern sugarcane, a highly allo-autopolyploid organism, has a very complex genome. In the present study, the karyotype and genome architecture of modern sugarcane were investigated, resulting in a genome assembly of 97 chromosomes (8.84 Gb).

[The current situation and the future of pediatric blood transfusion].

With advancements in clinical medicine, pediatric blood transfusion has evolved from traditional empirical practices to evidence-based approaches grounded in clinical research data. To better guide pediatric blood transfusion practices and improve clinical outcomes for pediatric patients, the National Health Commission has developed and issued "Guideline for pediatric transfusion". This article summarizes the unique aspects of pediatric blood transfusion, the application of blood component therapy in treating pediatric patients, the significance of interpreting the "Guideline for pediatric transfusion", and anticipates future developments in pediatric blood transfusion medicine.

PM Induces the Instability of Atherosclerotic Plaques by Activating the Notch Signaling Pathway In Vivo and In Vitro.

Fine particulate matter (PM) can exacerbate the instability of atherosclerotic plaques although the exact chemical process driving atherosclerosis remains unknown. In order to create atherosclerotic models, a high-fat diet and vitamin D3 injections were given to 56 Wistar rats in this investigation. The atherosclerotic rats were split into four groups at random and given different doses of PM (0, 1.