Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Atmospheric particulate matter (PM) is one of the main pollutants of air pollution, which adsorbs several harmful organic substances, heavy metals, bacteria, and viruses. Epidemiological research has demonstrated that PM exposure might alter subclinical markers of atherosclerosis while the mechanism is unclear. In the current study, macrophages and foam cells that were differentiated from THP-1 cells were exposed to PM (0, 25, 50, and 100 μg/mL). PM exposure reduce the expression of miR-200b-3p and miR-424-5p, thereby regulating the Notch signaling pathway in macrophages and foam cells, which affects the expression of lipid metabolism-related genes (ABCA1, LDLR, SR-A, SR-BI and CD36) and aggravates the dysfunction of lipid metabolism and leads to atherosclerosis. The study provides new ideas for the prevention and treatment of atherosclerosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tox.2025.154216 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of miR-200b-3p and miR-424-5p regulating notch signaling pathway on atherosclerosis induced by PMin vitro.
Toxicology
November 2025
Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China. Electronic address:
Atmospheric particulate matter (PM) is one of the main pollutants of air pollution, which adsorbs several harmful organic substances, heavy metals, bacteria, and viruses. Epidemiological research has demonstrated that PM exposure might alter subclinical markers of atherosclerosis while the mechanism is unclear. In the current study, macrophages and foam cells that were differentiated from THP-1 cells were exposed to PM (0, 25, 50, and 100 μg/mL).
View Article and Find Full Text PDFmiR-429 and miR-424-5p inhibit cell proliferation and Ca influx by downregulating CaSR in pulmonary artery smooth muscle cells.
Am J Physiol Cell Physiol
January 2019
Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei , People's Republic of China.
Cytosolic free Ca concentration is a key factor in pulmonary vasoconstriction and vascular remodeling of pulmonary artery smooth muscle cells (PASMCs). These processes contribute to pulmonary arterial hypertension and are influenced by expression of calcium-sensing receptor (CaSR). Although regulation of CaSR expression is precisely controlled, the contribution of microRNAs (miR) is incompletely understood.
View Article and Find Full Text PDF