Multi-mirror-aided digital image correlation for internal and external panoramic deformation measurement.

This study developed a variable-attitude multi-mirror-assisted digital image correlation method for realizing the simultaneous measurement of panoramic deformation inside and outside a tubular structure. The setup consists of a co-axial imaging system containing three variable-attitude optical mirrors and the necessary cold light source. The arrangement and attitude adjustment of the mirrors are the key to realizing panoramic imaging, thus enabling simultaneous imaging of the interior and exterior surfaces of a pipe.

Cell graph analysis in hepatocellular carcinoma: predicting local recurrence and identifying spatial relationship biomarkers.

A whole pathology section contains approximately 1,000,000 cells of various types, this large-scale heterogeneity of cells and non-cellular constituents constructs a mutually competitive community. Conventional pixel-based visual processing techniques are insufficient to accurately capture the complexities inherent with cell-entity deployment and formation strategy. Here, we conquered segmentation and classification of all cells on the whole pathology sections from 387 hepatocellular carcinoma (HCC) patients across six cohorts with 57 pathologists assisted.

TPEN loaded poly (lactide-co-glycolide) nanoparticles promote neuroprotection and optic nerve regeneration.

Development of novel therapeutics for retinal ganglion cells (RGCs) protection and axon regeneration in neurodegenerative diseases, for example, glaucoma, are critical challenges in clinical treatment. Utilization of N, N, N', N'-tetrakis-(2-Pyridylmethyl) ethylenediamine (TPEN), a specific chelator of Zn, revealed positive medical potentials. However, its therapeutic effect in promoting RGCs survival and axon regeneration is restricted due to the inefficient drug delivery and limited absorption.

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia.

Purpose: The purpose of this study was to determine the influence of optic nerve head (ONH) rotation and tilt on the structure-function (S-F) relationship differences between early open-angle glaucoma (OAG) with and without high myopia (HM).

Methods: A total of 164 eyes, including 69 early highly myopic glaucoma (HMG) eyes, 60 early OAG eyes, and 35 healthy HM eyes, were included. All the eyes underwent spectral-domain optical coherence tomography, standard automated perimetry, and fundus photography simultaneously.

Modulating Coordination Environment of Single Nickel Atom in Covalent Organic Framework to Enhance Photocatalytic Hydrogen Evolution Reaction.

Covalent organic frameworks (COFs) have emerged as fascinating platforms for photocatalytic hydrogen evolution reactions in recent years. However, the relationship between the coordination environment of metals in a covalent organic framework and catalytic properties is still rarely studied. In this study, a covalent organic framework (COF-BP), containing a benzothiazole unit with typical electron-withdrawing properties, was successfully synthesized from 4,4'-(benzo-2,1,3-thiadiazole-4,7-diyl)dianiline and 3,3',5,5'-tetraformyl-4,4'-biphenyldiol.

Confinement Microenvironment Regulation of Carbon Dots in Zeolite for Multi-Mode Time-Dependent Phosphorescence Color Evolution.

Matrix immobilization has been proven to be a favored method for enhancing the phosphorescence of carbon dots (CDs), however, it remains a significant challenge to realize time-dependent phosphorescence colors (TDPC) by embedding CDs with single emission center. In this study, we present a novel matrix-controlling strategy to regulate the microenvironment of CDs by doping limited Mn in zeolite. The surrounding environment influences the surface state of the CDs, leading to the formation of different excitons.

Modulating amacrine cell-derived dopamine signaling promotes optic nerve regeneration and preserves visual function.

As part of the central nervous system, the optic nerve, composed of axons from retinal ganglion cells (RGCs), generally fails to regenerate on its own when injured in adult mammals. An innovative approach to promoting optic nerve regeneration involves manipulating the interactions between amacrine cells (ACs) and RGCs. Here, we identified a unique AC subtype, dopaminergic ACs (DACs), that responded early after optic nerve crush by down-regulating neuronal activity and reducing retinal dopamine (DA) release.

Intracellular Zn promotes extracellular matrix remodeling in dexamethasone-treated trabecular meshwork.

Given the widespread application of glucocorticoids in ophthalmology, the associated elevation of intraocular pressure (IOP) has long been a vexing concern for clinicians, yet the underlying mechanisms remain inconclusive. Much of the discussion focuses on the extracellular matrix (ECM) of trabecular meshwork (TM). It is widely agreed that glucocorticoids impact the expression of matrix metalloproteinases (MMPs), leading to ECM deposition.

[Retracted] miR‑885‑5p upregulation promotes colorectal cancer cell proliferation and migration by targeting suppressor of cytokine signaling.

[This retracts the article DOI: 10.3892/ol.2018.

Reduced Zn promotes retinal ganglion cells survival and optic nerve regeneration after injury through inhibiting autophagy mediated by ROS/Nrf2.

The molecular mechanism of how reduced mobile zinc (Zn) affected retinal ganglion cell (RGC) survival and optic nerve regeneration after optic nerve crush (ONC) injury remains unclear. Here, we used conditionally knocked out ZnT-3 in the amacrine cells (ACs) of mice (CKO) in order to explore the role of reactive oxygen species (ROS), nuclear factor erythroid 2-related factor 2 (NFE2L2, Nrf2) and autophagy in the protection of RGCs and axon regeneration after ONC injury. We found that reduced Zn can promote RGC survival and axonal regeneration by decreasing ROS, activating Nrf2, and inhibiting autophagy.

Thiazolo[5,4-]thiazole-Based Metal-Organic Framework for Catalytic CO Cycloaddition and Photocatalytic Benzylamine Coupling Reactions.

Metal-organic frameworks (MOFs) with permanent porosity and multifunctional catalytic sites constructed by two or more organic ligands are regarded as effective heterogeneous catalysts to improve certain organic catalytic reactions. In this work, a pillared-layer Zn-MOF () was constructed by 2,3,5,6-tetrakis(4-carboxyphenyl)pyrazine (HTCPP) and 2,5-di(pyridin-4-yl)thiazolo[5,4-]thiazole (DPTZTZ). After activation, has a permanent porosity and moderate CO adsorption capacity.

Tafluprost promotes axon regeneration after optic nerve crush via Zn-mTOR pathway.

Purpose: To investigate whether Tafluprost could promote optic nerve regeneration in mice after optic nerve crush (ONC) and determine the underlying molecular mechanism.

Methods: Tafluprost was injected into the vitreous body immediately after ONC. The level of Zn in the inner plexiform layer (IPL) of the retina was stained using autometallography (AMG).

Te-hybridized zeolitic imidazolate frameworks-derived core-shell design toward dendrite-free Zn anode for long-term aqueous zinc-ion batteries.

Hypothesis: Aqueous zinc-ion batteries (AZIBs) have received considerable attention owing to their safety, low cost, and environmental benignity. However, the side reactions of hydrogen evolution revolution and Zn dendrite growth reduce the Coulombic efficiency and life span of AZIBs. To address these issues, we designed an artificial protective layer of a Te-hybridized core-shell zeolitic imidazolate framework (ZIF).

A graph network model for neural connection prediction and connection strength estimation.

. Reconstruction of connectomes at the cellular scale is a prerequisite for understanding the principles of neural circuits. However, due to methodological limits, scientists have reconstructed the connectomes of only a few organisms such as, and estimated synaptic strength indirectly according to their size and number.

The improvement effect of astaxanthin-loaded emulsions on obesity is better than that of astaxanthin in the oil phase.

Emulsion-based delivery systems have been reported to improve the solubility, stability and bioavailability of astaxanthin. In this study, the ability of astaxanthin-loaded emulsions (AL) to ameliorate obesity induced by a high-fat and high-sucrose diet was explored, using astaxanthin in the oil phase (ASTA) as a comparison. After the administration of AL, ASTA (30 mg per kg body weight), or saline on normal or obese mice for 4 weeks, the body fat accumulation levels, hepatic lipid contents and hepatic fatty acid profiles were detected, and AL showed better anti-obesity properties than ASTA.

Intercalation of Zinc Monochloride Cations by Deep Eutectic Solvents for High-Performance Rechargeable Non-aqueous Zinc Ion Batteries.

Zinc ion batteries have been extensively studied with an aqueous electrolyte system. However, the batteries suffer from a limited potential window, gas evolution, cathode dissolution, and dendrite formation on the anode. Considering these limitations, we developed an alternative electrolyte system based on deep eutectic solvents (DESs) because of their low cost, high stability, biodegradability, and non-flammability, making them optimal candidates for sustainable batteries.

Frequency and Spectrum of Mutations Induced by Gamma Rays Revealed by Phenotype Screening and Whole-Genome Re-Sequencing in .

Genetic variations are an important source of germplasm diversity, as it provides an allele resource that contributes to the development of new traits for plant breeding. Gamma rays have been widely used as a physical agent for mutation creation in plants, and their mutagenic effect has attracted extensive attention. However, few studies are available on the comprehensive mutation profile at both the large-scale phenotype mutation screening and whole-genome mutation scanning.

Generalized optical design and optimization of multipass cells with independent circle patterns based on the Monte Carlo and Nelder-Mead simplex algorithms.

In this paper, we propose an automatic approach to optimize the multipass cell (MPC) design with independent circle patterns. First, the Monte Carlo algorithm is performed to globally search for the characteristic values of the distance between two mirrors. Second, the Nelder-Mead simplex (NM) algorithm is applied to locally optimize the re-entry condition.

Genetic Variants of the Gene and Susceptibility of Rectal Cancer.

Background: Rectal cancer (RC) has been documented to be a highly invasive malignant neoplasm worldwide. Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine involved in cell-mediated immunity, immunoregulation, inflammation. In vitro and in vivo studies have identified that MIF was involved in the carcinogenesis and progression of RC.

Design of Core-Shell Quantum Dots-3D WS Nanowall Hybrid Nanostructures with High-Performance Bifunctional Sensing Applications.

Transition metal dichalcogenides (TMDCs) have recently attracted a tremendous amount of attention owing to their superior optical and electrical properties as well as the interesting and various nanostructures that are created by different synthesis processes. However, the atomic thickness of TMDCs limits the light absorption and results in the weak performance of optoelectronic devices, such as photodetectors. Here, we demonstrate the approach to increase the surface area of TMDCs by a one-step synthesis process of TMDC nanowalls from WO into three-dimensional (3D) WS nanowalls.

Three-Dimensional Molybdenum Diselenide Helical Nanorod Arrays for High-Performance Aluminum-Ion Batteries.

The rechargeable aluminum-ion battery (AIB) is a promising candidate for next-generation high-performance batteries, but its cathode materials require more development to improve their capacity and cycling life. We have demonstrated the growth of MoSe three-dimensional helical nanorod arrays on a polyimide substrate by the deposition of Mo helical nanorod arrays followed by a low-temperature plasma-assisted selenization process to form novel cathodes for AIBs. The binder-free 3D MoSe-based AIB shows a high specific capacity of 753 mAh g at a current density of 0.

High-Performance Rechargeable Aluminum-Selenium Battery with a New Deep Eutectic Solvent Electrolyte: Thiourea-AlCl.

Aluminum-sulfur batteries (ASBs) have attracted substantial interest due to their high theoretical specific energy density, low cost, and environmental friendliness, while the traditional sulfur cathode and ionic liquid have very fast capacity decay, limiting cycling performance because of the sluggishly electrochemical reaction and side reactions with the electrolyte. Herein, we demonstrate, for the first time, excellent rechargeable aluminum-selenium batteries (ASeBs) using a new deep eutectic solvent, thiourea-AlCl, as an electrolyte and Se nanowires grown directly on a flexible carbon cloth substrate (Se NWs@CC) by a low-temperature selenization process as a cathode. Selenium (Se) is a chemical analogue of sulfur with higher electronic conductivity and lower ionization potential that can improve the battery kinetics on the sluggishly electrochemical reaction and the reduction of the polarization where the thiourea-AlCl electrolyte can stabilize the side reaction during the reversible conversion reaction of Al-Se alloying processes during the charge-discharge process, yielding a high specific capacity of 260 mAh g at 50 mA g and a long cycling life of 100 times with a high Coulombic efficiency of nearly 93% at 100 mA g.

LncRNA MIR503HG is downregulated in Han Chinese with colorectal cancer and inhibits cell migration and invasion mediated by TGF-β2.

In this study we investigated the role of lncRNA MIR503HG in colorectal cancer (CRC). We found that MIR503HG was downregulated and TGF-β2 was upregulated in CRC included in this study. Low levels of MIR503HG were associated with poor survival of CRC patients within 5 years after admission.