Faecalibacterium prausnitzii alleviates Graves' orbitopathy by modulating short-chain fatty acid (SCFA) metabolism and inhibiting orbital fibrosis and adipogenesis.

Graves' orbitopathy (GO) is an autoimmune inflammatory disorder characterized by orbital fibrosis and adipose tissue expansion, leading to proptosis and ocular dysfunction. Recent evidence suggests that gut microbiota dysbiosis contributes to GO pathogenesis, particularly through alterations in short-chain fatty acid (SCFA) metabolism. This study investigated the role of Faecalibacterium prausnitzii (F.

Solid-State Thermal Decomposition in a Cu-Rich Cu-Ti-Zr Alloy.

Solid-state thermal decomposition in the Cu-13.3Ti-3.8Zr (at.

Combining biomarkers to predict the disease activity of graves' ophthalmopathy: a combinatory model of the NLR, TRAb and FT4.

Purpose: The aim of this study was to identify potential biomarkers associated with active Graves' ophthalmopathy (GO) and develop a model for predicting the occurrence and progression of active GO.

Methods: A retrospective study was conducted on 220 GO patients (n=120 in the active phase, n=100 in the stable phase) and 70 healthy controls. Laboratory and other clinical indicators were compared in GO patients at different stages and healthy controls.

Peripartum antihypertensive use and the risk of neonatal hypoglycemia and postpartum uterine atony: a retrospective cohort study.

Objectives: Determine whether peripartum antihypertensive use increases secondary uterotonic use, neonatal hypoglycemia, bradycardia, or NICU admission. Hypertensive disorders of pregnancy are common and increasing. Treatment includes beta- and calcium channel- blocking medications.

Comparison of Direct Aspiration With SOFIA Distal Access Catheter and Solitaire Retrievable Stent-Induced Thrombolysis for the Treatment of Acute Ischemic Stroke.

Direct aspiration with soft torqueable catheter optimized for intracranial access (SOFIA) distal access catheter and Solitaire retrievable stent-induced thrombolysis are two commonly used interventional therapy methods in acute ischemic stroke (AIS). Despite their distinctive advantages, these surgical methods need to be further studied and compared to help with treatment selection. Therefore, this study aims to analyze the distinct effects of SOFIA distal access catheter direct aspiration and Solitaire retrievable stent-induced thrombolysis in the treatment of AIS.

B-cell depletion therapy reduces retinal inflammation in experimental autoimmune uveoretinitis.

Objective: Non-infectious uveitis (NIU) is recognized as a group of autoimmune sight-threatening disorders with complex pathogenesis. This study aims to analyze the pathogenic role of B cells in NIU and evaluate the effectiveness of B cell depletion therapy in experimental autoimmune uveoretinitis (EAU) mice.

Methods: We performed high throughput transcriptome sequence on peripheral blood samples from healthy individuals (n = 6) and NIU patients (n = 12), and reanalyzed single-cell RNA transcriptome data of aqueous humor in NIU patients (n = 5).

Butyrate Ameliorates Graves' Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota.

Purpose: Graves' orbitopathy (GO), the common extrathyroidal complication of Graves' disease (GD), is characterized by orbital fibroblast stimulation, adipogenesis, and hyaluronan production. Recently, gut microbiota and its metabolites have garnered attention for their possible involvement in GO.

Methods: This study utilized an animal model of GO and examined the effects of butyrate treatment on orbital fibroblast cells and gut microbiota.

Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves' Ophthalmopathy.

Purpose: Graves' ophthalmopathy (GO), the most common extrathyroidal manifestation of Graves' disease, is disabling and disfiguring. Recent studies have shown that statins have a protective effect on individuals with GO. Statins were reported to trigger ferroptosis in some disorders, but little is known about whether statins protect against GO via ferroptosis.

Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study.

Objective: Intracerebral hemorrhage (ICH) is a common cerebrovascular disease characterized by high mortality and disability rates. Neuritin, significantly expressed in injured brain tissues, is implicated in the molecular mechanisms underlying acute brain injury. We aimed to explore the prognostic and predictive value of serum neuritin in ICH.

Design and evaluation of C18 stationary phases with different polar-embedded groups for liquid chromatography.

New stationary phases including polar embedded stationary phases that are capable of utilising green mobile phases have recently emerged. This study presents two straightforward strategies for preparing C18 phases with distinct polar-embedded groups: thioether (C18) and quaternary ammonium (C18). The two strategies were assessed based on convenience, cost, yield, and time efficiency.

Microstructure and Bioactivity of Ca- and Mg-Modified Silicon Oxycarbide-Based Amorphous Ceramics.

Silicon oxycarbide (SiOC), Ca- and Mg-modified silicon oxycarbide (SiCaOC and SiMgOC) were synthesized via sol-gel processing with subsequent pyrolysis in an inert gas atmosphere. The physicochemical structures of the materials were characterized by XRD, SEM, FTIR, and Si MAS NMR. Biocompatibility and in vitro bioactivity were detected by MTT, cell adhesion assay, and simulated body fluid (SBF) immersion test.

MGFusion: a multimodal large language model-guided information perception for infrared and visible image fusion.

Existing image fusion methods primarily focus on complex network structure designs while neglecting the limitations of simple fusion strategies in complex scenarios. To address this issue, this study proposes a new method for infrared and visible image fusion based on a multimodal large language model. The method proposed in this paper fully considers the high demand for semantic information in enhancing image quality as well as the fusion strategies in complex scenes.

Oxidation Behavior of Aluminide Coatings on Cobalt-Based Superalloys by a Vapor Phase Aluminizing Process.

In this work, the oxidation behavior of an aluminide coating at 900, 1000, and 1100 °C was investigated. The aluminide coating was prepared on a cobalt-based superalloy using a vapor phase aluminizing process, which is composed of a β-(Co,Ni)Al phase outer layer and a Cr-rich phase diffusion layer. The experimental results showed that the oxidation of the coating at 900-1100 °C all obey the parabolic law.

Microstructure Evolution and Mechanical Properties of 16-Layer 2195 Al-Li Alloy Components Manufactured by Additive Friction Stir Deposition.

The fabrication of multi-layer alloys by additive friction stir deposition (AFSD) results in a complicated microstructure and mechanical property evolution due to the repeated thermal inputs impacting the existing deposited layers. This work systematically studied the microstructure and mechanical properties of several areas (last layers, intermediate layers, and first layers) of a 16-layer 2195 alloy component fabricated by AFSD to ascertain the effect of repeated thermal cycling. The periodic heat input resulted in the minimal quantities of T-phase only appearing in the last layers of the sample, while the θ'-phase developed a complex precipitate with the δ' and β' phases.

Anesthetic Considerations and Blood Utilization for Placenta Accreta Spectrum.

The anesthetic management of the patient with placenta accreta spectrum begins before surgery by assessing the patient and their comorbidities and providing psychological preparation for the perioperative period. Choosing neuraxial or general anesthesia for surgery balances the procedure's clinical needs with the patient's desires. Intraoperatively, management of homeostasis during acute blood loss requires assessments of central volume to avoid over-transfusion.

Unravelling T-cell dynamics and immune responses in initial and recurrent uveitis.

This study aimed to identify novel serological targets and investigate immune responses in patients with non-infectious uveitis, focusing on differences between initial onset and recurrent episodes. Differential gene expression analysis, immunocyte typing and T-cell receptor (TCR) gene analysis were conducted on RNA-sequenced peripheral blood samples from healthy individuals (n = 6) and non-infectious uveitis patients (n = 12), divided into 6 patients each at initial onset and recurrent stages. Peripheral blood T-cell types were analysed using flow cytometry.

Zotarolimus alleviates post-trabeculectomy fibrosis via dual functions of anti-inflammation and regulating AMPK/mTOR axis.

Objective: Postoperative scar formation is the primary cause of uncontrolled intraocular pressure following trabeculectomy failure. This study aimed to evaluate the efficacy of zotarolimus as an adjuvant anti-scarring agent in the experimental trabeculectomy.

Methods: We performed differential gene and Gene Ontology enrichment analysis on rabbit follicular transcriptome sequencing data (GSE156781).

Tribocorrosion Behavior of NiCoCrMoCu Alloys Containing Different Carbides in Acidic Media at Various Applied Loads and Sliding Speeds.

In this study, the ball-on-disk sliding wear and tribocorrosion behavior in the HSO and HCl solution of NiCoCrMoCu alloys with carbon additions of 0.2, 1, 1.5, and 2 wt.

Optimizing the cell compatibility and mechanical properties in TiZrNbTa medium-entropy alloy/β-Ti composites through phase transformation.

Medium-entropy alloys (MEAs) typically exhibit outstanding mechanical properties, but their high Young's modulus results in restricted clinical applications. Mismatched Young's modulus between implant materials and human bones can lead to "stress shielding" effects, leading to implant failure. In contrast, β-Ti alloys demonstrate a lower Young's modulus compared to MEAs, albeit with lower strength.

Retention behavior of nucleosides and nucleobases on a 3 μm undecylenic acid-functionalized silica column in per aqueous liquid chromatography and hydrophilic interaction liquid chromatography separation modes.

A 3 μm undecylenic acid-functionalized stationary phase (UAS) was prepared for the separation of nucleosides and nucleobases using per aqueous liquid chromatography (PALC) and hydrophilic interaction liquid chromatography (HILIC). The retention behaviors of nucleosides and nucleobases in PALC and HILIC modes were explored by adjusting parameters such as water content, buffer concentration, pH of the mobile phase and column temperature. The experimental data and separation chromatogram demonstrated that PALC could provide retention comparable to that of HILIC for nucleosides and nucleobases.

Analysis of the Relationship Between the Changes of Serum SAA, LP-PLA2, sCD40L and Carotid Atherosclerosis Plaque in Patients with Acute Cerebral Infarction.

Objective: To explore the relationship between Serum amyloid protein A(SAA), lipoprotein-associated Phospholipase A2 (Lp-PLA2) and soluble CD40 ligand (sCD40L) in detecting the stability of carotid Atherosclerosis plaque.

Methods: We examined 90 patients admitted to our hospital with acute cerebral infarction from July 2020 to December 2022. Carotid artery ultrasounds were performed for all of them.

Effect of Heat Treatment States of Feedstock on the Microstructure and Mechanical Properties of AA2219 Layers Deposited by Additive Friction Stir Deposition.

This study is the first to research the microstructure and mechanical properties of the workpiece after additive friction stir deposition (AFSD) of the feedstock at different heat treatment stages. AA2219 aluminum alloys with three different heat treatment stages were selected as the feedstock, and alloys with dense structure were successfully prepared by the additive friction stir deposition AFSD process. Experimental results show that AFSD exhibits an excellent ability to refine grains and improve the uniform distribution of precipitates in the second phase, thereby improving the plasticity of AA2219 alloy after the AFSD process.

Enhanced Anti-Corrosion Performance of Co-Cr-Mo Alloy in Molten Al by Prior Oxidation Treatment.

Co-based alloys are promising alternatives to replace the currently used tool steels in aluminum die-casting molds for producing sophisticated products. Although the reaction is significantly less severe compared to that of tool steels, bare Co-29Cr-6Mo (CCM) alloy is still gradually corroded under molten Al, leading to the local failure of the alloy due to the formation of intermetallic compounds between the matrix and molten Al. This study indicated that prior oxidation treatment at 750 °C on CCM alloy is beneficial in enhancing the corrosion resistance of the alloy to molten Al.

Enhanced Mechanical Properties of Cast Cu-10 wt%Fe Alloy via Single-Pass Friction Stir Processing.

In this study, Cu-10 wt% Fe alloy in as-cast state was modified using friction stir processing (FSP). The microstructure evolution of Cu-10 wt% Fe alloys in different states was characterized in detail using scanning electron microscopy (SEM), electron backscatter diffraction (EBSD) and transmission electron microscopy (TEM). The results show that due to dynamic recrystallization, the FSPed Cu-10 wt% Fe alloy obtained a uniformly equiaxed ultrafine microstructure with low density of dislocation, high proportion of high-angle grain boundaries (HAGBs), and high degree of recrystallization.