m6A mRNA methylation initiated by METTL14 promotes STK11 translation and increases STK11 activity to induce anti-HER2 therapy resistance in breast cancer.

Resistance to HER2-targeted therapies presents a major challenge in the treatment of patients with HER2-positive breast cancer. N(6)-methyladenosine (m6A) modification plays a critical role in tumor progression; however, its role in mediating resistance to anti-HER2 therapy remains poorly defined. In trastuzumab-resistant HER2-positive breast cancer tissues, METTL14 expression is significantly upregulated and correlates with poor trastuzumab response.

Novel near-infrared solid-state probe for monitoring carbon monoxide in cholestatic liver injury and toxic hepatitis.

Carbon monoxide (CO) is an important gas transporter and is closely related to a variety of physiological and pathological processes. Many fluorescent probes have been prepared for detecting CO, but most of them suffer from water-soluble fluorophores, which diffuse easily and are limited for application . Herein, a new solid-state fluorophore (HPQ-IM-OH) is prepared by introducing isophorone to HPQ, which has a long emission wavelength (680 nm) and good diffusion-resistance ability.

Homogeneous Memristors with Tunable Decay Dynamics for Self-Adaptive Reservoir Computing.

Leveraging inherent nonlinear dynamics, memristors have demonstrated superior performance in reservoir computing (RC). However, the use of different materials for reservoir nodes and readout layers poses significant challenges to integration. Moreover, the reported RC systems generally employ fixed reservoir nodes with limited temporal dynamics, which severely restricts the processing of sequences with complex temporal features in practical applications.

Construction of a novel disulfidptosis-associated lncRNAs signature for risk features and immunotherapy in breast cancer.

Background: Disulfide death (disulfidptosis) is closely associated with tumor occurrence and progression. This study seeks to investigate the clinical prognostic value of disulfidptosis-related long non-coding RNAs (lncRNAs), explore their association with the tumor microenvironment, and evaluate their capacity to predict drug sensitivity in breast cancer (BRCA) patients.

Methods: From The Cancer Genome Atlas (TCGA) database, RNA sequencing expression profiles and corresponding clinical data of BRCA patients were obtained.

ATP-responsive nanoparticles for improved chemodynamic therapy and dual starvation therapy.

Cancer has become a serious threat to human health and the search for a safe and effective treatment method is particularly urgent. Chemodynamic therapy (CDT) is a non-invasive therapeutic method, but CDT still has certain disadvantages such as its limited therapeutic efficacy through overexpression of GSH and single treatment mode. In this paper, ZIF-based nanoparticles called Cu-SK-GOD@ZIF-90 are constructed for improved chemodynamic therapy and dual starvation therapy (ST).

Relationship between surface pollen and their vegetation in Hupingshan National Nature Reserve, Hunan Province, China.

Hupingshan National Nature Reserve, located in Hunan Province, South Central China, is characterized by rich biodiversity, complex floral composition, pronounced human perturbation, dominant secondary vegetation, low dominance of constructive species, and complex and diverse pollen assemblage characteristics. We explored the relationship between surface pollen assemblages and vegetation characteristics using 34 samples. The results showed that arboreal pollen accounted for 84.

Anion Doping Synergistic Strategy Achieving Multi-Interfaces and Modulated Dielectric Coupling for Efficient Electromagnetic Response.

Efficient microwave absorbers are needed to address the electromagnetic pollution caused by the proliferation of new radio technologies and equipment. Excellent microwave absorption performance can be achieved by controlling the dielectric constant. Heteroatom-doped bimetallic materials are promising electromagnetic wave absorption (EMA) materials due to their tunable structures and low cost.

MnO/MnS nanoparticles encapsulated in Lycopodium spores derived nitrogen-doped porous carbon as a cost-effective peroxymonosulfate activator for pollutant decontamination: Insight into the mechanism of electron transfer-dominated non-radical pathway.

The rational design and exploitation of cost-effective and robust catalysts for peroxymonosulfate (PMS) activation is of great significance. Herein, MnO/MnS nanoparticles encapsulated in Nitrogen-doped porous carbon skeleton (abbreviated as MnO/MnS@NPC) were first constructed through an easy two-step of impregnation along with subsequent pyrolysis technique and utilized to activate PMS for the elimination and mineralization of tetracycline (TC). Benefiting from the strong coupling of transition metal Mn with carbon-based material, the co-doping of heteroatom N and S, the enhanced electrical conductivity, and the hierarchical porous microarchitecture, the obtained MnO/MnS@NPC composite has been expected to present superior PMS activation capacity and pollutant elimination efficiency to its benchmark NPC and MnO@NPC, with 92.

Enhancement of Two Types of CO Conversion by Regulating Functional Thiophene Groups within Zn-MOF.

Sustainable conversion of epoxides and propargylic amines using CO could produce valuable chemical products. Efficient conversion generally requires harsh conditions such as noble-metal catalysts, cocatalysts, and toxic solvents, thereby underscoring the crucial need for environmentally friendly non-noble-metal metal-organic framework (MOF) catalysts. In this study, we designed a novel zinc-based metal-organic framework (MOF) with a 5-fold interpenetrating diamond framework, specifically {[Zn(DMTDC)(bpy)]·HO} (), where HDMTDC represents 3,4-dimethylthieno[2,3-]thiophene-2,5-dicarboxylic acid and bpy denotes 4,4'-bipyridine.

Diagnostic and Prognostic Value of Serum Golgi Protein 73 in Patients With Hepatitis B Virus-Associated Acute-on-Chronic Liver Failure.

Background And Aims: The prognosis and severity of hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) cannot be well-identified by serum biomarkers. The present study aims to determine the role of serum Golgi protein 73 (GP73) in predicting the prognosis and severity of liver necrotizing inflammation induced by HBV-ACLF.

Methods: A total of 427 chronic HBV-infected patients were included for the present study.

Synthesis of P(AM/AA/SSS/DMAAC-16) and Studying Its Performance as a Fracturing Thickener in Oilfields.

In order to solve the problems of long dissolution and preparation time, cumbersome preparation, and easy moisture absorption and deterioration during storage or transportation, acrylamide (AM), acrylic acid (AA), sodium p-styrene sulfonate (SSS), and cetyl dimethylallyl ammonium chloride (DMAAC-16) were selected as raw materials, and the emulsion thickener P(AM/AA/SSS), which can be instantly dissolved in water and rapidly thickened, was prepared by the reversed-phase emulsion polymerization method. DMAAC-16, the influence of emulsifier dosage, oil-water ratio, monomer molar ratio, monomer dosage, aqueous pH, initiator dosage, reaction temperature, reaction time, and other factors on the experiment was explored by a single-factor experiment, and the optimal process was determined as follows: the oil-water volume ratio was 0.4, the emulsifier dosage was 7% of the oil phase mass, the initiator dosage was 0.

Enabling Multicolor Information Encryption: Oleylammonium-Halide-Assisted Reversible Phase Conversion between CsPbX and CsPbX Nanocrystals.

Recently, halide perovskites have been recognized for their thermochromic characteristics, showing significant potential in information encryption applications. However, the limited luminescence color gamut hinders the encryption of complex multicolor information. Herein, for the first time, multicolor thermochromic perovskites with luminescence covering the entire visible spectrum have been designed.

Carbon Dots: A Versatile Platform for Cu Detection, Anti-Counterfeiting, and Bioimaging.

Carbon dots (CDs) have garnered extensive interest in basic physical chemistry as well as in biomedical applications due to their low cost, good biocompatibility, and great aqueous solubility. However, the synthesis of multi-functional carbon dots has always been a challenge for researchers. Here, we synthesized novel CDs with a high quantum yield of 28.

Synergistic Catalysis of Water-Soluble Exogenous Catalysts and Reservoir Minerals during the Aquathermolysis of Heavy Oil.

Oil serves as the essential fuel and economic foundation of contemporary industry. However, the use of traditional light crude oil has exceeded its supply, making it challenging to meet the energy needs of humanity. Consequently, the extraction of heavy oil has become crucial in addressing this demand.

Crossmodal sensory neurons based on high-performance flexible memristors for human-machine in-sensor computing system.

Constructing crossmodal in-sensor processing system based on high-performance flexible devices is of great significance for the development of wearable human-machine interfaces. A bio-inspired crossmodal in-sensor computing system can perform real-time energy-efficient processing of multimodal signals, alleviating data conversion and transmission between different modules in conventional chips. Here, we report a bio-inspired crossmodal spiking sensory neuron (CSSN) based on a flexible VO memristor, and demonstrate a crossmodal in-sensor encoding and computing system for wearable human-machine interfaces.

polymorphisms and bladder cancer risk in the Chinese Han population.

Background: The expression of has implications for the prognosis of female bladder cancer. However, this study aimed to explore the association between single nucleotide polymorphisms (SNPs) in and bladder cancer risk, as no prior research has addressed this association.

Research Design And Methods: We selected and genotyped five SNPs (rs4646, rs6493487, rs1062033, rs17601876, and rs3751599) in 217 patients and 550 controls using the Agena MassARRAY system.

Near-infrared fluorescent probe for the imaging of viscosity in fatty liver mice and valuation of drug efficacy.

Fatty liver disease affects at least 25 percent of the population worldwide and is a severe metabolic syndrome. Viscosity is closely related to fatty liver disease, so it is urgent to develop an effective tool for monitoring viscosity. Herein, a NIR fluorescent probe called MBC-V is developed for imaging viscosity, consisting of dimethylaniline and malonitrile-benzopyran.

Enhanced Aquathermolysis of Water-Heavy Oil-Ethanol Catalyzed by B@Zn(II)L at Low Temperature.

In order to study the synergistic effects of exogenous catalysts and in situ minerals in the reservoir during heavy oil aquathermolysis, in this paper, a series of simple supported transition metal complexes were prepared using sodium citrate, chloride salts and bentonite, and their catalytic viscosity reduction performances for heavy oil were investigated. Bentonite complex catalyst marked as B@Zn(II)L appears to be the most effective complex. B@Zn(II)L was characterized by scanning electron microscopy (SEM), Fourier-Transform Infrared (FTIR) spectroscopy, thermo-gravimetric analysis (TGA) and N2 adsorption-desorption isotherms.

Preparation and Properties of Reversible Emulsion Drilling Fluid Stabilized by Modified Nanocrystalline Cellulose.

Reversible emulsion drilling fluids can concentrate the advantages of water-based drilling fluids and oil-based drilling fluids. Most of the existing reversible emulsion drilling fluid systems are surfactant-based emulsifier systems, which have the disadvantage of poor stability. However, the use of modified nanoparticles as emulsifiers can significantly enhance the stability of reversible emulsion drilling fluids, but ordinary nanoparticles have the disadvantages of high cost and easily causing environmental pollution.

The application of artificial intelligence for Rapid On-Site Evaluation during flexible bronchoscopy.

Background: Rapid On-Site Evaluation (ROSE) during flexible bronchoscopy (FB) can improve the adequacy of biopsy specimens and diagnostic yield of lung cancer. However, the lack of cytopathologists has restricted the wide use of ROSE.

Objective: To develop a ROSE artificial intelligence (AI) system using deep learning techniques to differentiate malignant from benign lesions based on ROSE cytological images, and evaluate the clinical performance of the ROSE AI system.

Lithium-Induced Oxygen Vacancies in MnO@MXene for High-Performance Zinc-Air Batteries.

The traditional methods for creating oxygen vacancies in materials present several challenges and limitations, such as high preparation temperatures, limited oxygen vacancy generation, and morphological destruction, which hinder the application of transition metal oxides in the field of zinc-air batteries (ZABs). In order to address these limitations, we have introduced a pioneering lithium reduction strategy for generating oxygen vacancies in δ-MnO@MXene composite materials. This strategy stands out for its simplicity of implementation, applicability at room temperature, and preservation of the material's structural integrity.

Study on the Properties Changes of Reversible Invert Emulsion during the Process from O/W to W/O with Alkali.

The reversible emulsion drilling fluid system combines the advantages of both oil-based and water-based drilling fluids, which can achieve ideal results in different stages of drilling and completion, and the system can be reused to effectively reduce costs. However, the research on reversible emulsions mainly focuses on the development of new reversible emulsifiers, while the specific phase transformation mechanism of reversible emulsion systems is still unclear. In this paper, a stable reversible emulsion was prepared using the reversible emulsifier DMOB as a raw material, and the reversible emulsion performance of the alkali response from the O/W emulsion phase to the W/O emulsion was studied.

A near-infrared fluorescent probe for viscosity: Differentiating cancer cells from normal cells and dual-modal imaging in tumor mice.

As a basic parameter of the intracellular microenvironment, viscosity is closely related to the development of cancer. Thus, it is necessary to utilize a sensitive tool to visualize the viscosity in tumor cells and mice, which is helpful for the diagnosis of cancer. Herein, a novel dual-modal probe (IX-V) that has a near-infrared fluorescence (NIRF) and photoacoustic (PA) response to viscosity is synthesized.

Resource utilization of expired progesterone medicines as flow improver for waxy crude oils.

At present, the treatment of expired medicines mainly involves burning, which means waste of resources and carbon dioxide emissions, and it does not comply with the concept of resource recycling. In this study, in order to explore the resource utilization pathways of expired medicines, progesterone drugs were evaluated as crude oil flow improvers as an example. The results shows that progesterone injection (PI) and progesterone capsule (PC) both act as viscosity reducer and pour point depressant in different crude oil, and 500 ppm PI and 300 ppm PC are the best dosage respectively.