Structural changes, transfer trajectories, and driving forces of non-grain farmland in the main grain producing areas of central China.

Non-grain farmland (NGF), a significant threat to food security, has drawn attention from both academic and practical sectors. However, the interrelationships among internal structural transfer trajectories within NGF and the interactions of their multidimensional factors remain unclear. This study focuses on Henan Province and conducts a comprehensive analysis of NGF.

Effect of lateral versus supine positioning on hypoxaemia in sedated adults: multicentre randomised controlled trial.

Objectives: To evaluate the effect of lateral versus supine positioning on incidence of hypoxaemia in sedated patients and to provide evidence based recommendations for respiratory strategies.

Design: Prospective, multicentre, randomised controlled trial.

Setting: 14 tertiary hospitals in China, July to November 2024.

The clinical advantages of endoscopic submucosal dissection compared with endoscopic mucosal resection for early oesophageal cancer and pre-cancer lesions.

Objective: The objective of the study was to compare the effects of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) in the treatment of early oesophageal cancer.

Subjects And Methods: Eighty-six patients with early oesophageal cancer and precancerous lesions admitted to our hospital from November 2021 to December 2023 were randomly divided into a treatment group (ESD: 43 cases) and control group (EMR: 43 cases). The efficacy and safety of the two methods were compared.

Optimizing the performance of poly(lactic acid)/poly (butylene adipate-co-terephthalate) blends: Improved toughness, thermal resistance, and degradation property.

To overcome the limitations of poly(lactic acid) (PLA), such as poor toughness, high cost, and slow degradation, this study prepares PLA/PBAT/DBI blends via melt blending by introducing poly(butylene adipate-co-terephthalate) (PBAT) and a bio-based additive, dibutyl itaconate (DBI). DBI, a multifunctional small molecule exhibiting both plasticizing and compatibilizing capabilities, has found broad applicability across diverse fields. However, its compatibilization mechanism in polymer blend systems remains insufficiently studied.

Effects of Water-Soluble and Fat-Soluble Antioxidant Combinations in Oil-in-Water Emulsions on the Oxidative Stability of Walnut Kernels.

Walnuts, which are rich in unsaturated fatty acids (UFAs), are highly susceptible to oxidation during storage, leading to quality degradation. Consequently, antioxidant technologies for the oxidative stability of walnuts have garnered significant attention. The addition of antioxidants remains the most cost-effective and efficient method currently available, with synergistic effects enhancing the efficacy of mixed antioxidant combinations compared to single antioxidants.

SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1.

Ageing-induced skeletal muscle deterioration contributes to sarcopenia and frailty, adversely impacting the quality of life in the elderly. However, the molecular mechanisms behind primate skeletal muscle ageing remain largely unexplored. Here, we show that SIRT5 expression is reduced in aged primate skeletal muscles from both genders.

METTL1 Enhances RRP9 mRNA Stability Through m7G Modification to Drive Colorectal Tumorigenesis.

METTL1, a well-established RNA methyltransferase for the N(7)-methylguanosine (m7G) methylation modification, is responsible for human tumorigenesis. Here, we aimed to examine the activity and molecular determinants of METTL1 in colorectal cancer (CRC) development. METTL1 and ribosomal RNA processing 9 (RRP9) mRNA analysis was performed by quantitative PCR.

Formation of advanced glycation end-products and N-nitrosamines in salami of different recipes and fermented at different stages.

Most research on the formation of advanced glycation end-products (AGEs) and N-nitrosamines (NAs) in meat products has focused on high-temperature processing. The effects of low-temperature processing on AGEs and NAs formation have rarely been studied. This study investigated the effects of salt addition (0 %, 2 %, and 4 %) and lean-to-fat ratio (10:0, 8:2, and 6:4) on the formation of AGEs and NAs in Salami.

Mechanistic insights into advanced glycation end products production in glucose-lysine model system involved with ascorbic acid.

Ascorbic acid (AA), despite being an essential vitamin, is also a potential precursor to form advanced glycation end products (AGEs) in heat-processed foods. The dual action of AA (act as an inhibitor and a precursor concurrently) in AGEs formation in glucose (Glu)-lysine (Lys) model system has been found in our previous study. However, the mechanism underlying the dual role of AA has not been elucidated.

Radiotherapy-Associated Cellular Senescence and EMT Alterations Contribute to Distinct Disease Relapse Patterns in Locally Advanced Cervical Cancer.

A notable number of locally advanced cervical carcinoma (LACC) patients experience local or distant disease relapse following radiotherapy. The contribution of tumor microenvironment (TME) to tumor recurrence at different sites remains unclear. Here, single-nucleus RNA sequencing data from 28 pre- and on-treatment LACC samples from patients with different disease relapse patterns is analyzed.

Perspectives on biomarkers of reproductive aging for fertility and beyond.

Reproductive aging, spanning an age-related functional decline in the female and male reproductive systems, compromises fertility and leads to a range of health complications. In this Perspective, we first introduce a comprehensive framework for biomarkers applicable in clinical settings and discuss the existing repertoire of biomarkers used in practice. These encompass functional, imaging-based and biofluid-based biomarkers, all of which reflect the physiological characteristics of reproductive aging and help to determine the reproductive biological age.

Developing high-performance and sustainable polylactic acid/recycled polyolefin blends: Tuning the degree of functional group reaction and performance optimization.

In the current development of the plastics industry, the use of biodegradable and recycled plastics not only effectively reduces the volume of landfills and incineration but also significantly decreases environmental damage. However, the extensive application of biodegradable polylactic acid (PLA) is limited by its poor toughness and thermal properties. The study introduced recycled linear low-density polyethylene (R-LLDPE) and ethylene-octene copolymer (POE) to modify PLA, primarily based on their excellent toughness and thermal resistance.

The status of acetabulum in bipolar HIP replacements in orthopaedics oncology cases.

Bipolar hip endoprosthesis replacement is a commonly employed procedure in orthopaedic oncology that requires the resection and reconstruction of the proximal femur. With improving survival rates, issues of implant durability and acetabular wear have become increasingly important. The decision to replace the acetabulum in bipolar hip endoprosthesis replacement procedures remains a topic of debate.

Comparison of Different Diagnostic Criteria of 68Ga-Pentixafor PET/CT for the Classification of Primary Aldosteronism.

Context: 68Ga-Pentixafor positron emission tomography/computed tomography (PET/CT) is an emerging method for the classification diagnosis primary aldosteronism (PA). However, the diagnosis criteria are still controversial.

Objective: To compare the accuracy of different criteria of 68Ga-Pentixafor PET/CT in the classification diagnosis of PA.

Synergistic effects of dual reactive compatibilizers for high-performance fully biodegradable polylactic acid/poly (butyleneadipate-co-terephthalate) composites.

The PLA-g-(GMA-co-St) graft copolymer (PGS) was prepared using melt-free radical grafting technology, PGS and ESO were simultaneously employed as compatibilizers for the poly (lactic acid)/poly (butylene adipate-co-terephthalate) (PLA/PBAT) blends. The effects of the type and amount of compatibilizers on the properties of the blends were studied. The results reveal that the epoxy groups in PGS and ESO can interact with the terminal groups of PLA and PBAT.

Prospective Cohort Investigation on Physical Activity of Osteoporosis Outcomes (PAOPO) in Jidong: Objectives, Study Design, and Baseline Characteristics.

Objective: The aim of this study was to investigate the prospective association between physical activity (PA), independently or in conjunction with other contributing factors, and osteoporosis (OP) outcomes.

Methods: The Physical Activity in Osteoporosis Outcomes (PAOPO) study was a community-based cohort investigation. A structured questionnaire was used to gather the participants' sociodemographic characteristics.

Spatio-temporal variation and influencing factors of aero-sports tourism internet attention in Shaanxi Province, China.

Despite China's building into a leading sporting nation and sport-tourism integration high-quality development strategy in the 20th National Congress of the Communist Party of China, existing tourism studies seldom concern sport-tourism integration, especially their spatial hot spots and evolutional trend based on geospatial big data. This study aims to probe into the spatiality and the underlying mechanism of sport tourism through internet attention data in 2015, 2018, and 2021 by social network analysis, with a specific focus on aero-sports tourism. Shaanxi Province is chosen as the study site given its advantages of rich aero-sports tourism resources and various aero-sports modes (e.

Cardiovascular toxicity in antitumor therapy: biological and therapeutic insights.

The evolution of antitumor therapies has significantly improved cancer prognosis but has concurrently resulted in cardiovascular toxicities. Understanding the biological mechanisms behind these toxicities is crucial for effective management. Immunotherapy-related cardiovascular toxicities are primarily mediated by immune cells and secreted cytokines.

Ga-pentixafor PET/CT in the localization diagnosis of primary aldosteronism concurrent subclinical cushing's syndrsome: two case reports.

Purpose: Adrenal venous sampling (AVS) is recommended for subtyping primary aldosteronism (PA). However, in cases of PA, concurrent subclinical Cushing's syndrome (SCS) has the potential to confound AVS results. Pentixafor, a CXC chemokine receptor type 4-specific ligand, has been reported as a promising marker to evaluate functional nature of adrenal adenomas.

Phytosterols: Physiological Functions and Potential Application.

Dietary intake of natural substances to regulate physiological functions is currently regarded as a potential way of promoting health. As one of the recommended dietary ingredients, phytosterols that are natural bioactive compounds distributed in plants have received increasing attention for their health effects. Phytosterols have attracted great attention from scientists because of many physiological functions, for example, cholesterol-lowering, anticancer, anti-inflammatory, and immunomodulatory effects.

Coexistence of a novel chromosomal integrative and mobilizable element Tn7548 with two bla-carrying plasmids in a multidrug-resistant Aeromonas hydrophila strain K522 from China.

Objectives: Herein, we detected one multidrug-resistant Aeromonas hydrophila strain K522 co-carrying two bla genes together with a novel chromosomal integrative and mobilizable element (IME) Tn7548 from China. To reveal the genetic characteristics of the novel reservoir of bla and IME in Aeromonas, a detailed genomic characterization of K522 was performed, and a phylogenetic analysis of Tn7412-related IMEs was carried out.

Methods: Carbapenemases were detected by using the immunocolloidal gold technique and antimicrobial susceptibility was tested by using VITEK 2.