The HY5-NPR1 module governs light-dependent virulence of a plant bacterial pathogen.

Light is essential for plant development, but its influence on pathogen virulence and immunity remains poorly understood. Here, we found that the Pseudomonas syringae DC3000 type III effector, AvrPtoB, exhibits virulence exclusively upon light exposure. This light-dependent regulation is controlled by the Arabidopsis transcription factor ELONGATED HYPOCOTYL 5 (HY5), a central regulator of photomorphogenesis.

Microenvironment-driven transformable self-assembly nanoplatform enables spatiotemporal remodeling for rheumatoid arthritis therapy.

The aberrant vasculature within the inflamed joint cavity of rheumatoid arthritis (RA) not only exacerbates joint pathology but also restricts the effective delivery of therapeutic drugs. Herein, we propose a strategy that involves the rapid and sustained vasculature repair alongside microenvironment-driven drug delivery to achieve multifaceted RA management. The transformable, self-assembling nanoplatform specifically accumulates in the inflamed joint cavity guided by a vascular targeting peptide (STP).

Pilose antler peptide enhances diabetic fracture healing by modulating the CREB-Smad2/3-Runx2 signaling axis.

Ethnopharmacological Relevance: Cervi Cornu Pantotrichum, a cornerstone of traditional medicine, is prized for its bone-enhancing and metabolic-regulating effects. Pilose antler peptide (PAP), extracted from this remedy, offers a promising solution for diabetic fracture nonunion, a debilitating condition marked by hyperglycemia-impaired bone healing.

Aim Of The Study: This study investigates PAP's efficacy in accelerating diabetic fracture repair and delineates its molecular mechanisms, merging ethnopharmacological heritage with modern science.

Deciphering the Proteomic Landscape of Circulating Extracellular Vesicles in Human Abdominal Aortic Aneurysm.

Abdominal aortic aneurysm (AAA) is the most prevalent and lethal form of arterial aneurysm, frequently manifesting asymptomatically until a catastrophic rupture occurs. While various diagnostic imaging tools and several potential biomarkers have been explored for the purpose of early AAA screening, the usage of liquid biopsy such as extracellular vesicles (EVs)-carried protein for the early diagnosis of AAA is still being overlooked. In this study, we enrolled 18 AAA patients and nine healthy normal controls, including data from the National Drug Clinical Trial Organisation-Vascular Surgery (NDCTO) (in-house cohort) and the Second Clinical Medical College, Jinan University (Shenzhen People's Hospital) (external cohort).

Differentiating biosynthesis from heterotrophic nitrification/aerobic denitrification for total-nitrogen removal.

Although classical nitrification/denitrification is the common process for total-nitrogen removal in wastewater treatment, novel nitrogen-removal processes are being evaluated. Among them, nitrogen (N) removal in one aerobic stage has been promoted as heterotrophic nitrification and aerobic denitrification (HNAD). An alternate strategy for total-N removal in one aerobic stage is nitrogen assimilation for biomass synthesis.

Chemistry and biology of Stemona alkaloids.

The Stemonaceae family has been included in the Chinese Pharmacopoeia as an antitussive drug, and the alkaloids contained within this family have attracted much attention due to their diverse biological activities and unique structures. From 1962 to 2024, 262 Stemona alkaloids had been isolated and identification. However, the process of exploitation is hindered by the presence of low extraction and separation rates.

Preconception paternal exposure to zearalenone impairs male fertility and IVF embryo survival in mice.

Zearalenone (ZEA), a fungal mycotoxin commonly found in various human foods, exhibits a structural similarity to naturally occurring estrogen, raising significant concerns regarding its reproductive toxicity. This study aimed to assess the impact of preconceptional ZEA exposure on male reproductive health and early embryonic development. Healthy B6D2F1 male mice were exposed to corn oil or varying doses of ZEA for two weeks.

Alcohol Consumption Amount, Drinking Pattern, and the Trajectory of Multimorbidity: A Prospective Cohort Study.

This study aimed to investigate the impacts of both alcohol consumption amount and drinking pattern on the progression from healthy to first noncommunicable disease (FNCD), subsequently to multimorbidity, and ultimately to death. We conducted this analysis in the UK Biobank cohort (N = 284 744). Multimorbidity was defined as the coexistence of at least two noncommunicable diseases, including cancer, chronic respiratory disease, cardiovascular disease, and Type 2 diabetes.

The MYB transcription factor ClPC modulates petal color and chlorophyll accumulation in watermelon.

During the pre-anthesis stage, high chlorophyll levels in petals result in a green hue in many plants. Upon anthesis, chlorophyll degradation uncovers other pigments, thereby influencing pollinator attraction and reproductive success in insect-pollinated crops. In the watermelon accession WM109, a novel petal phenotype characterized by a yellow-green hue was observed, significantly different from the canonical yellow petal phenotype typically associated with this species.

Mitigating PCOS progression: The protective effect of C-phycocyanin on ovarian granulosa cell pyroptosis via the NRF2/NLRP3/GSDMD pathway.

Background: Pyroptosis is a proinflammatory cell death process that contributes to inflammatory diseases. C-Phycocyanin (C-PC) is a water-soluble protein pigment primarily derived from cyanobacteria, and it exhibits anti-inflammatory effects. However, the role of natural C-PC in pyroptosis in human ovarian granulosa cells (GCs), particularly in conditions like polycystic ovary syndrome (PCOS), remains unclear.

Effect of Rh Loading on the Performance of Rh/CeO in CH Combustion: Important Role of Forming RhO Nanoparticles.

In order to avoid the emission of CH into the air, catalytic combustion of CH is a practical solution, but it is challenging to develop efficient catalysts due to the inertness of CH. Herein, Rh/CeO catalysts with different Rh loadings were synthesized and compared. The catalytic activities in CH oxidation were found to increase with an increase of Rh loading.

Integration of Bioinformatics and Machine Learning Strategies Identifies Ferroptosis and Immune Infiltration Signatures in Peri-Implantitis.

Peri-implantitis (PI) is a chronic inflammatory disease that ultimately leads to the dysfunction and loss of implants with established osseointegration. Ferroptosis has been implicated in the progression of PI, but its precise mechanisms remain unclear. This study explores the molecular mechanisms of ferroptosis in the pathology of PI through bioinformatics, offering new insights into its diagnosis and treatment.

Substitution Index-Prediction Rules for Low-Potential Plateau of Hard Carbon Anodes in Sodium-Ion Batteries.

Establishing prediction rules for the low-potential plateau (LPP) of hard carbon (HC) anodes is crucial for constructing high-energy-density sodium-ion batteries (SIBs). While current studies suggest that the closed pores of HC can enhance the LPP performance, the rules for directly predicting the LPP from precursors have yet to be established. Here, prediction rules for the LPP of HC anodes in SIBs-the substitution index (Δ) of precursor are introduced.

Physicochemical Characterization and Oral Bioavailability of Curcumin-Phospholipid Complex Nanosuspensions Prepared Based on Microfluidic System.

: Curcumin has been proved to have promising prospects in the fields of anti-inflammation, antibacterial, anti-oxidation, and neuroprotection. However, its poor water solubility and stability in strong acid, as well as fast metabolism, lead to low bioavailability, making it difficult to develop further. This study aimed to improve the bioavailability of curcumin by using microfluidic preparation technology.

Pore modulation in coal-based hard carbon for sodium-ion batteries.

Designing the closed-pore structure of hard carbon to improve its low-voltage sodium storage capacity is both significant and challenging for the development of high-performance sodium-ion batteries. We utilized a briquetting process combined with a templating method to modulate the pore architecture. By adjusting the briquette pressure, we can regulate the degree of magnesium ion etching and the degree of cross-linking in the precursor, thereby augmenting the closed-pore content of hard carbon and boosting its sodium-storage performance at low potential.

Melatonin mediates the BMP4/MAPK signaling pathway to alleviate zearalenone-induced abnormal embryonic development in mice.

Zearalenone (ZEA) is a common mycotoxin found in crops that poses a threat to human health, particularly the female reproductive system. Here, we show that exposing mouse zygotes to ZEA in vitro significantly impairs embryo development, leading to embryo arrest. Remarkably, treatment of ZEA-exposed mouse embryos with melatonin significantly improved the blastocyst rates from approximately 40 % to nearly 80 %.

Identification of effective anti-osteosarcoma agents via screening of an in-house NQO1-targeted compound library.

Osteosarcoma is one of the most prevalent malignant bone tumors, and despite advances in treatment, significant improvements in survival rates for osteosarcoma patients remain elusive. There is an urgent need for developing novel molecules for the targeted treatment of osteosarcoma. NAD(P)H:quinone oxidoreductase 1 (NQO1) is highly overexpressed in osteosarcoma.

The impact of high-intensity interval training on insulin sensitivity and quality of life in women with overweight polycystic ovary syndrome.

BackgroundPolycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, characterized by menstrual irregularities, hyperandrogenism, and polycystic ovaries. Insulin resistance is central to its pathophysiology, contributing to metabolic disturbances and increased cardiometabolic risks. High-Intensity Interval Training (HIIT) has emerged as a promising intervention to improve metabolic health.

Comprehensive Multi-Omics Analysis Identifies FUT1 as a Prognostic and Therapeutic Biomarker Across Pan-Cancer.

Fucosyltransferase 1 encodes a Golgi membrane protein involved in H-antigen precursor production and plays a critical role in tumor-associated glycosylation and angiogenesis. While FUT1 is known to enhance tumor stemness, adhesion, migration, and drug resistance in specific cancers, its role across diverse cancer types and its association with clinical prognosis and molecular features remain unclear. In this study, FUT1 expression was systematically analyzed across 33 cancer types using data from multiple public databases, including CCLE, TCGA, and GTEx.

Effects of non-pharmacological interventions on the depressive outcomes in people with mild cognitive impairment: an overview of systematic reviews.

Objective: This study aimed to summarize and assess the certainty of evidence of non-pharmacological interventions (NPIs) on the depressive outcomes in people with mild cognitive impairment (MCI) based on published systematic reviews (SRs).

Method: Databases including PubMed, EMBASE, PsycINFO, the Cochrane Database of Systematic Reviews, CNKI, CBM, Wanfang and VIP database were searched from their inception to June 6, 2023. The methodological quality of the SRs was evaluated using the AMSTAR2 tool, and the quality of evidence was assessed using the Grading of Recommendation Assessment, Development and Evaluation (GRADE) framework.

Fine-tuning gibberellin improves rice alkali-thermal tolerance and yield.

Soil alkalinization and global warming are predicted to pose major challenges to agriculture in the future, as they continue to accelerate, markedly reducing global arable land and crop yields. Therefore, strategies for future agriculture are needed to further improve globally cultivated, relatively high-yielding Green Revolution varieties (GRVs) derived from the SEMIDWARF 1 (SD1) gene. Here we propose that precise regulation of the phytohormone gibberellin (GA) to optimal levels is the key to not only confer alkali-thermal tolerance to GRVs, but also to further enhance their yield.

Activated Graphite with Richly Oxygenated Surface from Spent Lithium-Ion Batteries for Microwave Absorption.

Designing spent graphite anodes from lithium-ion batteries (LIBs) for applications beyond regenerated batteries offers significant potential for promoting the recycling of spent LIBs. The battery-grade graphite, characterized by a highly graphitized structure, demonstrates excellent conductive loss capabilities, making it suitable for microwave absorption. During the Li-ion intercalation and deintercalation processes in battery operation, the surface layer of spent graphite (SG) becomes activated, forming oxygen-rich functional groups that enhance the polarization loss mechanism.

Ancestral carbonic anhydrase with significantly enhanced stability and activity for CO capture and utilization.

Carbonic anhydrases (CAs) has garnered increasing attention in carbon capture, utilization and storage (CCUS) due to their ecological friendliness. However, most of them suffer susceptibility to deactivation in harsh conditions. Herein, a reliable dataset was adopted for creating ancestral CAs through an optimized ancestral sequence reconstruction (ASR) method.

Policy research on role of traditional medicine in emergency health system construction based on the PMC index model: evidence from China.

Background: The integration of traditional Chinese medicine (TCM) into emergency health systems in China serves as a model for global policy development and refining the inclusion of traditional medicine in health emergencies.

Methods: This study investigated 13 public health emergency policies related to TCM released by the Chinese central government from 2003-2023. A PMC(Policy Modeling Consistency) index model was developed combining ROSTCM text mining analysis software.

Prevalence and Factors Associated With Elder Self-Neglect Among Community-Dwelling Older Adults: A Cross-Sectional Study.

Purpose: To report the prevalence and risk factors of elder self-neglect (ESN) among community-dwelling older adults ( = 604).

Method: The current cross-sectional study was conducted from July 2019 to October 2020 in Lanzhou City, China. ESN was determined by the Scale of Elderly Self-Neglect, which evaluates five dimensions: (a) medical health and care, (b) environmental sanitation and personal hygiene, (c) mental health, (d) safety, and (e) social engagement.