The HY5-NPR1 module governs light-dependent virulence of a plant bacterial pathogen.

Light is essential for plant development, but its influence on pathogen virulence and immunity remains poorly understood. Here, we found that the Pseudomonas syringae DC3000 type III effector, AvrPtoB, exhibits virulence exclusively upon light exposure. This light-dependent regulation is controlled by the Arabidopsis transcription factor ELONGATED HYPOCOTYL 5 (HY5), a central regulator of photomorphogenesis.

Identification of Crohn's Disease-Related Biomarkers and Pan-Cancer Analysis Based on Machine Learning.

: In recent years, the incidence of Crohn's disease (CD) has shown a significant global increase, with numerous studies demonstrating its correlation with various cancers. This study aims to identify novel biomarkers for diagnosing CD and explore their potential applications in pan-cancer analysis. : Gene expression profiles were retrieved from the Gene Expression Omnibus (GEO) database, and differentially expressed genes (DEGs) were identified using the "limma" R package.

Long-term effects of health during childhood on depressive symptoms in later life: evidence from a nationally representative survey in China.

Background: Childhood health significantly influences mental well-being in later life, but this relationship remains underexplored in China. This study aims to investigate the long-term associations between childhood health status and depressive symptoms in older adults, emphasizing the need for early interventions to promote lifelong mental health.

Methods: We utilized data from a nationally representative survey conducted across 28 provinces of China, comprising 15,581 adults aged 45 years and older.

Physical Cross-Linking of Cellulose Nanofibrils with Zein Particles as an Eco-Friendly Detergent.

Pickering particles can self-assemble to form a rigid barrier film at the oil-water interface, effectively inhibiting droplet aggregation and stabilizing the emulsion. This essay explores the potential of Zein/TOCNF (TEMPO-oxidized cellulose nanofiber) complex aqueous dispersion as an environmentally friendly, nontoxic, versatile, and inexpensive cleaning agent based on the Pickering effect. The Zein/TOCNF complex exhibited an improvement in its surface hydrophobicity compared to that of pure TOCNF, so that it could be used as Pickering emulsion stabilizers.

Copper-Catalyzed Carbonylative Cyclization of CO: A Promising Approach for Synthesis of Flavone.

Flavones are an important class of building blocks for numerous biologically active molecules, pharmaceuticals, and natural products. Reductive carbonylation of CO is a powerful method to provide high-value heterocycles quickly. However, examples of transition metal-catalyzed carbonylation to produce flavones using CO are quite scarce, and the related copper-catalyzed carbonylative cyclization of CO is not reported.

Prediction of cold region dew volume based on an ECOA-BiTCN-BiLSTM hybrid model.

This paper presents a hybrid prediction model, ECOA-BiTCN-BiLSTM, for predicting dew in cold areas. The model integrates BiTCN and BiLSTM neural networks to enhance performance. An enhanced Crayfish optimization algorithm (ECOA) with four mixed strategies was employed to optimize the model's hyperparameters and reduce the impact of arbitrary selection.

Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury.

Background: Extracellular vesicles (EVs) secreted by mesenchymal stromal cells (MSCs) have been shown to provide significant protection against renal ischemia-reperfusion injury (IRI). Hypoxia has emerged as a promising strategy to enhance the tissue repair capabilities of MSCs. However, the specific effects of hypoxia on MSCs and MSC-EVs, as well as their therapeutic potential in renal IRI, remain unclear.

Wind farms reduce grassland plant community diversity and lead to plant community convergence.

Climate warming has become a hot issue of common concern all over the world, and wind energy has become an important clean energy source. Wind farms, usually built in wild lands like grassland, may cause damage to the initial ecosystem and biodiversity. However, the impact of wind farms on the functional diversity of plant communities remains a subject with unclear outcomes.

Nanocellulose composites based on embedded europium-containing coordination polymers for the detection of antibiotics.

Developing sensitive and reliable methods for detecting antibiotics in water solutions is essential for protecting public health and the environment. Here, we report a novel fluorescent film with superior mechanical properties and detection response to ciprofloxacin (CIP), achieved through the in-situ growth of europium-based metal-organic frameworks on TEMPO-oxidized cellulose nanofibrils (TOCNF). Firstly, Eu(III) and 2,6-pyridinedicarboxylic acid (DPA) served as precursors, and a simple self-assembly strategy was employed to grow the composite film material (Eu-DPA@TOCNF) in situ on TOCNF, which exhibited characteristic emission peaks.

Hedyotis diffusa injection modulates the ferroptosis in bladder cancer via CAV1/JUN/VEGFA.

Hedyotis diffusa Willd. (HDW), a traditional Chinese medicinal plant, exhibits a variety of pharmacological effects and has anticancer potential for a wide range of cancer types; Ferroptosis is a non-apoptosis-regulated cell death induced by iron accumulation and subsequent lipid peroxidation; and there is currently an increasing interest in the therapeutic role of ferroptosis in cancer. However, the effects of HDW on bladder cancer and its underlying molecular mechanisms remain largely unknown.

Hydrophobic modification of cellulose nanofibers/bionic flower-like ZnO synergistically stabilized Pickering emulsion to enhance pesticide deposition.

Environmental issues arising from the low pesticide utilization rate make the development of environmentally friendly and low-cost pesticide carrier systems an urgent problem to be solved. Pickering emulsion systems have shown broad application prospects in pesticide delivery. In this study, dodecenyl succinic anhydride (DDSA) was used to hydrophobically modify cellulose nanofiber (D-CNF), and biomimetic flower-like zinc oxide (ZnO) particles were prepared by precipitation method at room temperature.

NPR1 promotes blue light-induced plant photomorphogenesis by ubiquitinating and degrading PIF4.

Light is a major determinant of plant growth and survival. NONEXPRESSER OF PATHOGENESIS-RELATED GENES 1 (NPR1) acts as a receptor for salicylic acid (SA) and serves as the key regulator of SA-mediated immune responses. However, the mechanisms by which plants integrate light and SA signals in response to environmental changes, as well as the role of NPR1 in regulating plant photomorphogenesis, remain poorly understood.

LMAN2 Promotes Breast Cancer Tumorigenesis and Drug Resistance by Interacting With MAPK9 via Activation of the MAPK Pathway.

Introduction: Breast cancer (BC) is the most prevalent malignancy among women worldwide. Lectin, mannose-binding 2 (LMAN2) is a cargo receptor engaged in the transport and sorting of glycoproteins. Despite its ubiquity, the function and underlying mechanisms of LMAN2 in BC continue to elude understanding.

A New Rat Model of Sacral Cord Injury Producing a Neurogenic Bladder and Its Functional and Mechanistic Studies.

Sacral spinal cord injury (SSCI) can disrupt bladder neuromodulation and impair detrusor function. Current studies provide limited information on the histologic and genetic changes associated with SSCI-related neurogenic lower urinary tract dysfunction (NLUTD), resulting in few treatment options. This study aimed to establish a simple animal model of SSCI to better understand the disease progression.

Plasma-derived exosomal hsa-miR-184 and hsa-mir-6766-3p as promising diagnostic biomarkers for early detection of children's cardiac surgery-associated acute kidney injury.

There is little known about the contribution of exosomal microRNAs (exomiRs) in the children's cardiac surgery-associated acute kidney injury (CSA-AKI). This study aimed to find diagnostic biomarkers for predicting CSA-AKI in children. A prospective observational study was conducted from April 2020 to March 2021.

Impact of hydrophobically modified cellulose nanofiber on the stability of Pickering emulsion containing insect protein.

Background: Cellulose nanofiber (CNF) is an ideal Pickering emulsion stabilizer because of its high aspect ratio and flexibility. CNF was hydrophobically modified by dodecenyl succinic anhydride and used to stabilize the simulated food emulsion system containing insect protein. The prepared dodecenyl succinate nanofiber (D-CNFs) was characterized by contact angle and laser particle size analyzer.

Implementation of an Enhanced Crayfish Optimization Algorithm.

This paper presents an enhanced crayfish optimization algorithm (ECOA). The ECOA includes four improvement strategies. Firstly, the Halton sequence was used to improve the population initialization of the crayfish optimization algorithm.

Potential mechanisms of cancer prevention and treatment by sulforaphane, a natural small molecule compound of plant-derived.

Despite recent advances in tumor diagnosis and treatment technologies, the number of cancer cases and deaths worldwide continues to increase yearly, creating an urgent need to find new methods to prevent or treat cancer. Sulforaphane (SFN), as a member of the isothiocyanates (ITCs) family, which is the hydrolysis product of glucosinolates (GLs), has been shown to have significant preventive and therapeutic cancer effects in different human cancers. Early studies have shown that SFN scavenges oxygen radicals by increasing cellular defenses against oxidative damage, mainly through the induction of phase II detoxification enzymes by nuclear factor erythroid 2-related factor 2 (Nrf2).

Metal ion stimulation-related gene signatures correlate with clinical and immunologic characteristics of glioma.

Background: Environmental factors serve as one of the important pathogenic factors for gliomas. Yet people focus only on the effect of electromagnetic radiation on its pathogenicity, while metals in the environment are neglected. This study aimed to investigate the relationship between metal ion stimulation and the clinical characteristics and immune status of GM patients.

Long-term intake of sulforaphene alleviates D-galactose-induced skin senescence by activating AMPK-Sirt 1 pathway.

D-Galactose (D-gal) accumulation triggers the generation of oxygen free radicals, resulting in skin aging. Sulforaphene (SFE), an isothiocyanate compound derived from radish seeds, possesses diverse biological activities, including protective effects against inflammation and oxidative damage. This investigation delves into the antioxidant impact of SFE on age-related skin injury.

Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway.

The transcription factor Bcl11b has been linked to neurodevelopmental and neuropsychiatric disorders associated with synaptic dysfunction. Bcl11b is highly expressed in dentate gyrus granule neurons and is required for the structural and functional integrity of mossy fiber-CA3 synapses. The underlying molecular mechanisms, however, remained unclear.

Increased long-distance and homo-trans interactions related to H3K27me3 in Arabidopsis hybrids.

In plants, the genome structure of hybrids changes compared with their parents, but the effects of these changes in hybrids remain elusive. Comparing reciprocal crosses between Col × C24 and C24 × Col in Arabidopsis using high-throughput chromosome conformation capture assay (Hi-C) analysis, we found that hybrid three-dimensional (3D) chromatin organization had more long-distance interactions relative to parents, and this was mainly located in promoter regions and enriched in genes with heterosis-related pathways. The interactions between euchromatin and heterochromatin were increased, and the compartment strength decreased in hybrids.

Effect of grazing and climatic factors on biodiversity-ecosystem functioning relationships in grassland ecosystems - a case study of typical steppe in Inner Mongolia, China.

Biodiversity underpins grassland ecological functions and productive capacities. By studying the mechanisms for the maintenance of species diversity in animal communities, we can provide important theoretical guidance for the optimization of grazing management and biodiversity protection. The typical grassland of Xilingol in Inner Mongolia, China, was used as the experimental area, and a grazing intensity experiment was set up.

Analysis of early clinical signs and risk factors for severe hemorrhagic cystitis after stem cell transplantation in children.

Introduction: To analyze the characteristics of early clinical symptoms of hemorrhagic cystitis (HC) after hematopoietic stem cell transplantation (HSCT) and the risk factors of severe HC.

Methods: We retrospectively analyzed 77 children with post-HSCT HC treated at our hospital between June 2013 and June 2021. Clinical characteristics were collected and catalogued.

Exploring the relationship between immune heterogeneity characteristic genes of rheumatoid arthritis and acute myeloid leukemia.

Background: People with autoimmune diseases are prone to cancer, and there is a close relationship between rheumatoid arthritis (RA) and acute myeloid leukemia (AML). The bone marrow (BM) is affected throughout the course of RA, with a variety of hematologic involvement. Hopes are pinned on rheumatoid arthritis research to obtain BM biomarkers for AML.