Machine learning-assisted CeO nanorod sensor platform for visual detection of paraoxon.

Here we report a machine learning-assisted CeO nanorod sensor platform, which can achieve real-time colorimetric detection of the selectivity of paraoxon with an accuracy rate of 90%. Its high selectivity comes from the fact that CeO nanorods selectively break the P-O bonds in paraoxon, and the product is yellow.

UiO-66(Ce) nanozymes with dual-site synergistic catalysis for efficient hydrolysis of organophosphorus poisons.

Nanozymes are a class of nanomaterials capable of mimicking the activity of phosphatase, offering sustainable hydrolysis and efficient catalytic strategies to address environmental pollution caused by organophosphorus pesticides (OPs). However, challenges such as low activity and insufficient mechanistic understanding of nanozymes remained critical concerns. Herein, UiO-66(Ce) was synthesized and loaded onto polyvinylidene difluoride (PVDF) to obtain UiO-66(Ce)/PVDF for hydrolysis of p-nitrophenol phosphate (p-NPP), a simulant of OPs.

β-cyclodextrin-modified silver nanoparticles for highly selective recognition of chiral Trp and its mechanism.

Chiral recognition plays a crucial role in the fields of chemistry, biomedicine, and food science. In this study, β-cyclodextrin-modified silver nanoparticles (β-CD@AgNPs) with enhanced chiral binding ability were successfully prepared using the reduction method and utilized for the selective recognition of tryptophan (Trp) enantiomers, one of the representatives of non-polar amino acids. Interestingly, the β-CD@AgNPs with L-Trp system exhibited a red color (with a new ultraviolet-visible (UV-vis) absorption peak at around 550 nm), while no change occurred with D-Trp.

Genetic liability to gut microbiota and inflammatory cytokines in relation to systemic lupus erythematosus risk: a multi-omics study.

Objectives: Systemic lupus erythematosus (SLE) has been associated with gut microbiota in some studies. There is no clear evidence that cytokines act as mediators.

Methods: We first assessed the differences in gut microbiota between SLE patients and healthy controls using 16S rDNA sequencing.

Naringenin Attenuates Ox-LDL-induced Injury in HUVECs by Regulating Lipophagy Partly through the SOCE Pathway.

Objective: Naringenin (NAR) is a naturally occurring tiny molecule that has a significant role in lipid metabolism. However, the molecular mechanism by which NAR is involved in lipid metabolism to protect ECs is not clear. This study aims to investigate the effect of NAR on autophagy in oxidized low-density lipoprotein (ox-LDL)-treated human umbilical vein endothelial cells (HUVECs) and its potential molecular mechanisms.

Environmental regulation, coal de-capacity, and PM2.5 in China.

This paper examines how the removal of excess coal production capacity has affected the air quality in China. A coal de-capacity policy, including a reduction in coal, downscaling of the pollution in mines, and strict regulation of coal production, was implemented in 2016. However, until now studies have paid little attention to the effects of coal de-capacity on air pollution.

Predicting and validating the risk of interstitial lung disease in systemic lupus erythematosus.

Objective: Our study aimed toconstruct a web-based calculator to predict high risk patients of interstitial lung disease (ILD) in systemic lupus erythematosus (SLE).

Methods: This retrospective study comprised training and test cohorts, including 581 and 86 patients, respectively. Univariate, least absolute shrinkage and selection operator (LASSO), random forest (RF), eXtreme Gradient Boosting (XGBoost), and logistic regression (LR) analyses were performed.

Stilbene glycosides alleviate atherosclerosis partly by promoting lipophagy of dendritic cells.

Atherosclerosis (AS) is a chronic inflammatory disease resulting from lipid metabolism disorders and immune imbalances. Dendritic cells (DCs) are key cells that regulate adaptive and adaptive immunity. When DCs engulf excessive amounts lipids, their function is altered, thereby, accelerating the inflammatory process of AS.

Proteomic Profiling of Unannotated Microproteins in Human Placenta Reveals XRCC6P1 as a Potential Negative Regulator of Translation.

Ribosome profiling and mass spectrometry have revealed thousands of previously unannotated small and alternative open reading frames (sm/alt-ORFs) that are translated into micro/alt-proteins in mammalian cells. However, their prevalence across human tissues and biological roles remains largely undefined. The placenta is an ideal model for identifying unannotated microproteins and alt-proteins due to its considerable protein diversity that is required to sustain fetal development during pregnancy.

Construction and application of fetal loss risk model in systemic lupus erythematosus patients with mild disease severity.

Background: This dynamic nomogram model was developed to predict the probability of fetal loss in pregnant patients with systemic lupus erythematosus (SLE) with mild disease severity before conception.

Methods: An analysis was conducted on 314 pregnancy records of patients with SLE who were hospitalized between January 2015 and January 2022 at Shenzhen People's Hospital, and the Longhua Branch of Shenzhen People's Hospital. Data from the Longhua Branch of the Shenzhen People's Hospital were utilized as an independent external validation cohort.

Drug pair of Cornus officinalis and Radix achyranthis bidentatae improves renal injury of hypertension by regulating metabolic reprogramming mediated by eNOS.

Objective: To explore the effects and possible mechanisms of the drug pair Cornus officinalis and Radix achyranthis bidentatae (SYR-NX) on improving hypertensive kidney damage.

Method: SYR-NX, a formulation of Cornus officinalis and Radix Achyranthis Bidentatae with a dose ratio 1:2.5, was used in this experiment.

A liposome encapsulated methylene blue-mediated electrochemical and UV-visible dual mode split-type immunoassay for the detection of 17β-estradiol.

Herein, we fabricated an electrochemical (EC) and UV-visible absorption (UV-vis) dual mode split-type immunoassay for the detection of 17β-estradiol (E2), which was mediated by liposome encapsulated methylene blue (MB@lip). MB molecule acted as the probe in the EC and UV-vis absorption dual mode detections, and its release was controlled by liposome. The competitive immune recognition was conducted between the E2 in the sample and E2 conjugated bovine serum protein (E2-BSA) adsorbed on the 96-wells plate in combining with E2 antibody labeled with MB@lip (E2-Ab/MB@lip).

Multi-elemental stoichiometric ratios of atmospheric wet deposition in Chinese terrestrial ecosystems.

Intense human activities have significantly altered the concentrations of atmospheric components that enter ecosystems through wet and dry deposition, thereby affecting elemental cycles. However, atmospheric wet deposition multi-elemental stoichiometric ratios are poorly understood, hindering systematic exploration of atmospheric deposition effects on ecosystems. Monthly precipitation concentrations of six elements-nitrogen (N), phosphorus (P), sulfur (S), potassium (K), calcium (Ca), and magnesium (Mg)-were measured from 2013 to 2021 by the China Wet Deposition Observation Network (ChinaWD).

Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5.

The conserved WD40-repeat protein WDR5 interacts with multiple proteins both inside and outside the nucleus. However, it is currently unclear whether and how the distribution of WDR5 between complexes is regulated. Here, we show that an unannotated microprotein EMBOW (endogenous microprotein binder of WDR5) dually encoded in the human SCRIB gene interacts with WDR5 and regulates its binding to multiple interaction partners, including KMT2A and KIF2A.

Atmospheric wet organic nitrogen deposition in China: Insights from the national observation network.

Organic nitrogen (N) is an important component of atmospheric reactive N deposition, and its bioavailability is almost as important as that of inorganic N. Currently, there are limited reports of national observations of organic N deposition; most stations are concentrated in rural and urban areas, with even fewer long-term observations of natural ecosystems in remote areas. Based on the China Wet Deposition Observation Network, this study regularly collected monthly wet deposition samples from 43 typical ecosystems from 2013 to 2021 and measured related N concentrations.

Phosphorus level impacts luteolin effect on Microcystis aeruginosa growth and microcystin-pollution risk - Novel perspective from correlation between exopolymers substances fractions and microcystin-production/release.

Luteolin as a phytogenic algicide can inhibit the growth and microcystins (MCs) release of Microcystis, a dominant genus during cyanobacterial blooms, but how phosphorus (P) level impacts luteolin effect on its growth and MC-pollution risk is unclear. By employing Microcystis aeruginosa as test alga, this study addressed this concern and explored response mechanisms from novel insights of relationship between extracellular polysaccharide (ex-poly) and protein (ex-pro) contents and MC-production/release. At each P level (0.

BONCAT-based Profiling of Nascent Small and Alternative Open Reading Frame-encoded Proteins.

RIBO-seq and proteogenomics have revealed that mammalian genomes harbor thousands of unannotated small and alternative open reading frames (smORFs, <100 amino acids, and alt-ORFs, >100 amino acids, respectively). Several dozen mammalian smORF-encoded proteins (SEPs) and alt-ORF-encoded proteins (alt-proteins) have been shown to play important biological roles, while the overwhelming majority of smORFs and alt-ORFs remain uncharacterized, particularly at the molecular level. Functional proteomics has the potential to reveal key properties of unannotated SEPs and alt-proteins in high throughput, and an approach to identify SEPs and alt-proteins undergoing regulated synthesis should be of broad utility.

The Impact of Extreme Temperature Shocks on the Health Status of the Elderly in China.

With the accelerating process of climate change, long-term exposure to extreme temperatures could threaten individuals' physical health, especially for the vulnerable population. This paper aims to investigate the long-term effects of extreme temperature exposure on the health of the elderly in the context of climate change and aging. Different from most of the existing literature in environmental economics, we define the relative extreme temperature exposure based on the local temperature pattern.

A ratiometric electrochemical sensor based on Cu-coordinated molecularly imprinted polymer and porous carbon supported Ag nanoparticles for highly sensitive and selective detection of perphenazine.

In this work, a ratiometric electrochemical sensor was developed for the detection of perphenazine (PPZ). The sensor was constructed by electrodepositing Cu-coordinated molecularly imprinted polymer (Cu-MIP) on Ag nanoparticles (NPs) modified flexible porous carbon cloth. The Cu-MIP showed highly electrochemical response because of the enhanced adsorptive ability and electronic properties of Cu chelation; Ag NPs could provide a stable and effective reference signal for ratiometric quantification.