Machine learning-assisted CeO nanorod sensor platform for visual detection of paraoxon.

Here we report a machine learning-assisted CeO nanorod sensor platform, which can achieve real-time colorimetric detection of the selectivity of paraoxon with an accuracy rate of 90%. Its high selectivity comes from the fact that CeO nanorods selectively break the P-O bonds in paraoxon, and the product is yellow.

UiO-66(Ce) nanozymes with dual-site synergistic catalysis for efficient hydrolysis of organophosphorus poisons.

Nanozymes are a class of nanomaterials capable of mimicking the activity of phosphatase, offering sustainable hydrolysis and efficient catalytic strategies to address environmental pollution caused by organophosphorus pesticides (OPs). However, challenges such as low activity and insufficient mechanistic understanding of nanozymes remained critical concerns. Herein, UiO-66(Ce) was synthesized and loaded onto polyvinylidene difluoride (PVDF) to obtain UiO-66(Ce)/PVDF for hydrolysis of p-nitrophenol phosphate (p-NPP), a simulant of OPs.

β-cyclodextrin-modified silver nanoparticles for highly selective recognition of chiral Trp and its mechanism.

Chiral recognition plays a crucial role in the fields of chemistry, biomedicine, and food science. In this study, β-cyclodextrin-modified silver nanoparticles (β-CD@AgNPs) with enhanced chiral binding ability were successfully prepared using the reduction method and utilized for the selective recognition of tryptophan (Trp) enantiomers, one of the representatives of non-polar amino acids. Interestingly, the β-CD@AgNPs with L-Trp system exhibited a red color (with a new ultraviolet-visible (UV-vis) absorption peak at around 550 nm), while no change occurred with D-Trp.

Versatile and programmable dual-mode logic gold nanoflares for intracellular correlated DNA repair enzymes imaging.

In situ monitoring of correlated DNA repair enzyme activities in living cells is crucial for clinical and biomedical research. Here, we introduce a versatile, programmable dual-mode logic gold nanoflares strategy for OR/AND gate logic imaging the activity of apurinic/apyrimidinic endonuclease 1 (APE1) and flap endonuclease 1 (FEN1) within cells. The logic gold nanoflares were designed via conjugating enzyme-activatable sites modified branched double-stranded DNA structures to gold nanoparticles.

A DNA concatemer-encoded CRISPR/Cas12a fluorescence sensor for sensitive detection of Pb based on DNAzymes.

Lead pollution presents a significant threat to ecological systems and human health, underscoring the urgent need for highly sensitive detection methods. Herein, we introduce a novel DNA concatemer-encoded CRISPR/Cas12a fluorescence sensor (MDD-Cas12a) for sensitive detection of Pb based on DNAzymes. To accomplish this, we designed a substrate strand containing a long DNA concatemer encoding multiple protospacer adjacent motifs (PAMs) and protospacer sequences for activation of the CRISPR/Cas12a system.

High-performance self-supporting AgCoPO/CFP for hydrogen evolution reaction under alkaline conditions.

Electrochemical water decomposition to produce hydrogen is a promising approach for renewable energy storage. It is vital to develop a catalyst with low overpotential, low cost and high stability for hydrogen evolution reaction (HER) under alkaline conditions. Herein, we used a simple hydrothermal method to obtain a AgCo(CO) precursor on the surface of carbon fiber paper (CFP).

Charge-Switchable CuO Nanozyme with Peroxidase and Near-Infrared Light Enhanced Photothermal Activity for Wound Antibacterial Application.

Bacterial infection is still a thorny problem threatening human health, and nanozymes offer a promising alternative strategy to combat the health threat posed by bacterial infection. However, the antibacterial efficacies of nanozymes are unsatisfactory because of low catalytic activity of nanozymes and their inability to trap bacteria. Herein, a multifunctional nanozyme, polydopamine (PDA)-modified copper oxide (CuO-PDA) is designed to overcome this challenge.

Effects of king grass and rice straw hay on apparent digestibility and ruminal microorganisms of buffalo.

The purpose of this study was to explore the effects of Rice straw and King grass on apparent digestibility, ruminal bacterial, and fungus composition in buffaloes. Three ruminal fistulated buffaloes were used in a 3 × 2 Latin square design. The dietary treatments were king grass and straw hay.

Electrochemical enantioselective sensor for effective recognition of tryptophan isomers based on chiral polyaniline twisted nanoribbon.

Effective enantioselective recognition with chiral nanomaterials remains a challenge in the field of chemistry and biology. In this paper, a pair of left- and right-handed polyaniline (defined as S-PANI and R-PANI) were synthesized by chemical oxidation of aniline to form a specially twisted nanoribbon, which was induced by enantiomeric camphorsulfonic acid. Both S-PANI and R-PANI were used to construct electrochemical chiral sensors for the discrimination of tryptophan isomers (D- and L-Trp).

Iterative Learning Control With Data-Driven-Based Compensation.

The robust iterative learning control (RILC) can deal with the systems with unknown time-varying uncertainty to track a repeated reference signal. However, the existing robust designs consider all the possibilities of uncertainty, which makes the design conservative and causes the controlled process converging to the reference trajectory slowly. To eliminate this weakness, a data-driven method is proposed.

Poly(glycine)/graphene oxide modified glassy carbon electrode: Preparation, characterization and simultaneous electrochemical determination of dopamine, uric acid, guanine and adenine.

A novel poly(glycine) (p-GLY)/graphene oxide (GO) composite based sensor (p-GLY/GO) was successfully prepared on glassy carbon electrode by simple electropolymerization. Electrochemical responses of analytes on p-GLY/GO modified electrode were studied by cyclic voltammetry and differential pulse voltammetry. The results demonstrated that p-GLY/GO modified electrode showed a favorable application for the simultaneous determination of dopamine (DA), uric acid (UA), guanine (GU) and adenine (AD).

Simultaneous voltammetric determination of guanine and adenine by using a glassy carbon electrode modified with a composite consisting of carbon quantum dots and overoxidized poly(2-aminopyridine).

A composite consisting of carbon quantum dots (CQDs) and overoxidized poly(2-aminopyridine) (PAPox) was deposited on a glassy carbon electrode (GCE) through electrochemical polymerization and electrochemical oxidation. The modified GCE was used for the simultaneous determination of guanine and adenine. Electrochemical responses to guanine and adenine were investigated by cyclic voltammetry and differential pulse voltammetry.

Efficacy and Tolerability of Different Interventions in Children and Adolescents with Attention Deficit Hyperactivity Disorder.

Background: Our study is an analysis of multiple publications involving assessing the comparable efficacy and tolerability of six interventions, which are lisdexamfetamine dimesylate (LDX), atomoxetine (ATX), methylphenidate (MPH), clonidine hydrochloride (CLON), guanfacine extended release (GXR), and bupropion, for young patients (6-18 years old) suffering from attention deficit hyperactivity disorder (ADHD).

Methods: A conventional meta-analysis (MA) was performed to give direct comparisons and a network meta-analysis (NMA) was used to show the combination of direct and indirect evidence. Ranking preference for all the interventions under a certain outcome was given by the surface of cumulative ranking curve area (SUCRA).