BDH2 promotes GLIPR1 promoter methylation and thus increases 5-FU sensitivity in colorectal cancer.

5-Fluorouracil (5-FU) is an effective drug in the treatment of colorectal cancer (CRC); however, the development of acquired resistance to 5-FU poses a great challenge in clinical practice. Through the analysis of public datasets, we found that reduced 3-Hydroxybutyrate Dehydrogenase 2 (BDH2) expression in CRC tissues predicted poor survival in CRC patients. Low expression of BDH2 in clinical CRC tissue samples predicted a higher degree of malignancy.

Automated Prediction of Item-Level Arat Scores From Wearable Sensors.

The demand for neurorehabilitation is projected to increase drastically over the next decades, creating a need to automate and enhance the efficiency of clinical processes. Clinical assessments are important to track treatment effectiveness and to tailor therapy approaches. We here develop a scoring prediction system for the Action Research Arm Test (ARAT), a common clinical assessment for upper limb function in stroke.

Anticancer Potential of [Formula: see text]-Sitosterol: A Comprehensive Exploration of Mechanisms and Therapeutic Prospects.

This paper comprehensively examines the anticancer mechanisms and therapeutic potential of β-sitosterol, a naturally occurring phytosterol found in various plants. β-Sitosterol has shown significant efficacy in inhibiting tumor growth and metastasis through various biological pathways, including inducing apoptosis, arresting cell cycle progression, and suppressing cell proliferation, invasion, and migration. We highlight the key mechanisms by which β-sitosterol exerts its effects, such as modulating apoptosis-related signaling pathways like those of the Bcl-2 family proteins and reactive oxygen species production.

Intraoperatively preventive intraperitoneal perfusion chemotherapy with lobaplatin in colorectal cancer: a prospective, randomised, controlled, multicentre study.

Background: Peritoneal metastasis (PM) after radical surgery is an important cause of treatment failure in colorectal cancer (CRC). Intraoperative intraperitoneal perfusion chemotherapy may be an effective method for preventing postoperative PM in patients with CRC. This study aimed to explore the safety and feasibility of intraoperatively preventive intraperitoneal perfusion chemotherapy using lobaplatin for CRC.

Co-Culture of With and Impact the Metabolism and Flavor of Fermented Milk.

Incorporating into fermented milk alters the balance between and . We investigated the bacterial interaction and metabolism post-fermentation and during 21-day storage. Utilizing non-targeted metabolomics and electronic nose technology, we assessed impacts on product quality and flavor.

Comprehensive Analysis of GPSM2: From Pan-Cancer Analysis to Experimental Validation.

G-protein signalling modulator 2 (GPSM2) plays an important role in maintaining cell polarisation and regulating the cell cycle; however, a systematic and comprehensive analysis of GPSM2 in cancer is still lacking. Using extensive multi-omics data, we explored the pan-cancer expression levels of GPSM2 from multiple perspectives and its association with prognosis, diagnosis, tumour stemness, immune-related genes, immune cell infiltration, genomic instability, and response to immunotherapy. We also elucidated the potential pan-cancer biological functions of GPSM2 using gene set enrichment analysis (GSEA) and searched for targeted drugs that affect GPSM2 expression using connectivity map analysis.

Assessment for antibiotic resistance in : A practical and interpretable machine learning model based on genome-wide genetic variation.

() antibiotic resistance poses a global health threat. Accurate identification of antibiotic resistant strains is essential for the control of infection. In the present study, our goal is to leverage the whole-genome data of to develop practical and interpretable machine learning (ML) models for comprehensive antibiotic resistance assessment.

Impact of the potassium transporter TaHAK18 on wheat growth and potassium uptake under stressful K conditions.

Potassium (K), an indispensable nutrient for plant growth and development, plays a crucial role in plant stress resistance. Within the K regulatory network in plants, the HAK/KUP/KT gene family comprises a dominant group of K transport proteins responsible for K uptake and transport. This study functionally characterized the wheat gene TaHAK18, which encodes a putative K transporter.

Icariin improves erectile function in spontaneously hypertensive rats by downregulating GRK2 in penile cavernous tissue.

Background: Hypertension is an independent risk factor for erectile dysfunction (ED). Icariin can improve erectile function of spontaneous hypertensive rats (SHRs). GRK2 is closely related to the phosphorylation of eNOS and endothelial function.

Trends in Colorectal Cancer Peritoneal Metastases Research: A Comprehensive Bibliometric Analysis.

Background: Colorectal cancer (CRC) stands as the third most prevalent malignancy globally and is recognized as the second leading cause of cancer-related mortality. Notably, nearly 50% of individuals diagnosed with CRC ultimately develop metastatic disease, with the peritoneum emerging as the second most frequent site for metastatic spread. Recent advancements in therapeutic frameworks have enhanced both survival rates and quality of life metrics for patients afflicted with colorectal cancer peritoneal metastases (CRCPM).

Mixed-variable graphical modeling framework towards risk prediction of hospital-acquired pressure injury in spinal cord injury individuals.

Developing machine learning (ML) methods for healthcare predictive modeling requires absolute explainability and transparency to build trust and accountability. Graphical models (GM) are key tools for this but face challenges like small sample sizes, mixed variables, and latent confounders. This paper presents a novel learning framework addressing these challenges by integrating latent variables using fast causal inference (FCI), accommodating mixed variables with predictive permutation conditional independence tests (PPCIT), and employing a systematic graphical embedding approach leveraging expert knowledge.

Dissecting the roles of prosaposin as an emerging therapeutic target for tumors and its underlying mechanisms.

As a dual-function protein, prosaposin (PSAP) is a lysosome-associated protein that participates in a variety of cellular processes. In the lysosome, PSAP is processed to activate enzymes that degrade lipids. In addition, PSAP proteins located extracellularly are involved in cancer progression, such as proliferation and tumor death suppression signaling.

Cell Polarity-related Gene PTK7, a Potential Diagnostic Biomarker in Pan-cancer.

Background: PTK7 (Protein Tyrosine Kinase 7), a member of the receptor protein tyrosine kinase family, was originally discovered in colon cancer cells. It plays a pivotal role in numerous developmental and physiological processes, particularly in the regulation of cell polarity. Despite accumulating evidence of PTK7's significant influence on tumor development, a comprehensive pan-cancer analysis of PTK7 has yet to be conducted.

Bioinspired Sulfobetaine Borneol Fluorinated Amphiphilic Polymers for Marine Antifouling and Fouling Release Applications.

The development of nontoxic antifouling coatings in static marine environments is urgent. Herein, the successful synthesis of sulfobetaine borneol fluorinated polymers (PEASBF) by a free radical polymerization method is reported. The PEASBF coatings exhibit outstanding antifouling activity, which effectively resists the adhesion of (FITC-BSA adhesion rate: 0.

Robust Feature Selection for BP Estimation in Multiple Populations: Towards Cuffless Ambulatory BP Monitoring.

Current blood pressure (BP) estimation methods have not achieved an accurate and adaptable approach for ambulatory diagnosis and monitoring applications of populations at risk of cardiovascular disease, generally due to a limited sample size. This paper introduces an algorithm for BP estimation solely reliant on photoplethysmography (PPG) signals and demographic features. It automatically obtains signal features and employs the Markov Blanket (MB) feature selection to discern informative and transmissible features, achieving a robust space adaptable to the population shift.

Tightly focusing metalens based on the high order Bessel function.

We propose a new, to the best of our knowledge, type of metalens of which the phase profile is extracted from the higher-order Bessel function. A light beam passing through this metalens would focus along the circular trajectory and produces a tightly focusing field. Utilizing phase binarization, we provide a method to design the geometric-phase dielectric metasurface both for phase and polarization modulations.

A Pickering emulsion stabilized by Chitosan-g-Poly(N-vinylcaprolactam) microgels: Interface formation, stability and stimuli-responsiveness.

Pickering emulsions stabilized by solid particles are more stable and environmentally friendly compared to traditional surfactants. Herein, a series of Chitosan-g-Poly(N-vinylcaprolactam) (CS-g-PNVCL) microgel particles were synthesized via a free radical surfactant-free emulsion copolymerization and the obtained particles were used to stabilize Pickering emulsions. It is found that the ratio (CS/PNVCL = 60 wt%) was optimal to produce Pickering emulsions.

Optical feedback noise-immune cavity-enhanced optical heterodyne molecular spectrometry for sub-Doppler-broadened detection of CH: publisher's note.

This publisher's note contains a correction to Opt. Lett.49, 202 (2024)10.

A novel PCDscore based on programmed cell death-related genes can effectively predict prognosis and therapy responses of colon adenocarcinoma.

Emerging evidence suggests a correlation between oncogenesis and programmed cell death (PCD). However, comprehensive studies that incorporate all identified PCD-related genes to guide colon adenocarcinoma (COAD) prognosis and precision treatment strategies are lacking. In this study, a series of bioinformatics analyses were comprehensively conducted using data from the TCGA-COAD, GSE17538, and GSE39582 cohorts.

Optical feedback noise-immune cavity-enhanced optical heterodyne molecular spectrometry for sub-Doppler-broadened detection of CH.

A novel, to the best of our knowledge, noise-immune cavity-enhanced optical heterodyne molecular spectrometry (NICE-OHMS) has been developed, utilizing optical feedback for laser-to-cavity locking with a common distributed-feedback diode laser. The system incorporates active control of the feedback phase and feedforward control of the laser current, allowing for consecutive laser frequency detuning by scanning a piezoelectric transducer (PZT) attached to the cavity. To enhance the fidelity of the spectroscopic signal, wavelength-modulated (wm) NICE-OHMS is implemented.

Associations between insomnia and large vessel occlusion acute ischemic stroke: An observational study.

Objectives: This study explored the association between insomnia and the clinical outcome of large vessel occlusion Acute Ischemic Stroke (AIS) and attempted to explore its potential mechanisms from the perspectives of inflammation and oxidative stress.

Methods: AIS patients who underwent endovascular treatment for large vessel occlusion at Binzhou Central Hospital from 2018 to 2022 (n = 508) were included. Patients were divided into an insomnia group and a non-insomnia group.

Self-calibrated NICE-OHMS based on an asymmetric signal: theoretical analysis and experimental validation.

As an ultra-sensitive detection technique, the noise-immune cavity enhanced optical heterodyne molecular spectroscopy (NICE-OHMS) technique has great potential for assessment of the concentration of trace gases. To determine gas concentrations at the ppt or lower level with high accuracy, it is desirable that the technique exhibits self-calibration (or calibration-free) capabilities. Although being sensitive, NICE-OHMS has so far not demonstrated any such ability.

The role of non-coding RNA in the diagnosis and treatment of -related gastric cancer, with a focus on inflammation and immune response.

() is one of the globally recognized causative factors of gastric cancer (GC). Currently, no definite therapy and drugs for -related GC have been widely acknowledged although infection could be eradicated in early stage. Inflammation and immune response are spontaneous essential stages during infection.

Flexible trajectory control of Bessel beams with pure phase modulation.

Spatial phase modulation has become an important method for the design of new self-accelerating light beams. Based on the transverse-longitudinal mapping of Bessel beam, we propose a method of pure phase modulation to directly convert a zero-order Bessel beam into a self-accelerating beam, of which the propagation trajectories can be flexibly predesigned. We experimentally demonstrate three typical types of curves that the modulated Bessel beam propagates along, and the parabolic, spiral, and teleporting self-accelarating beams are realized.