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We propose a new, to the best of our knowledge, type of metalens of which the phase profile is extracted from the higher-order Bessel function. A light beam passing through this metalens would focus along the circular trajectory and produces a tightly focusing field. Utilizing phase binarization, we provide a method to design the geometric-phase dielectric metasurface both for phase and polarization modulations. We demonstrate two metalenses for circularly and radially polarized output beams at 633 nm, with the measured 0.737λ and 0.616λ focal spots, respectively. Theoretically, it can realize a super-diffraction-limit spot (0.38λ). This work can extend the way of realizing tightly focused optical devices.
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http://dx.doi.org/10.1364/OL.517256 | DOI Listing |
Adv Biol (Weinh)
September 2025
Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Growth factors play a crucial role in regulating cellular processes such as proliferation, differentiation, and survival. Their activities are tightly modulated to ensure proper physiological functioning, with dysregulation often contributing to disease pathogenesis. Among these, the insulin-like growth factor (IGF) system that encompasses IGF-1 and IGF-receptor binding proteins is pivotal in maintaining overall cellular health by regulating growth, repair, and metabolic regulation.
View Article and Find Full Text PDFBMC Biotechnol
August 2025
Chair of Biochemical Engineering (AVT.BioVT), RWTH Aachen University, 52074, Aachen, Germany.
Background: Cell-free protein synthesis (CFPS) is one approach to address the increasing demand for complex recombinant proteins in various applications, especially in the pharmaceutical sector. CFPS offers a variety of advantages like the ability to express cytotoxic proteins, no need for transformations or screening of strains and, thus, reduced production times. Often industrially relevant proteins require post-translational modifications (PTM).
View Article and Find Full Text PDFJ Neurochem
August 2025
Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
Neurotransmitter release plays a fundamental role in brain communication. This is mediated via the exocytosis of neurotransmitter-containing synaptic vesicles (SVs) at the presynapse. After fusion with the presynaptic plasma membrane, SVs are regenerated by endocytosis and recycled back into functional pools.
View Article and Find Full Text PDFJ Med Robot Res
April 2025
The University of Tennessee, Knoxville, Department of Mechanical, Aerospace, and Biomedical Engineering.
Concentric push-pull robots delivered through flexible endoscopes work best if their laser-cut transmission tubes have high axial stiffness, high torsional stiffness, and low bending stiffness. This paper simultaneously addresses all three output stiffness values in the transmission design problem, explicitly considering axial stiffness, whereas prior work on laser-cut tube design has focused on the bending/torsional stiffness ratio. We demonstrate an inherent trade-off present in existing laser-cut patterns: it is difficult to simultaneously achieve high axial stiffness and low bending stiffness because these properties are very tightly correlated.
View Article and Find Full Text PDFAutism Dev Lang Impair
August 2025
Department of Speech and Language Therapy, University of Peloponnese, Kalamata, Greece.
Background And Aims: Minimally verbal (MV) autistic children constitute a considerable portion of the autism spectrum, representing approximately one-third of the autistic individuals. Despite the urgency of understanding this population, relatively few studies have focused specifically on the language abilities of MV autistic children. This study aims to examine the language abilities of Greek-speaking preschool-aged MV children with autism prior to intervention.
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