Bromine-Functionalized Covalent Organic Frameworks Enhancing the Desorption Efficiency and Enabling Preconcentration of Brominated Pollutants for Mass Spectrometry Detection.

Covalent organic frameworks (COFs) exhibit exceptional adsorption capacity but suffer from challenging desorption. In this study, a bromine-functionalized magnetic COF composite (FeO@COF-Br) was synthesized via bromodimethylsulfonium bromide-mediated bromination of imine-linked COF on FeO nanospheres (FeO@COF), where the COF framework was constructed by 1,3,5-tris(4-formylphenyl)benzene and 2,6-diamino-3,5-diethynylpyridine. Compared with pristine FeO@COF, FeO@COF-Br enhanced desorption efficiencies for brominated contaminants by about 30% while maintaining adsorption capacity.

Site-specific protein lipoylation analysis aldehyde-acetal probe labelling and reversible enrichment (DA-Lipo).

Protein lipoylation regulates metabolic processes closely related to cancer and neurodegeneration, but only five human lipoylated proteins have been identified, underscoring the need for robust analytical methods. We present DA-Lipo, a one-step labelling/enrichment strategy for site-specific lipoylation analysis. Terephthalaldehyde monodiethylacetal selectively tags lipoyl-peptides cyclic thiol-aldehyde chemistry, enabling reversible enrichment and MS detection with a diagnostic immonium ion (419.

Myocardial Blood Flow and the Retinal Microvasculature Across the Spectrum From Normal to Failing Hearts.

Deficiency of the myocardial microcirculation plays a role in the pathogenesis of heart failure (HF). We aimed to investigate the association of myocardial blood flow (MBF) and the retinal microvasculature with left ventricular (LV) function and its potential mediators. In healthy controls (HCs; n = 48), patients with cardiovascular risk factors (CVRF; n = 49) and patients with compensated HF (CHF; n = 52), we assessed LV diastolic filling pressure (E/e'), LV ejection fraction (LVEF), and global longitudinal strain (GLS) associated with MBF and the retinal arteriole-to-venule ratio (AVR), using multivariable regression models, while considering their direct contributions to LV function and the indirect contributions running via NT-proBNP.

Pathological complete response and prognostic predictive factors of neoadjuvant chemoimmunotherapy in early stage triple-negative breast cancer.

Background: Neoadjuvant chemoimmunotherapy (nCIT) has shown promise in treating early-stage triple-negative breast cancer (eTNBC), but predictive biomarkers for pathological response and prognosis remain poorly defined.

Objective: This study aimed to explore pathological complete response and prognostic predictive factors in eTNBC patients treated with nCIT.

Materials And Methods: We retrospectively analyzed 112 eTNBC patients who underwent surgery after nCIT at Sun Yat-sen University Cancer Center between June 2019 and June 2023.

Triazolone-Functionalized Magnetic Nanoparticles for Hemoglobin Purification and Proteomics-Driven Biomarker Discovery in Diabetic Blood.

Hemoglobin, particularly glycated hemoglobin, serves as the gold standard for diagnosing diabetes in clinical settings. In this study, a triazolinone derivative, 3-chloromethyl-1,2,4-triazol-5-one (CMTO), was conjugated to polyethylenimide-modified magnetic nanoparticles via an amination reaction, resulting in the formation of a novel composite material, CMTO@FeO-NH. Molecular simulations revealed that the carbonyl group of CMTO underwent tautomerization to an enol form under neutral pH conditions.

Intrinsically Luminescent Nematic Liquid Crystals Enabling High-Brightness Full-Color and White Circularly Polarized Luminescence via Chiral Coassembly.

Circularly polarized luminescence (CPL) materials with simultaneous high dissymmetry factor (g) and brightness are pivotal for advanced photonic applications but remain challenging due to inherent trade-offs betwwen g value and photoluminescenc quantum yield (PLQY). Here, we report a supramolecular engineering strategy to construct intrinsically luminescent chiral nematic liquid crystal (N*-LC) films via coassembly of luminescent liquid crystals (LLCs) and chiral dopant. First, five intrinsic LLCs molecules (2PFQ, 2PFBQ, 2PFB, 2PFSe, and 2PFS) were synthesized by combining the biphenyl framework with dioctyl-functionalized fluorene, achieving exceptional nematic phases and high brightness with PLQY up to 99%.

Instant synthesis of bimetallic CuCo PBA nanozyme for efficient colorimetric immunoassay of carcinoembryonic antigen.

Colorimetric immunoassays are widely used for biomarker detection, offering advantages of simplicity, sensitivity, and cost-effectiveness. Recent advancements focus on improving the catalytic activity of nanozymes for enhancing the sensitivity and accuracy of such assays. Bimetallic CuCo Prussian blue analog (CuCo PBA) has emerged as promising candidates due to their excellent peroxidase-like activity.

Accurately sensing analysis of active adenine DNA glycosylase (MutY) via the high identification/excision capability to specific base-mismatches of dsDNA chains.

Adenine DNA glycosylase (MutY) is a crucial member of DNA glycosylase family, and the abnormal expression of the human MutY homologs is associated with the pathogenesis of various diseases, therefore, convenient and cost-effective assessing the activity of MutY holds significant biological and medical importance. Herein, the precise identification/excision capacity of MutY to mismatched G-A base pair of dsDNA chains and the DNA-template-dependant fluorescence behaviors of copper nano cluster (CuNCs) was exploited for the accurate sensing of active MutY. Hairpin DNA with G-A base mismatch was excised by MutY to produce dsDNA chains with repetitive AAT-TTA base pairs.

Machine learning-based classification and prediction of typical Chinese green tea taste profiles.

The taste of Chinese green tea is highly diverse. In this study, a combination of unsupervised and supervised learning methods was utilized to develop a model for classifying and predicting typical Chinese green tea taste. Three clustering methods were assessed based on quantitative descriptive analysis (QDA) results, with the Hierarchical-K means method chosen to classify 88 tea infusions into seven distinct taste types.

Efficient and Rapid Extraction of Gold from E-Waste via Tailoring the Skeleton Environment of Covalent Organic Framework.

The recovery and repurposing of noble metal from electronic waste has attracted significant attention due to the tremendous benefits to the economy and environment but is of great challenge. Herein, a two-dimensional oxygen-rich COF material, named TbDa-COF, was fabricated via integrating 1,3,5-tris(4-formylphenyl)benzene (TFPB) and oxygen-rich 3,3'-dihydroxybenzidine (DHB) into a π-conjugated framework. TbDa-COF permits selective gold recovery through local coordination and electrostatic interaction, which is then followed via in situ reduction to form gold nanoparticles (AuNPs) within its skeleton.

RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic-nuclear shuttling in human triple-negative breast cancer.

Background: Resistance to paclitaxel-based chemotherapy is the major obstacle in triple-negative breast cancer (TNBC) treatment. However, overcoming paclitaxel resistance remains an unsolved problem. The present study aimed to determine whether paclitaxel treatment impairs Aly/REF export factor (ALYREF) cytoplasmic-nuclear shuttling, its mechanism, and the role of ubiquitinated ALYREF in paclitaxel resistance.

Retrospective comparative survival analysis of ablation plus systemic therapy versus systemic therapy alone for breast cancer liver metastases, stratified by extrahepatic metastases status.

Background: Current decision-making for the treatment of breast cancer liver metastases (BCLM) using ablation lacks strong evidence, especially for patients combined with extrahepatic metastases.

Purpose: To assess whether ablation plus systemic therapy (AS) improves survival outcomes in patients with BCLM compared to systemic therapy alone.

Materials And Methods: This retrospective study analyzed patients with BCLM who received either AS or systemic therapy alone.

Sensitive and rapid fluorescent detection of metronidazole based on stable light-emitting vinylene-linked covalent organic framework.

Development of ultra-sensitive and rapid fluorescent nanoprobe for quantitative and targeted monitoring of metronidazole is of crucial practical significance, but is of great challenge. Herein, a vinyl-linked covalent organic frameworks (sp-BNTP-COF) was fabricated via integrating the 1,3,5-tris-(4-formylphenyl) triazine with 5,5'-bis(cyanomethyl)-2,2'-bipyridine into the skeleton. As-obtained sp-BNTP-COF exhibited excellent luminescence characteristics with an absolute fluorescence quantum yield of 8 %.

PTPN20 promotes metastasis through activating NF-κB signaling in triple-negative breast cancer.

Background: Cancer metastasis remains a major challenge in the clinical management of triple-negative breast cancer (TNBC). The NF-κB signaling pathway has been implicated as a crucial factor in the development of metastases, but the underlying molecular mechanisms remain largely unclear.

Methods: PTPN20 expression was evaluated using data from the Sweden Cancerome Analysis Network-Breast and The Cancer Genome Atlas database, as well as by western blotting and immunohistochemistry in 88 TNBC patients.

Chiral ionic organic single-crystal and its exfoliated two-dimensional nanosheets with enhanced enantioseparation.

A chiral ionic organic single-crystal (CIOC) was prepared for the first time through ionic self-assembly using bipyridium chiral ionic liquid (CIL) and 4,4'-biphenyldisulfonic acid (BDA). The CIOC can be ultrasonically exfoliated to produce two-dimensional nanosheets (2D-NSs). The 2D-NSs presented enhanced enantioseparation compared to the CIOC and CIL when used as gas chromatography stationary phase, which may be due to the exfoliated 2D-NSs exhibiting greater exposure of functional groups.

Targeting the SPC25/RIOK1/MYH9 Axis to Overcome Tumor Stemness and Platinum Resistance in Epithelial Ovarian Cancer.

In epithelial ovarian cancer (EOC), platinum resistance, potentially mediated by cancer stem cells (CSCs), often leads to relapse and treatment failure. Here, the role of spindle pole body component 25 (SPC25) as a key determinant promoting stemness and platinum resistance in EOC cells, with its expression being correlated with adverse clinical outcomes is delineated. Mechanistically, SPC25 acts as a scaffolding platform, orchestrating the assembly of an SPC25/RIOK1/MYH9 trimeric complex, triggering RIOK1-mediated phosphorylation of MYH9 at Ser1943.

Effect of potassium fulvate on continuous tobacco cropping soils and crop growth.

Long-term continuous cropping of tobacco causes dysbiosis of soil microbial communities, the imbalance of soil nutrients, and the increase of pathogenic bacteria, which will slow the growth and development of tobacco plants, reduce the production quality, and cause significant losses to tobacco production and tobacco farmers. The application of Potassium fulvic acid can not only provide nutrients, but also inhibit the propagation of pathogens in soil along with raising the amount of organic matter in the soil, which is an effective way to improve soil health. In this experiment, Tobacco variety SNT60 was used as the test material, and 6 treatments were set up by pot test, they were: no fertilisation control group (CK), tobacco special fertiliser (NPK), 3.

Novel three-dimensional fibrous covalent organic frameworks constructed silver amalgam bridging for efficient organic dye adsorption and removal.

The construction of covalent organic frameworks (COFs) with unique structures has great significance in exploring the structure-function relationship and extending their potential applications. Fibrous COFs have demonstrated superior performance in specific application scenarios owing to the distinctive three-dimensional (3D) structure. Herein, we report a facile strategy for the fabrication of 3D COF nanofiber by exploiting silver amalgam as a bridging agent to assemble one-dimensional-extended PA-COF modules into a tubular structure.

A violet light-emitting diode-based gas-phase molecular absorption device for measurement of nitrate and nitrite in environmental water.

A simple and sensitive device for the detection of nitrite and nitrate in environmental waters was developed based on visible light gas-phase molecular absorption spectrometry. By integrating a detection cell (DC), semiconductor refrigeration temperature-controlling system (SRTCY), and nitrite reactor into a sequential injection analysis system, trace levels of nitrite and nitrate in complex matrices were successfully measured. A low energy-consuming light-emitting diode (violet, 400-405 nm) was coupled with a visible light-to-voltage converter (TSL257) to measure the gas-phase molecular absorption.

Demographic Disparities in Drive Times to the Nearest Audiologist in the United States.

Purpose: Audiological services are underused, possibly because patients need to drive long distances to see a provider. In this study, we measured the association of drive times to the nearest audiologist with population density, income, ethnicity, race, and distance to the nearest audiology graduate program.

Method: Drive times for each census block group to the nearest audiologist were measured using census data, the National Provider Identifier Registry, and a geographic analyzing tool called ArcGIS for all block groups within the United States.

Occurrence of Chlorinated Derivatives of Bisphenol S in Paper Products and Their Potential Health Risks through Dermal Exposure.

The occurrence of chlorinated derivatives of bisphenol S (Cl-BPS) and BPS was investigated in nine types of paper products ( = 125), including thermal paper, corrugated boxes, mail envelopes, newspapers, flyers, magazines, food contact paper, household paper, and business cards. BPS was found in all paper product samples, while Cl-BPS were mainly found in thermal paper (from below the limit of detection ( View Article and Find Full Text PDF

Sulfur vacancy-enhanced InS hollow microtubes for photocatalytic Cr (VI) and tetracycline removal.

Morphological regulation and defect engineering are efficient methods for photocatalytic technology by improving photon absorption and electron dissociation. Herein, InS hollow microtubes with S-vacancies (MIS) were fabricated via a simple solvothermal reaction using In-based metal-organic frameworks (In-MOFs) as a precursor. Experimental results demonstrate that the hollow structure and optimal S-vacancies can jointly accelerate the photocatalytic reaction, attributed to a larger specific surface area, more active sites, and faster electron transfer efficiency.

Intercalating of AIEgens into MoS nanosheets to induce crystal phase transform for enhanced photothermal and photodynamic synergetic anti-tumor therapy.

A MoS-based nanotherapeutic platform was developed for synergetic photothermal and photodynamic anti-tumor therapy. AIEgens TFPy-SH molecules were intercalated into MoS nanosheets (MoS NSs) with S-deficiencies to give the nanocomposite MoS-TFPy. The AIEgens intercalation expanded the interlayer spacing of MoS NSs and induced the transform of MoS crystal phase from 2H to 1T, offering MoS-TFPy nanocomposite high molar absorption coefficient (5.