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Article Abstract
A MoS-based nanotherapeutic platform was developed for synergetic photothermal and photodynamic anti-tumor therapy. AIEgens TFPy-SH molecules were intercalated into MoS nanosheets (MoS NSs) with S-deficiencies to give the nanocomposite MoS-TFPy. The AIEgens intercalation expanded the interlayer spacing of MoS NSs and induced the transform of MoS crystal phase from 2H to 1T, offering MoS-TFPy nanocomposite high molar absorption coefficient (5.65 L g cm), excellent photothermal conversion efficiency under near-infrared (NIR) laser irradiation (38.3%), and favorable intracellular reactive oxygen species (ROS) generation capacity. The positively charged MoS-TFPy were mainly distributed in mitochondria after cell up-taking, and achieved 1+1>2 anti-tumor effect attributed to its favorable photothermal and photodynamic properties. The high structure and physiological stability, favorable biocompatibility, excellent photothermal and photodynamic therapy effect make the MoS-TFPy nanoplatform an promising candidate in biomedical clinical applications.
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| http://dx.doi.org/10.1016/j.talanta.2024.125677 | DOI Listing |
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