Bromine-Functionalized Covalent Organic Frameworks Enhancing the Desorption Efficiency and Enabling Preconcentration of Brominated Pollutants for Mass Spectrometry Detection.

Covalent organic frameworks (COFs) exhibit exceptional adsorption capacity but suffer from challenging desorption. In this study, a bromine-functionalized magnetic COF composite (FeO@COF-Br) was synthesized via bromodimethylsulfonium bromide-mediated bromination of imine-linked COF on FeO nanospheres (FeO@COF), where the COF framework was constructed by 1,3,5-tris(4-formylphenyl)benzene and 2,6-diamino-3,5-diethynylpyridine. Compared with pristine FeO@COF, FeO@COF-Br enhanced desorption efficiencies for brominated contaminants by about 30% while maintaining adsorption capacity.

Novel Laser-Assisted Electrospray Ionization Mass Spectrometry (Laser-Assisted ESI-MS): A Sensitive Method for Determining Tetrabromobisphenol A and Its Derivative.

Efficient ionization is essential for sensitive mass spectrometry (MS) analysis. Herein, a novel laser-assisted electrospray ionization (laser-assisted ESI) source was developed to efficiently ionize low-polar and thermal unstable compounds. By irradiating the electrospray nozzle with a simple and low-cost laser probe (450 nm, 500 mW), the sample droplets were stimulated with a laser beam as well as the high voltage of the electrospray, which significantly enhanced the ionization efficiency.

Association between Life's Essential 8 and Atherogenic Index of Plasma in adults: insights from NHANES 2007-2018.

Introduction: Cardiovascular Disease (CVD) has become a significant global public health challenge, contributing to rising mortality rates. This study aims to investigate the relationship between Life's Essential 8 (LE8) and the Atherogenic Index of Plasma (AIP), providing insights into the assessment and improvement of Cardiovascular Health (CVH).

Methods: We conducted an analysis of data from 8,215 U.

Identification of novel tetrabromobisphenol A byproducts in industrial chemicals and the environment near a manufacturing site: an overlooked source of novel pollutants.

To evaluate the migration, transformation, and fate of tetrabromobisphenol A (TBBPA) in the environment, the transformation/degradation (T/D) products of TBBPA and byproducts of industrial production should be distinguished. Herein, 7 reported T/D products (R1-R7) and 7 novel byproducts (N1-N7) of TBBPA were identified in industrial-grade TBBPA chemicals by using high-performance liquid chromatography coupled ion trap mass spectrometry and high-resolution mass spectrometry with a suspect screening strategy. The possible formation pathways of these byproducts were attributed to the bromination, debromination, methylation, demethylation, hydroxylation, substitution, and radical coupling reactions of bisphenol A (BPA), BPA impurities, and TBBPA.

FDA-Approved Secukinumab Alleviates Glial Activation and Immune Cell Infiltration in MPTP-Induced Mouse Model of Parkinson's Disease.

Interleukin-17A (IL-17A) has been implicated in the progression of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). However, the effect of the FDA-approved Secukinumab (SEC), an IL-17A inhibitor, on PD remains unclear. This study aimed to investigate the neuroprotective effect of SEC and its potential mechanisms in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD.

Demystifying death: a qualitative study using the behavior change wheel framework to explore the palliative care education experiences of doctors, nurses, and community residents.

Objective: To explore the palliative care education experiences of doctors, nurses, and community residents.

Methods: A semi-structured interview was conducted with 2 doctors, 8 nurses and 9 community residents in Jinan. Content analysis and behavior change wheel theory were used to analyze the interview content.

The learning experiences and career development expectations of Chinese nursing master's degree students: A qualitative investigation.

Aim: To explore the learning experiences and career development expectations of nursing master's degree students.

Background: With increasing demands for improved quality of life, there is a growing need for nursing graduate programs in clinical care. However, the existing training programs for nursing master's students in China require improvement.

A violet light-emitting diode-based gas-phase molecular absorption device for measurement of nitrate and nitrite in environmental water.

A simple and sensitive device for the detection of nitrite and nitrate in environmental waters was developed based on visible light gas-phase molecular absorption spectrometry. By integrating a detection cell (DC), semiconductor refrigeration temperature-controlling system (SRTCY), and nitrite reactor into a sequential injection analysis system, trace levels of nitrite and nitrate in complex matrices were successfully measured. A low energy-consuming light-emitting diode (violet, 400-405 nm) was coupled with a visible light-to-voltage converter (TSL257) to measure the gas-phase molecular absorption.

Recommended Tool Compounds for Modifying the Cystic Fibrosis Transmembrane Conductance Regulator Channel Variants.

Cystic fibrosis (CF) is a genetic disorder arising from variations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, leading to multiple organ system defects. CFTR tool compounds are molecules that can modify the activity of the CFTR channel. Especially, patients that are currently not able to benefit from approved CFTR modulators, such as patients with rare CFTR variants, benefit from further research in discovering novel tools to modulate CFTR.

Occurrence of Chlorinated Derivatives of Bisphenol S in Paper Products and Their Potential Health Risks through Dermal Exposure.

The occurrence of chlorinated derivatives of bisphenol S (Cl-BPS) and BPS was investigated in nine types of paper products ( = 125), including thermal paper, corrugated boxes, mail envelopes, newspapers, flyers, magazines, food contact paper, household paper, and business cards. BPS was found in all paper product samples, while Cl-BPS were mainly found in thermal paper (from below the limit of detection ( View Article and Find Full Text PDF

A comparison analysis of the somatic mutations in early-onset gastric cancer and traditional gastric cancer.

Background: Early onset gastric cancer (EOGC) has been on the rise in recent years and differs slightly in pathology from traditional gastric cancer (TGC). Somatic mutations have an essential role in the development of gastric cancer. We aimed to investigate these two types of gastric cancers at the level of somatic mutations and to further understanding of gastric cancer development.

Global burden of stomach cancer attributable to smoking from 1990 to 2019 and predictions to 2044.

Objectives: This study aimed to assess the global temporal trends of stomach cancer attributable to smoking from 1990 to 2019 and to predict the global burden by 2044.

Study Design: This was a comprehensive analysis based on data provided by the Global Burden of Disease Study 2019.

Methods: Based on the Global Burden of Disease Study 2019, mortality, disability-adjusted life years (DALYs), and corresponding age-standardised rates of stomach cancer attributable to smoking by sociodemographic index (SDI), region, country, sex, and age were used to assess temporal trends from 1990 to 2019 by calculating the average annual percentage change (AAPC).

Dry Powder Inhalation for Lung Delivery in Cystic Fibrosis.

Pulmonary drug delivery has long been used for local and systemic administration of different medications used in acute and chronic respiratory diseases. Certain lung diseases, such as cystic fibrosis, rely heavily on chronic treatments, including targeted lung delivery. Pulmonary drug delivery possesses various physiological advantages compared to other delivery methods and is also convenient for the patient to use.

Temporal and spatial variability of dynamic microstate brain network in early Parkinson's disease.

Changes of brain network dynamics reveal variations in macroscopic neural activity patterns in behavioral and cognitive aspects. Quantification and application of changed dynamics in brain functional connectivity networks may contribute to a better understanding of brain diseases, and ultimately provide better prognostic indicators or auxiliary diagnostic tools. At present, most studies are focused on the properties of brain functional connectivity network constructed by sliding window method.

Capturing the Abnormal Brain Network Activity in Early Parkinsons Disease With Mild Cognitive Impairment Based on Dynamic Functional Connectivity.

The early Parkinson's disease (PD) with mild cognitive impairment (ePD-MCI) is a typical non-motor symptom reflected by the brain dysfunction of PD, which can be well depicted by the dynamic characteristics of brain functional connectivity networks. The aim of this study is to determine the unclear dynamic changes in functional connectivity networks induced by MCI in early PD patients. In this paper, the electroencephalogram (EEG) of each subject was reconstructed into the dynamic functional connectivity networks with five frequency bands based on adaptive sliding window method.

Simple high-performance liquid chromatography-ultraviolet method for simultaneous separation and detection of 14 bisphenol pollutants in building materials.

A high-performance liquid chromatography-ultraviolet method was developed for rapidly and simultaneously analyzing novel and typical bisphenols in building materials, including bisphenol S, diphenolic acid, bisphenol F, bisphenol E, bisphenol A, bisphenol B, bisphenol AF, bisphenol AP, bisphenol C, bisphenol FL, bisphenol Z, bisphenol BP, bisphenol M, and bisphenol P. By using a Kromasil 100-5 C18 column, these bisphenols were completely separated in 40 min via gradually increasing the concentration of methanol in the mobile phase from 45 to 80% during the elution process. In particular, this method achieved the synchronous analysis of bisphenol S, diphenolic acid, bisphenol FL, bisphenol BP, and bisphenol M through HPLC, which were difficult to separate and had to be identified and detected through mass spectrometry.

Mapping and Development Role of CFTR in Lung and Gastrointestinal Tract of Cystic Fibrosis Patients.

In cystic fibrosis (CF) the ability of the CF transmembrane conductance regulator (CFTR) protein to mediate chloride and water transport is disrupted. While much progress has been made in CF research leading to effective treatments to improve CFTR function, including small molecule modulators, patients present with varying disease manifestations and responses to therapy. For many CF-affected organs, disease onset is known to occur during development before treatments can be administered and progresses over time leading to irreversible damage to these organs.

Association of Plasma and Electroencephalography Markers With Motor Subtypes of Parkinson's Disease.

Objective: The aim of this study was to investigate the correlations of plasma neurodegenerative proteins and electroencephalography (EEG) dynamic functional network (DFN) parameters with disease progression in early Parkinson's disease (PD) with different motor subtypes, including tremor-dominant (TD) and postural instability and gait disorder (PIGD).

Methods: In our study, 33 patients with PD (21 TD and 12 PIGD) and 33 healthy controls (HCs) were enrolled. Plasma neurofilament light chain (NfL), α-synuclein (α-syn), total-tau (t-tau), β-amyloid 42 (Aβ42), and β-amyloid 40 (Aβ40) levels were measured using an ultrasensitive single-molecule array (Simoa) immunoassay.

Simultaneous preconcentration and pre-column derivatization for rapid analysis of nitrilotriacetic acid in environmental waters by high performance liquid chromatography.

A simplified sample pretreatment procedure was developed for quantitative measurement of nitrilotriacetic acid (NTA) in environmental water. On the basis of coordination capacity between NTA and metal ions, aluminum-based metal organic framework (MOF, MIL-53(Al)) was adopted for the adsorption of NTA, followed by stripping with copper sulfate as the eluent. The adsorbed NTA was converted into Cu-NTA during the desorption process, which facilitated the ensuing measurement by high performance liquid chromatography (HPLC).

A Panel of Plasma Biomarkers for Differential Diagnosis of Parkinsonian Syndromes.

Objective: The aim of our study is to explore the most reliable panel of plasma biomarkers for differential diagnosis of parkinsonian syndromes (PDSs). We selected five kinds of neurodegenerative proteins in plasma: neurofilament light chain (NfL), α-synuclein (α-syn), total tau, β-amyloid 42 (Aβ42) and β-amyloid 40 (Aβ40), and investigated the diagnostic value of these biomarkers.

Methods: A total of 99 plasma samples from patients with Parkinson's disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy, and age-matched healthy controls (HCs) were enrolled in our study.

Deep learning reveals personalized spatial spectral abnormalities of high delta and low alpha bands in EEG of patients with early Parkinson's disease.

Parkinson's disease (PD) is one of the most common neurodegenerative diseases, and early diagnosis is crucial to delay disease progression. The diagnosis of early PD has always been a difficult clinical problem due to the lack of reliable biomarkers. Electroencephalogram (EEG) is the most common clinical detection method, and studies have attempted to discover the EEG spectrum characteristics of early PD, but the reported conclusions are not uniform due to the heterogeneity of early PD patients.

Performance intensification of CO absorption and microalgae conversion (CAMC) hybrid system via low temperature plasma (LTP) treatment.

CO absorption and microalgae conversion (CAMC) hybrid system is a promising alternative for simultaneous carbon capture and utilization. It can not only overcome the challenge of high energy consumption solvent thermal regeneration in chemical CO absorption, but also enhance the carbon conversion efficiency in biological conversion process. However, the discordance between CO absorption and bio-conversion rate has become the key to limiting the development of CAMC system.

Simultaneous and sensitive detection of multiple small biological molecules by microfluidic paper-based analytical device integrated with zinc oxide nanorods.

In this work, ZnO nanorods (ZnO NRs) with different sizes were hydrothermally grown on the surface of Whatman filter paper for the fabrication of a microfluidic paper-based device (μPAD) for the simultaneous detection of glucose and uric acid. As dual enzymatic reaction was employed for the colorimetric detection in this μPAD, the presence of ZnO NRs promoted the enzyme immobilization thus significantly enhancing the colorimetric signal. The coffee ring effect was effectively conquered by the uniform distribution of ZnO NR as well as a specialized double-layered μPAD design.

Enhanced Peroxidase-mimicking Activity of Plasmonic Gold-modified Mn O Nanocomposites through Photoexcited Hot Electron Transfer.

Enzyme-mimicking artificial nanomaterials often termed nanozymes have broad applications in many fields, including biosensing, pollutant degradation and cancer diagnosis. Herein, we introduce a plasmonic gold nanoparticle-modified Mn O nanozyme (Mn O -Au). Visible or near infrared light excitation into the plasmonic absorption band of the surface-bound gold nanoparticles enhances the catalytic oxidation of tetramethylbenzidine (TMB).

Observation of photoassociation spectroscopy of ultralong 37D + 6SCs Rydberg molecules.

We present an experimental observation of 37D + 6SCs Rydberg-ground molecules by employing a two-photon photoassociation method. Two distinct Rydberg-ground molecular signals, deep and shallow bound molecules, are observed at the red detuning of atomic line. In theory, the model of scattering interaction between the Rydberg electron and ground-state atom is used to simulate the experiments.