Similar coordination environments promote indium-doped MOF-74-Co precatalysts for oxygen evolution reaction.

The sluggish kinetics of the oxygen evolution reaction (OER) necessitate the use of efficient, non-precious metal catalysts. This work reports the rational design of an indium-doped bimetallic metal-organic framework (MOF-74-CoIn) as a precatalyst, achieved through post-synthetic modification of MOF-74-Co. Structural and spectroscopic analyses confirm that In(III) incorporation induces CoO bond contraction while preserves the overall structural integrity.

Eight previously undescribed flavonoids and four previously undescribed bibenzyls from Macaranga kurzii and their potential antiviral activities.

Eight previously undescribed flavonoids, named makurziis A-H (1-8), four previously undescribed bibenzyls, named mayankurziis A-D (9-12), as well as nine known compounds were isolated from the ethyl acetate extract of dried stems and leaves of Macaranga kurzii. Their structures were thoroughly elucidated through detailed spectroscopic analysis and comparison with existing literature data. Additionally, the structures of compounds 3 and 7 were further confirmed by single-crystal X-ray diffraction analysis.

Spatial Confinement in Structural Biomimetic Catalysts: Enhancing Sulfur-Chain Homolysis and Enzyme-like Activity for High-Performance Lithium-Sulfur Batteries.

Our study addresses the critical challenges of sluggish sulfur reaction kinetics and severe lithium polysulfide shuttling in high-energy-density lithium-sulfur batteries under high sulfur loading and lean electrolyte conditions. Inspired by the structure of cytochrome c oxidase, we designed an enzyme-mimetic Fe-TCPP@Cu-BTC catalyst with spatial confinement effects. Its spatially confined configuration induces the homolytic cleavage of LiS to LiS and accelerates their subsequent conversion to LiS.

From mitochondrial dysregulation to ferroptosis: Exploring new strategies and challenges in radioimmunotherapy (Review).

Ferroptosis is an iron‑dependent, lipid peroxidation‑driven form of regulated immunogenic cell death (ICD). ICD has demonstrated potential to overcome resistance to conventional cancer therapies, enhancing the efficacy of treatments such as chemotherapy, radiotherapy, immunotherapy and photodynamic therapy. Notably, in the context of radiotherapy, ferroptosis serves a key role, particularly when combined with radioimmunotherapy.

Elucidating the Role and Regulatory Mechanism of BpbZIP5 in the Saline-Alkaline Stress Response in Betula platyphylla.

Saline-alkali conditions are regarded as among the most serious abiotic stressors that impede plant growth and lead to substantial reductions in plant yields. The bZIP transcription factor (TF) exerts a crucial function in plant adaptation to various environmental stresses. However, its function and mechanisms in conferring tolerance to saline-alkali (NaHCO) stress remain insufficiently characterized.

Prediction model for cytomegalovirus infection following hematopoietic stem cell transplantation in patients with β-thalassemia major.

Background: Cytomegalovirus infection is a common complication following hematopoietic stem cell transplantation that significantly influences clinical outcomes.

Objectives: To develop and validate a predictive model for cytomegalovirus infection risk in patients with β-thalassemia major undergoing hematopoietic stem cell transplantation.

Design: Retrospective cohort study.

Balloon-assisted ExoSeal closure for inadvertent subclavian artery cannulation following central venous catheterization: A case report.

Accidental arterial puncture is a rare but significant complication associated with central venous catheterization. This report describes a case of inadvertent subclavian artery catheterization that was successfully managed with the ExoSeal vascular closure device. A female patient in her early 30s was hospitalized for severe acute pancreatitis that necessitated cannulation of the right subclavian vein.

Condensation-Enhanced DNA Nanotracker on Facilitating Spatially Selective Intracellular miRNA Profiling and Robust Gene Therapy/Chemotherapy.

Intracellular miRNA imaging and cooperative gene therapy are significant for cancer diagnosis and treatment. However, the spatial-selective imaging and therapeutic potential of RNA through programmable DNA probes is extremely hindered due to the disorder, low local concentration, and easy degradation toward the sensing/therapeutic-associated DNA probes. To address this, we spatially confined sensing probes and therapeutic siRNA within a highly ordered spherical DNA condensed tracker (GREAT) engineered for activation by target miRNA-221.

Outcomes of electronic health interventions for patients with heart failure: a network meta-analysis.

Aims: The aim of this study was to compare the effectiveness of different types of tele-interventions in improving exercise capacity and cardiac function in patients with heart failure.

Methods: We searched five databases from inception to September 2024 for randomized controlled trials (RCTs) of telerehabilitation in people with heart failure. The primary outcomes were 6‑min walk distance (6MWD) and left ventricular ejection fraction (LVEF).

Programmable spherical nucleic acids integrated with MOF-confined copper nanoclusters facilitate electrochemiluminescence detection of prostate-specific biomarkers.

Alpha-methylacyl-CoA racemase (AMACR) is a promising prostate cancer biomarker due to its high specificity in distinguishing prostate cancer from benign prostatic diseases. However, its low abundance in biological environments presents a significant detection challenge. To address this, we developed an innovative all-in-one s̲pherical n̲ucleic a̲cid (SNA) platform for highly sensitive and selective electrochemiluminescence (ECL) detection of AMACR.

Constructing of Ni-Nx Active Sites in Self-Supported Ni Single-Atom Catalysts for Efficient Reduction of CO to CO.

The electrochemical carbon dioxide reduction reaction (CORR) represents a promising approach for achieving CO resource utilization. Carbon-based materials featuring single-atom transition metal-nitrogen coordination (M-N) have attracted considerable research attention due to their ability to maximize catalytic efficiency while minimizing metal atom usage. However, conventional synthesis methods often encounter challenges with metal particle agglomeration.

Phase Engineering Modulates the Electronic Structure of the IrO/MoS Heterojunction for Efficient and Stable Water Splitting.

The engineering of dual-functional catalytic systems capable of driving complete water dissociation in acidic environments represents a critical requirement for advancing proton exchange membrane electrolyzer technology, yet significant challenges remain. In this work, we investigate an IrO/MoS/CNT heterostructure catalyst demonstrating enhanced bifunctional performance for both the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) under acidic conditions. Strategic incorporation of IrO into the MoS/CNT heterojunction induces a partial phase transformation from 2H to the metastable 1T configuration in MoS, thereby modulating the electronic structure of IrO and improving the catalytic performance for overall water splitting.

Prenylated isoflavonoids with anti-inflammatory activities from the twigs and leaves of Maclura fruticosa.

Six new prenylated isoflavonoids, named maccosas A-F (1-6), together with ten known prenylated isoflavonoids (7-16) were isolated from the twigs and leaves of Maclura fruticosa. Compounds were isolated by various column chromatographic methods including silica gel, sephadex LH-20, and semi-preparative HPLC. Their structures were elucidated by a combination of 1D and 2D NMR techniques, mass spectrometry, and comparison of their spectral data with those in the literature.

Comparison of Visual Saliency for Dynamic Point Clouds: Task-free vs. Task-dependent.

This paper presents a Task-Free eye-tracking dataset for Dynamic Point Clouds (TF-DPC) aimed at investigating visual attention. The dataset is composed of eye gaze and head movements collected from 24 participants observing 19 scanned dynamic point clouds in a Virtual Reality (VR) environment with 6 degrees of freedom. We compare the visual saliency maps generated from this dataset with those from a prior task-dependent experiment (focused on quality assessment) to explore how high-level tasks influence human visual attention.

Co-MOF-derived carbon nanomaterials with size-controlled FeCo alloys for oxygen evolution.

A porous carbon material with size-controlled FeCo alloys and carbon nanotubes (CNTs) was obtained from pyrolysis of a Co-based metal-organic framework (MOF), followed by the Fe-etching process and CNT growth. This catalyst (CoOF-1-FeCoNC-CNT) displayed satisfactory OER activity, attributed to its large specific surface area, improved electrical conductivity, and the synergistic effect of the bimetallic FeCo alloy.

Construction of robust Cu-MOFs from bifunctional pyridine-hydroxamate linkers for photocatalytic CO reduction.

Robust Cu-MOFs with distinct topologies were prepared from the same bifunctional 4-pyridine-hydroxamate ligand. A favourable collection of porosity, framework stability, electronic structure, and photochemical properties was revealed for the SUM-33 MOF, which was later experimentally verified as an efficient and selective photocatalyst for CO-to-CO conversion.

Bibliometrics of the current state of application of teletechnology in the rehabilitation of patients with heart and large blood vessel disease.

The first publication on the use of teletechnology in heart and large blood vessels dates back to 1961. Since then, the study of teletechnology in heart and large blood vessels has become popular, and the number of publications has drastically increased. Hence, it is imperative to establish a comprehensive research framework that enables researchers and other stakeholders to understand the use of remote technologies in heart and large blood vessels.

Engineering DNA Nanodevices with Multi-site Recognition and Multi-signal Output for Accurate Intracellular LncRNA Imaging.

Dynamic DNA nanodevices, known for their high programmability and controllability, are pivotal in intracellular biomarker imaging. However, these nanodevices often suffer from inadequate detection sensitivity and specificity due to limited cellular loading capacity and low signal feedback. Herein, we engineered an integrated ulti-site rcognition and ulti-signal utput of fou-leaf clover dnamic DNA nanodevice () that enables sensitive and accurate intracellular long noncoding RNA (lncRNA) imaging.

In(III)-Catalyzed 1,2-Hydrophosphorylation of 3-Alkynyl-3-hydroxyisoindolinones to 3,3-Disubstituted Isoindolinones Featuring Both Phosphoryl and Alkynyl Groups at the C3-Position.

We report a highly regioselective 1,2-addition of P(O)-H compounds to the in situ generated β,γ-alkynyl-α-ketimine derived from 3-alkynyl-3-hydroxyisoindolinones, which provided a general protocol for the preparation of 3,3-disubstituted isoindolinones featuring both phosphoryl and alkynyl groups at a quaternary carbon center. The use of only 2-5 mol % of an inexpensive catalyst (In(ClO)·8HO or Bi(OTf)) allowed the smooth output of the desired products under mild conditions (25 °C, 0.5-24 h) with a broad substrate scope (35 examples) in up to >99% yield.

Ubiquitination in diabetes and its complications: A perspective from bibliometrics.

Background: Diabetes has a substantial impact on public health, highlighting the need for novel treatments. Ubiquitination, an intracellular protein modification process, is emerging as a promising strategy for regulating pathological mechanisms. We hypothesize that ubiquitination plays a critical role in the development and progression of diabetes and its complications, and that understanding these mechanisms can lead to new therapeutic approaches.

Strategically Engineered Metal Cluster-Rare Earth Oxide Heterojunction Catalyst for High-Performance Lean Electrolyte Lithium-Sulfur Batteries.

Developing high-energy-density lithium-sulfur batteries faces serious polysulfide shuttle effects and sluggish conversion kinetics, often necessitating the excessive use of electrolytes, which in turn adversely affects battery performance. Our study introduces a meticulously designed electrocatalyst, Cu-CeO@N/C, to enhance lean-electrolyte lithium-sulfur battery performance. This catalyst, featuring in situ synthesized Cu clusters, regulates oxygen vacancies in CeO and forms Cu-CeO heterojunctions, thereby diminishing sulfur conversion barriers and hastening reaction kinetics through the generation of S/S intermediates.

BpMYB06 acts as a positive regulatory factor in saline-alkaline stress resistance by binding to two novel elements.

Saline-alkaline salinity is recognized as one of the most severe abiotic stress factors, limiting plant growth and resulting in significant yield losses. MYB transcription factors (TFs) are crucial for plant tolerance to abiotic stress. However, the roles and regulatory mechanism of MYB TFs underlying saline-alkaline stress tolerance have not yet been investigated in Betula platyphylla.

Supramolecular DNA Nanodevice Assembled via RCA and HCR Cascade Reaction on Tetrahedral DNA Nanostructure for Sensitive Detection and Intracellular Imaging of Dual-miRNAs Associated with Liver Cancer.

Herein, a supramolecular DNA nanodevice was formed via the rolling circle amplification (RCA) and hybridization chain reaction (HCR) cascade reaction on a tetrahedral DNA nanostructure (TDN) to achieve simultaneous sensitive detection and intracellular imaging of dual-miRNAs related to liver cancer. The supramolecular DNA nanodevice effectively addressed the limitations of low probe loading capacity in traditional TDN nanodevices by enriching plenty of signal probes around a single TDN, significantly enhancing the fluorescence signal. Impressively, the supramolecular DNA nanodevice with a TDN fulcrum and dense DNA structure imparted the nanodevice with strong rigidity, ensuring the stability of the signal probes to decrease aggregation quenching for further increasing the fluorescence response.

Photoelectron Therapy Preventing the Formation of Bacterial Biofilm on Titanium Implants.

The exogenous bacterial infection and formation of biofilm on the surface of titanium implants can affect the adhesion, proliferation, and differentiation of cells associated with osteogenesis, ultimately leading to surgical failure. This study focuses on two critical stages for biofilm formation: i) bacterial adhesion and aggregation, ii) growth and proliferation. The titanium with well-organized titania nanotube arrays is first modified by nitrogen dopants, then loaded with CuFeSe nanoparticles to form a p-n heterojunction.