Regulation of sub-Tg solid-state surface crosslinking of reactive polyarylene ether substrate into loose nanofiltration membranes for dyes desalination.

The scalable fabrication of high performance dyes desalination loose nanofiltration (LNF) membrane through facile thermal annealing remains challenging due to the susceptible pore collapse. Herein, we have developed a metal ion mediated sub-Tg thermal crosslinking protocol, which can convert the phase inverted reactive polymeric ultrafiltration substrate into LNF membrane showing high permselectivity as well as resistance to both extremely acid and alkaline solution. The original ultrafiltration substrate was composed of scalable-produced reactive polyarylene ether amidoxime (PEA) that was pre-crosslinked with ferric ions.

Promising Therapeutic Targets for Intracranial Aneurysms: A Systematic druggable genome-wide Mendelian Randomization.

Background: Intracranial aneurysm (IA), known as pathological dilation of cerebral arteries,commonly occurring at bifurcating arteries,carries a high risk of severe morbidity and mortality if left untreated.Although the treatment and early diagnosis have significantly improved,the complex pathophysiological process of IA formation presents significant challenges in the development of targeted therapies.Efficient disease-modifying therapies for IA are not yet available.

Case Report: Multidisciplinary management of primary omental pregnancy involving intraoperative ultrasound.

Introduction: Primary omental pregnancy (OP) is very rare, and achieving an accurate diagnosis has always been a challenge for obstetricians, gynecologists, and sonographers. Our attempt to utilize intraoperative ultrasonography has facilitated a definitive diagnosis for masses lacking obvious purple or blue characteristics under observation. This approach could provide a solution for challenges faced in intraoperative diagnosis.

Characterization of the Flavors and Organoleptic Attributes of Petit Manseng Noble Rot Wines from the Eastern Foothills of Helan Mountain in Ningxia, China.

To investigate the effect of infection severity on the flavor characteristics of Petit Manseng noble rot wine, this study analyzed wines produced from Petit Manseng grapes grown in the eastern foothills of Helan Mountain, Ningxia, China. The grapes were categorized into three groups based on infection status: uninfected, mildly infected, and severely infected with . Headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME-GC-MS) and an electronic nose were employed to detect and analyze the aroma components of wines under the three infection conditions.

Prediction model for cytomegalovirus infection following hematopoietic stem cell transplantation in patients with β-thalassemia major.

Background: Cytomegalovirus infection is a common complication following hematopoietic stem cell transplantation that significantly influences clinical outcomes.

Objectives: To develop and validate a predictive model for cytomegalovirus infection risk in patients with β-thalassemia major undergoing hematopoietic stem cell transplantation.

Design: Retrospective cohort study.

Study on the mechanism of skeletal deformity of Lateolabrax maculatus induced by low temperature stress.

Low-temperature culturing leads to skeletal deformities in juvenile spotted sea bass (Lateolabrax maculatus), reducing survival rate and indeed significantly impacting the aquaculture industry. Aimed to investigating the molecular mechanisms behind cold-induced skeletal deformities, in the present study, histological analysis was performed on the bones of spotted sea bass cultured at low and normal temperatures, with deformity rates assessed using the Alizarin Red staining method. It was found that the spotted sea bass cultured at low temperatures exhibited varying degrees of skeletal deformities in different regions, particularly in the spinal.

Cross-neutralization ability of anti-MERS-CoV monoclonal antibodies against a variety of merbecoviruses.

In the 21st century, three severe human coronavirus infections have occurred. One of them is the Middle East respiratory syndrome coronavirus (MERS-CoV), a merbecovirus belonging to the family , is a human pathogenic coronavirus first detected in 2012. Several monoclonal antibodies (mAbs) have been developed for both therapeutics and prevention of MERS-CoV infection.

Intelligent Thermoelectric Sensing with Sustainable Strain-Hardening Geopolymeric Composites.

Traditional thermoelectric (TE) building materials are limited in both performance and durability, requiring enhancements for effective energy solutions. This research investigates strain-hardening geopolymeric composites (SHGC) for TE sensing applications. The influence of metal oxides on mechanical strength and TE characteristics is evaluated using isothermal calorimetry, computed tomography scanning, and focused ion beam (FIB)-transmission electron microscopy analysis.

Causal relationship between immune mediators and parkinson's disease: A Mendelian randomization analysis.

Numerous studies have revealed a correlation between immune system dysfunction and Parkinson's disease (PD), yet the causal link between them remains unclear. To investigate the causal relationship between immune mediators and Parkinson's disease (PD), we conducted two independent Mendelian Randomization (MR) analyse using genetic variants associated with 731 immune cell phenotypes and 91 circulating inflammatory proteins as instrumental variables. The genetic variant data for immune cell phenotypes were derived from a genome-wide association study (GWAS) involving 3,757 individuals, while the genomic protein quantitative trait loci (pQTL) data for circulating inflammatory proteins were sourced from a GWAS dataset comprising 14,824 individuals of European descent.

Coexisting tubal pregnancy and intrauterine pregnancy during a natural pregnancy, first diagnosed via ultrasonography: A case report.

Rationale: The coexistence of intrauterine and extrauterine pregnancies is termed heterotopic pregnancy (HP). Most reported cases of HP occur after assisted reproductive technology, and HP in a natural pregnancy (NP) is very rare, often discovered intraoperatively. HP is a significant challenge for obstetricians, gynecologists, and sonographers.

ZSG-Net: A Zero-Shot Super-Resolution Guided Network for Ultrasound Image Segmentation and Classification.

Automated ultrasound (US) image analysis is hindered by challenges stemming from low resolution, noise, and non-uniform grayscale distribution, which compromise image quality. While many existing studies address these issues using super-resolution (SR) techniques, they often focus exclusively on SR without considering downstream tasks or tailoring to the unique characteristics of US images. In this work, we propose ZSG-Net, a zero-shot super-resolution-guided network, designed to bridge the gap between US image quality enhancement and its benefits in segmentation and classification.

Global, Regional, and National Burden of Brain and Central Nervous System Cancer, with a Secondary Analysis of Retinoblastoma, 1990-2021: Analysis for the Global Burden of Disease Study.

Background: Brain and central nervous system cancers represent a significant and increasing global health burden. Although biologically distinct, retinoblastoma was included as a secondary objective to assess its unique impact on pediatric populations.

Methods: A comprehensive analysis of the burden of these cancers was conducted, evaluating incidence, prevalence, mortality, and disability-adjusted life years in 2021.

Unveiling genetic and biological links: exploring the intersection of autoimmune and psychiatric disorders.

Background: A substantial body of observational evidence suggests the genetic link between autoimmune system diseases and psychiatric disorders. However, the shared genetic mechanisms remain largely unclear. This study aims to systematically explore these genetic correlations and identify potential therapeutic targets through integrative bioinformatics analyses.

Polymeric immunoglobulin receptor (pIgR) in cancer progression: a critical role and potential therapeutic target.

Polymeric immunoglobulin receptor (pIgR) is a crucial receptor that primarily mediates the transcytosis of immunoglobulins A and M across epithelial cells, emerging as an essential participant in modulating both mucosal immunity and innate immunity. Recently, pIgR dysregulation in cancer has garnered widespread attention. It exhibits distinct mechanisms and effects across various cancer types with significant clinical value as a biomarker for malignant tumor diagnosis and prognosis evaluation.

Radial artery intima-media thickening is a sensitive marker of atherosclerosis and coronary artery stenosis, a lesson from a 6-year study of a spontaneous monkey model.

Atherosclerosis is the primary driver of cardiovascular and cerebral vascular diseases globally. Atherosclerotic plaques have been detected in multiple arterial locations, such as the aorta, carotids, and coronaries. However, it remains uncertain if there are variations in susceptibility and association among arteries of different calibers.

HSD17B1-mediated trophoblast differentiation lowers estrogen levels in early-onset preeclampsia.

Early-onset preeclampsia (EOPE) with fetal growth restriction (FGR) is a severe hypertensive disorder of pregnancy characterized by placental dysfunction and estrogen deficiency. Based on single-cell RNA sequencing (scRNA-seq) profiling of specific placental trophoblast subtypes from EOPE-FGR and normotensive pregnancies, we identified HSD17B1, which encodes a key enzyme mediating estradiol conversion, as the central dysregulated node in EOPE pathogenesis. Multi-modal computational analysis (cluster annotation, cellular proportion calculation, comparison of differentially expressed genes, and characterization of cellular developmental trajectories) revealed key expression dynamics during syncytiotrophoblast (SCT) differentiation, with substantial suppression in EOPE specimens.

Prediction models of breast cancer molecular subtypes based on multimodal ultrasound and clinical features.

Background And Aims: Breast cancer classify into four molecular subtypes: Luminal A, Luminal B, HER2-overexpressing (HER2), and triple-negative (TNBC) based on immunohistochemical assessments. The multimodal ultrasound features correlate with biological biomarkers and molecular subtypes, facilitating personalized, precision-guided treatment strategies for patients. In this study, we aimed to explore the differences of multimodal ultrasound features generated from conventional ultrasound (CUS), shear wave elastography (SWE) and contrast-enhanced ultrasound (CEUS) between molecular subtypes of breast cancer, investigate the value of prediction model of breast cancer molecular subtypes based on multimodal ultrasound and clinical features.

Recent advances in transition metal sulfide-based electrode materials for supercapacitors.

Supercapacitors, as highly promising charge storage systems, have attracted much attention due to their fast charging and discharging rates, high power density, and longer service life. However, compared to rechargeable batteries, the low energy density of supercapacitors limits their practical applications. Rational design of advanced electrode materials shows great potential to address the above issue.

Coenzyme Q10 supplementation in adult-onset focal segmental glomerulosclerosis caused by the Chinese common pathogenic variant c.737G > A (p.Ser246Asn) in the gene.

COQ8B nephropathy, a mitochondrial disorder caused by mutations in the gene, is a major pediatric genetic focal segmental glomerulosclerosis (GFSGS) etiology and stands out as one of the few treatable forms with good response to coenzyme Q10 (CoQ) supplementation. As the diagnosis and clinical experience of COQ8B nephropathy were predominantly in the pediatric population, the long-term efficacy of CoQ supplementation and its application in the adult-onset patients remains largely unknown. Here, we report three cases of adult-onset FSGS from unrelated families, all carrying the Chinese common  mutation (c.

MUNet: Multi-Scale Feature Acquisition and Multi-Input Edge Supplement Based on UNet for Efficient Segmentation of Breast Tumor in Ultrasound Images.

The morphological characteristics of breast tumors play a crucial role in the preliminary diagnosis of breast cancer. However, malignant tumors often exhibit rough, irregular edges and unclear, boundaries in ultrasound images. Additionally, variations in tumor size, location, and shape further complicate the accurate segmentation of breast tumors from ultrasound images.

A Mechanistic Approach Toward Enhanced Remediation Potential of Thiacloprid by Zero-Valent Iron/Biochar Supplemented with Organic Acids.

The excessive levels of neonicotinoid insecticides, particularly thiacloprid (THI), in the environment have become a significant threat to ecosystems. This study investigates the catalytic degradation of THI using pinewood biochar (PBC), zero-valent iron (ZVI), and ZVI/PBC composite, with a particular focus on the reaction activity modulation mediated by organic acids (humic acid: HA and oxalic acid: OA). Reductive dechlorination dominated THI degradation as observed by Cl release kinetics.

A Novel Glia-immune humanized mouse model for investigation of HIV CNS infection and neuroinflammation.

Although combined antiretroviral therapy (ART) is successful in suppressing viral replication, HIV persists in anatomic reservoirs, including the central nervous system (CNS). Current models, such as HSC-reconstituted humanized mice, lack matched human glia in the brain, limiting insights into HIV CNS infection and pathogenesis. We developed a novel glia-immune humanized mouse model integrating human glial cells in the brain with donor-matched human immune reconstitution in peripheral blood and lymphoid tissues.

New scoring system for the evaluation obstructive degrees based on computed tomography for obstructive colorectal cancer.

Background: The degree of obstruction plays an important role in decision-making for obstructive colorectal cancer (OCRC). The existing assessment still relies on the colorectal obstruction scoring system (CROSS) which is based on a comprehensive analysis of patients' complaints and eating conditions. The data collection relies on subjective descriptions and lacks objective parameters.

Integrated genetic analysis and single cell-RNA sequencing for brain image-derived phenotypes and Parkinson's disease.

Background: Previous studies have reported Parkinson's disease (PD) patients usually have changes in brain image-derived phenotypes (IDPs). However, the role of genetic factors in their association and biological mechanism remains unclear. We aimed to unveil genetic and biological links between brain IDPs and PD.

NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of HS into the synovium.

Background: Aberrant proliferation and inflammation of fibroblast-like synoviocytes (FLSs) significantly contribute to the pathogenesis of rheumatoid arthritis (RA). Deficiency of hydrogen sulfide (HS) is a driving force for the development of RA, and the short half-life of the HS-releasing donor sodium hydrosulfide (NaHS) limits its clinical application in RA therapy. Designing a targeted delivery system with slow-release properties for FLSs could offer novel strategies for treating RA.