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Article Abstract
Six new prenylated isoflavonoids, named maccosas A-F (1-6), together with ten known prenylated isoflavonoids (7-16) were isolated from the twigs and leaves of Maclura fruticosa. Compounds were isolated by various column chromatographic methods including silica gel, sephadex LH-20, and semi-preparative HPLC. Their structures were elucidated by a combination of 1D and 2D NMR techniques, mass spectrometry, and comparison of their spectral data with those in the literature. Furthermore, compounds 1 and 7 exhibited anti-inflammatory activity with IC values of 4.11 and 1.45 μM. Detection of cellular pyroptosis and western blot assay suggested that compound 1 reduced the number of PI-positive cells and inhibited Nigericin-induced pyroptosis of J774A.1 cells.
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