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Article Abstract
This is the report of the HPLC-MSn-guided isolation of new anti-inflammatory prenylated isoflavonoids and pterocarpans from the stems of using GNPS molecular networking as the main tool. Cluster analysis guided the isolation of five new prenylated isoflavonoids, diffusiflavone A-E ( and ), two prenylated pterocarpans, diffusicarpan A and B ( and ), and two known compounds 6-prenylorobol () and 3--methylquercetin (). The in vitro anti-inflammatory potential of compounds and was assessed in macrophages induced with lipopolysaccharide (LPS). Compounds , , , and were observed to have a reduction in NO levels in at least one of the concentrations tested (1.25, 2.5, 5, 10, and 20 μg/mL) and also reduced IL-1β and IL-6 cytokines, especially diffusicarpan A which reduced cytokine levels in all the concentrations tested.
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| http://dx.doi.org/10.1021/acsomega.5c00866 | DOI Listing |
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