Eight previously undescribed flavonoids and four previously undescribed bibenzyls from Macaranga kurzii and their potential antiviral activities.

Eight previously undescribed flavonoids, named makurziis A-H (1-8), four previously undescribed bibenzyls, named mayankurziis A-D (9-12), as well as nine known compounds were isolated from the ethyl acetate extract of dried stems and leaves of Macaranga kurzii. Their structures were thoroughly elucidated through detailed spectroscopic analysis and comparison with existing literature data. Additionally, the structures of compounds 3 and 7 were further confirmed by single-crystal X-ray diffraction analysis.

Investigating the impact of protein S-sulfhydration modification on vascular diseases: A comprehensive review.

The post-translational modification of cysteine through redox reactions, especially S-sulfhydration, plays a critical role in regulating protein activity, interactions, and spatial arrangement. This review focuses on the impact of protein S-sulfhydration on vascular function and its implications in vascular diseases. Dysregulated S-sulfhydration has been linked to the development of vascular pathologies, including aortic aneurysms and dissections, atherosclerosis, and thrombotic diseases.