Knowledge mapping of exosomes in ischemic stroke: a bibliometric analysis.

Background: Ischemic stroke is a disease in which local ischemia and hypoxia of brain tissues are caused by obstruction of blood vessels in the brain, which in turn triggers brain tissue damage and neurological dysfunction. Recent studies have made significant progress in understanding the role of exosomes in ischemic stroke. Exosomes exhibit anti-inflammatory, immunomodulatory, anti-apoptotic, angiogenic, and neuroregenerative effects, as well as glial scar reduction and drug delivery effects in ischemic stroke.

Application of lean management in medical laboratories to help treat patients with acute stroke.

This study investigated the application effect of lean management in the treatment of acute stroke in medical laboratories and evaluated the impact on laboratory turnaround time (TAT) and operator satisfaction. In this study, 287 patients with acute stroke were selected from the Second People's Hospital of Hunan Province and divided into a control group (129 cases, before lean management) and an experimental group (158 cases, after lean management). Lean management measures included establishing fast transfer channels, information management, optimisation of the centrifuge configuration, priority management, personnel training, use of the 6 S method, and visual management to optimise the process.

Immune dysregulation in ulcerative colitis: pathogenic mechanisms and therapeutic strategies of traditional Chinese medicine.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized primarily by immune dysregulation. Its pathogenesis involves multiple factors, including dysregulation of T-cell subsets, hypersecretion of pro-inflammatory cytokines, imbalance in the gut microbiota, and disruption of the intestinal barrier. Among T-cell subsets, abnormal activation of Th1 and Th17 cells, in conjunction with Treg dysfunction, significantly amplifies local pro-inflammatory signals.

Efficacy and safety of traditional Chinese medicine Elian Granule for chronic atrophic gastritis: a multi-center, randomized, double-blind, placebo-controlled study.

Objective: This multi-center, randomized, double-blind, placebo-controlled study aimed to evaluate the clinical efficacy and safety of Elian Granule in treating chronic atrophic gastritis (CAG).

Methods: Over a 24-week period, 240 CAG patients were randomized to receive either Elian Granule or placebo. Primary outcomes included histological improvement of gastric mucosa via biopsy, while secondary outcomes assessed dyspepsia symptom scores and quality of life (QOL) scores.

High pathogenicity of emerging porcine G9P[23] and G11P[7] rotavirus for newborn piglets in China.

In order to better understand the pathogenicity of the current porcine A group rotavirus (PoRVA) field strains, AHBZ2304 (G9P[23]) and AHBZ2303 (G11P[7]) isolated from diarrhea suckling piglets were selected for pathogenicity analysis in the present study. Experimental inoculation of colostrum-deprived 2-day-old piglets revealed that both isolates caused severe clinical sings, high level of virus shedding and significant damage to the small intestinal villi. Additionally, both gross and microscopic lung lesions were identified at 72 h post infection (HPI) compared to control.

Endoplasmic reticulum stress in gut inflammation: Implications for ulcerative colitis and Crohn's disease.

Eukaryotic cells contain the endoplasmic reticulum (ER), a prevalent and intricate membranous structural system. During the development of inflammatory bowel disease (IBD), the stress on the ER and the start of the unfolded protein response are very important. Some chemicals, including 4μ8C, small molecule agonists of X-box binding protein 1, and ISRIB, work on the inositol-requiring enzyme 1, turn on transcription factor 6, and activate protein kinase RNA-like ER kinase pathways.

Construction and immunogenicity analysis of a recombinant baculovirus targeting the N protein of SARS-CoV-2.

Objectives: This study aimed to construct recombinant baculoviruses capable of expressing the nucleocapsid N protein of SARS-CoV-2 and to assess the effects of co-administration with sodium butyrate on its expression and immunogenicity.

Results: The recombinant BmNPV expressed green fluorescent protein in BmN cells and N protein in mammalian cells. The addition of sodium butyrate significantly enhanced the expression of N protein in HEK293T cells.

Involvement of the NLRP3/IL-1β pathway in activation and effector functions of γδT17 cells in patients with ulcerative colitis.

Background: The interleukin-17 (IL-17) mediated aberrant immune-inflammatory response plays a paramount role in ulcerative colitis (UC). γδT17 cells are one of the critical sources of IL-17, but the role they play in UC remains under debate.

Aim: To clarify the role of γδT17 cells in patients with mild-to-moderate UC.

Angel and devil: the protective immunity and pathogenic inflammation of tissue resident memory T cells in ulcerative colitis.

Ulcerative colitis (UC) is an incurable autoimmune disease. Patients with UC endure the burden of recurrent flare-ups and face a substantial economic burden due to long-term medication. The complex etiology and unclear pathogenesis pose a significant challenge to the development of effective and curative treatments.

Integrative investigation on the mechanisms of modified Zuojin pill (SQQT) in ameliorating gastric metaplasia.

Ethnopharmacological Relevance: Zuojin pill is a well-known traditional Chinese medicine (TCM) for treating gastric disorders. The modified Zuojin pill (SQQT) has been used in the treatment of gastric metaplasia (GM) in China for decades. However, the mechanisms of SQQT treat GM remain unclear.

Deciphering the Role of CD14 in -associated Gastritis and Gastric Cancer: Combing Bioinformatics Analysis and Experiments.

Gastric cancer (GC) is the third leading cause of cancer-related death and is associated with high mortality and morbidity. (HP) infection is the most important cause of GC. We aimed to identify the core genes of HP caused GC and further elucidate the underlying mechanisms.

Characterization and functional analysis of the small heat shock protein HSP19.5 in Bombyx mori in response to Nosema bombycis infection.

Small heat shock proteins (sHSPs) are molecular chaperones known for their role in maintaining cellular homeostasis and protecting cells from various environmental stresses. This study focuses on the silkworm small heat shock protein HSP19.5 and its potential functions in the context of Nosema bombycis infection, a microsporidian pathogen causing severe disease in the sericulture industry.

Untangling immune cell contributions in the progression from GERD to Barrett's esophagus and esophageal cancer: Insights from genetic causal analysis.

Background: Esophageal adenocarcinoma (EAC) is a rapidly increasing malignancy with significant morbidity and mortality. The progression from gastroesophageal reflux disease (GERD) to Barrett's esophagus (BE) and ultimately to EAC is thought to be influenced by chronic inflammation and immune cell dynamics. Despite the observed correlations in observational studies, the causal relationships between immune cell phenotypes and this disease continuum remain unclear.

Uncovering anaerobic oxidation of methane and active microorganisms in landfills by using stable isotope probing.

Anaerobic oxidation of methane (AOM) coupled electron acceptor reduction has been shown to regulate methane (CH) emissions from the habitats. Landfill is one of the most important anthropogenic CH emission sources. However, the effect of electron acceptors on the AOM process and its microbial mechanism in landfills is poorly characterized.

The impact of carbohydrate quality on gut health: Insights from the NHANES.

Background: High- and low-quality carbohydrate diets are linked to gut health. However, their specific relationship with constipation or diarrhea is unclear. This study uses 2005-2010 NHANES data to examine the relationship between carbohydrate quality and constipation and diarrhea, and to identify suitable populations for different carbohydrate diets.

Wind Turbine Blade Fault Detection Method Based on TROA-SVM.

Wind turbines are predominantly situated in remote, high-altitude regions, where they face a myriad of harsh environmental conditions. Factors such as high humidity, strong gusts, lightning strikes, and heavy snowfall significantly increase the vulnerability of turbine blades to fatigue damage. This susceptibility poses serious risks to the normal operation and longevity of the turbines, necessitating effective monitoring and maintenance strategies.

Genistein alleviates rheumatoid arthritis by inhibiting fibroblast-like synovial exosome secretion regulated by the Rab27/nSMase2/Mfge8 pathway.

Genistein (GEN), the predominant soy isoflavone in legumes, exhibits potential anti-rheumatoid arthritis (RA) effects. This study aims to explore the role of GEN in alleviating RA by regulating exosome secretion and the inflammatory microenvironment through the Rab27/nSMase2/Mfge8 pathway in collagen-induced arthritis (CIA) mice and . studies revealed that GEN treatment significantly reduced paw swelling in CIA mice and protected the integrity of knee and ankle joints in CIA mice.

Chemoprevention Strategies for Precancerous Gastric Lesions Beyond Helicobacter pylori Eradication.

Gastric cancer (GC) is a significant global health challenge, particularly in high-incidence regions like East Asia. Despite improvements in screening and treatment, the progressive nature of precancerous lesions-such as atrophic gastritis, intestinal metaplasia, and dysplasia-necessitates effective prevention strategies. This review evaluates the role of chemoprevention in GC, focusing on agents designed to target these precancerous lesions.

Beyond metaplasia: unraveling the complex pathogenesis of autoimmune atrophic gastritis and its implications for gastric cancer risk.

Autoimmune gastritis (AIG) is a chronic inflammatory condition characterized by immune-mediated destruction of gastric parietal cells, leading to oxyntic atrophy, achlorhydria and hypergastrinemia. While AIG was historically linked to gastric adenocarcinoma and type I neuroendocrine tumors (NETs), recent evidence suggests the risk of adenocarcinoma in AIG is lower than previously believed, particularly in Helicobacter pylori (H. pylori)-negative patients.

Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Colitis in Mice via the Modulation of NF-B and Nrf2/HO-1 Pathways.

This study aims to reveal the potential molecular mechanisms of modified Gegen Qinlian decoction (MGQD) in relieving ulcerative colitis (UC). C57BL/6J mice were used to establish experimental colitis via dextran sodium sulfate (DSS). Body weight, disease activity index (DAI), spleen weight, colon length, and histopathologic features were measured to evaluate the therapeutic effects of MGQD on mice with UC.

Efficacy and safety of Jianpi Qinghua granules for non-erosive reflux disease with spleen deficiency and damp-heat syndrome: a multicenter, randomized, double-blind, placebo-controlled clinical trial.

Background: Non-erosive reflux disease (NERD), the most frequent phenotype of gastroesophageal reflux disease, presents without visible esophageal mucosal damage but significantly impacts patients' quality of life. Current treatments like proton pump inhibitors show limited efficacy for many NERD patients, necessitating alternative approaches. Jianpi Qinghua (JQ) granules, a traditional Chinese medicine, have shown promise in treating NERD by targeting symptoms of spleen deficiency and damp-heat syndrome.

Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis.

Background: Previous studies have suggested an association between inflammatory bowel disease (IBD), and pancreatitis, including acute pancreatitis (AP) and chronic pancreatitis (CP). We aimed to examine the potential causal relationship between IBD and pancreatitis using the Mendelian randomization (MR) method.

Methods: We obtained data from genome-wide association studies (GWASs) in European individuals for IBD and its main subtypes, Crohn's disease (CD) and ulcerative colitis (UC) (31,665 IBD cases, 13,768 UC cases, 17,897 CD cases and 33,977 controls).

Glucose-regulated protein 78 regulates the subunit-folding of the CCT complex by modulating gene expression and protein interaction in the microsporidian Nosema bombycis.

Chaperonin containing tailless complex polypeptide 1 (CCT) functions as a molecular chaperone and is essential for ensuring proper protein folding. Glucose-regulated protein 78 (GRP78/Bip), also a type of chaperone, not only assists in folding of proteins, but also facilitates the transportation of proteins into the endoplasmic reticulum (ER) via the Sec protein complex. In this study, we identified the CCTη of N.

Effect of Mixing Erythritol and Its Fluorine Analogues to Suppress Supercooling.

Erythritol is a latent heat storage material suitable for the utilization of unused heat in the medium temperature range of 100-250 °C. However, the supercooling characteristic of sugar alcohols reduces the energy utilization efficiency. In this study, erythritol and its fluorine analogues are mixed to suppress supercooling.

Herbal placebo response in clinical trials on irritable bowel syndrome: a systematic review and meta-analysis.

Aim Of The Study: To systematically evaluate the herbal placebo response in randomized controlled trials (RCTs) of herbal medicine on irritable bowel syndrome (IBS).

Materials And Methods: We searched for RCTs with herbal placebo groups for IBS in PubMed, EMBASE, the Cochrane Library, the China National Knowledge Infrastructure (CNKI), the Wan Fang database and Sinomed database from 31 January 1994 to November 2023, and the quality of the literature was evaluated by the Cochrane risk of bias assessment criteria. The primary outcome indicators were response rate, abdominal pain and stool improvement rate, which were analyzed by single-group rate meta-analysis.