Comparative Evaluation of Stress Distribution and Permeability Characteristics in Bentonite Cutoff Walls Using CPTU and ABAQUS Methods.

Bentonite materials are extensively used in cutoff walls at landfill sites. This study calculates the stress and permeability characteristics of bentonite materials using the piezocone penetration test (CPTU) and ABAQUS simulations. The lateral effective stress of bentonite materials is evaluated using arching models, lateral squeezing models, and a modified lateral squeezing model.

Sustainable synthesis of Ce-La loaded ontoCitrus limonfor phosphate removal: Performance and regeneration studies.

Efficient phosphate (P) treatment and resource recovery from water are crucial environmental challenges in water pollution management. In this study, a bimetallic La-Ce nanoparticle Citrus limon residue-based biosorbent was developed through a solvothermal synthesis method, using fruit waste as the raw material. This research work revealed that the surface of the agricultural waste became rough and uniformly layered through La and Ce after modification.

Case report and literature review: novel TXNRD2 compound heterozygous variants in familial glucocorticoid deficiency type 5.

Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder characterized by isolated glucocorticoid deficiency. Mutations of , , , , and have been implicated in FGD pathogenesis. To date, only four families with associated familial Glucocorticoid Deficiency Type 5 (FGD5) have been reported worldwide.

Oxidative stress in ARDS: mechanisms and therapeutic potential.

Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by acute lung inflammation, increased vascular permeability, and hypoxemic respiratory failure. Oxidative stress, driven by excessive reactive oxygen species (ROS), is a key contributor to ARDS pathogenesis, causing cellular damage, inflammation, and alveolar-capillary barrier disruption. This review elucidates the mechanisms of oxidative stress in ARDS, focusing on ROS production via NADPH oxidase (NOX) and mitochondria, which activate pathways like NF-κB and MAPK, promoting pro-inflammatory cytokine release.

Establishing an algorithm for molecular genetic diagnostics in Chinese children with brachydactyly type E.

Background: Brachydactyly type E (BDE) is characterized by variable shortening of metacarpals or metatarsals, often involving phalanges. It may occur as an isolated anomaly or as part of congenital syndromes. With advancements in molecular diagnostic technologies, how genetic testing enhances the precise diagnosis of BDE remains unclear.

Association of microplastics in human cerebrospinal fluid with Alzheimer's disease-related changes.

To investigate potential associations between cerebrospinal fluid (CSF) microplastics and Alzheimer's disease (AD) pathology or cognitive function. The study included two cohorts: Cohort 1 comprised 17 amyloid-positive and 15 amyloid-negative subjects, while Cohort 2 consisted of 11 amyloid-positive subjects. All amyloid-positive participants in Cohort 1 completed one-year follow-up.

A novel compound DBZ alleviates chronic inflammatory pain and anxiety-like behaviors by targeting the JAK2-STAT3 signaling pathway.

Chronic pain profoundly disrupts patients' daily lives and places a heavy burden on their families. Tanshinol Borneol Ester (DBZ), a novel synthetic derivative, has demonstrated anti-inflammatory and anti-atherosclerotic effects, yet its impact on the central nervous system remains largely unexplored. This study systematically examines the central nervous system effects of DBZ through a combination of in vivo, in vitro, network pharmacology, and molecular docking approaches.

Detection and classification of Shiitake mushroom fruiting bodies based on Mamba YOLO.

To address the challenges of high labor intensity and low harvesting efficiency in shiitake mushroom production and management, this article presents a novel detection and classification method based on mamba-YOLO. This method adheres to the picking standards and grade specifications for shiitake mushrooms, enabling the automatic detection and quality grading of the mushrooms. Experiments conducted on a self-constructed shiitake mushroom dataset demonstrate that mamba-YOLO achieves precision (P), recall (R), mean average precision calculated at an IoU threshold of 50% (mAP@0.

Broadband-Detection and Low-Operating-Voltage Photodetectors Based on Metal Oxide/Perovskite Quantum Dot Heterojunctions.

To achieve comprehensive environmental monitoring, photodetectors with broad operational wavelength range are crucial for capturing realistic wide-spectrum signals and supporting integrated system operations. This study presents a high-performance photodetector based on InSrO nanofiber (NF)/CsPbBr quantum dot (QD) heterojunctions, achieving broadband detection (230-500 nm) and ultralow operating voltage (0.05 V).

Endoplasmic reticulum stress in gut inflammation: Implications for ulcerative colitis and Crohn's disease.

Eukaryotic cells contain the endoplasmic reticulum (ER), a prevalent and intricate membranous structural system. During the development of inflammatory bowel disease (IBD), the stress on the ER and the start of the unfolded protein response are very important. Some chemicals, including 4μ8C, small molecule agonists of X-box binding protein 1, and ISRIB, work on the inositol-requiring enzyme 1, turn on transcription factor 6, and activate protein kinase RNA-like ER kinase pathways.

A sensitive method for simultaneous screening exposure to 14 alkylating agents based on tripeptide adducts: an efficient approach for chemical weapon verification and chemical impurity profiling in plasma samples.

For the implementation of the Chemical Weapons Convention, the Organisation for Prohibition of Chemical Weapons (OPCW) designates laboratories for the analysis of chemicals that can be used as chemical warfare agents (CWAs). In these laboratories, analytical methods for detecting CWAs have been developed for environmental and biomedical samples. Protein adducts from exposed biomedical samples are an important type of biomarker for verification of their abuse.

3D Printed Flexible Zinc-Ion Battery for Real-Time Health Monitoring Devices.

The growing need for multifunctional wearable electronics for mobile applications has triggered the demand for flexible and reliable energy storage devices. 3D printing technology has emerged as a promising and attractive method for manufacturing these devices. This study presents the design and fabrication of a flexible quasi-solid-state Zn-ion battery using the direct-writing 3D printing technique.

Severe angiostrongyliasis with neuropsychiatric symptoms in vulnerable adults: Early diagnosis via next-generation sequencing and successful treatment.

Angiostrongylus cantonensis (AC) is a parasite that occasionally infects humans, causing eosinophilic meningitis (EM). In this study, we identified two adult males with severe angiostrongyliasis being treated at the ICU. Both presented with mental and behavioral abnormalities and were initially treated for psychiatric disorders before showing symptoms like cough, fever, and altered consciousness.

Carbon quantum dots in spectrofluorimetric analysis: A comprehensive review of synthesis, mechanisms and multifunctional applications.

Carbon quantum dots (CQDs), as a representative nanomaterial, have demonstrated promising applications in fluorescence analysis owing to their unique optical properties, low cytotoxicity and exceptional biocompatibility. This review systematically summarizes recent advances in synthesis strategies, detection mechanisms and applications of CQDs for sensing metal ions (e.g.

Involvement of the NLRP3/IL-1β pathway in activation and effector functions of γδT17 cells in patients with ulcerative colitis.

Background: The interleukin-17 (IL-17) mediated aberrant immune-inflammatory response plays a paramount role in ulcerative colitis (UC). γδT17 cells are one of the critical sources of IL-17, but the role they play in UC remains under debate.

Aim: To clarify the role of γδT17 cells in patients with mild-to-moderate UC.

Comparative Analysis of Gastroesophageal Reflux Disease Animal Model Methods: A Data Mining of the Past Decade.

Purpose: The differences in the animal model construction of different subtypes of gastroesophageal reflux disease (GERD) have not been clearly demonstrated at present. We aim to reveal the characteristics and differences between them.

Methods: The literature related to GERD animal model construction in the past decade was searched and data on animal strains, modeling modes, modeling cycles, and detection indices were extracted, and the results were presented by using descriptive statistical methods of frequency and relative frequency.

Integrative investigation on the mechanisms of modified Zuojin pill (SQQT) in ameliorating gastric metaplasia.

Ethnopharmacological Relevance: Zuojin pill is a well-known traditional Chinese medicine (TCM) for treating gastric disorders. The modified Zuojin pill (SQQT) has been used in the treatment of gastric metaplasia (GM) in China for decades. However, the mechanisms of SQQT treat GM remain unclear.

Deciphering the Role of CD14 in -associated Gastritis and Gastric Cancer: Combing Bioinformatics Analysis and Experiments.

Gastric cancer (GC) is the third leading cause of cancer-related death and is associated with high mortality and morbidity. (HP) infection is the most important cause of GC. We aimed to identify the core genes of HP caused GC and further elucidate the underlying mechanisms.

The effect of physical activity and life events on mental health of college students: the mediating role of psychological vulnerability.

Background: Life events are important risk factors for negative psychology such as depression and anxiety. However, individuals who experienced the same life events might not necessarily develop mental health problems. Some inherent psychological qualities among individuals may determine their mental health status under life events.

Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Colitis in Mice via the Modulation of NF-B and Nrf2/HO-1 Pathways.

This study aims to reveal the potential molecular mechanisms of modified Gegen Qinlian decoction (MGQD) in relieving ulcerative colitis (UC). C57BL/6J mice were used to establish experimental colitis via dextran sodium sulfate (DSS). Body weight, disease activity index (DAI), spleen weight, colon length, and histopathologic features were measured to evaluate the therapeutic effects of MGQD on mice with UC.

Enhanced removal of Ni and Co from wastewater using a novel 2-hydroxyphosphonoacetic acid modified Mg/Fe-LDH composite adsorbent.

While technological advancements in treating electroplating wastewater continue, removing high concentrations of Ni and Co remains a challenge. Surface functionalization of clay has emerged as a pivotal approach for effectively removing heavy metals, rivaling intercalation modification in its effectiveness. This study investigated the adsorption performance and mechanisms of a phosphonate-modified layered double hydroxide material, employing batch experiments and simulation calculations to elucidate the impact of surface modification on adsorption behavior.

Herbal placebo response in clinical trials on irritable bowel syndrome: a systematic review and meta-analysis.

Aim Of The Study: To systematically evaluate the herbal placebo response in randomized controlled trials (RCTs) of herbal medicine on irritable bowel syndrome (IBS).

Materials And Methods: We searched for RCTs with herbal placebo groups for IBS in PubMed, EMBASE, the Cochrane Library, the China National Knowledge Infrastructure (CNKI), the Wan Fang database and Sinomed database from 31 January 1994 to November 2023, and the quality of the literature was evaluated by the Cochrane risk of bias assessment criteria. The primary outcome indicators were response rate, abdominal pain and stool improvement rate, which were analyzed by single-group rate meta-analysis.

Modified Zuojin pill alleviates gastric precancerous lesions by inhibiting glycolysis through the HIF-1α pathway.

Background: Gastric precancerous lesions (GPL) typically originates from chronic gastritis (CG), and the changes in glycolysis mediated by the HIF-1α pathway during the progression from CG to GPL are unclear. Modified Zuojin pill (SQQT) is a traditional Chinese herbal formula used for treating GPL. However, the underlying mechanism has not been fully elucidated.

Magnetism-Functionalized Lanthanide MOF-on-MOF with Plasmonic Differential Signal Amplification for Ultrasensitive Fluorescence Immunoassays.

The successful application of fluorescence immunoassays for clinical diagnosis requires stable photoluminescent materials and highly efficient signal amplification strategies. In this work, the magnetism-functionalized lanthanide MOF-on-MOF (FeO@SiO@MOF-on-MOF) was synthesized through intermolecular (van der Waals) interaction-assisted growth and further homogeneous epitaxial growth, which significantly improved the fluorescence performances and uncovered the underlying mechanism. The quantum chemical theory calculation and experimental studies revealed that the introduced magnetic FeO@SiO not only endowed magnetic separation capability but also promoted fluorescence performances, which increased the energy transfer of the intersystem crossing process and suppressed the luminescence of ligands and aggregation-induced quenching.