Clinicopathologic characteristics and predictive nomogram of skip lymph node metastasis in gastric cancer.

Background: Lymph node (LN) status is an independent factor affecting the prognosis of gastric cancer patients. Skip metastasis is a pattern of LN metastasis across a peritumoral (PT) area to an extra-peritumoral (EP) area. The purpose of the present study was to determine the clinical characteristics and establish a predictive nomogram for skip metastasis in gastric cancer.

The Promotion of Cell Proliferation by Food-Derived Bioactive Peptides: Sources and Mechanisms.

Cell proliferation plays a pivotal role in multiple physiological processes, including osteoporosis alleviation, wound healing, and immune enhancement. Numerous novel peptides with cell proliferation-promoting activity have been identified. These peptides exert their functions by modulating key cellular signaling pathways, thereby regulating diverse biological processes related to cell proliferation.

On semi-supervised estimation using exponential tilt mixture models.

Consider a semi-supervised setting with a labeled dataset of binary responses and predictors and an unlabeled dataset with only the predictors. Logistic regression is equivalent to an exponential tilt model in the labeled population. For semi-supervised estimation of regression coefficients in logistic regression, we develop further analysis and understanding of a statistical approach using exponential tilt mixture (ETM) models and maximum nonparametric likelihood estimation, while allowing that the class proportions may differ between the unlabeled and labeled data.

Insight into the mechanisms of milk protein synthesis via peptides derived from Micropterus salmoides.

Breast milk is widely acknowledged as the safest food for infants. However, current breastfeeding rates fall below the guidelines established by the World Health Organization. This study aimed to investigate the impact of Micropterus salmoides peptides (MS) on lactation in human mammary epithelial cells (MCF-10A cells) and to elucidate its mechanism.

Nanosensor Detection of Synaptic Glutamate Release and Its Enhancement in Long-term Potentiation.

Long-term potentiation (LTP) performing as long-lasting increase in synaptic strength after tetanic stimulation, is one kind of vital synaptic plasticity in hippocampal neurons and involved in learning and memory mechanisms. Postsynaptic effect through protein expression and receptor migration in LTP has been widely studied, while presynaptic contribution remains indeterminate for lack of strategy for real-time monitoring glutamate (Glu) release and exocytotic dynamics change inside the synapse. Herein, a novel Glu nanosensor is fabricated which is equipped with a conical tip and can be inserted into synaptic cleft of cultured hippocampal neurons.

Optimization and performance study of large aspect ratio SiC microgrooves by waterjet assisted laser machining.

Silicon carbide (SiC) ceramics hold significant application value in high-end fields such as semiconductors and aerospace due to their exceptional mechanical properties and thermal stability. Large-aspect-ratio (LAR) microgrooves in ceramics are crucial for enabling advanced functionalities in various applications, including microfluidic devices, microelectromechanical systems (MEMS), and thermal management systems, where precise control over fluid flow, structural integrity, and heat dissipation is required. However, their extreme hardness poses challenges for traditional mechanical machining, including low efficiency and severe tool wear, while laser machining is prone to defects such as heat-affected zones and recast layers.

Multi-biosensing hairband for emergency health assessment.

Blood analysis is regarded as the gold standard for monitoring analytes in clinical diagnostics. However, the time-consuming and site-limited nature often delays medical interventions that are crucial for patients in emergency scenarios. Herein, a weavable multi-biosensor array is developed through coaxial wet spinning for real-time multiplex detection of sweat biomarkers (pH, Na, K, and Ca) and body temperature.

CeO Nanoparticles Reduce Oxidative Stress and Delay the Degeneration of Intervertebral Disc.

The oxidative stress of the body can destroy the homeostasis and lead to a series of adverse outcomes. In recent years, nano-enzyme materials, as a new hotspot in materials science, have been gradually applied in various fields because of their enzyme-like activities at the nanoscale and their ability to regulate various physiological processes in organisms. In this study, we developed a novel cerium oxide (CeO) nano-enzyme drug and demonstrated that the nano-enzyme can effectively improve oxidative stress levels and delay disc degeneration in rats.

Comparative Pathogenicity of PCV2, PCV3, and PCV4 in Piglets: Insights Into Clinical, Pathological, and Immunological Features.

Porcine circoviruses (PCVs) have been a significant concern in swine health, with PCV2 being a well-established pathogen. However, the newly discovered PCV3 and PCV4 have emerged, and their impact on piglets remains less understood. Understanding their pathogenicity is crucial for effective porcine health management.

Challenges and opportunities for early childhood intervention services in Singapore: addressing user satisfaction.

Since the COVID-19 pandemic, there has been a gap between primary stakeholders' expectations of adaptive early childhood intervention (ECI) services and their actual experiences with these services. This is despite governments' and service operators' swift pivot from on-site service delivery to home-based, virtual and hybrid modes, and cross-sector collaboration with private providers and pre-schools. In this article, we share our preliminary evidence from in-depth interviews with parents and clinicians regarding the perceived challenges to post-pandemic ECI services.

Left ventricular septal pacing combined with left ventricular pacing improves acute electric resynchronization, hemodynamic responses and clinical outcomes: results of SPORT study.

Aims: Left bundle branch pacing is effective for cardiac resynchronization therapy (CRT), but the role of left ventricular septal pacing (LVSP) for CRT remains controversial due to lack of LBB capture. We hypothesized that combining LVSP with LV pacing (LVP) may provide additional benefits.

Methods And Results: This prospective observational study enrolled consecutive patients undergoing LVSP for CRT.

Multi-dimensional analysis of single particles with sequential dual-nanopipette sensors.

Nanoparticles play crucial roles in a wide range of scientific and industrial fields. Analysing the physicochemical characteristics of nanoparticles is of paramount importance in identifying and classifying different particles. However, due to their small size and inherent heterogeneity, comprehensive analysis of the size and shape, especially the complex surface characteristics, of individual particles is still confronted with challenges.

B-Bridge Regulated Asymmetric Dual-Atomic Catalysts for Synergistically Enhanced Styrene Mineralization and CO Reduction.

Developing innovative resource utilization strategies to achieve sustainable recycling of waste-to-fuel is highly desirable, yet the design of cost-effective bifunctional catalysts with dual high-efficiency remains unexplored. While the Fenton-like reaction relies on enhancing peroxymonosulfate (PMS) adsorption and accelerating interfacial electron transfer to improve kinetic rates, CO reduction is constrained by sluggish kinetics and competing hydrogen evolution reaction. Herein, we construct a bifunctional catalyst (NiFe-BNC) featuring dual-atomic active sites by introducing boron atoms into a biomass-derived chitosan substrate rich in functional groups, which optimizes atomic coordination environments.

Ag/FeO-Catalyzed Fabrication of Flexible Printed Circuits: Integrated UV-Curing and Electroless Plating Process.

The development of a highly adaptable and efficient method for the rapid design and fabrication of durable flexible circuit boards on various substrates, especially heat-sensitive ones, holds great significance for sensors and actuators. Herein, we fabricated a development of high-performance flexible circuits by integrating ultraviolet (UV) curing and electroless plating technologies, utilizing a photocurable layer of the Ag/FeO catalyst deposited onto a thin-film substrate designed for heat-resistant applications. The microstructure, stability, and durability of the fabricated flexible printed circuits (FPCs) were comprehensively characterized.

Risk of Switch to Mania/Hypomania in Bipolar Depressive Patients Treated with Antidepressants: A Real-World Study.

The use of antidepressants in the treatment of bipolar depression remains controversial due to concerns about their potential to induce mood polarity switches. This multinational observational study aims to examine the association between the use of antidepressants and the risk of hypomanic/manic switch among bipolar depressive patients. Four electronic health record databases (IQVIA Disease Analyzer Germany, IQVIA Disease Analyzer France, IQVIA US Hospital Charge Data Master, and Beijing Anding Hospital) and one administrative claims database (IQVIA US Open Claims) were analyzed, and the study period covered from January 2013 until December 2017.

Orienting and accelerating Zn migration by strategic interfacial engineering for achieving highly stable zinc anodes.

Aqueous zinc-ion batteries (AZIBs) have emerged as a promising alternative to lithium-ion batteries owing to their abundant zinc resources, low cost, environmental friendliness, and impressive theoretical specific capacity of 820 mAh g. However, zinc anodes face significant challenges, including short cycle lifetimes and poor reversibility, primarily due to rampant dendrite growth and the inevitable hydrogen evolution reaction (HER). To address these issues, an artificial protective layer of Ca-doped LaCrO (denoted as LCCO2) was coated onto zinc foil utilizing a facile doctor blade casting method.

Combustion Behavior Characteristics of Transformer Jet Fire with Multiple Factors.

Transformer jet fire is one of the most serious types of substation fire accidents, which often causes heavy casualties and property losses and even causes other secondary disasters, further expanding the impact of thermal disasters. Compared with the jet fire formed by the leakage of gaseous combustibles during production, transportation, and storage, the research on the combustion behavior of transformer jet fire under multiple factors, such as flame shape and flame height, is relatively scarce. This study used the research method of combining experimental research with theoretical analysis.

Naringin regulates the cGAS-STING pathway to improve mitochondrial dysfunction and ferroptosis after myocardial ischemia-reperfusion injury.

Myocardial ischemia-reperfusion injury (MI/RI) is a crucial complication of reperfusion treatment for myocardial infarction. Naringin (Nar) is a flavonoid with identified cardioprotective functions. This study aimed to explore the protective mechanisms of Nar against MI/RI, specifically focusing on its modulation of the cGAS-STING pathway.

Dual-Interface Nanopipette Sensor for Electrochemical Interferent Shielding.

Enzyme-based sensors have been widely utilized for their superior selectivity. However, they cannot distinguish the same kind of redox mediators from different sources. Typically, both the HO produced in glucose (analyte) oxidation by glucose oxidase (GOD) and the endogenous HO (interferent) existing in the detection system can be simultaneously measured, causing inaccurate results in glucose detection.

Nonlinear Optical Response of Tungsten Carbide Thin Film as Saturable Absorber at 1 μm and Its Application for Passively Q-Switched Nd:YAG Lasers.

Pulsed lasers have a wide range of applications in scientific and industrial fields, and the saturable absorber (SA) is the core device of pulsed lasers. Tungsten carbide (WC) has garnered significant attention due to its exceptional physicochemical properties, making it a promising candidate for optoelectronic applications, particularly as an SA in pulse lasers. This study is the first to report the nonlinear optical properties of WC thin film at a 1064 nm wavelength and its use as an SA device to generate pulsed lasers.

Factors influencing healthy dietary behavior changes among patients with gestational diabetes mellitus during pregnancy: A meta-synthesis using the theoretical domains framework.

Aims: To examine factors that facilitate and impede healthy dietary behavior modification in patients with gestational diabetes mellitus (GDM). Additionally, it sought to assess the strength of the evidence for these factors and offer insights into promoting positive behaviors.

Methods: This systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting standards.

VibTac: A High-Resolution High-Bandwidth Tactile Sensing Finger for Multi-Modal Perception in Robotic Manipulation.

Tactile sensing is pivotal for enhancing robot manipulation abilities by providing crucial feedback for localized information. However, existing sensors often lack the necessary resolution and bandwidth required for intricate tasks. To address this gap, we introduce VibTac, a novel multi-modal tactile sensing finger designed to offer high-resolution and high-bandwidth tactile sensing simultaneously.

Implementing Multimodal Hardware Security with 2D α-InSe Ferroelectric Transistor.

Security is a critical challenge in the integrated circuit (IC) industry, yet device-level hardware security remains largely underexplored. Most existing solutions necessitate modifications to current technology nodes and typically address only a single security threat, leaving them vulnerable to diverse attacks while incurring substantial costs in area, energy, and resources. In this study, an out-of-the-box security solution is proposed that integrates an in-memory sensing and computing (IMSC) architecture based on α-InSe transistor, specifically designed for versatile and multimodal secure applications.

VEGF secreted by human dental pulp stem cell promotes spinal cord injury repair by inhibiting microglial pyroptosis through the PI3K/AKT pathway.

Background: Spinal cord injury (SCI) remains a devastating central nervous system disorder. The complex pathological microenvironment following SCI, particularly the imbalance in neuroinflammation, contributes to its therapeutic challenges. Microglial pyroptosis, a type of programmed cell death, is pivotal in exacerbating neuroinflammation and secondary tissue damage after SCI.

Acculturation and educational involvement among Chinese immigrant parents: The mediating role of emotional well-being.

Acculturation and parental educational involvement, life satisfaction, and depression are intertwined in Chinese immigrant families. This study investigated the relationship between Chinese immigrant parents' acculturation and educational involvement, with a particular focus on examining the mediating effects of their life satisfaction and depression on this relationship. Participants were 250 Chinese immigrant parents (M = 43.