Pyroptosis-Mediator GSDMD in Plasma: A Potent Biomarker Lung Cancer Diagnosis and Prognosis Assessment.

Objective: Lung cancer's high mortality is linked to late diagnosis, with current methods having limitations. This study aimed to evaluate the diagnostic efficacy of Gasdermin D (GSDMD) in lung cancer and explore its biological functions.

Methods: A total of 114 lung cancer patients, 87 patients with pulmonary nodules, and 100 healthy controls were enrolled.

Synthetic MRI study of brain volume and subcortical myelin in various Parkinson's disease motor subtypes.

Alterations in brain volume and subcortical myelin content (MyC) between tremor-dominant (TD) and postural instability and gait difficulty (PIGD) subtypes of Parkinson's (PD) disease remain unclear. This study investigated whole-brain volume and subcortical myelin content differences among PD motor subtypes using synthetic MRI. Ninety-two PD patients (39 TD and 53 PIGD) and 39 healthy controls were included.

Clinical features, treatment and prognosis analysis of distant metastatic esophageal cancer.

Esophageal cancer (EC) is one of the most common malignant tumors in China. EC is characterized by a poor clinical prognosis, with many patients being diagnosed at advanced stages. This study utilized data from the Surveillance, Epidemiology, and End Results (SEER) database.

Macrophage Response to Avirulent and Virulent Mycobacterium tuberculosis and Anti-TB Effects of Exosome Treatment.

Tuberculosis (TB) returned as the leading cause of death from a single infectious agent in 2023. Human-macrophages and their secreted exosomes play important roles in combating invading Mycobacterium tuberculosis (Mtb). However, panoramic analysis of the underlying immune mechanism for infected macrophages, package mechanism and anti-TB effect of Mtb treated exosomes remain understood.

A novel multi-modal retrieval framework for tracking vehicles using natural language descriptions.

Recent advances in multimodal and contrastive learning have significantly enhanced image and video retrieval capabilities. This fusion provides numerous opportunities for multi-dimensional and multi-view retrieval, especially in multi-camera surveillance scenarios in traffic environments. This paper introduces a novel Multi-modal Vehicle Retrieval (MVR) system designed to retrieve the trajectories of tracked vehicles using natural language descriptions.

Exploring the decision-making process of Chinese older adults transitioning to continuing care retirement communities: a qualitative study.

Background: China's rapidly aging population and the limitations of traditional home-based care have prompted many older adults and their families to consider Continuing Care Retirement Communities (CCRCs) as a comprehensive option. However, the decision-making process for this transition remains underexplored. This study aims to systematically explore how older adults navigate the decision to move to CCRCs, to guide service improvements and inform policy.

Explainable classification of Parkinson's disease with different motor subtypes by analyzing the synthetic MRI quantitative parameters of subcortical nuclei.

Objectives: To explore differences in quantitative parameters of subcortical nuclei using synthetic MRI across different motor subtypes of Parkinson's Disease (PD), and to develop an interpretable model for distinguishing PD subtypes.

Methods: A total of 102 PD patients, including 43 Tremor-Dominant (TD) subtype and 59 Postural Instability and Gait Difficulty (PIGD) subtype and 42 age- and gender-matched healthy controls (HCs) were included. T1, T2, Proton Density (PrD), and Myelin Content (MYC) were extracted from 16 subcortical nuclei.

The role and therapeutic value of NUSAP1 in human cancers.

In recent years, the incidence of cancer has increased, and early diagnosis and treatment are key to cancer treatment. Nucleolar and spindle-associated protein 1 (NUSAP1) is a crucial mitotic regulator. NUSAP1 binds to microtubules and mediates their attachment to chromosomes, ensuring the accurate distribution of genetic material to the two daughter cells.

Hyperbaric oxygen for paroxysmal sympathetic hyperactivity syndrome after acute carbon monoxide poisoning.

JOURNAL/mgres/04.03/01612956-202603000-00002/figure1/v/2025-06-28T140100Z/r/image-tiff Paroxysmal sympathetic hyperactivity syndrome (PSH) is common in patients with severe craniocerebral injuries. Carbon monoxide poisoning (ACOP) may lead to secondary PSH, and hyperbaric oxygen (HBO) is an important treatment method for ACOP that can promote the dissociation of carboxyhemoglobin and reduce the long-term sequelae of ACOP.

Targeting inflammasomes as an immunotherapeutic strategy for cancer.

Inflammasomes are essential regulators of innate immunity, inflammation, and cellular apoptosis, and they have surfaced as significant modulators of cancer progression and regulation. Inflammasomes are macromolecular complexes assembled in response to damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). They induce inflammation via the oligomerization and activation of caspases.

Development of a biomimetic nanoparticle platform for apigenin therapy in triple-negative breast cancer.

Background: This study investigates the therapeutic potential and mechanisms of Apigenin (AGN) in treating triple-negative breast cancer (TNBC). Although AGN is recognized for its anti-tumor properties, its specific mechanisms in TNBC remain unclear.

Methods: To identify key genes associated with AGN's effects on breast cancer, we utilized network pharmacology, conducting Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses.

Anti-Aging Effects and Mechanisms of Cod Collagen Peptides (CCPs) in .

Given the growing interest in natural compounds for promoting healthy aging, this study aimed to investigate the potential of cod collagen peptides (CCPs), a readily available marine resource, to extend lifespan and improve health. Lifespan assays were performed on treated with different concentrations of CCPs. Furthermore, various stress resistance assays, including those evaluating oxidative and thermal stress, were conducted.

Primary cilium restricts TGF-β/SMAD signaling induced RIBEs in the co-culture model.

Transforming growth factor β (TGF-β) is the predominant cytokine responding to ionizing radiation and participates in radiation induced bystander effects (RIBEs). Primary cilia (PC) coordinates with multiple signaling pathways, exhibit specialized functions in TGF-β signal transduction. Our previous studies using a medium transfer model revealed that PC modulates RIBEs by restricting TGF-β signaling.

Heterojunction Derived Efficient Charge Separation for High Sensitivity Self-Powered Flexible Photodetectors toward Real-Time Heart Rate Monitoring.

Real-time and accurate heart rate monitoring is crucial in the field of disease prevention and early diagnosis. Compared with the conventional rigid heart rate sensors, wearable flexible devices have unique advantages, such as convenient, high comfortable to the skin, and low data extraction errors. Currently, the available flexible electronic devices encounter with large power consumption, low detectivity, and slow response time, restricting their further commercial applications.

LZTS2 methylation as a potential diagnostic and prognostic marker in LIHC and STAD: Evidence from bioinformatics and in vitro analyses.

The rising mortality rate from cancer, driven by the absence of reliable biomarkers, highlights the pressing need for advanced diagnostic and prognostic strategies. This study investigates LZTS2's role as a pan-cancer biomarker, emphasizing its predictive value for immunotherapy and therapeutic targeting. Unlike existing biomarkers such as AFP in hepatocellular carcinoma or HER2 in gastric cancer, which exhibit tissue-specific utility, LZTS2 demonstrates unique cross-cancer applicability, as evidenced by its consistent dysregulation in both liver hepatocellular carcinoma (LIHC) and stomach adenocarcinoma (STAD) alongside emerging associations with other malignancies.

Investigation of the Insulation Characteristics of TPU/EP Composites Under Cold Thermal Shock.

To improve the issue of the decreased toughness and electrical performance of epoxy resin (EP) in thermal shock environments, we prepared thermoplastic polyurethane elastomer (TPU)-filled modified EP composites. We also studied the mechanical and electrical performance of these composites, which had different TPU filling contents, under thermal shock conditions. The results indicated that after 240 h of thermal cycling between -15 °C and 100 °C, the TPU/epoxy composites, when compared to unmodified EP, exhibited a 10.

Overall survival of patients with de Novo HER2-positive metastatic breast cancer in the Netherlands from 2008 to 2017: A population-based cohort study of systemically treated patients.

Aim: This study aims to determine whether real-world overall survival (OS) of patients with de Novo HER2-positive (HER2 +) metastatic breast cancer (MBC) in the Netherlands improved over time.

Methods: Data of patients diagnosed with de Novo HER2 + MBC in 2008-2017 were retrieved from the Netherlands Cancer Registry. OS was estimated per two-year period using the Kaplan-Meier method and compared using the log-rank test for trend and the multivariable Cox proportional hazards analysis, adjusted for baseline characteristics and local therapy.

Homocysteine induces endometrial ferroptosis via MAPK pathway in recurrent pregnancy loss.

Background: Recurrent pregnancy loss (RPL) with complex etiology and elevated homocysteinemia (HCY) has been recognized one of the risk factors, however the mechanism of HCY participation in RPL are not fully elucidated.

Methods: Samples from RPL_HHCY, RPL_NHCY and controls were used to metabolomics and proteomic analysis. Cell counting kit-8 assay, EdU assay kit, wound healing assay and induced decidualization were performed to observe the HCY induced dysfunction of human endometrial stromal cells (hESCs).

Metabolomics profiling identifies diagnostic metabolic signatures for pregnancy loss: a cross-sectional study from northwestern China.

Objective: To identify potential diagnostic metabolic biomarkers for pregnancy loss (PL) by performing untargeted metabolomics analysis.

Methods: The present study performed untargeted metabolomics analysis on plasma samples from PL patients (n=70) and control subjects (n=122) using liquid chromatography‒mass spectrometry (LC‒MS). Metabolic profiles were evaluated using orthogonal partial least squares discriminant analysis (OPLS-DA), and pathway enrichment analysis was conducted via the KEGG database.

[Current status and reflections on the development of acupuncture-moxibustion technical specification in China].

Acupuncture-moxibustion technical specifications are a crucial component of the acupuncture-moxibustion standardization system. This study reviews the current development status of acupuncture-moxibustion technical specifications in China, and analyzes their classifications and characteristics. It is found that the scope and classification of acupuncture technical specifications remain unclear in academic circles, and the development process faces numerous difficulties and challenges.

VEGF secreted by human dental pulp stem cell promotes spinal cord injury repair by inhibiting microglial pyroptosis through the PI3K/AKT pathway.

Background: Spinal cord injury (SCI) remains a devastating central nervous system disorder. The complex pathological microenvironment following SCI, particularly the imbalance in neuroinflammation, contributes to its therapeutic challenges. Microglial pyroptosis, a type of programmed cell death, is pivotal in exacerbating neuroinflammation and secondary tissue damage after SCI.

[Role of medical experience in the formulation of acupuncture-moxibustion clinical practice guidelines].

From the perspective of evidence integration and utilization in guidelines, based on the carrier variety, medical experience is composed of the literature on the practical experience of medical scholars recorded in the ancient and modern time, and the individual opinions in the expert consensus. These two types of carrier for medical experience play the different roles in the key steps during formulating the acupuncture-moxibustion guidelines. Three values are summarized, named being conductive to centering the key clinical questions and strongly representing these questions; being used as a basis to judge the clinical applicability of the recommended regimens; and facilitating the recommendation.

Comparison of different approaches applied for surgical correction of partial anomalous pulmonary venous connection.

Background: Right anterolateral thoracotomy or left anterolateral thoracotomy applied to partial anomalous pulmonary venous connection correction have been reported to obtain cosmetic and less invasive outcomes as alternative approaches to median sternotomy. However, the application of different approaches is still confusing. We compared the perioperative and mid-term outcomes to seek indications of different approaches and guide surgical treatment of partial anomalous pulmonary venous connection.

Pyroptosis-Mediator GSDMD in Plasma: A Promising Biomarker for Early Diagnosis of Type 2 Diabetes.

Objective: This study investigates the potential of plasma Gasdermin D (GSDMD) as a novel biomarker for early diagnosis and monitoring of type 2 diabetes mellitus.

Methods: We conducted a comparative analysis of clinical indicators among newly diagnosed diabetes patients, those with prediabetes, and healthy controls, finding significantly elevated plasma GSDMD levels in the diabetes group (P < 0.05).