Palladium-Catalyzed Asymmetric Aminomethylative Pyridonation of Conjugated Dienes.

A novel palladium-catalyzed asymmetric aminomethylative pyridonation of conjugated dienes with -acetals and 2-hydroxypyridines was established, which provided a direct and reliable method for the synthesis of a wide range of γ-aminated N-substituted 2-pyridones with good to excellent enantioselectivities. The simple BF was identified as an effective cocatalyst to improve the reaction efficiency, and DFT calculations revealed that proton transfer between the aminomethylated allylic palladium species and 2-hydroxypyridine promoted by BF is crucial for obtaining good reactivity.

Amplification of Laguerre-Gaussian laser pulses in plasma by copropagating Gaussian pulses.

Laguerre-Gaussian (LG) laser beams have many interesting applications due to their unique field structure. However, the generation of intense LG beams remains challenging because of the limited damage threshold of intensity for optical elements used for the conversion from normal Gaussian beams to LG beams. Here, we propose a plasma-based scheme to amplify a LG pulse through energy transfer from copropagating multiple Gaussian pulses as pumps.

A Bifunctional Sulfone Reagent for Asymmetric Aminomethylative Sulfonylation of Dienes.

Sulfone reagents have emerged as highly versatile coupling partners in transition-metal catalysis, owing to their exceptional reactive flexibility. However, current C-SO activation strategies in sulfone reagents remain constrained to introducing single- or double-electron acceptors onto the departing sulfonyl moieties, which inadvertently diminishes the reactivity of the resulting sulfinate and prevents its reutilization. To tackle the long-standing dichotomy between C-SO bond cleavage and reconstruction, we report a neighboring nitrogen-directed C-SO activation strategy, thereby inventing a novel aminomethyl sulfone reagent.

Multiple endocrine neoplasia type 1 with neuroglycopenic symptoms with a novel heterozygous MEN1 gene mutation.

Background: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder caused by mutations in the MEN1 gene located on the long arm of chromosome 11.

Case Presentation: A 32-year-old male was admitted to the Division of Endocrinology with a three-year history of recurrent episodes of altered consciousness and abnormal mental behavior. Laboratory tests and imaging studies revealed primary hyperparathyroidism (PHPT), multiple pancreatic adenomas, and a pituitary adenoma.

Multifunctional hydrogel with self-healing and recyclability based on self-catalytic Fe/TA system for sustainable E-skin application.

Hydrogel-based materials for e-skin applications have aroused tremendous attention due to their ability to simulate human skin's sensory capabilities and possess mechanical properties comparable to those of skin. When used as sensors attached to the skin, hydrogels are inevitably subject to damage, highlighting the need for self-healing properties. Furthermore, the lack of recyclability in traditional hydrogel sensors is detrimental to sustainability.

Utilizing carboxymethyl cellulose sodium/sodium lignosulfonate hydrogel to build efficient electrolyte/electrode interfaces for multifunctional high-performance supercapacitors.

Although hydrogel electrolytes have attracted much attention in flexible supercapacitors, the interfacial contact between the electrolyte and electrode is a key factor restricting the development of supercapacitors. In this work, we constructed a hydrogel supercapacitor by endowing the hydrogel electrolyte with excellent adhesion properties and adopting an interfacial integration strategy, which effectively improves the interfacial contact problem. A multifunctional PCL hydrogel was successfully prepared with excellent tensile properties (1976 %) and self-healing ability through the semi-interpenetrating network formed by carboxymethyl cellulose sodium and polyacrylamide chains, as well as multiple physical interactions.

Investigation of the Insulation Characteristics of TPU/EP Composites Under Cold Thermal Shock.

To improve the issue of the decreased toughness and electrical performance of epoxy resin (EP) in thermal shock environments, we prepared thermoplastic polyurethane elastomer (TPU)-filled modified EP composites. We also studied the mechanical and electrical performance of these composites, which had different TPU filling contents, under thermal shock conditions. The results indicated that after 240 h of thermal cycling between -15 °C and 100 °C, the TPU/epoxy composites, when compared to unmodified EP, exhibited a 10.

Associations of the triglyceride-glucose index and triglyceride-glucose/body mass index with all-cause mortality in Chinese centenarians.

Background: The triglyceride-glucose (TyG) index and triglyceride-glucose/body mass index (TyG-BMI) have been shown to be associated with cardiovascular and cerebrovascular disorders and the risk of death. The aim of this study was to explore the relationships of the TyG index and TyG-BMI with all-cause mortality among Chinese centenarians.

Methods: Data from the China Hainan Centenarian Cohort Study (CHCCS) were analyzed.

Application of flavonoid compounds suppresses the cotton aphid, .

Introduction: The cotton aphid is a significant polyphagous crop pest and has evolved a high level of resistance to neonicotinoids and other insecticides. Flavonoids, plant phytonutrients, have shown promise as natural insect deterrents and growth inhibitors. However, comprehensive evaluations of the effects of flavonoids on are currently lacking.

Dietary supplementation with conjugated linoleic acid induces anemia with combined features of megaloblastic and hemolytic anemia.

This study investigates whether dietary supplementation with conjugated linoleic acids (CLA) induces anemia in mice. Male Kunming White mice were randomly assigned to two groups: one fed a CLA-supplemented diet and the other a linoleic acid (LA)-supplemented diet as control. Compared with those in LA group, periodic manual erythrocyte counts revealed red blood cells (RBCs) in CLA group significantly reduced on days 47 (p < 0.

A tyramine receptor gene LsTAR2 is involved in reproduction and feeding in the small brown planthopper Laodelphax striatellus.

Tyramine (TA) is an important biogenic amine present in the central nervous system of insects, and mediates a variety of physiological and behavioral functions via tyramine receptors (TARs). However, TARs have not yet been characterized in planthoppers, and their physiological functions remain poorly understood in rice pests. Here, we cloned a tyramine receptor gene (LsTAR2) from the small brown planthopper Laodelphax striatellus, one of the most destructive rice pests.

Spring festival firework activities exacerbate toxic effects of aerosol essential components.

Fireworks cause short-term deterioration of air quality but related health effects remain unclear. This study evaluated the impact of typical fireworks on the chemical composition of atmospheric aerosols and their toxic effects during the Chinese Spring Festival (SF). The concentrations of firework-related water-soluble ions, metallic elements, organic carbon, and elemental carbon during the SF are 1.

Constructing coral reef-like imprinted structure on molecularly imprinted nanocomposite membranes based on nanospheres with hydrophilic multicores for selective separation of acteoside.

Molecularly imprinted nanocomposite membranes (MINMs) have shown great superiority in selective separation of acteoside (ACT) from phenylethanoid glycosides in Cistanche tubulosa. Herein, ACT-based MINMs (A-MINMs) with coral reef-like imprinted structure were proposed and developed for specifically separating ACT molecules. The nanospheres with hydrophilic multicores (NHMs) were introduced into polyvinylidene fluoride (PVDF) powders to obtain NHMs@PVDF membranes by a phase inversion method.

Functional characterization of β-adrenergic-like octopamine receptors in planthopper reproduction and feeding.

As an essential biogenic amine in invertebrates, octopamine (OA) regulates multiple physiological and behavioral processes via binding to octopamine receptors (OARs). The small brown planthopper Laodelphax striatellus is an important agricultural pest. However, little is known about OARs in L.

Tailored chiral phosphoramidites support highly enantioselective Pd catalysts for asymmetric aminoalkylative amination.

Even though tuning electronic effect of chiral ligands has proven to be a promising method for designing efficient catalysts, the potential to achieve highly selective reactions by this strategy remains largely unexplored. Here, we report a palladium-catalyzed enantioselective ring-closing aminoalkylative amination of aminoenynes enabled by rationally tuning the remote electronic property of 1,1'-binaphthol-derived phosphoramidites. With a tailored 6,6'-CN-substituted 1,1'-binaphthol-derived phosphoramidite as a ligand, a broad range of aromatic amines are compatible with this reaction, allowing the efficient synthesis of a series of enantioenriched exocyclic allenylamines bearing saturated N-heterocycles with up to >99% enantiomeric excess.

Silver-Catalyzed Thio-Claisen Rearrangement of Aryl Sulfoxides with AIBN.

The Pummerer reaction represents a well-known transformation of sulfoxides. Mechanistically, this reaction is initiated by the generation of the thionium ion, whereas forming such intermediates typically requires the use of a stoichiometric amount of activating reagent. In this regard, we report the activator-free Pummerer-type transformation, a silver-catalyzed thio-Claisen rearrangement of aryl sulfoxides with AIBN.

Dynamic amine sorting enables multiselective construction of unsymmetrical chiral diamines.

Precisely differentiating chemicals featuring minor discrepancies is the prerequisite for achieving high selectivities in both chemical synthesis and biological activities. However, efficient strategies to differentiate and sort such congeneric compounds are lacking, posing daunting challenges for synthetic endeavours aimed at their orderly incorporation. Here we report a dynamic amine-sorting strategy that incorporates the chemoselective formation of the aminomethyl cyclopalladated complex to achieve the efficient differentiation of amine congeners.

Advances in the application of carbon dots-based fluorescent probes in disease biomarker detection.

Carbon dots (CDs), as an emerging nanomaterial, have shown tremendous potential in disease biomarker detection. CDs can selectively interact with different target molecules, enabling highly sensitive and specific detection of these biomolecules. Compared to traditional detection methods, CDs sensors offer advantages such as rapid response, high detection sensitivity, and low cost.

Functional analyses of dopamine receptors involved in virus transmission and reproduction in the small brown planthopper Laodelphax striatellus.

Dopamine (DA) is the most abundant biogenic amine present in the insect central nervous system, and regulates multiple functions in physiology and behaviors through dopamine receptors (DARs). The small brown planthopper Laodelphax striatellus is an important agricultural pest and causes serious damage by transmitting diverse plant viruses, such as rice stripe virus (RSV). However, DARs have not yet been molecularly characterized in planthoppers, and their roles in virus infection and transmission remain largely unknown in insect vectors.

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions.

JOURNAL/nrgr/04.03/01300535-202507000-00032/figure1/v/2024-09-09T124005Z/r/image-tiff A microgravity environment has been shown to cause ocular damage and affect visual acuity, but the underlying mechanisms remain unclear. Therefore, we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under microgravity.

Discovery of a Novel ASM Direct Inhibitor with a 1,5-Diphenyl-pyrazole Scaffold and Its Antidepressant Mechanism of Action.

Multiple studies have confirmed that acid sphingomyelinase (ASM) activity is associated with depression. The discovery of direct inhibitors against ASM is of great significance for exploring antidepressants and their mechanisms of action. Herein, a series of novel phenylpyrazole analogues were rationally designed and synthesized.

Radiometric thermometry of point targets based on dual-band infrared imaging.

The observation area of a point target, which is usually inaccessible, is a necessary condition when utilizing the conventional single-band infrared radiometric thermometry method, as the image gray level inevitably undergoes dispersion. Otherwise, significant errors will be generated, seriously affecting the applicability of infrared radiometric thermometry for distant point targets in the external field. To address the above issue, the infrared radiometric thermometry method for point targets has been researched.