A Series of (M = Ni/Co) Clusters with Different Solvents and Auxiliary Ligands for Near-Infrared Photothermal Conversion and Aldol Condensation Reaction.

By adjusting the solvents, nitrogen-containing auxiliary ligands, and transition metal salts, we successfully constructed 11 new aluminum-transition heterometallic clusters of and . They possess the same metal cores with different terminal-coordinated solvents and nitrogen-containing auxiliary ligands. Given their structural differences, we investigated the variations in the photothermal effects and aldol condensation catalytic reaction.

SPON2 acts as a tumor promoter in HR-positive/HER2-negative breast cancer by regulating β-catenin signaling.

Background: Spondin-2 (SPON2) expression is associated with various types of cancer, but its role in breast cancer (BC) remains ambiguous, especially in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) BC.

Methods: The expression of SPON2 in HR+/HER2- BC tissues and adjacent tissues was detected using immunohistochemical staining and western blotting. Cell proliferation and migration were assessed via CCK-8 assay, EdU assay, and transwell assay.

-Poly[[[aqua-copper(II)]-μ-hydroxido-κ :-μ-[3-(4-1,2,4-triazol-4-yl)benzoato]-κ : ] monohydrate].

In the title compound, {[Cu(CHNO)(OH)(HO)]·HO]} , the Cu cation is situated on a twofold rotation axis and is coordinated by two triazole N atoms from two different 3-(4-1,2,4-triazol-4-yl)benzoate (3-tba) ligands, by two hydroxyl O atoms and by a water O atom, forming a coordination environment inter-mediate between a square pyramid and a trigonal bipyramid. The Cu ions are connected by 3-tba ligand and a hy-droxy group into polymeric chains parallel to [001]. O-H⋯O hydrogen bonds and C-H⋯O inter-actions consolidate the crystal structure.

Diagnosis model for gastric submucosal tumor based on multiple decision trees comprising endoscopic and endoscopic ultrasonography features.

Background: The clinical course and manifestations of subepithelial lesions (SEL) patients tend to vary from different pathological types, therefore the accurate diagnosis of SEL would undoubtedly be beneficial to the treatment and prognosis of SEL patients. Based on the decision tree method, we developed a novel classification model for SELs by combining endoscopy with endoscopic ultrasound (EUS).

Methods: We retrospectively collected data from 469 patients hospitalized in the Affiliated Hospital of Qingdao University between January 2017 to November 2021 for endoscopic resection.

When "Aging" meets "Intelligence": smart health cognition and intentions of older adults in rural Western China.

Background: Population aging is occurring at an unprecedented pace, rendering "healthy aging" a critical issue of global importance. China is at the forefront of this demographic transformation and faces substantial challenges, especially in its western rural regions. In this context, smart health technology, propelled by advancements in medical care and information technology, emerges as a vital strategy to address the challenges associated with aging.

Frailty: An Important Determinant Influencing Glycaemic Control in Elderly Chinese Patients Diagnosed With Type 2 Diabetes.

Few studies have investigated blood glucose levels and complication management in elderly patients with type 2 diabetes (T2D) at community hospitals in China. The objective of this study was to investigate the factors influencing blood glucose control in elderly patients with T2D. One thousand one hundred and fifty elderly patients (age ≥ 65 years) with T2D were involved in the study to assess blood glucose control, health status (including comorbidities and cognitive status), complication management, and adherence to medication according to the guidelines of the American Diabetes Association.

Effects of work cessation on cognitive functioning in rural older adults in China: a cross-sectional study based on CHARLS.

Objectives: This study investigated the effects of work cessation on cognitive function among older adults in rural China. Given that cognitive disorders affect 6.04% of individuals aged 60 and above-with higher prevalence in rural areas-understanding this relationship is critical.

Perioperative management of patients on GLP-1 receptor agonists: Risks, recommendations, and future directions-A narrative review.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly being used for glycemic control and weight management. One of their key mechanisms of action is thought to be delaying gastric emptying. This review explores the perioperative risks associated with GLP-1RAs use, particularly the increased risk of gastric content retention and pulmonary aspiration.

Modulation of RASD2 by miRNA-485-5p Drives Thyroid Cancer Progression and Metastasis.

This study investigates the role of RASD2 (Ras Homolog Enriched In Striatum) in thyroid carcinoma progression and its modulation by microRNA-485-5p. Differential RASD2 expression patterns were initially identified through bioinformatic analysis of public databases. Immunohistochemical staining and quantitative reverse transcription PCR (qRT-PCR) validated these findings in clinical specimens and cell lines.

A Highly Selective and Sensitive Turn-on Fluorescent Probe for Al Detection: Properties and Applications.

The development of fluorescent probe for Al detection is of great significance in environmental and biological systems, and helps to study the role of aluminum ions in physiological and pathological processes. Therefore, a new aluminum ion fluorescent probe (2-hydroxy-5-methylbenzylidene)picolinohydrazide (HMPC) based on hydrazide Schiff base has been successfully synthesized and characterized. HMPC demonstrated a remarkable selectivity and pronounced enhancement in its fluorescence emission specifically towards Al ions, which was attributed to the influence of intramolecular proton transfer and intramolecular charge transfer effect.

Water-Stable AlNi Polynuclear Heterometallic Compound for Near-Infrared Photothermal Conversion.

In this paper, a polynuclear heterometallic compound (HO)[AlNi(OH)(MBA-NO)(HO)] (AlNi, HMBA-NO = 2-hydroxy-3-methoxy-5-nitrobenzoic acid) with a seven-star disk metal core has been synthesized by the solvothermal method. AlNi has good stability in water and several organic solvents, and its solid powder shows a good photothermal effect under 980 nm laser irradiation, and the temperature can reach 138.8 °C within 100 s under 1.

Erratum: Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway.

[This corrects the article DOI: 10.1016/j.omtn.

Microemulsion-based drug delivery system identifies pepper alkaloids as anti-obesity compounds.

Obesity is a significant contributor to various metabolic diseases such as heart disease and diabetes. Due to the adverse effects of synthetic anti-obesity drugs, natural products from functional food plants, which mimic the effects of synthetic chemicals, present promising alternatives. However, many natural plant-derived compounds are poorly soluble in water, resulting in low bioavailability within the gastrointestinal tract, a key limitation for the effectiveness of many hydrophobic substances.

GPR171 restrains intestinal inflammation by suppressing FABP5-mediated Th17 cell differentiation and lipid metabolism.

Background: GPR171 suppresses T cell immune responses involved in antitumour immunity, while its role in inflammatory bowel disease (IBD) pathogenesis remains unclear.

Objective: We aimed to investigate the role of GPR171 in modulating CD4 T cell effector functions in IBD and evaluate its therapeutic potential.

Design: We analysed GPR171 expression in colon biopsies and peripheral blood samples from patients with IBD and assessed the impact of GPR171 on CD4 T cell differentiation through administration of its endogenous ligand (BigLEN).

Polarity and fluorescent fractions of manure dissolved organic matter could affect differently the adsorption and desorption of antibiotics in soils.

The impacts of manure dissolved organic matter (DOM) on the adsorption and desorption of veterinary antibiotics in soils have not been fully explored. In this study, the effects of pig manure (PM) DOM and its hydrophilic and hydrophobic fractions on antibiotic adsorption and subsequent desorption in three topsoils of bamboo stands under different fertilization conditions (control, with heavy manure application, and with heavy manure application suspended) were examined by batch experiments, with the aid of excitation-emission matrix fluorescence spectroscopy, Fourier transformed infrared spectroscopy, and X-ray photoelectron spectroscopy. The addition of 100 mg-C L PM DOM was found to increase the adsorption (in terms of the Freundlich affinity coefficient (K)) of florfenicol by 71.

Chromosome-Level Genome Assembly of the Heptageniid Mayfly Parafronurus youi (Ephemeroptera), and Its Annotation.

As a group of winged insects (Pterygota) retaining many primitive characteristics, genomic research on mayflies remains highly limited, posing challenges to the study of their origin and evolution. In this study, we present the first chromosome-level genome assembly of the Chinese endemic mayfly Parafronurus youi utilizing Illumina short-read, PacBio long-read, and Hi-C sequencing technologies. The high-quality genome is 412.

Efficacy of Different Acupuncture Techniques for Pain and Dysfunction in Patients with Knee Osteoarthritis: A Randomized Controlled Trial.

Introduction: Various acupuncture techniques are widely applied in clinics for pain control and dysfunction relief in patients with knee osteoarthritis (KOA). The purpose of this trial was to investigate whether the different acupuncture techniques were more effective in treating joint pain and dysfunction than were sham acupuncture or drug treatment in patients with KOA and to determine the differences in efficacy among them.

Methods: In this multi-center, single-blind, randomized, controlled trial, participants were randomly assigned to the manual acupuncture (MA), electroacupuncture (EA), warm-needling acupuncture (WA), mild moxibustion (MM), sham acupuncture (SA), or drug treatment (Celebrex) groups.

A novel perspective on survival prediction for AML patients: Integration of machine learning in SEER database applications.

Objective: The purpose of this study is to explore the epidemiological characteristics of acute myeloid leukemia (AML) and establish a more accurate model for predicting the prognosis of AML patients based on machine learning.

Methods: We obtained clinical data of a total of 87,090 AML patients between 1975 and 2019 from the SEER database. First, we used Kaplan-Meier analysis to examine the prognosis of patients in different strata.

Aluminum Cluster Molecular Ring-Based Heterometallic Framework Materials for Iodine Capture.

With the development of the nuclear industry, the risk of elements that are difficult to degrade in nuclear fission has been gradually increasing. Therefore, the efficient capture of iodine (I) has attracted considerable attention in recent years. The aluminum cluster-based metal framework materials show great advantage in iodine adsorption due to the designable pore sizes, excellent physicochemical stability, and cheap raw materials.

A self-assembled fluorescent nanoprobe recognized by FA1 site for specifically selecting HSA: Its applications in hemin detection, cell imaging and fluorescent tracing drug delivery.

As naturally essential biomacromolecule, HSA has become diagnostic indicators for various diseases and universal carriers for anticancer drug delivery, therefore, fluorescence detection and labeling for HSA possess significant application value in the biomedical field. In this paper, hydrazide Schiff base fluorescent probe NDQC was designed and synthesized, which self-assembled into nanoparticles in aqueous solution system and demonstrated excellent selectivity and sensitivity towards HSA. Through displacement assay and molecular docking simulation, the binding of NDQC with HSA in FA1 site was demonstrated, thereby no obvious fluorescence signal presented for homologous protein BSA due to their structural differences in binding site.

Associations between ABO, FUT2 and chronic pancreatitis: A comprehensive meta-analysis of multiple cohorts and public biobanks.

Objectives: Associations of ABO blood group specifying transferases A/B (ABO) and fucosyltransferase 2 (FUT2) with CP remain inconclusive. We aimed to comprehensively investigate the associations by Chinese sequencing cohorts and external cohorts.

Methods: First, we analyzed the distributions of ABO blood groups and FUT2 status, along with lead single nucleotide polymorphisms (SNPs) at ABO (rs8176693 C/T) and FUT2 (rs632111 A/G) gene loci in Chinese low-coverage whole-genome sequencing discovery cohort.

[Construction of Key Technology System for Mine Ecological Restoration Under System Perspective].

Mine ecological restoration has experienced a long-term development process in China, in which various technologies have been constantly developing and integrating. Based on the related theoretical research and field program, the technical system of mine ecological restoration was constructed, and the characteristics of key technologies were specifically grasped. In this research, the environment, including natural elements and the spatial environment, is the object of mine ecological restoration, which requires further long-term investigation and monitoring.

[Inhibition of PRDX1 protein expression and promotion of apoptosis of colorectal cancer cells by furanodienone via inducing ROS generation from NOX4-derived mitochondria].

This study explored the generation site and regulation mechanism of reactive oxygen species(ROS) in the apoptosis of colorectal cancer cells induced by furanodienone(Fur). RKO cells were treated with 200 μmol·L~(-1) of Fur, and the changes in intracellular nicotinamide adenine dinucleotide phosphate oxidase(NOX) activity were detected by the NOX activity detection method. The control group, Fur group, diphenyleneiodonium(DPI) inhibitor group for general NOX, mitochondrial-targeted antioxidant(MitoTEMPO) group, Fur+DPI group, Fur+MitoTEMPO group, and H_2O_2 positive control group were set up.

Prognostic prediction models for postoperative patients with stage I to III colorectal cancer based on machine learning.

Background: Colorectal cancer (CRC) is characterized by high heterogeneity, aggressiveness, and high morbidity and mortality rates. With machine learning (ML) algorithms, patient, tumor, and treatment features can be used to develop and validate models for predicting survival. In addition, important variables can be screened and different applications can be provided that could serve as vital references when making clinical decisions and potentially improving patient outcomes in clinical settings.