[Effect of acupuncture on intracerebral mitochondrial function in mice with cerebral hemorrhage].

Objectives: To observe the effect of acupuncture on the recovery of neurological function in mice with intracerebral hemorrhage (ICH), so as to explore its mechanism of regulating mitochondria in brain tissue of ICH mice through the utilization of RNA sequencing and m6A methylation sequencing technology.

Methods: Twenty-four male C57BL/6J mice were ramondly divided into sham operation, model, and acupuncture groups (=8 in each group). The ICH model was established by injection of the rat's auto-blood (10 μL) into the right caudatum region.

 (Rosaceae), a new species from Hubei, China.

In the present paper, we describe a new species, (P.subg.Cerasus), from Hubei, China, based on long-term field observations.

[Mechanisms of acupuncture in inhibition of ferroptosis in intracerebral hemorrhage mice based on RNA m6A methylation sequencing].

Objectives: To observe the effect of acupuncture on N6-methyladenosine (m6A) methylation and ferroptosis in brain tissue of mice with intracerebral hemorrhage (ICH), so as to explore its mechanisms underlying promoting neural function recovery.

Methods: Fifty-four male C57BL/6J mice were randomly divided into sham operation, model and acupuncture groups, with 18 mice in each group. The ICH model was established by injection of the mouse's auto-blood (10 μL) into the right caudate nucleus.

Towards sustainable development: The role of the carbon emission trading scheme in improving energy enterprises' carbon performance.

Carbon emission trading scheme (CET) has become a vital environmental regulation driving sustainable development within enterprises. Simultaneously, given the substantial contribution of carbon emissions from Chinese energy industry to the overall carbon footprint, it is imperative for energy enterprises to improve carbon performance. Thus, using data from listed Chinese energy enterprises between 2009 and 2020, this paper examines the impact and mechanisms of CET on carbon performance through a difference-in-difference empirical test.

[The key to acupuncture-moxibustion diagnosis and examination lies in the "knowledge" of both doctors and patients - revisiting the "Yi Zhi Wei Shu, Yi Tong Wei Shu"].

The correct selection of the stimulated site is the key to the effectiveness of acupuncture and moxibustion. In the present paper, we propose that in the treatment of Jingjin (muscle, tendon, fascia, ligament, etc.) disease, the stimulated position of acupuncture or moxibustion should be determined by careful examination, rather than only selection of the fixed acupoints.

Design, Synthesis and Bioactive Evaluation of Topo I/ Dual Inhibitors to Inhibit Oral Cancer via Regulating the PI3K/AKT/NF-κB Signaling Pathway.

The significantly rising incidence of oral cancer worldwide urgently requires the identification of novel, effective molecular targets to inhibit the progression of malignancy. DNA topoisomerase I (Topo I) is a well-established target for cancer treatment, and many studies have shown that different cancer cell genes could be targeted more selectively with one type of Topo I inhibitor. In this report, a new scaffold pyridothieno[3,2-]isoquinoline 11,11-dioxide was designed via the combination of the key fragment or bioisoster of Topo I inhibitor azaindenoisoquinolines and G-quadruplex binder quindoline.

Efficacy of Different Acupuncture Techniques for Pain and Dysfunction in Patients with Knee Osteoarthritis: A Randomized Controlled Trial.

Introduction: Various acupuncture techniques are widely applied in clinics for pain control and dysfunction relief in patients with knee osteoarthritis (KOA). The purpose of this trial was to investigate whether the different acupuncture techniques were more effective in treating joint pain and dysfunction than were sham acupuncture or drug treatment in patients with KOA and to determine the differences in efficacy among them.

Methods: In this multi-center, single-blind, randomized, controlled trial, participants were randomly assigned to the manual acupuncture (MA), electroacupuncture (EA), warm-needling acupuncture (WA), mild moxibustion (MM), sham acupuncture (SA), or drug treatment (Celebrex) groups.

Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients, may mediate immune evasion.

Background: For the first time, we investigated the oncological role of plexin domain-containing 1 (), also known as tumor endothelial marker 7 (TEM7), in hepatocellular carcinoma (HCC).

Aim: To investigate the oncological profile of in HCC.

Methods: Based on The Cancer Genome Atlas database, we analyzed the expression of in HCC.

Design and synthesis of luotonin A-derived topoisomerase targeting scaffold with potent antitumor effect and low genotoxicity.

Conventional topoisomerase (Topo) inhibitors typically usually exert their cytotoxicity by damaging the DNAs, which exhibit high toxicity and tend to result in secondary carcinogenesis risk. Molecules that have potent topoisomerase inhibitory activity but involve less DNA damage provide more desirable scaffolds for developing novel chemotherapeutic agents. In this work, we broke the rigid pentacyclic system of luotonin A and synthesized thirty-three compounds as potential Topo inhibitors based on the devised molecular motif.

 (Leguminosae), a new species from Central China.

A new species , from western Hubei Province, Central China is described and illustrated. The new species is morphologically similar to and , but differs from both by its spreading pubescent indumentum on stems and petioles, longer petioles, white bracts, whitish or yellow corolla, longer claw of the keel-petal, hairy pods and smaller seeds.

Design and synthesis of pseudo-rutaecarpines as potent anti-inflammatory agents via regulating MAPK/NF-κB pathways to relieve inflammation-induced acute liver injury in mice.

Pseudo-natural products (PNPs) design strategy provides a great valuable entrance to effectively identify of novel bioactive scaffolds. In this report, novel pseudo-rutaecarpines were designed via the combination of several privileged structure units and 46 target compounds were synthesized. Most of them display moderate to potent inhibitory effect on LPS-induced NO production and low cytotoxicity in RAW264.

[Modified acupuncture at sphenopalatine ganglion for allergic rhinitis: a randomized controlled trial].

Objective: To observe the effect of modified acupuncture at sphenopalatine ganglion for allergic rhinitis (AR).

Methods: A total of 80 patients with AR were randomly divided into an observation group and a control group, 40 cases in each group. In the observation group, modified acupuncture at sphenopalatine ganglion was given, 30 min each time, 2 times a week and with an interval of 3-4 days.

Aberrant intra- and internetwork functional connectivity patterns of the anterior and posterior hippocampal networks in schizophrenia.

Aim: Schizophrenia is associated with abnormal hippocampal structure and function. Available evidence suggests that the anterior and posterior hippocampus are differentially affected by schizophrenia pathology. This study was designed to provide new insight into the anterior and posterior hippocampus in schizophrenia from the perspective of functional connectivity.

polymorphism rs61955196 is associated with schizophrenia in a Chinese Han population.

Background: Schizophrenia (SCZ) is a complex disease which can be affected by both genetic and environmental factors. Prenatal famine exposure may cause changes in DNA methylation levels of genes. Meanwhile, maternal nutrition during pregnancy is a pivotal environmental factor in the development of SCZ.

Anfibatide alleviates inflammation and apoptosis via inhibiting NF-kappaB/NLRP3 axis in ischemic stroke.

Recent evidence suggests that Nod-like receptor protein-3 (NLRP3) inflammasome is a key mediator of inflammatory response and can induce the activation of apoptosis signaling pathways in ischemic stroke. In this research, we assessed the effects of anfibatide (ANF) on inflammatory and apoptosis in cerebral ischemic injury and the potential mechanisms. Middle cerebral artery occlusion (MCAO) model was established on male Sprague-Dawley rats to induce cerebral ischemia/reperfusion (I/R) injury in vivo.

Acupuncture inhibits mammalian target of rapamycin, promotes autophagy and attenuates neurological deficits in a rat model of hemorrhagic stroke.

Background: Intracerebral hemorrhage (ICH) accounts for approximately 15% of all stroke cases. Previous studies suggested that acupuncture may improve ICH-induced neurological deficits. Therefore, we investigated the effects of acupuncture on neurological deficits in an animal model of ICH.

Nuciferine improves high-fat diet-induced obesity reducing intestinal permeability by increasing autophagy and remodeling the gut microbiota.

Nuciferine (NF) has received extensive attention due to its medicinal value in the treatment of metabolic diseases, such as obesity; however, to date, the effects of NF on obesity-related intestinal permeability, autophagy and the gut microbiota have not been investigated. Herein, C57BL/6J mice were fed either a chow or a high-fat diet (HFD) with or without NF for 8 weeks. The results showed that NF supplement reduced weight gain, fat accumulation and intestinal permeability in the HFD mice accompanied by improved autophagy.

[Effects of antimicrobial peptide GH12 on the morphology and composition of cariogenic three-species biofilm].

Objectives: To evaluate the effects of antimicrobial peptide GH12 designed on the structure, morphology, and composition of a cariogenic three-species biofilm.

Methods: The cariogenic three-species biofilm consis-ted of the cariogenic () and commensal bacteria () and (). The biofilm was treated using GH12 (2, 4, and 8 mg·L), and untreated biofilm was used as the control.

THBS1/CD47 Modulates the Interaction of γ-Catenin With E-Cadherin and Participates in Epithelial-Mesenchymal Transformation in Lipid Nephrotoxicity.

Hyperlipidemia, an important risk factor for cardiovascular and end-stage renal diseases, often aggravates renal injury and compromises kidney function. Here, histological analysis of human kidney samples revealed that high lipid levels induced the development of renal fibrosis. To elucidate the mechanism underlying lipid nephrotoxicity, we used two types of mouse models (Apoe and C57BL/6 mice fed a 45 and 60% high-fat diet, respectively).

Brain morphometric abnormalities in boys with attention-deficit/hyperactivity disorder revealed by sulcal pits-based analyses.

Aim: Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder associated with widespread brain morphological abnormalities. Here, we utilized a sulcal pits-based method to provide new insight into the atypical cortical folding morphology in ADHD.

Methods: Sulcal pits, the locally deepest points in each fold, were first extracted from magnetic resonance imaging data of 183 boys with ADHD (10.