Synergistic self-calibration strategy based on nano-cornucopia MOFs for accurate HER-2 detection in precision breast cancer diagnosis.

With its high porosity and tunable properties, metal-organic frameworks (MOFs) serve as nano-cornucopias, unlocking limitless possibilities in biosensing applications. Herein, we designed an ultrasensitive biosensor leveraging MOFs as a multifunctional nano-platform to implement a synergistic self-calibration strategy for the ultra-accurate quantification of breast cancer-related human epidermal growth factor receptor-2 (HER-2). This approach integrates (1) ratiometric electrochemistry for built-in correction to minimize non-specific interference and (2) dual-modal electrochemical and colorimetric detection for enhanced accuracy through cross-validation.

CDDO-imidazolide ameliorates sepsis-induced ARDS by enhancing mitophagy via the Nrf2 pathway to prohibit alveolar macrophage pyroptosis and HMGB1 release.

Accumulating evidence suggests that NLRP3-mediated alveolar macrophage (AM) pyroptosis and subsequent high mobility group box protein 1 (HMGB1) secretion play significant roles in the pathogenesis of acute respiratory distress syndrome (ARDS). Nrf2 has been shown to be individually involved in regulating pyroptosis. In this study, we investigate the ability of CDDO-imidazolide, a potent Nrf2 activator, to regulate AM pyroptosis and HMGB1 secretion in sepsis-associated ARDS, along with its underlying mechanism.

Salinity decreases the soil organic carbon stock while increasing its stability: A case study in the coastal region of China.

The influence of soil salinity on carbon sequestration is largely unknown, and this is stopping us from being able to accurately evaluate the carbon sequestration capacity of soils with different salinity levels. Fifty-one soil samples were thus collected from Wudi County, China, along a salinity gradient. The density fractionation and Fourier-transform mid-infrared spectroscopy were employed to determine soil organic carbon (SOC) content, constitution and characteristics.

Metal-based nanoparticles in natural aquatic environments: concentrations, toxic effects and kinetic processes.

Metal-based nanoparticles (MNPs) are widely used in many aspects of production and life, resulting in their detection in various types of aquatic environments globally with mass concentrations mostly in the range of ng/L-μg/L. Therefore, more attention should be paid to considering realistic situations and exposure scenarios at environmentally relevant MNPs concentrations. With the support of new technology and methods, the environmental concentration distribution of MNPs in the aquatic environment was investigated and sorted out.

Pollutant distribution in vertebrates across scales: Organs, cells, and organelles.

Pollutant accumulation patterns are essential for understanding their toxicity mechanisms and health risks. Accurately identifying pollutant accumulation sites and toxicity targets requires an integrated understanding of their distribution across multiple scales. This review systematically examines recent advances in the multi-scale distribution of environmental pollutants in vertebrates, spanning organ, cellular, and subcellular levels.

Binding of per- and polyfluoroalkyl substances with liver and serum proteins in rats: implications for physiologically based pharmacokinetic modelling.

Understanding the binding between per- and polyfluoroalkyl substances (PFAS) and proteins is essential for elucidating their toxicokinetics and tissue distribution. Here, we quantified the binding affinities of 14 PFAS to rat liver fatty acid-binding protein (rL-FABP) and rat serum albumin (RSA). Results showed that PFAS exhibit strong binding affinities (K) to the rL-FABP (10 ∼ 10 M), particularly among medium- to long-chain perfluorinated carboxylic acids (PFCAs).

Inhibition of Farnesoid-x-receptor signaling during abdominal sepsis by dysbiosis exacerbates gut barrier dysfunction.

Background And Aims: Bacterial translocation and intestinal dysbiosis due to gut barrier dysfunction are widely recognized as major causes of the initiation and development of intra-abdominal sepsis. Systemic bacterial translocation and hepatic activation of the myeloid differentiation primary response gene 88 (Myd88) can disturb bile acids (BAs) metabolism, further exacerbating intestinal dysbiosis. The farnesoid X receptor (FXR) and fibroblast growth factor (FGF) 15/19 are well known to be involved in the control of BAs synthesis and enterohepatic circulation.

A sensing strategy based on novel pyrene-functionalized MOFs for sVCAM-1 detection and prognostic assessment in coronary heart disease.

Coronary heart disease (CHD) remains a significant global health concern, with exercise therapy playing a crucial role in rehabilitation. Optimizing exercise intensity is essential, as both insufficient and excessive exercise may lead to suboptimal or adverse outcomes. In response to this challenge, we developed Adaptive Posture-Balance Cardiac Rehabilitation Exercise (APBCRE), which integrates postural balance training with aerobic exercise.

A multifunctional biosensor for linked monitoring of inflammation indicators in hypertension drug evaluation and companion diagnostics.

Hypertension, often called the "silent killer", is a prevalent chronic disease closely linked to inflammation. However, most current methods monitor only single indicator, providing a limited view of inflammation in hypertension progression. To address this, we developed a multifunctional biosensor featuring a dual target linked monitoring (DTLM) Probe for the simultaneous detection of IL-6 and CRP, two key inflammatory markers in hypertension progression.

Modelling the size distribution and bioaccumulation of gold nanoparticles under mixture exposure.

To assess the bioaccumulation and toxicity of nanoparticles (NPs), analyzing and modelling the relationship between the size distribution of NPs in organisms and the exposure particle size distribution represents an important challenge. Previous studies mostly focused on the NPs with single size. However, the size distribution of NPs is wide and variable in the natural environment.

Effect of high flow nasal cannula oxygenation on incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity: multicentre randomised controlled trial.

Objective: To determine whether high flow nasal cannula (HFNC) oxygenation can reduce the incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity.

Design: Multicentre, randomised, parallel group trial.

Setting: Three tertiary hospitals in Shanghai, China.

Clinical Trial of Ozonated Water Enema for the Treatment of Fibromyalgia: A Randomized, Double-Blind Trial.

Background: The pathogenesis of fibromyalgia (FM) is currently unknown. Many patients with this condition are not effectively treated, and disorders of the intestinal dysbiosis have been identified in patients with FM. This trial aimed to investigate whether ozonated water enema could alleviate the symptoms of FM by improving intestinal dysbiosis in these patients.

Toxicological effects of the environmental pollutant perfluoronanoic acid on the ground-dwelling arthropod Solenopsis invicta.

Perfluorononanoic acid (PFNA), widely employed in surfactants, coatings, plastics, corrosion inhibitors, and fire-extinguishing agents, is less regulated than PFOS or PFOA but displays higher bioaccumulation and potential toxicity. Most toxicity assessments have focused on mammals, fish, and algae, with limited research on ground-dwelling arthropods, especially ants. Here, we examined PFNA's toxic effects on red imported fire ants (RIFAs), a prevalent ground-dwelling species in South China.

Effects of Transcutaneous Electrical Acupoint Stimulation on the Incidence of Hypoxia in Elderly Patients Undergoing Painless Gastrointestinal Endoscopy: A Randomized Controlled Trial.

Hypoxia is not uncommon in elderly patients during painless gastrointestinal endoscopy. This study aimed to determine the effectiveness of transcutaneous electrical acupoint stimulation (TEAS) in reducing the occurrence of hypoxia symptoms in elderly patients. Patients were randomly and equally grouped into sham control ( = 109) or TEAS group ( = 109) by using the random number table method.

Enhancing ergonomics in E-waste disassembly: the impact of collaborative robotics on muscle activation and coordination.

Disassembly, as a part of the electronic waste (e-waste) management process, is a labour-intensive task. The emergence of collaborative robots (cobots) provides a robotic solution to reduce the human efforts during disassembly. This study evaluated muscle activation patterns during cobot-assisted e-waste disassembly using surface electromyography (EMG).

An oriented self-assembly biosensor with built-in error-checking for precise midkine detection in cancer diagnosis and prognosis evaluation.

Midkine (MDK) is a neurotrophic growth factor highly expressed during embryogenesis, currently recognized as a multifaceted factor in cancer progression and drug resistance. MDK has demonstrated greater accuracy than existing biomarkers. Serum MDK is a valuable indicator for the non-invasive early detection of tumors.

Unraveling Reactivity Origin of Oxygen Reduction at High-Entropy Alloy Electrocatalysts with a Computational and Data-Driven Approach.

High-entropy alloys (HEAs), characterized as compositionally complex solid solutions with five or more metal elements, have emerged as a novel class of catalytic materials with unique attributes. Because of the remarkable diversity of multielement sites or site ensembles stabilized by configurational entropy, human exploration of the multidimensional design space of HEAs presents a formidable challenge, necessitating an efficient, computational and data-driven strategy over traditional trial-and-error experimentation or physics-based modeling. Leveraging deep learning interatomic potentials for large-scale molecular simulations and pretrained machine learning models of surface reactivity, our approach effectively rationalizes the enhanced activity of a previously synthesized PdCuPtNiCo HEA nanoparticle system for electrochemical oxygen reduction, as corroborated by experimental observations.

Causal associations between dietary factors and colorectal cancer risk: a Mendelian randomization study.

Background: Previous epidemiological studies have found a link between colorectal cancer (CRC) and human dietary habits. However, the inherent limitations and inevitable confounding factors of the observational studies may lead to the inaccurate and doubtful results. The causality of dietary factors to CRC remains elusive.

Tracking the Cellular Degradation of Silver Nanoparticles: Development of a Generic Kinetic Model.

Understanding the degradation of nanoparticles (NPs) after crossing the cell plasma membrane is crucial in drug delivery designs and cytotoxicity assessment. However, the key factors controlling the degradable kinetics remain unclear due to the absence of a quantification model. In this study, subcellular imaging of silver nanoparticles (AgNPs) was used to determine the intracellular transfer of AgNPs, and single particle ICP-MS was utilized to track the degradation process.

Fecal Microbiota Transplantation Improves Clinical Symptoms of Fibromyalgia: An Open-Label, Randomized, Nonplacebo-Controlled Study.

Fibromyalgia (FM) is a complex and poorly understood disorder characterized by chronic and widespread musculoskeletal pain, of which the etiology remains unknown. Now, the disorder of the gut microbiome is considered as one of the main causes of FM. This study aimed to investigate the potential benefits of fecal microbiota transplantation (FMT) in patients with FM.

A simultaneous strategy with multiple-signal amplification and self-calibration for ultrasensitive assay of miRNA-21 based on 3D MNPs-IL-rGO-AuNPs.

MicroRNA-21 (miRNA-21) is a significant biomarker for the development and progression of diverse cancers but is present in relatively low concentrations. Detecting such low-abundance molecules accurately can be challenging, especially in early-stage cancers where the concentration may be even lower. Herein, a self-calibration biosensing platform based on 3D novel MNPs-IL-rGO-AuNPs nanocomposites was successfully established for the ultrasensitive detection of miRNA-21.

Remimazolam Dosing for Gastroscopy: A Randomized Noninferiority Trial.

Background: Remimazolam, an ultra-short-acting benzodiazepine, may provide adequate sedation for endoscopy while causing less cardiovascular or respiratory disturbance than propofol. Although fixed-dose administration is suggested, body weight affects the volume of the central chamber and thus affects the sedation depth that can be achieved by the first dose. This study aimed to compare the efficacy and safety of different doses of remimazolam and propofol by body weight for sedation during gastroscopy.

Anesthetic management of thoracotomy for massive intrathoracic solitary fibrous tumor of the pleura: a case report.

Backgrounds: Solitary fibrous tumor of the pleura (SFTP) is a rare thoracic tumor and usually asymptomatic. Massive SFTP may affect adjacent organs and tissues including pulmonary vasculature, bronchus and heart. A thoracotomy for massive SFTP is necessary in severe case.