An integrated Janus antibacterial hydrogel with rapid photoresponsive adhesive/tough anti-adhesive bi-layer for enhanced wound healing and suppression of postoperative tissue adhesion.

The Janus adhesive wound dressings exhibit properties analogous to human skin. Specifically, they must possess both adhesive and non-adhesive characteristics to function effectively. The adhesive property ensures secure attachment to the wound site, while the non-adhesive side acts as a protective barrier against external contaminants.

A prospective study of transorbital ultrasound multimodal imaging in the detection and evaluation of increased intracranial pressure.

Background: To develop and validate a multimodal transorbital ultrasound model for noninvasive detection of increased intracranial pressure (IICP) by integrating anatomical and hemodynamic parameters.

Methods: In this prospective diagnostic study, 136 neurology patients scheduled for lumbar puncture underwent pre-procedural ultrasound measurement of optic nerve sheath diameter (ONSD), ONSD-to-eyeball transverse diameter ratio (ONSD/ETD), and central retinal artery hemodynamics (peak systolic velocity [PSV], resistance index [RI]). Patients were classified as IICP (CSF pressure > 200 mmH₂O) or normal ICP (NICP) groups.

Efficient segmentation of intraoperative anatomical landmarks in laparoscopic cholecystectomy based on deep learning.

Background: Laparoscopic cholecystectomy is the gold standard procedure for the treatment of benign gallbladder diseases, but there is the risk of intraoperative bile duct injury, which can lead to surgical failure and cause significant social and economic burden. When surgeons rely on visual inspection to identify tissue structures during laparoscopic cholecystectomy, subjective factors such as experience, psychological factors, and fatigue can compromise the intraoperative recognition of anatomic landmarks. The positioning of anatomical landmarks by the surgeon in the pre-dissection phase of laparoscopic cholecystectomy is relatively vague and requires step-by-step exploration as the surgery progresses, becoming clearer in the post-dissection phase.

Reliability and Reproducibility of the EOS 3D Imaging System in Measuring TT-TG Distance in Patients With Recurrent Patellar Dislocation.

Background: In clinical practice, preoperative radiographic assessment of the tibial tuberosity-trochlear groove (TT-TG) distance in patients with recurrent patellar dislocation (RPD) typically relies on conventional computed tomography (CT). A novel EOS imaging system may be a new option for measuring the TT-TG, which provides less radiation and costly time to perform.

Purpose: To determine the reliability and reproducibility of the EOS 3-dimensional (3D) imaging system to measure TT-TG values.

Notchplasty and Radiofrequency Ablation for Anterior Cruciate Ligament Mucoid Degeneration and Ganglion Cysts Associated With Intercondylar Notch Stenosis.

Mucoid degeneration of the anterior cruciate ligament (ACL) and associated ganglion cysts can cause chronic knee pain and motion restriction, often due to intercondylar notch stenosis. This technical note describes an arthroscopic approach combining notchplasty and radiofrequency ablation to relieve impingement while preserving ACL integrity. The procedure involves diagnostic arthroscopy, cyst debridement, and targeted notchplasty at 3 key areas: superior-lateral anterior rim, anterior roof, and posterolateral roof.

A shape complementarity strategy based on NCA029 enables potent HsClpP agonists for the treatment of small cell lung carcinoma.

Owing to its essential role in maintaining mitochondrial homeostasis, activation of HsClpP is potentially a promising strategy for treating a wide range of cancers, including small cell lung carcinoma (SCLC). In this work, by using a shape complementarity strategy, we designed and synthesized a series of HsClpP agonist based on NCA029, a non-imipridone HsClpP agonist identified in our previous work. Among these derivatives, compound 8o exhibited approximately 5-fold greater binding affinity than NCA029 with HsClpP due to attachment of an additional ring structure at the β-position of NCA029's double bond.

Analysis and design of a 1-bit circularly polarized reconfigurable transmitarray for bandwidth and efficiency enhancement.

Spin-decoupled strategy is essential for ensuring broad axial ratio (AR) bandwidth in circularly-polarized (CP) metasurfaces. However, existing CP metasurfaces based on discrete phase mostly suffer from narrow AR bandwidth and low aperture efficiency due to insufficient rotational phase. In this work, what we believe to be a novel 1-bit CP reconfigurable transmit-array (TA) is proposed to simultaneously improve AR bandwidth and aperture efficiency.

Mechanism by which SUGT1 downregulates FH to promote proliferation and migration in serous ovarian cancer.

Background: SUGT1 (Suppressor of the G2 allele of SKP1) and FH (fumarate hydratase) have recently garnered significant attention from the research community. SUGT1 functions as a molecular chaperone, regulating the stability and activity of various proteins, while FH is a key enzyme in the tricarboxylic acid cycle, catalyzing the reversible conversion of fumarate to malate. Existing literature has established their essential roles in signaling, tumorigenesis, and cancer progression.

Engineered iron-sulfur carriers for efficient mixotrophic and sulfur autotrophic denitrification in low carbon to nitrogen ratio municipal wastewater: Mechanisms of biofilm enhancement and electron transfer promotion.

Sulfur autotrophic denitrification (SAD) offers a sustainable solution for nitrogen removal in low carbon to nitrogen ratio (C/N) municipal wastewater, yet its efficiency and startup time pose significant challenges. To overcome these, we developed iron-sulfur-modified carriers (FeS@MC) and integrated them into an in-situ sequencing batch reactor (S-Fe-SBR), which successfully achieved rapid startup (16 days) of SAD under low C/N conditions. The mechanisms revealed that FeS@MC's hierarchical porous structure promoted biofilm colonization and selective enrichment of sulfur-oxidizing bacteria (e.

Two-dimensional robot-assisted physeal-sparing medial patellofemoral ligament reconstruction can achieve favourable clinical outcomes for skeletally immature patients with recurrent patellar dislocation.

Purpose: The surgical treatment of recurrent patellar dislocation (PRD) in adolescents faces particular difficulties, since the integrity of open growth plates may be compromised by standard surgical methods used in adults. This study aimed to review a series of adolescents with RPD who underwent robot-assisted physeal-sparing medial patellofemoral ligament (MPFL) reconstruction, compare the clinical results with those of a non-robot-assisted group, and measure the vertical distance between Schöttle point and the physis intraoperatively.

Methods: This retrospective clinical analysis included 55 adolescents with RPD who had no significant bone deformities and underwent MPFL reconstruction using either a robot-assisted technique or a non-robot-assisted method between February 2019 to November 2023.

Therapeutic Potential of PDA@CeO2 in Suppressing Hepatic Stellate Cell Activation and Preventing Liver Fibrosis.

Objective: Liver fibrosis replaces healthy tissue with scar tissue, potentially leading to cirrhosis and cancer. ROS drive this process by activating hepatic stellate cells. This study tests the hepatoprotective effects of PDA@CeO nanoparticles in scavenging ROS, inhibiting HSC activation, and delaying fibrosis, using 2D-SWE to assess treatment efficacy.

Bentonite and gallotannin-mediated silver nanoparticle-modified chitosan biofilms for food preservation.

In view of the increasingly severe environmental hazards posed by traditional plastic packaging materials, this study develops a biodegradable chitosan (CS) film to address deficiencies in water solubility and mechanical properties, thereby promoting its wide application in the field of food packaging. A novel antioxidant, antibacterial, and biodegradable food packaging film was synthesized using natural bentonite (Bt) and gallic acid (GA) - mediated silver nanoparticles (AgNPs). This is the first study to integrate Bt, GA, and in-situ-synthesized AgNPs into chitosan films for synergistic antioxidant/antibacterial enhancement.

Arthroscopic Suture and Transfemoral Fixation for Acute Posterior Cruciate Ligament Femoral Avulsion Fracture.

Acute posterior cruciate ligament (PCL) femoral avulsion fractures in adults are rare. This is a very specific injury often diagnosed with magnetic resonance imaging to evaluate PCL continuity, and avulsion fractures are evaluated preoperatively via 3-dimensional computed tomography. We describe a modified technique for arthroscopic transfemoral suture of the PCL-femoral ligament combined with Versalok fixation to preserve the native femoral insertion of the PCL and ligament tension.

Pollutant distribution in vertebrates across scales: Organs, cells, and organelles.

Pollutant accumulation patterns are essential for understanding their toxicity mechanisms and health risks. Accurately identifying pollutant accumulation sites and toxicity targets requires an integrated understanding of their distribution across multiple scales. This review systematically examines recent advances in the multi-scale distribution of environmental pollutants in vertebrates, spanning organ, cellular, and subcellular levels.

LINC02888 promotes HGSOC progression and immune evasion via PPIB-mediated stabilization of LAPTM5 mRNA and inhibition of RIG-I-like receptor signaling.

Background: High-grade serous ovarian cancer (HGSOC) remains highly lethal due to late diagnosis and chemoresistance. Long noncoding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. This study investigates the role of the cytoplasmic lncRNA LINC02888 in HGSOC.

Synergistic multi-crosslinked networks in chitosan/Gallic acid/Fe composite biofilms with high UV resistance and antioxidant properties.

Food spoilage leads to plenty of food being wasted every year. Safe and multifunctional food preservation packaging is urgently required to prevent food from contamination. Chitosan/gallic acid/Fe (CSGA-Fe) composite films were synthesized by incorporating gallic acid (GA) and Fe into a chitosan solution.

Spesolimab in generalized pustular psoriasis complicated by acrodermatitis continua of Hallopeau: a case report and mechanistic insights.

A 62-year-old Chinese woman presented to the hospital for help with generalized pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH). While conventional treatments failed to achieve significant improvement, the patient received two doses of spesolimab, and the effect was remarkable. No adverse reactions were observed in the follow-up period.

Voacamine initiates the PI3K/mTOR/Beclin1 pathway to induce autophagy and potentiate apoptosis in acute myeloid leukemia.

Background: Acute myeloid leukemia (AML) is notoriously prevalent as a malignant hematological neoplasm, and commonly prescribed combination chemotherapeutic treatments invariably involve unanticipated toxicities. Therefore, identifying potential single agent with definitive multi-target and multi-pathway anti-tumor properties is an emerging strategy for the effective treatment of AML.

Purpose: The present study aimed to investigate how voacamine (VOA) regulated apoptosis and autophagy to suppress the progression of AML.

Identification of AKTIP as a biomarker for fibrolamellar carcinoma using WGCNA and machine learning.

Unlabelled: Fibrolamellar carcinoma (FLC) is a rare form of liver carcinoma with limited diagnostic and therapeutic options. In this study, we utilized the GSE57727 and E-MTAB-1503 datasets, downloaded from GEO and ArrayExpress, respectively, to explore hub genes for FLC diagnosis and potential therapeutic agents. Through the integration of multiple machine learning approaches and drug sensitivity databases, we identified AKTIP as a potential diagnostic biomarker for FLC.

Robot-Assisted Individualized Medial Patellofemoral Ligament Reconstruction in Skeletally Immature Patients With Recurrent Patellar Dislocation: A Single-Center Retrospective Study.

Background: The surgical treatment of patellar instability in children and adolescents can be challenging, as successful surgical techniques used in adults may pose a risk to the open growth plate when applied in this younger population.

Purpose: To review a series of adolescent patients with recurrent patellar dislocation who underwent robot-assisted individualized medial patellofemoral ligament (MPFL) reconstruction.

Study Design: Case series; Level of evidence: 4.

Pretibial abscess associated with instrumentation-specific infection after anterior cruciate ligament reconstruction: A case report.

Pretibial abscess is a rare but serious complication after anterior cruciate ligament (ACL) reconstruction. We report six cases of pretibial abscesses from 364 ACL reconstructions at our center between January 2022 and June 2023. Patients presented with poor wound healing, sinus tract formation, and magnetic resonance imaging showed fluid accumulation and bone marrow edema in the tibial tunnel but no deep infection.

Decipher the single-cell level responses to chemotherapy in pancreatic ductal adenocarcinoma by a cross-time context graph model.

Gemcitabine is commonly used for pancreatic ductal adenocarcinoma (PDAC), one of the most lethal cancer types. However, the drug resistance is a critical challenge for improving the PDAC chemotherapy. Here, we applied single-cell RNA sequencing (scRNA-seq) on PDAC patient-derived xenograft (PDX) models to study the complex cellular responses related to the gemcitabine resistances.

Guillain-Barré Syndrome Secondary to Herpes Zoster: A Rare Case Report of Death and Literature Review.

Introduction: Herpes zoster (HZ) is a common infectious skin disease, and postherpetic neuralgia is the most feared and common complication. Guillain-Barré syndrome (GBS) is a rare complication of HZ.

Case Presentation: An exceptional case presenting GBS following HZ with a subsequent lethal issue is presented.

GSH-Responsive Heterodimeric Dual-Targeted Nanomedicine Modulates EMT to Conquer Paclitaxel-Induced Invasive Breast Cancer Metastasis.

Paclitaxel (PTX), although effective against primary breast cancer, presents formidable clinical challenges due to severe toxicity and pro-metastatic potential, a critical concern as distant metastasis causes 90% of breast cancer-related deaths. To address these limitations, we designed and prepared a tumor microenvironment-responsive nanoprodrug, PTX-SS-3'HPT@RGD-HA NPs, that engineered RGD peptide-modified hyaluronic acid (HA) nanocarriers encapsulating the antimetastatic 3'-hydroxy pterostilbene (3'HPT) and PTX heterodimer linked by a glutathione (GSH)-cleavable disulfide bond. These nanoparticles targeting CD44 and αvβ receptors overexpressed in aggressive breast cancer cells and synergized enhanced permeability and retention effects with receptor-mediated endocytosis, facilitating superior tumor-specific drug deposition and GSH-activated payload release and .

Emergence of Small Nucleic Acids as Drugs in Precision Medicine.

Small nucleic acid drugs including antisense oligonucleotides, small interfering RNAs, microRNAs, and aptamers, among others, have revolutionized the pharmaceutical industry in the 21st century, offering novel therapeutic strategies for a myriad of diseases through precise gene expression regulation or protein synthesis modulation. As of December 2024, 19 small nucleic acid drugs have been approved globally, with applications primarily in treating rare and hereditary conditions, metabolic diseases, and ophthalmological disorders, demonstrating great clinical potential. This review provides an overview of the classification, mechanism of action, technical challenges, and addressing strategies for small nucleic acid drugs, with a focus on the indications for market-available drugs, aiming to equip healthcare professionals with a thorough understanding and practical guidance on their utilization.