Impact of vaccination strategy adjustments on antibody levels against measles, rubella, mumps, and varicella in China: a single-center serological survey.

Objective: This study evaluated trends in population immunity against measles, rubella, mumps, and varicella in Suqian City (2005-2024) using serological surveys (2019-2024) and incidence data, incorporating participants with known/unknown vaccination statuses to explore immunity dynamics amid evolving policies, and inform public health planning.

Methods: Serum samples from 541 (2019) and 506 (2024) healthy participants were analyzed for virus-specific IgG antibodies using ELISA. Disease incidence data were obtained from China's National Notifiable Disease Reporting System.

MiR-146a participates in regulating the progression of periodontitis through the Wnt/β-catenin signaling pathway.

Objectives: This study aims to investigate the potential role of miR-146a/Wnt/β-catenin signaling axis in the pathogenesis of periodontitis, using LPS-stimulated hPDLCs as a cell model.

Methods: Saliva samples were collected from the subjects and qRT-PCR was used to detect the expression of miR-146a and β-catenin in saliva. Clinical parameters, including probing depth (PD) and attachment loss (AL), were measured and their correlation with miR- 146a and β-catenin levels was determined.

Space-Confined Synthesis of Sulfonated Covalent Organic Framework‒Polymer Membranes for Enhanced Osmotic Energy Conversion.

Osmotic energy, an infinite, clean energy source, can be efficiently harnessed through reverse electrodialysis using ion-selective membranes. While polymeric membranes are excellent candidates due to their solution-processability and scalability, their non-uniform pore architecture and high resistance limit their power density output. Here, an in situ space-confined synthesis strategy is proposed to fabricate sulfonated covalent organic frameworks within a sulfonated polymeric network, resulting in interconnected, well-defined ion channels.

Preparation and Performance Evaluation of Coated Tracer Sand for Segmental Fracturing of Horizontal Wells.

Multistage fracturing technology for horizontal wells has become a core technology for the effective development of shale and other unconventional oil and gas resources. Following the fracturing and modification of horizontal wells, reliable monitoring of the fracturing effect of each interval, the return of drainage, and the fluid production profile during subsequent production is an important prerequisite for further optimization of the fracturing program and sustainable and effective development. The use of coated tracer sand allows the fracturing effect of horizontal good segments to be assessed and the fluid production profile of horizontal wells to be evaluated in real-time during production.

Quantum dynamics in multistate harmonic models using tensor-train thermofield dynamics and semiclassical mapping dynamics.

We present quantum dynamics of the multi-state harmonic (MSH) model using numerically exact tensor-train (TT)-based calculations. The MSH model provides a general framework for mapping a realistic system onto an effective model Hamiltonian, which is defined in extended spatial dimensions, ensuring consistent reorganization energies between all state pairs. Its analytic structure allows efficient propagation of wavepackets via a rank-adaptive TT-KSL scheme and rigorous finite-temperature dynamics via TT-thermofield dynamics.

Development of a matching framework for voluntary services provided to home-dwelling older adults by nursing faculty and students based on the Kano model.

Background: As population aging accelerates, volunteer services provide meaningful community support for older adults. However, evidence is limited on how to align their needs with the service intentions of nursing faculty and students to develop appropriate frameworks.

Methods: Data were collected through self-designed demand-supply matching questionnaires from nursing faculty and students (March 26 - April 25, 2023) and older adults (May 24 - July 7, 2023) using convenience sampling.

Oxidized sediment recycling as a driver for postsubduction porphyry copper formation.

The mechanisms driving the elevated oxidation state of postsubduction porphyry magmas and porphyry copper mineralization are still not fully understood. We present an integrated study of trace elemental and Mg-Hg isotopic compositions of pre-, syn-, and postcollisional magmatic rocks from the eastern Gangdese belt in southern Tibet. Our findings show increased magmatic oxidation states linked to the enrichment of terrigenous sediments from Neo-Tethys subduction to postcollision, as evidenced by distinctive mass-independent Hg isotope fractionation in postcollisional porphyries (ΔHg = -0.

Thermal Marangoni natural convection enables directional transport across immiscible liquids.

The ability to control molecular transport across immiscible liquid interfaces is critical for applications in manufacturing, biotechnology, and space research. Such transport mechanisms have garnered attention for their intriguing behavior and transformative potential in technology and science for a long time. Here, we demonstrate that unsteady temperature fields drive directional transport of water molecules across the oil-water interface, where weakened hydrogen bonding orients hydroxyl groups toward the oil phase.

Isoform characterization of mA in single cells identifies its role in RNA surveillance.

The distribution of mA across various RNA isoforms and its heterogeneity within single cells are still not well understood. Here, we develop mA-isoSC-seq, which employs both Oxford Nanopore long-read and Illumina short-read sequencing on the same 10x Genomics single-cell cDNA library with APOBEC1-YTH induced C-to-U mutations near mA sites. Through mA-isoSC-seq on a pooled sample of three cell line origins, we unveil a profound degree of mA heterogeneity at both the isoform and single-cell levels.

First-Principles Investigation of Excited-State Lattice Dynamics and Mechanical Properties in Diamond.

The study of the excited-state properties of diamond is crucial for understanding its electronic structure and surface physicochemical properties, providing theoretical support for its applications in optoelectronic devices, quantum technologies, and catalysis. This research employs Density Functional Theory (DFT) with the fixed electron occupation method to simulate the electron excitation. Using the Generalized Gradient Approximation (GGA) within DFT, we systematically investigated the excited-state characteristics of diamond by simulating the transfer of a fraction of electrons from the Highest Occupied Crystal Orbital (HOCO) to the Lowest Unoccupied Crystal Orbital (LUCO).

Modeling and simulation of steam-enhanced extraction: Parameter effect of injected steam-air mixture on NAPL remediation at contaminated sites.

Steam enhanced extraction (SEE) shows great potential for the remediation of sites contaminated by non-aqueous phase liquids (NAPLs). The condensation of the injected steam, which is induced by subsurface temperature gradients, is recognized as crucial in hindering the remediation of NAPLs. To quantitatively examine the complex process for an optimal design, this study formulates a thermo-hydro-concentration-moisture coupled two-phase flow model.

Precision and Efficacy of Digital Technology in Orthognathic Surgery for Facial Asymmetry Correction: A Quantitative Analysis.

Objectives: To evaluate the efficacy of digital technology-assisted design in orthognathic surgery for patients with facial asymmetry.

Materials And Methods: The study comprised 30 patients with facial asymmetry. Mimics software was used to digitally simulate surgical plans and create guide plates for orthognathic surgery.

symbionts benefit whitefly fertilization by regulating the maternal protein Tudor-mediated piRNA pathway.

Although it is widely recognized that nutritional symbionts can manipulate host reproduction, the underlying molecular and cellular mechanisms are largely unclear. The facultative symbiont in bacteriocyte induces female-biased sex ratio of whiteflies. Here, we demonstrate that a maternal gene () and its encoded protein have lower expression levels in ovaries of cured whiteflies.

Targeting Regnase-1 unleashes CAR T cell antitumor activity for osteosarcoma and creates a proinflammatory tumor microenvironment.

Negative regulators of T cell function represent promising targets to enhance the intrinsic antitumor activity of CAR T cells against solid tumors. However, the endogenous immune ecosystem in solid tumors often represents an immunosuppressive therapeutic barrier to CAR T cell therapy, and it is currently unknown whether deletion of negative regulators in CAR T cells reshapes the endogenous immune landscape. To address this knowledge gap, we developed CAR T cells targeting B7-H3 in immune-competent osteosarcoma models and evaluated the intrinsic and extrinsic effects of deleting a potent negative regulator called Regnase-1 (Reg-1).

Exploring the Mechanisms of Cyclosporine Therapy in Aplastic Anemia: A Data-Independent Acquisition Proteomics Approach.

Rationale: Clinically, cyclosporine (CsA) plays a crucial role in the treatment of aplastic anemia (AA) and has demonstrated significant therapeutic efficacy. We applied DIA-based quantitative proteomics to analyze plasma protein profiles in AA patients, aiming to identify proteins and pathways modulated by CsA, thereby elucidating its therapeutic mechanisms.

Methods: Plasma samples from three AA patients pre- and post-CsA treatment underwent data-independent acquisition proteomics.

Study on polishing mechanisms of BEOL metal interconnects based on chemical and mechanical synergy.

Chemical mechanical polishing (CMP) is the sole process capable of achieving the required flatness and surface roughness for photolithography without any obvious distortion in the multilevel metal interconnects. As semiconductor manufacturing advances to the next process node, the introduction of new materials and structures has proposed higher performance standards for polishing slurries, resulting in the slurry composition becoming increasingly critical to the overall polishing process. In this work, ReaxFF-based molecular dynamics (MD) is employed to investigate the copper (Cu) CMP process in various slurries, aiming to uncover the chemical interactions of different components and the atomistic mechanisms involved in Cu atom removal.

Reforestation potential for integrated mangrove aquaculture target at realizing a synergy of ecological and economic benefits.

Integrated mangrove aquaculture is a viable approach to achieving mangrove ecological restoration and enhancing the economic benefits of aquaculture. In this study, a novel decision-making framework was developed to optimize site selection for the conversion of low-economic-performance aquaculture ponds into integrated mangrove aquaculture systems. This framework was established through the integration of a habitat suitability model and social cost analysis, ensuring both ecological feasibility and economic viability.

Comparative analysis of the impact of moral sensitivity on service behavior between Chinese and Pakistani nurses.

Background: The service behavior of nurses is highly important for enhancing the level of hospital nursing care. However, there is currently a lack of research exploring the impact of moral sensitivity on the service behavior of nurses from an ethical perspective. Additionally, less is known about the effects of nationality differences on this relationship.

Application of Metabolomics and the Discovery of Potential Serum Biomarkers for Diuretic Resistance in Heart Failure.

Background: Diuretic resistance (DR) is characterized by insufficient fluid and sodium excretion enhancement despite maximum loop diuretic doses, indicating a phenotype of refractory heart failure (HF). Recently, metabolomics has emerged as a crucial tool for diagnosing and understanding the pathogenesis of various diseases. This study aimed to differentiate diuretic-resistant patients from non-resistant HF to identify biomarkers linked to the emergence of DR.

STING-mediated mitochondrial DNA release exacerbates PANoptosis in liver ischemia reperfusion injury.

STING, a pentameric transmembrane protein, plays a vital role in regulating the innate immune response to viral and bacterial infections. Recent research has underscored its significance in acute liver injury, yet its involvement in hepatic ischemia-reperfusion injury (HIRI) has not been thoroughly explored. To bridge this knowledge gap, we embarked on a comprehensive study using wild-type mice to investigate STING activation following surgical intervention for HIRI.

A Self-Replenishing Lubricant Slippery Coating with Low Interfacial Toughness for Enhancing Large-Scale Deicing Efficiency.

Ice accumulation on industrial and operational surfaces presents formidable challenges, necessitating effective deicing solutions for diverse applications. In this study, we develop a self-replenishing slippery lubricant (SRLS) coating designed to enhance large-scale deicing efficiency and overcome the limitations of existing low-ice-adhesion surfaces. The SRLS coating is based on a polyorganosilazane (PSZ) matrix infused with silicone oil-loaded hollow mesoporous SiO microspheres (SO@HMSs).

Broadband-Responsive Rubbery Stretchable Vertical-Structured Photodetectors Based on Rubbery Stretchable Transparent Conductors.

A rubbery stretchable conductor with high conductivity and transparency is crucial for the development of rubbery stretchable vertical-structured photodetectors. However, the development of such a rubbery conductor is still nascent. Here, we report the scalable manufacturing of rubbery stretchable transparent conductors (RSTCs) and the development of a rubbery stretchable vertical-structured photodetector (RSVPD).

Spatial retention, absorption, transport, and enrichment of microplastics in mangrove sediment complex system.

Mangrove areas are the major sink of pollutants such as microplastics (MPs, less than 5000 μm in diameter). The spatial retention, transport, and accumulation of microplastics (MPs) within the complex mangrove sediment system has become a hotspot in the field of emerging contaminants. In this study, the Xiaoguansha mangrove forest in Guangxi Province, China, was selected as a representative case to investigate the horizontal and vertical distribution of MPs in sediments.

Direct All-Atom Nonadiabatic Semiclassical Simulations for Electronic Absorption Spectroscopy of Organic Photovoltaic Non-Fullerene Acceptor in Solution.

We investigate the linear absorption spectra of the organic photovoltaic nonfullerene acceptor Y6 in chloroform using perturbative and nonperturbative approaches with atomistic details. Direct nonadiabatic semiclassical mapping dynamics reveal population and coherence evolution during and after ultrafast light pulse, revealing dominant absorption to the state and subsequent oscillatory polarization. The simulated spectra accurately reproduce experimental peak positions and broadening, corresponding to transitions from the ground state to the , , and excited states.

Specific soil factors drive the differed stochastic assembly of rhizosphere and root endosphere fungal communities in pear trees across different habitats.

Introduction: is tolerant to diverse environmental conditions and is commonly planted in infertile habitats (such as beaches and ridges) to conserve arable land for cereal crops. Symbiotic fungi in the rhizosphere and root endosphere benefit host plants by enhancing their resilience to nutritional deficiencies under stressful conditions. However, the mechanisms underlying the assembly of these symbiotic fungal communities in the roots of across different habitats remain poorly understood.