Network pharmacology prediction and experimental validation to explore the potential mechanism of Danggui Shaoyao San against Acute Kidney Injury.

Ethnopharmacological Relevance: Acute kidney injury (AKI) is a growing worldwide health concern. Danggui Shaoyao San (DGSYS) was an frequently-used representative prescription to "promote blood and water and harmonize the body" in traditional Chinese medicine, and its underlying mechanism against AKI remains to be elucidated.

Aim Of The Study: To investigate the protective effect and potential molecular mechanism of DGSYS in alleviating AKI by network pharmacology and experiment validation.

Genomic analysis of Paracoccus homiensis HT-F reveals its role in marine sulfur cycling.

Dimethylsulfoniopropionate (DMSP) is a ubiquitous organosulfur compound produced by various marine organisms and plays a central role in global sulfur and carbon cycling through microbial catabolism. In this study, we present the complete genome sequence and functional annotation of Paracoccus homiensis HT-F, a marine bacterium isolated from intertidal algae of the Yellow Sea, China. The genome comprises a 2,714,952 bp circular chromosome with a GC content of 63.

Metal-Free, Regiodivergent -Alkylation of 1-Indazoles Enabled by Brønsted Acid Catalysis.

The catalytic -selective functionalization of indazoles is pivotal in medicinal chemistry; however, achieving regiodivergent -alkylation remains challenging due to the aromatic stabilization and tautomeric equilibrium of indazoles. Herein, we report a metal-free, Brønsted acid-catalyzed alkylation of 1-indazoles using sulfoxonium ylides, which affords excellent -selectivity and good yields. Modulation of the catalyst enables switchable /-alkylation.

Analysis of paper types based on three dimensional fluorescence spectroscopy combined with Resnet34.

Printing paper represents one of the most prevalent forms of physical evidence in document forensics, where accurate brand and model identification provides critical investigative leads. To enable rapid, precise identification of commercial printing paper brands, we propose a novel method combining 3D fluorescence spectroscopy with an enhanced ResNet34 network. First, 3D fluorescence contour maps of diverse paper brands were acquired across excitation (280-420 nm) and emission (300-592 nm) wavelengths.

Room-temperature, self-powered hydrogel-based flexible chemosensors for nitrogen dioxide detection enabled by zinc-air batteries.

The development of flexible gas sensors is of growing interest in wearable electronics. However, developing a gas sensor with low operating temperature, high sensitivity, and rapid response remains a huge challenge. Herein, we first develop a polyacrylamide-sodium acrylate-sodium citrate (PAM-Na-SC) hydrogel electrolyte, and design a hydrogel-based nitrogen dioxide (NO) gas sensor enabled by zinc-air batteries (ZABs).

Nitrogen-Driven Orchestration of Lateral Root Development: Molecular Mechanisms and Systemic Integration.

N, as plants' most essential nutrient, profoundly shapes root system architecture (RSA), with LRs being preferentially regulated. This review synthesizes the intricate molecular mechanisms underpinning N sensing, signaling, and its integration into developmental pathways governing LR initiation, primordium formation, emergence, and elongation. We delve deeply into the roles of specific transporters (NRT1.

Marine Photovoltaic Industry Development: A Review of its Impact on Aquatic Environmental Elements and Future Perspectives.

With renewables, marine photovoltaic (PV) harnessing solar energy gains momentum, promising vast ocean space for power generation with significant benefits.Recent studies indicate that while marine PV systems are designed to address environmental challenges, they can also cause unintended ecological consequences. Mitigating potential negative impacts on aquatic environments has therefore become a critical research priority.

Activation of Locus Coeruleus-Hippocampus Tyrosine Hydroxylase Projection Contributes to the Surgical Incision Pain-Induced Memory Consolidation Enhancement in Mice.

Aims: The mechanism underlying postoperative post-traumatic stress disorder (PTSD) remains unclear. However, studies have shown that acute postoperative pain is an independent risk factor for PTSD, which is also closely related to memory consolidation enhancement. Preoperative patients often experience unpleasant traumatic events, and postoperative pain usually occurs in the memory consolidation stage of these events.

Hard-Template Synthesis of Inverse Opal Macroporous NiO-SnO Heterojunction for Enhanced Acetone Detection.

Chemiresistive gas sensors have emerged as a promising technology for gas detection, due to their real-time response, low costs, high sensitivity, excellent stability, and facile fabrication. However, the full realization of their potential is currently constrained by the scarcity of sensing materials capable of delivering high selectivity and ultrafast response. In this study, we prepared a three-dimensional inverse opal macroporous SnO doped with NiO (3DIO NiO-SnO).

A concept reflecting relative visual acuity insufficiency among low and moderate myopia students in east of China: Yicheng Myopia Study.

Background: Myopia has shown a sharp upward trend worldwide and has become a global public health concern. However, there were insufficient correction rates all over the world. This study aimed to investigate the prevalence of myopia and spectacle-wearing rate in primary and high school students in Yicheng, as well as analyze the risk factors of myopia onset and development.

Epidemiological trends of laboratory-confirmed influenza cases driven by meteorological factors in Anhui Province, China: a multi-city time-series analysis.

Background: Influenza poses a significant threat to public health, potentially influenced by environmental factors. However, the role of meteorological factors (MFs) on influenza risks in China remains underexplored. This study explored the effect of MFs on laboratory-confirmed influenza (LCI) cases in Anhui, China.

Quercetin enhances the cold storage effect on human umbilical cord mesenchymal stem cells in Celsior solution.

Mesenchymal stem cells (MSCs) are being increasingly applied in regenerative medicine and tissue engineering, with proven therapeutic value in different in vivo models. However, the clinical use of mesenchymal stem cells (MSCs) requires an effective short-term preservation method to provide time for cells to be transported from their production facilities to clinical destinations. This study revealed that after 5 days of hypothermic storage at 4 °C followed by 1-h rewarming, MSCs preserved in quercetin-supplemented Celsior solution (a common organ hypothermic preservation solution) exhibited significantly higher viability compared to those in Celsior solution alone.

Clinical decision-making for uveal melanoma radiotherapy: comparative performance of experienced radiation oncologists and leading generative AI models.

Background: Uveal melanoma is the most common primary intraocular malignancy in adults, yet radiotherapy decision-making for this disease often remains complex and variable. Although emerging generative AI models have shown promise in synthesizing vast clinical information, few studies have systematically compared their performance against experienced radiation oncologists in this specialized domain. This study examined the comparative accuracy of three leading generative AI models and experienced radiation oncologists in guideline-based clinical decision-making for uveal melanoma.

Harnessing non-equilibrium hot electrons in a quantum-engineered ternary heterostructure for sub-ppb C9 biomarker detection.

Photoactivated sensors offer a safe, low-power alternative to thermal sensors, yet their performance against trace concentrations of weakly reactive biomarkers is fundamentally crippled by the rapid energy loss of photogenerated carriers electron relaxation into the band-edge. This process limits the number of electrons available for sensing. Here, we overcome this limitation by introducing a new principle: non-equilibrium hot-electron-mediated chemoresistance.

Engineered membraneless organelles in for enhanced indigoidine biosynthesis and antimicrobial peptide production.

Liquid-liquid phase separation (LLPS)-driven membraneless organelles (MLOs) have been employed to enhance metabolic efficiency in various microbial cell factories. However, their application in the industrial bacterium has not been explored. Here, we report the formation of liquid protein condensates in using the RGG domain of LAF-1.

Perylene diimide-based photocatalysts: from molecular design to emerging applications.

Perylene diimide (PDI)-based semiconductor materials show significant promise for photocatalytic environmental decontamination and the conversion of energy resources but suffer from inefficient photocarrier separation which greatly limits their activity. Consequently, designing PDI-based photocatalysts to enhance carrier separation has become a major research focus. This persistent challenge has positioned the rational design of PDI-based architectures to enhance carrier dissociation kinetics and elevate functional efficacy as a central focus point of research in the field of contemporary photocatalysis.

Association of volatile organic compounds with bone mineral density and osteoporosis: a cross-sectional study.

Background: This study aimed to assess the associations between volatile organic compounds (VOCs) and osteoporosis based on a national sample of US adults.

Methods: A total of 991 participants from the National Health and Nutrition Examination Survey were included to investigate the relationships between VOCs and osteoporosis. Logistic regression models were employed to evaluate these associations.

Association between female reproductive factors and new-onset pancreatic cancer risk: a prospective cohort study.

The link between female reproductive factors and pancreatic cancer risk is unclear. This study examined these associations in a large prospective cohort and explored potential modification by genetic susceptibility. We analyzed data from 196 563 women in the UK Biobank using multivariable Cox proportional hazards models.

Ligand Engineering-Enhanced Catalytic Activity of Octanuclear Zn(II)-Siloxane Clusters for Advanced Lithium-Sulfur Batteries.

Polynuclear metal clusters (PMC) with atomically defined architectures exhibit unique electrochemical catalytic behaviors in lithium-sulfur battery (LSB). Nevertheless, the precise fabrication of PMC with tailored configurations, and a comprehensive understanding of their structure-dependent property evolution, remains a formidable challenge. Herein, ligand engineering is employed to upgrade octanuclear Zn(II)-siloxane-PhPz clusters by grafting one more benzene ring onto azopyrazole ligand to form octanuclear Zn(II)-siloxane-BiPhPz clusters (OZSBPC).

HSP90 inhibition induces oncogenic EGF receptor degradation to suppress cell growth in non-small cell lung cancer.

Resistance to tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) patients with epidermal growth factor (EGF) receptor mutations severely limits the efficacy of cancer therapies. Therefore, there is an urgent clinical demand to find novel therapeutic strategies that can produce durable responses for such patients. EGF receptor-L858R is a common activating mutation and T790M/C797S can account for acquired resistance to EGF receptor-TKI like gefitinib.

Clinical characteristics and timing of intervention in 195 neonatal simple ovarian cysts: a 20-year single-center retrospective analysis.

Purpose: To characterize neonatal simple ovarian cysts (SOCs) and determine the optimal timing for intervention based on real-world clinical outcomes.

Methods: A retrospective analysis included 163 neonates (195 SOCs) surgically managed at the Third Affiliated Hospital of Zhengzhou University from 2004 to 2024. SOCs were grouped by presence or absence of adverse outcomes and further stratified by diameter (< 30 mm, 30-40 mm, ≥ 40 mm).

Molecular Characterization of Tick-Borne Pathogens in Jiangxi Province: A High Prevalence of , and in in Cattle from Ganzhou City, China.

, , and species are emerging tick-borne pathogens that cause zoonotic diseases, including rickettsiosis, anaplasmosis, and ehrlichiosis in both human and animal populations. This study aimed to investigate the prevalence of these pathogens in cattle-associated ticks from Ganzhou City, Jiangxi Province, China. Through molecular characterization using multilocus sequence analysis (16S , , , and genes), we analyzed 392 ticks collected from March to September in 2022.

Neurotoxic impacts of neonicotinoid pesticide residues in Chinese honey on Apis mellifera L.

Background: The threat to bees of neonicotinoid pesticides (NEOs) has raised concern. However, data on the disruption of the bee nervous system following long-term low-dose exposure are lacking. In this study, six NEOs were quantified in 31 honey samples from China, and their behavioral effects on bees were evaluated.

Prevalence and risk of metabolic dysfunction-associated steatotic liver disease in patients with sarcopenic obesity: a systematic review and meta-analysis.

Background: The coexistence of sarcopenia and obesity has been established as a pivotal factor driving the pathological progression of metabolic dysfunction-associated steatotic liver disease (MASLD). This study systematically evaluates the prevalence and risk of MASLD in patients with sarcopenic obesity (SO).

Method: A comprehensive literature search was conducted in PubMed, Cochrane Library, EMBASE, Web of Science and SCOPUS up to March 2025.

Comparison of the therapeutic effects of modified 15-mm incision minimally invasive approach with the conventional approach in the treatment of AO 23-B3 distal radius fractures.

Background: The classic surgical technique of the 15-mm incision minimally invasive approach is not suitable for AO 23-B3 distal radius fractures (abbreviated B3). We have modified this technique for B3. This study aimed to investigate the efficacy of the modified 15-mm incision minimally invasive approach with the conventional ORIF approach in the treatment of B3.