Case Report: Late simultaneous metastasis of renal clear cell carcinoma to the ampulla and breast.

We present the case of a 67-year-old female who developed simultaneous metastases to the ampulla of Vater and the breast. Her medical history is significant for a radical nephrectomy performed twenty-one years prior for renal cell carcinoma (RCC). The patient was referred for evaluation due to the development of progressive jaundice, fatigue, and weight loss.

A similar effect of fibrinogen on efficacy and safety of tenecteplase alteplase in acute ischemic cerebrovascular events (TRACE II) trial.

Background And Objectives: Hemostasis factors affecting clot patterns, particularly fibrinogen, may influence the effectiveness of intravenous thrombolysis (IVT). We aimed to investigate the impact of differences in fibrinogen plasma levels on the efficacy and safety of tenecteplase alteplase in an acute ischemic cerebrovascular events-II (TRACE-II) trial.

Methods: In a multi-center, prospective, open-label, end-point blinded, randomized, controlled trial.

Metabolic versatility enables acetogens to colonize ruminants with diet-driven niche partitioning.

Enteric methane emissions are energy losses from farmed ruminants and contribute to global warming. Diverting electrons and H2 flow toward beneficial fermentation products would mitigate ruminal methane emissions while improving feed efficiency. Acetogens can direct H2 and electrons to acetate production via the Wood-Ljungdahl pathway, but methanogens have more competitive H2 affinities.

Comparative physicochemical properties and anti-inflammatory activity of natural and artificial musk for quality evaluation.

In this study, we conducted a comprehensive comparative analysis of the physicochemical properties of natural musk (NM) and artificial musk (AM), focusing on their ultrastructure, volatile constituents, alcohol-soluble compounds, amino acid composition, inorganic element content and anti-inflammatory activity. Advanced analytical techniques such as scanning electron microscopy (SEM), gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS), amino acid auto analyzer (AAA), and inductively coupled plasma-mass spectrometry (ICP-MS) were utilized to evaluate the differences in their physicochemical properties. The results of the study showed that SEM could distinguish NM and AM based on their surface morphology.

Alteration in gut microbiota accompanied by increased intestinal permeability and Tfh/Tfr imbalance in patients with active SLE.

Background: Increased intestinal permeability and altered intestinal microbiota may influence cytokine regulatory immunity in systemic lupus erythematosus (SLE). This study aimed to elucidate the relationship between intestinal flora alters and follicular helper T cells (Tfh), regulatory T cells (Treg) cells, and cytokines in SLE.

Methods: In total, 23 patients with active SLE (SLE-A group), 18 patients with stable SLE (SLE-nA group), and 24 healthy controls (HC group) were enrolled.

Lewis Base-Catalyzed DYKAT of Racemic Chlorosilanes En Route to Si-Stereogenic Silazanes.

A dynamic kinetic asymmetric transformation (DYKAT) of racemic chlorosilanes into Si-stereogenic silazanes has been developed. The chiral isothiourea catalyst ()-benzotetramizole facilitates silylamination with sulfonamides, yielding ()-silazanes with ≥99:1 after one recrystallization. The approach is distinct from the conventional desymmetrization strategy using dihydrosilanes, expanding the synthetic toolbox for Si-stereogenic silazanes.

Colchicine for preventing stroke in patients with and without intracranial atherosclerotic stenosis: a prespecified analysis of a randomized clinical trial.

Background: The effect of colchicine on subsequent stroke among patients with and without symptomatic intracranial artery stenosis (sICAS) and whether age modifies such effect are not known.

Methods: In this prespecified subgroup analysis of CHANCE-3, a randomized, double-blind, placebo-controlled clinical trial conducted at 244 centers in China between 11 August 2022 and 13 April 2023 (ClinicalTrials.gov number, NCT05439356), we included 7567 patients with ischemic stroke or transient ischemic attack and assessments of intracranial arteries at baseline.

Comparison of the host-pathogen interactions between Pseudomonas plecoglossicida and Nocardia seriolea in a cell line derived from head kidney of yellow large croaker.

Nocardia seriolae and Pseudomonas plecoglossicida are two important pathogenic bacterial species in aquaculture, causing visceral granulomatous disease in large yellow croaker (Larimichthys crocea) and other economically important fish species. However, the difference of host-pathogen interactions between these two bacteria have not been well defined. In present study, ultrastructural changes, cell cytotoxicity, production of reactive oxygen species (ROS), apoptosis, ferroptosis, and transcriptomic profiles induced by P.

Efects of Y-6 Sblingual Tablets for Paients with Acte Ischemic Stok (FUTURE): a phase II, randomised, double-blind, double-dummy, placebo-controlled, parallel trial.

Background: Acute ischaemic stroke, due to its high mortality and disability rates, imposes a significant economic and social burden worldwide. Typically, endovascular treatment within the therapeutic window is provided to salvage the ischaemic penumbra; however, even when recanalisation is successful during endovascular treatment, the clinical outcomes may still be disappointing. This highlights the necessity of further research, so as to discover better solutions to futile recanalisation and improve patient outcomes.

Outcomes of Time to Treatment With Reteplase for Acute Ischemic Stroke: The RAISE Trial Subgroup.

Background: The efficacy of intravenous thrombolysis is time-dependent. Reteplase has been shown to be superior to alteplase in certain acute ischemic stroke patients.

Objectives: The authors aimed to delineate the associations of stroke onset-to-treatment time (OTT) on the therapeutic benefits and clinical risks with reteplase in comparison to alteplase.

Influence of impaired renal function on the outcomes of patients with acute ischaemic stroke treated with intravenous tenecteplase and alteplase: a post hoc analysis of the TRACE-2 trial.

Objective: Limited evidence is available regarding the risk-benefit ratio of thrombolytic therapy in patients with stroke and renal impairment complications, particularly for the drug tenecteplase. Therefore, we examined the association of impaired renal function with the safety and efficacy of intravenous thrombolytic treatment (IVT) in patients with acute ischaemic stroke (AIS).

Methods: A post hoc analysis of a randomised controlled trial (ClinicalTrials gov.

Application of Cardiac Rehabilitation Aerobic Exercise in Patients with Stable Angina in Coronary Heart Disease.

A novel exercise protocol for cardiac rehabilitation aerobic (CRA) has been developed by Hebei Sport University, demonstrating efficacy in patients with coronary heart disease (CHD). The objective of this study was to evaluate the impact of CRA on precise cardiac rehabilitation (CR) for CHD patients presenting with stable angina pectoris. The study cohort comprised patients with stable angina who were categorized into three groups: the CRA group (n = 35), the power bicycles (PB) group (n = 34), and the control group (n = 43).

Chinese stroke association guidelines on reperfusion therapy for acute ischaemic stroke 2024.

Background: Stroke remains a major global health challenge, with China experiencing a significant burden due to its high incidence and severe outcomes. Reperfusion therapies, such as intravenous thrombolysis and endovascular thrombectomy, have shown substantial benefits in improving early outcomes for ischaemic stroke. Recent clinical trials have validated the safety and efficacy of a broader range of thrombolytic agents and expanded the eligible patient populations for both intravenous thrombolysis and mechanical thrombectomy.

Neuronal LAG3 facilitates pathogenic α-synuclein neuron-to-neuron propagation.

Lymphocyte activation gene 3 (LAG3) is a key receptor involved in the propagation of pathological proteins in Parkinson's disease (PD). This study investigates the role of neuronal LAG3 in mediating the binding, uptake, and propagation of α-synuclein (αSyn) preformed fibrils (PFFs). Using neuronal LAG3 conditional knockout mice and human induced pluripotent stem cells-derived dopaminergic (DA) neurons, we demonstrate that LAG3 expression is critical for pathogenic αSyn propagation.

Safety and efficacy of intravenous recombinant human prourokinase for acute ischaemic stroke within 4·5 h after stroke onset (PROST-2): a phase 3, open-label, non-inferiority, randomised controlled trial.

Background: Intra-arterial prourokinase has been shown to be a promising thrombolytic agent in patients with acute ischaemic stroke. Given the global shortage of thrombolytics, we aimed to assess the non-inferiority of intravenous recombinant human prourokinase compared with alteplase in patients with acute ischaemic stroke who were ineligible for or who refused endovascular thrombectomy.

Methods: PROST-2 was a phase 3, open-label, non-inferiority, randomised controlled trial conducted at 61 hospitals in China.

Tenecteplase vs Alteplase for Patients With Acute Ischemic Stroke: The ORIGINAL Randomized Clinical Trial.

Importance: Tenecteplase is a bioengineered variant of alteplase with greater fibrin specificity and a longer half-life, allowing single-bolus administration. Evidence on the treatment effect of tenecteplase 0.25 mg/kg in Chinese patients with acute ischemic stroke (AIS) is limited.

Safety and efficacy of GD-11 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial.

Background: GD-11, a novel brain cytoprotective drug, was designed to be actively taken up and transported across the blood-brain barrier via the glucose transporter. This study aimed to evaluate the safety and efficacy of GD-11 for improving the recovery of patients with acute ischaemic stroke (AIS).

Methods: A double-blind, randomised, placebo-controlled, phase 2 trial was conducted at 15 clinical sites in China.

First-in-human study to assess the safety, tolerability, and pharmacokinetics of intravenous SHPL-49 following single- and multiple-ascending-dose administration in healthy adults.

SHPL-49 is an innovative glycoside derivative that is synthesized by structural modifications of salidroside，demonstrating therapeutic effects on animal models of ischemia in pre-clinical experiments. A phase I, single-center, randomized, double-blind, placebo-controlled, single and multiple dose administration study of SHPL-49 was conducted in healthy Chinese volunteers. In single-ascending-dose (SAD) study, 32 subjects randomized 6:2 to receive SHPL-49 (30 mg, 75 mg, 150 mg, 300 mg) or placebo with 30 minutes infusion.

Terror catastrophizing: association with anxiety, depression, and transgenerational effects.

Terror catastrophizing, defined as an ongoing fear of future terrorist attacks, is associated with a higher incidence of anxiety disorders, among other psychological impacts. However, previous studies examining terror catastrophizing's relationship to other mental health disorders are limited. The current study sought to determine if patients diagnosed with anxiety and depression would experience increased terror catastrophizing.

Colchicine in patients with acute ischaemic stroke or transient ischaemic attack (CHANCE-3): multicentre, double blind, randomised, placebo controlled trial.

Objectives: To assess the efficacy and safety of colchicine versus placebo on reducing the risk of subsequent stroke after high risk non-cardioembolic ischaemic stroke or transient ischaemic attack within the first three months of symptom onset (CHANCE-3).

Design: Multicentre, double blind, randomised, placebo controlled trial.

Setting: 244 hospitals in China between 11 August 2022 and 13 April 2023.