Competition-Coupling Trade-Off of Supramolecular Interactions in Janus Composite Quasi-Solid Electrolytes Enables High-Safety and Long-Life Lithium Metal Batteries.

The LiAlTi(PO) (LATP)-polymer composite solid electrolyte offers environmental stability and safety for high-energy lithium metal batteries (LMBs), yet suffers from interfacial instability and high interfacial resistance. Herein, a Janus self-supporting skeleton (J-SSK) is engineered via multi-scale coupling of poly(vinylidene fluoride-trifluorethylene) (PVDF-TrFE), LATP, 2-(3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl) ureido) ethyl methacrylate (UPyMA) monomer, where intermolecular multiple hydrogen bonds reinforce mechanical robustness while the Janus structure isolates LATP from direct Li contact. In situ copolymerizing vinylene carbonate (VC) and UPyMA monomer in J-SSK to construct Janus composite quasi-solid electrolyte (J-CQSE) achieves seamless integration of electrode/electrolyte interfaces and establishes hierarchical coupling across J-SSK, polymer matrix, and lithium salts.

Comparative physicochemical properties and anti-inflammatory activity of natural and artificial musk for quality evaluation.

In this study, we conducted a comprehensive comparative analysis of the physicochemical properties of natural musk (NM) and artificial musk (AM), focusing on their ultrastructure, volatile constituents, alcohol-soluble compounds, amino acid composition, inorganic element content and anti-inflammatory activity. Advanced analytical techniques such as scanning electron microscopy (SEM), gas chromatography-mass spectrometry (GC-MS), liquid chromatography-mass spectrometry (LC-MS), amino acid auto analyzer (AAA), and inductively coupled plasma-mass spectrometry (ICP-MS) were utilized to evaluate the differences in their physicochemical properties. The results of the study showed that SEM could distinguish NM and AM based on their surface morphology.

Mechanisms of vascular endothelial cell injury triggered by blood glucose changes in gestational diabetes mellitus.

Aims: The precise pathogenic mechanism of long-term detrimental effects on mothers and infants resulting from gestational diabetes (GDM) remains unclear. This study aimed to examine the long-term detrimental consequences of GDM on mothers and newborns, particularly the impact of glucose concentration variations on vascular endothelial cells and its possible pathogenic mechanisms.

Materials And Methods: An analysis was conducted on the clinical data of 68 healthy pregnant women and 67 pregnant women diagnosed with GDM.

Exploring Potential Health Risk of Chenxiang Huaqi Tablets Based on Inorganic Elemental Evaluation Using ICP-MS.

Chenxiang Huaqi Tablet (CXHQT) is a Chinese patent medicine preparation composed of 10 traditional Chinese herbs. In this study, the concentrations of 23 inorganic elements in CXHQT were determined by inductively coupled plasma mass spectrometry (ICP-MS). The fingerprint of the elements was established, the chemometrics and element correlation analysis were carried out, and the health risk assessment of heavy metals and harmful elements was performed.

Structural optimization and pharmacological evaluation of diphenyl amine esters as anti-hepatocellular carcinoma agents by targeting TAR RNA-binding protein 2.

Hepatocellular Carcinoma (HCC), a leading cause of cancer-related death in the world, urgently requires novel therapeutic strategies and drug targets. The TRBP-Dicer complex plays a critical role in miRNA biosynthesis, which can be regulated by small molecules to exert anti-cancer effects. This study presented the structural modification of the natural product (-)-Gomisin M1(GM), resulting in the synthesis of 37 derivatives with a diphenyl amine ester scaffold.

An Optimized Microwave-Assisted Extraction and Evaluation of Amino Acids Content and Nutritional Value in from Different Origins.

The aim of this study is to establish a rapid and convenient microwave-assisted digestion method for sample pretreatment to evaluate amino acids in (CF). The microwave digestion method was optimized to extract amino acids from CF, and the differences in amino acids in CF from different origins and different processing states were analyzed and evaluated. The influences of digestion temperature, digestion time, and liquid-material ratio on extraction effect were investigated by sing factor test and response surface method (RSM), and the extraction conditions were optimized.

Assessment of health risk and identification of pollution sources of heavy metals in water in Chongqing's wastewater treatment plants based on ICP-MS.

Chongqing is located upstream of the Yangtze River and within the Three Gorges Reservoir Area. Boasting a dense hydrological network comprising interconnected rivers, tributaries, and reservoirs, the condition of the natural environment in Chongqing is intrinsically linked to drinking water safety. To evaluate the regional distribution, pollution levels, health risks, and sources of 12 heavy metals, a total of 90 water samples (30 influent sewage, 30 effluent sewage, and 30 tap water samples) were systematically collected from 30 wastewater treatment plants (WWTPs) across Chongqing.

Continuous monitoring and comparative genetic analysis of attached outbreak species of Ulva prolifera in the Southern Yellow Sea.

With years of green tide outbreaks in the Southern Yellow Sea (SYS) and climate change, early findings over multiple years suggest that the green tide may originate from various pathways. Previous studies have identified attached outbreak species of U. prolifera in the intertidal zone along the SYS coast.

Design, Synthesis, and Antitumor Activity Evaluation of 2-Phenylthiazole-5-Carboxylic Acid Derivatives Targeting Transactivation Response RNA-Binding Protein 2.

Transactivation response (TAR) RNA-binding protein 2 (TRBP) plays a critical role in microRNA (miRNA) biosynthesis, with aberrant expression linked to various cancers. Previously, we identified , a phenyloxazole derivative that disrupts the TRBP-Dicer interaction in hepatocellular carcinoma (HCC). In this study, we optimized this scaffold and substituent, leading to the discovery of , a 2-phenylthiazole-5-carboxylic acid derivative with nanomolar inhibitory activity (EC = 0.

Identification and odor exposure regulation of odorant-binding proteins in .

The highly developed sensitive olfactory system is essential for Scott (Hemiptera: Pentatomidae) adults, an widely distributed natural predatory enemy, to locate host plants. During this process, odorant-binding proteins (OBPs) are thought to have significant involvement in the olfactory recognition. However, the roles of OBPs in the olfactory perception of are not frequently reported.

Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism.

Dysfunction of calcium channels is involved in the development and progression of some cancers. However, it remains unclear the role of calcium channel inhibitors in tumor immunomodulation. Here, calcium channel blocker lacidipine is identified to potently inhibit the enzymatic activity and expression of indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism.

Allosteric inhibition of the tyrosine phosphatase SHP2 enhances the anti-tumor immunity of interferon α through induction of caspase-1-mediated pyroptosis in renal cancer.

Interferon alpha (IFNα) leads to therapeutic effects on various tumors, especially renal cell cancer (RCC), by directly protecting against tumors cell proliferation or indirectly inducing an anti-tumor immune response. However, new combination therapies are needed to enhance the efficacy of IFNα and reduce its adverse effects during long-term treatment. In this study, we found that the anti-proliferative effects of IFNα on RCC cells in vitro and in vivo were greater after the allosteric inhibition of SHP2 by SHP099 than after treatment with enzymatic inhibitors of SHP2.

New insights into the function and therapeutic potential of RNA-binding protein TRBP in viral infection, chronic metabolic diseases, brain disorders and cancer.

RNA-binding proteins (RBPs) and non-coding RNAs are crucial trans-acting factors that bind to specific cis-acting elements in mRNAs, thereby regulating their stability and translation. The trans-activation response (TAR) RNA-binding protein (TRBP) recognizes precursor microRNAs (pre-miRNAs), modulates miRNA maturation, and influences miRNA interference (mi-RNAi) mediated by the RNA-induced silencing complex (RISC). TRBP also directly binds and mediates the degradation of certain mRNAs.

Insight into the interaction between amino acids and SO: Detailed bonding modes.

Context: Amino acids are a highly effective and environmentally friendly adsorbent for SO. However, there has been no comprehensive study of the binding modes between amino acids and SO at the molecular level. In this paper, the binding modes of three amino acids (Asp, Lys, and Val) with SO are studied comprehensively and in detail using quantum chemical calculations.

Behind the Non-Uniform Breakup of Bubble Slug in Y-Shaped Microchannel: Dynamics and Mechanisms.

Bubble flow in confined geometries is a problem of fundamental and technological significance. Among all the forms, bubble breakup in bifurcated microchannels is one of the most commonly encountered scenarios, where an in-depth understanding is necessary for better leveraging the process. This study numerically investigates the non-uniform breakup of a bubble slug in Y-shaped microchannels under different flow ratios, Reynolds numbers, and initial bubble volumes.

Plant-Based Meat Proteins: Processing, Nutrition Composition, and Future Prospects.

The growing need for plant-based meat alternatives promotes the rapid progress of the food industry. Processing methods employed in plant-based meat production are critical to preserving and enhancing their nutritional content and health benefits, directly impacting consumer acceptance. Unlike animal-based food processing, the efficiency of protein extraction and processing methods plays a crucial role in preserving and enriching the nutritional content and properties.

Nuclear modifier YARS2 allele correction restored retinal ganglion cells-specific deficiencies in Leber's hereditary optic neuropathy.

Leber's hereditary optic neuropathy (LHON) is a maternally transmitted eye disease due to the degeneration of retinal ganglion cells (RGCs). Mitochondrial 11778G > A mutation is the most common LHON-associated mitochondrial DNA (mtDNA) mutation. Our recent studies demonstrated some LHON families manifested by synergic interaction between m.

Case Report: Prenatal diagnosis of fetal tetrasomy 9p initially identified by non-invasive prenatal testing.

Tetrasomy 9p is a rare syndrome characterized by fetal growth restriction, Dandy-Walker malformation, cardiac anomalies, and facial abnormalities and is discovered by ultrasound during the prenatal examination. Herein, we report a fetus of tetrasomy 9p without obvious phenotypic manifestations during the first trimester that was identified by non-invasive prenatal testing (NIPT). NIPT revealed that the gain of 9p24.

Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis.

MicroRNAs (miRNAs) are key players in human hepatocellular carcinoma (HCC) tumorigenesis. Therefore, small molecules targeting components of miRNA biogenesis may provide new therapeutic means for HCC treatment. By a high-throughput screening and structural simplification, we identified a small molecule, CIB-3b, which suppresses the growth and metastasis of HCC and by modulating expression profiles of miRNAome and proteome in HCC cells.

Electrochemically promoted oxidative α-cyanation of tertiary and secondary amines using cheap AIBN.

The electrochemical α-cyanation of tertiary and secondary amines has been developed by using a cheap cyanide reagent, azobisisobutyronitrile (AIBN). The CN radical, generated through -BuNBr-meidated electrochemical oxidation, participates in a novel α-cyanation reaction under exogenous oxidant-free conditions.

Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations.

Purpose: To investigate the mechanism underlying the synergic interaction between Leber's hereditary optic neuropathy (LHON)-associated ND1 and mitochondrial tyrosyl-tRNA synthetase (YARS2) mutations.

Methods: Molecular dynamics simulation and differential scanning fluorimetry were used to evaluate the structure and stability of proteins. The impact of ND1 3635G>A and YARS2 p.

A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating β-TrCP E3 Ubiquitin Ligase.

The aberrant activation of a signal transducer and activator of transcription 3 (STAT3) restrains type I interferon (IFN) α/β-induced antiviral responses and is associated with the development of cancer. Designing specific STAT3 inhibitors will thus provide new options for use as IFN therapy. Herein, we identified a novel small molecule, dimethyl 2-(4-(2-(methyl(phenyl(p-tolyl)methyl)amino)ethoxy)benzyl)malonate (CIB-6), which can inhibit the IFN-α-induced interferon stimulated response element (ISRE) luciferase reporter (IC value = 6.