-alkyl Dithiocarbamates Synthesis through Electrochemical Multicomponent Reaction of Thiols, Hydrogen Sulfide, and Isocyanides.

Dithiocarbamates synthesis is extremely important in plenty of biomedical and agrochemical applications, especially fungicide development, but remains a great challenge. In this work, we have successfully developed a multicomponent reaction protocol to convert HS into -alkyl dithiocarbamates under constant current conditions. No additional oxidants nor additional catalysts are required, and due to mild conditions, the reactions display a broad substrate scope, including varieties of thiols or disulfides.

Electrosynthesis of -thiocarbamates with disulfides as a sulfur source.

An electrochemical oxidative synthesis of -thiocarbamates by a carbamothioation reaction a three-component coupling reaction (disulfide, water and isocyanide) is developed, which avoids the use of external oxidants and generates only hydrogen gas as the by-product. With NHI as the mediator and electrolyte, the desired -thiocarbamates were obtained in good yields in an undivided cell at room temperature.

Electrochemically promoted oxidative α-cyanation of tertiary and secondary amines using cheap AIBN.

The electrochemical α-cyanation of tertiary and secondary amines has been developed by using a cheap cyanide reagent, azobisisobutyronitrile (AIBN). The CN radical, generated through -BuNBr-meidated electrochemical oxidation, participates in a novel α-cyanation reaction under exogenous oxidant-free conditions.