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Article Abstract
A dynamic kinetic asymmetric transformation (DYKAT) of racemic chlorosilanes into Si-stereogenic silazanes has been developed. The chiral isothiourea catalyst ()-benzotetramizole facilitates silylamination with sulfonamides, yielding ()-silazanes with ≥99:1 after one recrystallization. The approach is distinct from the conventional desymmetrization strategy using dihydrosilanes, expanding the synthetic toolbox for Si-stereogenic silazanes.
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| http://dx.doi.org/10.1021/acs.orglett.5c01844 | DOI Listing |
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