Pesticide-fertilizer interactions: nutrient effects on wheat detoxification of prothioconazole.

Background: Prothioconazole (PTC), a triazole fungicide, and its metabolite prothioconazole-desthio (dPTC) present potential phytotoxic risks in crops. However, the mechanisms governing their uptake and detoxification in wheat remain unknown. This study aimed to determine how macronutrients and endogenous signaling compounds regulate PTC absorption and metabolism in wheat seedlings.

The Transcendent Patterning of Medical Pluralism: Religion and Medical Practices Among Miao Migrants in China.

Based on ethnographic fieldwork on the medical practices of Miao internal migrants in China, in this article we critique the hierarchical and discrete ontologies of "pluralism" prevalent in anthropological studies of medical pluralism. It examines how Miao migrants construct an informal pluralistic medical system that integrates shamanistic ritual healing, herbalism, and "folk" biomedicine within a pragmatically grounded yet spiritually coherent framework rooted in Miao religion and cosmologies. Furthermore, we explore how their medical-seeking practices, grounded in a transcendent ontology of well-being, operate through affective economies of trust and , thereby enhancing their medical resilience and socio-economic embeddedness into local society.

Rice phyllosphere bacteria mediates beneficial responses to pesticide stress.

Pesticides are essential for agricultural productivity; however, pose significant risks to ecosystems and human health due to their persistence and non-target effects. This study investigates the role of phyllosphere bacteria Stenotrophomonas sp., in mitigating pesticide stress and enhancing plant resilience.

Integration LC-MS/MS and molecular modeling techniques to elucidate the molecular mechanisms of goat whey protein-IgG interactions.

Cow milk allergy is one of the common food allergy, and goat milk is a potential alternatives. However, research on its sensitization is limited, and its practicle application remains controversial. This study combined molecular docking and molecular dynamics simulation to investigate hotspot residues and epitopes of goat α-lactalbumin (α-LA) and β-lactoglobulin (β-LG).

Artemisiae Annuae Herba: from anti-malarial legacy to emerging anti-cancer potential.

Modern medical approaches to cancer treatment face significant obstacles, including limited therapeutic options, narrow drug applicability, and rapid development of drug resistance. Consequently, re-evaluating traditional medicinal plants and natural compounds has emerged as a promising strategy to address this public health issue, particularly amid challenges in developing novel pharmaceuticals. Artemisiae Annuae Herba, a versatile natural drug renowned for its established efficacy against malaria and for other diverse pharmacological activities, is gaining recognition for its anti-cancer potential due to the unique structures and biological effects of its constituents.

InterPAD is a database of drug-drug interaction between phytochemicals and anticancer drugs.

The plant kingdom is a crucial source of potential medicines, with medicinal plants playing a significant role, they have been used to treat various diseases, including cancer. Phytochemicals have emerged as promising candidates for enhancing conventional cancer treatment strategies, particularly in addressing the persistent challenges associated with such therapies. For a long time, combined therapy has been widely adopted to overcome the limitations of monotherapies.

Serratia marcescens Sm85 produces dimethyl disulfide defense against rice sheath blight and effects on phyllosphere bacterial community.

Background: Rice sheath blight (RSB), caused by Rhizoctonia solani Kuhn, significantly impacts rice yield and quality. The extensive use of chemical pesticides, while often effective, requires high application rates, causes environmental damage, is expensive, and contributes to the development of pesticide resistance. The lack of reliability and robustness of these conventional techniques necessitates the development of sustainable and environmentally friendly agricultural practices.

Heat shock protein mediates the fumigation activity of terpinen-4-ol and limonene against Tribolium confusum.

Background: Terpinen-4-ol and limonene are important active components used to control storage pests, comprising an effective strategy to reduce the utilization of chemical pesticides and postpone the development of resistance.

Results: Terpinen-4-ol and limonene had significant fumigation activity against Tribolium confusum, which showed positive association with temperature. Two heat shock protein genes (HSPs) (TcfHSP16.

Glutathione S-transferase in mediating adaptive responses of oats (Avena sativa) to osmotic and cadmium stress: genome-wide analysis.

Background: Glutathione S-transferases (GSTs) are essential multifunctional enzymes. In the face of abiotic stresses such as drought and heavy metal exposure, plants utilize GSTs for detoxification and antioxidant defense, as these enzymes facilitate the conjugation of glutathione (GSH) with toxic compounds. Specific details of this process, however, remain unknown.

QBEmax is a sequence-permuted and internally protected base editor.

Cytosine base editors (CBEs) show promise for multiplex gene knockout applications, but impure edits, indels and off-targets still frequently occur. We describe here QBEmax, which exhibits high efficiency, low indel and off-targets and high product purity with up to 99.8% of edits comprised of C-to-T.

Tracking host-guest recognition in cells by a BODIPY·CB[7] complex.

Interested in host·guest binding events in cellular environments, intracellular recognition between fluorescent BODIPY and cucurbit[7]uril was explored for lysosome tracking in living cancer cells. Sequential deaggregation from spontaneously dimerized BODIPY was unusually discovered upon complexation with CB[7].

Synergistic Strategies for Lung Cancer Immunotherapy: Combining Phytochemicals and Immune-Checkpoint Inhibitors.

Lung cancer remains one of the most widespread and deadliest malignant tumors globally, with a particularly high mortality rate among all cancers. Recently, immunotherapy, particularly immune checkpoint inhibitors (ICIs), has emerged as a crucial treatment strategy for lung cancer patients, following surgical intervention, radiotherapy, chemotherapy, and targeted drug therapies. However, the therapeutic limitations are caused owing to their low response rate and undesirable side effects such as immune-related pneumonitis.

Honokiol-Magnolol-Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti-PD-1 Immunotherapy in Colorectal Cancer by Triggering GSDME-Dependent Pyroptosis.

Significant progress is made in the treatment of metastatic colorectal cancer (mCRC) patients, however, therapeutic options remain limited for patients with mCRC. In recent years, traditional Chinese medicine (TCM) has gained significant attention. Among these, Huangqin Houpo decoction has demonstrated efficacy in mCRC treatment.

Tuning Absorption State and Intermolecular Potential of Organic Semiconductors for Narrowband Ultraviolet Photodetection.

Narrowband response of organic semiconductors determines the band selectivity and anti-interference of the organic photodetectors, which are pursued for a long time but have not yet been resolved in the UV band. Herein, a feasible strategy is developed to realize narrowband UV response by tuning the absorption state and intermolecular potential of organic semiconductors. The as-designed non-Donor-Acceptor molecule, 2,5-diphenylthieno[3,2-b]thiophene (2,5-DPTT), exhibits narrowband absorption by fully suppressing the charge transfer state absorption.

BRA-YOLOv7: improvements on large leaf disease object detection using FasterNet and dual-level routing attention in YOLOv7.

Tea leaf diseases are significant causes of reduced quality and yield in tea production. In the Yunnan region, where the climate is suitable for tea cultivation, tea leaf diseases are small, scattered, and vary in scale, making their detection challenging due to complex backgrounds and issues such as occlusion, overlap, and lighting variations. Existing object detection models often struggle to achieve high accuracy in detecting tea leaf diseases.

Molecular composition difference of electron donating moieties between natural organic matter and effluent organic matter probed by chlorine dioxide.

Lignin- and tannin-like phenolic compounds are shown to be the major compositions of electron donating moieties (EDM) of aquatic natural organic matter (NOM). However, little is known about the compositions of EDMs within effluent organic matter (EfOM). In the present study, chlorine dioxide (ClO) was used as a selectively oxidative probe to investigate the difference in the molecular composition of EDM between NOM and EfOM due to its high selectivity towards electron-rich compounds.

Allergenicity evaluation of an extensively hydrolyzed infant formula based on cow milk protein.

Cow milk protein allergy (CMPA) is the most common food allergy in infants. Currently, hypoallergenic infant formulas on the market are mainly divided into extensively hydrolyzed whey protein formulas and extensively hydrolyzed casein formulas. There are few extensively hydrolyzed infant formulas (EHFs) with a similar protein composition to breast milk.

Honokiol enhances the sensitivity of cetuximab in KRAS mutant colorectal cancer through destroying SNX3-retromer complex.

: the proto-oncogene is frequently mutated in colorectal cancer (CRC), leading to inherent resistance against monoclonal antibodies targeting the epidermal growth factor receptor (EGFR), such as cetuximab. Therefore, addressing the primary resistance and expanding the indications for target therapy have become critical challenges. : the screening of a natural product library against KRAS mutant CRC cells was conducted, leading to the discovery of a small molecule compound that sensitive to the KRAS mutation site.

CR-YOLOv9: Improved YOLOv9 Multi-Stage Strawberry Fruit Maturity Detection Application Integrated with CRNET.

Strawberries are a commonly used agricultural product in the food industry. In the traditional production model, labor costs are high, and extensive picking techniques can result in food safety issues, like poor taste and fruit rot. In response to the existing challenges of low detection accuracy and slow detection speed in the assessment of strawberry fruit maturity in orchards, a CR-YOLOv9 multi-stage method for strawberry fruit maturity detection was introduced.

Assessing spatiotemporal population density dynamics from 2000 to 2020 in megacities using urban and rural morphologies.

Rapid urbanization has resulted in the substantial population growth in metropolitan areas. However, existing research on population change of the cities predominantly draws on grid statistical data at the administrative level, overlooking the intra-urban variegation of population change. Particularly, there is a lack of attention given to the spatio-temporal change of population across different urban forms and functions.

Does the use of chlorantraniliprole during queen development adversely impact health and viability?

The queen is the sole reproductive individual and the maturing brood replenishes the shorter-lived worker bees. Production of many crops relies on both pesticides and bee pollination to improve crop quantity and quality. Despite the certain knowledge on chemical pesticides caused damage to worker bee physiology and behavior, our understanding of the relationship between honeybee queen development and chemical pesticides remains weak.

Detection Model of Tea Disease Severity under Low Light Intensity Based on YOLOv8 and EnlightenGAN.

In response to the challenge of low recognition rates for similar phenotypic symptoms of tea diseases in low-light environments and the difficulty in detecting small lesions, a novel adaptive method for tea disease severity detection is proposed. This method integrates an image enhancement algorithm based on an improved EnlightenGAN network and an enhanced version of YOLO v8. The approach involves first enhancing the EnlightenGAN network through non-paired training on low-light-intensity images of various tea diseases, guiding the generation of high-quality disease images.

Topology and giant circular dichroism of enantiomorphic Kagome bands in a designed covalent organic framework.

Covalent organic frameworks (COFs) are an emerging class of crystalline organic materials that have shown potential to be a new physical platform. In this work, a designed COF named AB-COF, which has novel enantiomorphic Kagome bands, is proposed and a feasible route to synthesize it is given. a combination of first-principles calculations and tight-binding analysis, we investigate the electronic structures and the phase interference of the COF.