Roadmap for Next-Generation Electrochemical Energy Storage Technologies: Secondary Batteries and Supercapacitors.

The transition from fossil fuels to environmentally friendly renewable energy sources is crucial for achieving global initiatives such as the carbon peak and carbon neutrality. The use of secondary batteries and supercapacitors based on electrochemical energy storage principles provides high energy density, conversion efficiency, and rapid response times, offering essential solutions for stabilizing and ensuring the reliability of energy supply from renewable sources despite their intermittency. In recent years, increased demands for higher energy density, improved rate performance, longer cycle life, enhanced safety, and cost-effectiveness have driven researchers to delve deeper into electrode materials, electrolytes, and storage mechanisms in secondary batteries.

Kinsenoside derivatives mitigate acute liver injury in mice via MAPK pathway-mediated oxidative stress suppression.

Acute liver injury (ALI), primarily induced by drugs and toxins, is characterized by rapid progression and high mortality. The lack of effective therapeutic agents presents a serious clinical challenge, underscoring the urgent need for novel drug development. Herein, we report two novel kinsenoside (KD) derivatives, KCM and KCF, synthesized via a two-step chemical strategy, which exhibit potent hepatoprotective effects in acetaminophen (APAP)- and thioacetamide (TAA)-induced ALI mouse models.

Application of nanomaterials in central nervous system disorders.

There is a common mechanism in the pathogenesis of central nervous system diseases: Neuronal damage causes a dissipation of the intermediate metabolites, triggering a wider range of injury and inflammation. Due to the selective permeability of the blood-brain barrier, the drug treatment of neurological diseases is not effective. Nanomedicine, with good biocompatibility and high plasticity, can pass through the blood-brain barrier through various mechanisms and targeted the lesion: The nano-delivery system helps drugs cross the blood-brain barrier while taking advantage of its high drug-loading capacity to achieve combined treatment; Nano-enzymes can simulate the enzymatic reaction in biological body to remove metabolic substances, and are more stable and economical than biological enzymes; Individual nanomedicine can regulate the differentiation process of neural stem cells from the genetic level, increase the number of neurons, and repair injured nerves.

Tumor Cell Membrane-Coated Oxygen-Evolving Carbon Nitride Nanozymes Combined with Curcumenol Delivery for Lung Cancer Therapy via 'Open-Source Throttling' Strategy.

Although nanozyme-mediated catalytic therapy presents promising prospects for cancer therapy, insufficient tumor targeting, a hypoxic tumor environment and high glutathione (GSH) levels limit its efficacy. Herein, a novel biomimetic Ce-doped carbon nitride nanozyme (MCeCN) with multiclass enzyme catalytic activity, oxygen generation, and targeted delivery of curcumenol (Cur) is developed for the combined treatment of non-small-cell lung cancer (NSCLC). Owing to the wrapping of the A549 cell membrane, these biomimetic nanoparticles demonstrate effective active targeting of NSCLC.

Identification of Quercetin as a Natural MMP1 Inhibitor for Overcoming Cisplatin Resistance in Epithelial Ovarian Cancer.

It is challenging to find a therapeutic Chinese medicine monomer (CHMs) for platinum-resistant patients, who currently have few treatment options, due to the complex mechanisms and the large number of CHMs available. This study aimed to identify CHM to overcome cisplatin resistance in EOC through bioinformatics analysis with experiment. This study used a strategy opposite to conventional network pharmacology.

A comparison of postoperative outcomes between robotic-assisted and laparoscopic-assisted total gastrectomy: a comprehensive meta-analysis and systematic review.

Background: The application of robot-assisted technology in gastric cancer surgery is gradually gaining attention from surgeons. In this meta-analysis, our main objective was to assess whether robot-assisted techniques are more advantageous than laparoscopic-assisted technology in total gastrectomy.

Methods: We searched Pubmed, Embase, Web of Science, and Cochrane Library databases for clinical studies published before October 2023 comparing robotic-assisted total gastrectomy (RATG) and laparoscopic-assisted total gastrectomy (LATG) for gastric cancer.

Research progress of gene editing technology in neurological diseases.

Gene editing (GE) technology is a genetic manipulation technique based on artificial nucleases that enables the precise modification of DNA or RNA. With the development of technology, GE in disease treatment is becoming increasingly widespread, playing an essential role in haematology, cancer, and neurological disorders (ND). This review describes the principles, advantages, and limitations of four GE technologies, focusing on the fourth generation of GE (next-generation GE).

Linking Hyperuricemia to Cancer: Emerging Evidence on Risk and Progression.

Purpose Of Review: Metabolic disorders significantly contribute to cancer burden globally. Uric acid (UA), a recognized metabolic risk factor linked to gout, also promotes insulin resistance, fatty liver, inflammation, and carcinogenesis. This systematic review evaluates UA's dual role in cancer, synthesizing epidemiological, mechanistic, and clinical evidence to clarify its potential as a therapeutic target.

Pan-cancer multi-omics analysis to identify the potential pro-oncogenic properties of GREM1 as a promising targets for cancer prognosis and therapeutics.

We aimed to investigate the potential pro-oncogenic properties of GREM1 by Pan-cancer multi-omics analysis. Accumulating evidence has highlighted that GREM1 (Gremlin 1), serves as an inhibitor of BMP (Bone Morphogenetic Protein) family, involve in bone related diseases, carcinogenesis, cell stemness, and cell differentiation. However, the effect and underlying mechanism of GREM1 on the cancer biology remain largely elusive.

Phosphatidylserine-decorated delivery platform helps alleviate acute lung injury via potentiating macrophage targeting.

Acute lung injury (ALI) is a life-threatening inflammatory disease with high morbidity and mortality. It is urgent to develop more effective therapeutic strategies against ALI. Phosphatidylserine (PtdSer) expressed on the surface of apoptotic cells not only allows for macrophage binding and recognition but also drives anti-inflammatory signaling within the macrophage.

Application of artificial intelligence technology in the economic development of urban intelligent transportation system.

With the rapid development of the social economy and the gradual improvement of residents' living standards, the increasing number of urban cars has exacerbated urban traffic congestion. This article analyzed the application of artificial intelligence (AI) technology in five aspects of urban intelligent transportation systems. Artificial intelligence technology was used in traffic data collection and processing to provide accurate data support for traffic decision-making.

Near-infrared MoTiC MXene gelatin-chitosan hydrogels with antioxidative, anti-inflammation activity for osteoarthritis treatment.

Knee Osteoarthritis (OA) is prevalent in older adults which eventually lead to disability. Current treatment only alleviates symptoms but does not cure the disease. Herein, we implanted MoTiC MXene gelatin-chitosan hydrogels into the osteoarthritis knee joint in mice and treated with 808 nm laser radiation.

Harnessing phytochemicals: Innovative strategies to enhance cancer immunotherapy.

Cancer immunotherapy has revolutionized cancer treatment, but therapeutic ineffectiveness-driven by the tumor microenvironment and immune evasion mechanisms-continues to limit its clinical efficacy. This challenge underscores the need to explore innovative approaches, such as multimodal immunotherapy. Phytochemicals, bioactive compounds derived from plants, have emerged as promising candidates for overcoming these barriers due to their immunomodulatory and antitumor properties.

N-acetylglucosaminyl 1-phosphate transferase (GPT) is a facilitator in Bombyx mori Nucleopolyhedrovirus proliferation.

GPT is a conserved ER-resident transmembrane protein that catalyzes the initial step of protein N-glycosylation in vertebrates. However, to date, there have been no reports on GPT in silkworms. In the present study, we identified a GPT ortholog in the B.

Chlorin e6: a promising photosensitizer of anti-tumor and anti-inflammatory effects in PDT.

Photodynamic therapy (PDT) involves the activation of photosensitizers (PSs) by visible laser light at the target site to catalyze the production of reactive oxygen species, resulting in tumor cell death and blood vessel closure. The efficacy of PDT depends on the PSs, the amount of oxygen, and the intensity of the excitation laser. PSs have been extensively researched, and great efforts have been made to develop an ideal photosensitizer.

Butyrolactone I blocks the transition of acute kidney injury to chronic kidney disease in mice by targeting JAK1.

Chronic kidney disease (CKD) is a disease that affects more than 850 million people. Acute kidney injury (AKI) is a common cause of CKD, and blocking the AKI-CKD transition shows promising therapeutic potential. Herein, we found that butyrolactone I (BLI), a natural product, exerts significant nephroprotective effects, including maintenance of kidney function, inhibition of inflammatory response, and prevention of fibrosis, in both folic acid- and ureteral obstruction-induced AKI-CKD transition mouse models.

Aspergixanthones L-T, nine undescribed prenylxanthone derivatives from Aspergillus stellatus.

Nine undescribed prenylxanthone derivatives, aspergixanthones L-T (1-9), were isolated from the fungus Aspergillus stellatus. Compound 4 represents the first propionylated prenylxanthone, while compounds 7-9 are the first examples of prenylxanthones adorned with a 2,3-butanediol group. Their structures with absolute configurations were elucidated based on comprehensive spectroscopic analyses, ECD calculation, single-crystal X-ray diffraction, Mo(OAc) induced ECD experiment, and Mosher's method.

Lingguizhugan Decoction in the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.

Objective: This study systematically evaluated the efficacy and safety of Ling Gui Zhu Gan Decoction for treating non-alcoholic fatty liver disease.

Methods: Registered under CRD42024501460 on the PROSPERO platform, we searched eight major databases, including Web of Science, PubMed, Cochrane, Embase, China National Knowledge Infrastructure, Wanfang database, Chinese Scientific Journals Database, and Chinese Biomedicine Database, from inception to December 2023 for randomized controlled trials on Ling Gui Zhu Gan Decoction in non-alcoholic fatty liver disease treatment. We extracted data on total efficiency, TC, TG, ALT, AST, GGT, and HOMA-IR, analyzing results with RevMan 5.

[Serum metabolomics reveals effects of standard decoction and formula granules of Paeoniae Radix Rubra on rat model of heat toxin and blood stasis].

This study aims to compare the effects and mechanisms of the standard decoction and formula granules of Paeoniae Radix Rubra in regulating the metabolism in the rat model of heat toxin and blood stasis. SD rats were randomized into control, model, standard decoction, and formula granules groups. After 14 days of administration, the rats in the latter three groups were subjected to subcutaneous injection with carrageenan and intraperitoneal injection with bacterial lipopolysaccharide for the modeling of heat toxin and blood stasis.

Cell membrane fusion composite lipid nanocarrier: preparation and evaluation of anti-tumor effects.

With the advancements in nanotechnology and biomaterials science, the development of nanodrug delivery systems (Nano-DDSs) has provided opportunities for the realization of precise targeted treatment of malignant tumors. Liposomes have become a type of DDS with early clinical application and mature development due to their excellent tissue-targeting capacity and outstanding biocompatibility. However, several obstacles remain, such as recognition and clearance by the immune system, a short half-life, and poor tumor targeting.

Artificially Modified NK Cell-Based Synergistic Immuno-Gene-Photodynamic Therapy for Cancer.

Background: The immunotherapeutic approach utilizing Natural Killer (NK) cells for cancer treatment has garnered significant interest owing to its inherent cytotoxicity, immunomodulatory properties, demonstrated safety in in vivo studies. However, multiple immunosuppressive mechanisms in the tumor microenvironment (TME) suppress the anticancer effect of NK cells in the treatment of solid tumors. Herein, a smart NK cell drug delivery system (DDS) with photo-responsive and TME-responsive properties was designed.

Nickel-Induced Dual Carbon Networks Encapsulating Phase Change Materials for Photothermal Conversion and Storage.

Bifunctional phase change materials (PCMs) with efficient energy storage and photothermal conversion capabilities have tremendous potential to be applied in advanced thermal management. However, classical organic PCMs with high latent heat are challenged by poor light harvesting, low thermal conductivity, and leakage risks. Here, we design a unique dual-carbon network with Ni nanoparticles (NPs), confined carbon nanotubes (CNTs) shuttling in carbon honeycombs (CH), namely, CH@Ni-CNTs, to encapsulate paraffin wax (PW) that can facilitate the light capture and photothermal conversion dynamics.

Current views on mechanisms of the FLASH effect in cancer radiotherapy.

FLASH radiotherapy (FLASH-RT) is a new modality of radiotherapy that delivers doses with ultra-high dose rates. The FLASH effect was defined as the ability of FLASH-RT to suppress tumor growth while sparing normal tissues. Although the FLASH effect has been proven to be valid in various models by different modalities of irradiation and clinical trials of FLASH-RT have achieved promising initial success, the exact underlying mechanism is still unclear.

Epigenetic changes driven by environmental pollutants in lung carcinogenesis: a comprehensive review.

Lung cancer remains the leading cause of cancer-related mortality globally, with environmental pollutants identified as significant risk factors, especially for nonsmokers. The intersection of these pollutants with epigenetic mechanisms has emerged as a critical area of interest for understanding the etiology and progression of lung cancer. Epigenetic changes, including DNA methylation, histone modifications, and non-coding RNAs, can induce alterations in gene expression without affecting the DNA sequence and are influenced by environmental factors, contributing to the transformation of normal cells into malignant cells.

Advances in mesenchymal stem cell-centered stem cell therapy in the treatment of hypoxic-ischemic injury.

Hypoxic-ischemic brain damage (HIBD) is a leading cause of neonatal death and neurological dysfunction for which no particularly effective treatment is available. Stem cells possess multi-directional differentiation potential and can secrete a variety of cytokines. They not only have the ability to replace tissue and repair lesions but also improve neurological damage caused by HIBD through paracrine mechanisms, including anti-apoptosis, reduction of inflammation, and promotion of endogenous repair.