Notoginsenoside R1 attenuates tendinopathy through inhibiting inflammation and matrix metalloproteinases expression.

Research Purpose: The purpose of this study is to demonstrate the effectiveness of Notoginsenoside R1 (NGR1) in treating tendinopathy and to reveal its potential mechanisms.

Materials And Methods: This study performed a preliminary network-based assessment of the potential targets that NGR1-associated in the treatment of tendinopathy, which includes PPI network analysis, GO enrichment, KEGG pathway enrichment analysis, and molecular docking. The therapeutic efficacy of NGR1 was then assessed using a collagenase-induced rat model of tendinopathy.

Tailoring polysaccharide tanning agents with a broad molecular weight distribution from corncob biomass: A dual solution for sustainable leather processing and waste valorization.

The shift toward chromium-free eco-leather manufacturing has spurred interest in biomass-based tanning agents. However, their suboptimal molecular size and poor solubility hinder effective leather penetration. In this study, biomass-derived tanning agents were developed from corncob hemicellulosic polysaccharides (CPs) with tailored molecular weights, isolated via alkali extraction and acid-alcohol precipitation, followed by partial epoxidation.

Association of SIRT6 Expression With Risk of Pneumonitis Induced by Radiotherapy in Cancer Patients.

Thoracic tumours represent a significant proportion of malignant cancers. While radiotherapy (RT) improves prognosis, it can also lead to side effects such as radiation-induced pneumonitis (RP). Since SIRT6 is involved in DNA repair, energy metabolism and inflammation, this study aims to investigate the expression of SIRT6 in lymphocytes as a potential biomarker and therapeutic target for RP.

Gelatin-Induced Synthesis of Strain-Engineered Spherical CuO Nanoparticles for Efficient Nitrate Reduction to Ammonia.

The electrochemical reduction of nitrate to ammonia offers an environmentally sustainable pathway for nitrogen fixation. However, achieving both efficiency and selectivity in nitrate reduction presents a formidable challenge, due to the involvement of sluggish multielectron transfer processes. Herein, the successful synthesis of spherical Cu₂O nanoparticles (s-Cu₂O) exhibiting significant compressive strain effects, achieved through a one-pot method using gelatin as a structural modifier, is reported.

[Early clinical efficacy study on the efficacy of a three-stage conservative Chinese medicine external treatment for acute lateral ankle ligament injuries].

Objective: To evaluate the clinical effect of a new three-phase Chinese medicine (CM) external treatment for acute lateral ankle ligament injuries.

Methods: From July to December 2023, 64 patients with acute lateral ankle ligament injuries were randomly assigned to receive either the new three-phase CM external treatment combined with the POLICE(protect, optimal loading, ice, compression, elevation) treatment (observation group) or the POLICE treatment (control group), with 32 cases in each group. The observation group consisted of 17 males and 15 females, with an average age of(30.

Atomic-scale Ru anchored on chromium-shavings as a precursor for a pH-universal hydrogen evolution reaction electrocatalyst.

In the leather manufacturing industry, the management of substantial quantities of solid waste containing chrome shavings remains a formidable challenge. Concurrently, there is a pressing need for the development of pH-universal and economically viable electrocatalysts for the hydrogen evolution reaction (HER). In response to these intertwined challenges, this study proposes an innovative approach wherein the amino groups present on the surface of chrome shavings are utilized to immobilize single ruthenium atoms during pyrolysis, thereby facilitating the synthesis of hydrogen evolution electrocatalysts.

Masking Strategy Constructed Metal Coordination Hydrogels with Improved Mechanical Properties for Flexible Electronic Sensors.

Metal coordination hydrogels (MC-HGs) that introduce dynamically coordinate bonds together with metal ionic conduction have attracted considerable attention in flexible electronics. However, the traditional method alleged to have technical scalability faces the challenge of forming MC-HGs with a "core-shell" structure, which undoubtedly reduces the whole mechanical properties and ionic stimulation responsiveness required for flexible electronics materials. Herein, a novel strategy referred to as "masking" has been proposed based on the theory of the valence bond and coordination chemistry.

Development of an activatable Lysosome-targeted fluorescent probe for the detection of endogenous ONOO levels.

The liver plays a crucial role in several important processes in the human body, including metabolism, detoxification, and immune function. When the liver experiences acute injury, it can cause significant harm and requires prompt detection. Traditional biomarkers lack specificity and cannot detect changes in real-time, making them unsuitable for monitoring pathological processes.

High-value utilization of Cr-containing sludge: Eco-friendly and ultra-low-cost electrocatalyst for efficient OER in alkaline media from Cr-containing sludge.

Economically sustainable development requires more viable waste recycling solutions. In this context, we address the problem of utilizing chromium-containing sludge, a prevalent and environmentally hazardous waste. Meanwhile, sustainable energy development must develop ecology-friendly and low-cost electrocatalysts for the oxygen evolution reaction (OER) in alkaline media.

Self-assembled nano-particles of chitosan amphiphilic derivative for formaldehyde fluorescent detection and its application in test strips.

Excessive levels of formaldehyde (FA) represent serious health risks. Aiming at the detection of formaldehyde content, this paper proposes a self-assembly method of proportional nanoprobes. Spherical nanoparticles (NPs) were prepared by one-step condensation reaction between rhodamine B (RhB) and chitosan (CS).

Intelligent detection strategy and bioimaging application of dual-responsive Hg and ONOO using near-infrared probes.

Mercury is a highly toxic heavy metal pollutant. Mercury and its derivatives pose serious threats to the environment and the health of organisms. Numerous reports have indicated that Hg exposure induces a burst of oxidative stress in organisms, causing severe damage to the health of the organism.

Facile degradation of chitosan-sodium alginate-chromium (III) gel in relation to leather re-tanning and filling.

Natural polysaccharide hydrogel, exemplified by chitosan‑sodium alginate (CS-SA), has been prevailing in adsorption of chromium (III) (Cr(III)) containing contaminant. However, the traditional desorption of CS-SA-Cr(III) to recycle the adsorbent faces the problems including chemical desorbents secondary pollution, resource waste of the terminal CS-SA adsorbents, and tedious work of reusing the desorbed Cr(III). Herein, the adsorption product, CS-SA-Cr(III) gel, was degraded to CS/SA/Cr(III) sol and applied in leather re-tanning and filling processes directly.

Converting commonly-used paper into nano-engineered fluorescent biomass-based platform for rapid ClO quantitative detection in living cells and water sources.

Hypochlorous acid (HClO) and derivative ionic form (ClO) are significant components of reactive oxygen species, and thus various diseases are correlatively related to the concentration of ClO. Recently, paper-based indicators have been confirmed to be efficient strategy for sensing hazardous and noxious substances. However, most of these materials can only achieve qualitative detection of the substrates.

A Schiff-based AIE fluorescent probe for Zn detection and its application as "fluorescence paper-based indicator".

A Schiff-based aggregation induced emission (AIE) fluorescent probe with excited intramolecular proton transfer (ESIPT) mechanism was synthesized by grafting 2-hydrazinobenzothiazole onto 2,6-diformyl-4-methylphenol. The probe recognizes Zn selectively and sensitively, accompanied by a significant fluorescence emission increasement change from light yellow-green to strong green. Additionally, a stabilization time of at least 30 min was kept in the recognition process.

Comparative efficacy of osteochondral autologous transplantation and microfracture in the knee: an updated meta-analysis of randomized controlled trials.

Introduction: More than 19% of patients undergoing knee arthroscopies suffers from articular cartilage defects. The chondral or osteochondral lesion has negative impacts on the knee joints function and the life quality of patients. However, the treatment remains challenging as hyaline cartilage is not renewable.

[Comparison of the efficacy between open and arthroscopic Latarjet procedure in the treatment of anterior shoulder instability:a Meta-analysis].

Objective: To compare the clinical efficacy between open and arthroscopic Latarjet procedure in the treatment of anterior shoulder instability by using Meta-analysis.

Methods: Search PubMed, Medline, Embase, Cochrane, China National Knowledge Infrastructure(CNKI), Wanfang database, China Biological Literature system(CBM) and VIP database. Review all retrospective or prospective cohort studies and randomized controlled trials on open and arthroscopic Latarjet procedure for anterior shoulder instability.

A novel chemosensor for the distinguishable detections of Cu and Hg by off-on fluorescence and ratiometric UV-visible absorption.

A novel dual-functional chemosensor, derived from the conjugation of rhodamine B with a quinoline derivative (RHQ), was firstly synthesized with high efficiency and cost-effectiveness for the distinguishable detections of Cu and Hg via ring-opening and ring-forming mechanism. The chemosensor exhibits highly selective and distinguishable responses for Cu and Hg in CHCN-HO (4:1, v/v) with off-on fluorescence and ratiometric ultraviolet-visible (UV-Vis) absorption changes. Additionally, Cu is identified by opening a rhodamine spirocycle with a UV-Vis absorption band, at around 560 nm and fluorescence turn-on.

One-pot preparation of a multi-functional enzymatically generated gelatin hydrogel with controllable antibacterial and hemorheological properties.

The creation of multi-functional bio-hydrogels with tunable properties that meet in vivo demands is significant but remains challenging. Inspired by host-guest chemistry, a novel multi-functional gelatin-based bio-hydrogel with tunable antibacterial and hemorheological properties (TAH-GEL) is synthesized via an in situ one-pot strategy. TAH-GEL not only exhibits excellent mechanical properties but also shows promising self-healing and bio-compatibility features.

A dual-channel chemosensor based on 8-hydroxyquinoline for fluorescent detection of Hg and colorimetric recognition of Cu.

A novel dual-channel chemosensor, 7-allylquinolin-8-ol (AQ), was synthesized based on 8-hydroxyquinoline for selective fluorescence detection of Hg and colorimetric recognition of Cu. The chemosensor reacted with Hg and generated a new Hg-containing compound with significantly enhanced fluorescence, which turned from faint blue to strong green. Further experiments indicated that AQ could be used to quantitatively detect Hg via fluorescence spectroscopy with a low detection limit (2.

Radii-dependent self-assembly of chiral lanthanide complexes: synthesis, chirality, and single-molecule magnet behavior.

A pair of 3-methoxysalicylhydrazone-based homochiral ligands constructed chiral trinuclear and pentanuclear complexes with La and Dy ions, respectively, which indicates that the radii controlled the self-assembled structures. Chiral transfer during the self-assembly processes was confirmed by crystal structure analysis and CD spectroscopy. Then, magnetic investigations demonstrated that the chiral Dy complexes exhibited typical single-molecule magnet behavior.

Developing super tough gelatin-based hydrogels by incorporating linear poly(methacrylic acid) to facilitate sacrificial hydrogen bonding.

Mechanically robust protein-based hydrogels are strongly desired but their construction remains a significant challenge. In this work, gelatin, together with methacrylic acid, is used to construct a novel hydrogen-bonded hydrogel through a facile low-temperature polymerization and a subsequent dry-swell process. The obtained gel is extremely stiff and tough with a high Young's modulus and a fracture energy of 11 MPa and 8.