Disassembly of chiral hydrogen-bonded frameworks into single-unit organometallic helices for enantioselective amyloid inhibition.

Chiral nanostructures hold transformative potential across diverse fields, yet their assembly construction remains hindered by the high entropic barrier of dissymmetric building units. Inspired by biological structural dynamics, we construct two chiral copper-based hydrogen-bonded frameworks [D(L)-Cu-crystals] via hydrogen-bonded assembly using chiral metal-organic helical as the building unit. Single-crystal X-ray diffraction elucidates hierarchical chirality evolution from asymmetric coordinations to helical chains and framework packing.

Minimized Δ: drive thermally activated delayed fluorescence materials in photodynamic therapy.

The energy gap (Δ) between the singlet state (S) and the triplet state (T) and the T lifetime are important factors in determining the efficiency of photodynamic therapy (PDT). Owing to intersystem crossing (ISC) between S and T, a smaller Δ becomes a key factor in the design of photosensitizers (PSs). Attractively, thermally activated delayed fluorescence (TADF) materials exhibit a small Δ, fully utilizing photon energy and achieving simultaneous improvement in both the energy gap and lifetime.

Remote AI Screening for Parkinson's Disease: A Multimodal, Cross-Setting Validation Study.

PARK is a web-based artificial intelligence (AI) tool for remote screening of Parkinson's disease (PD) using video and audio recordings of speech, facial expression, and motor tasks performed via webcam. The study draws on data from 1,865 participants across diverse global demographics and recording environments, including supervised clinical settings and unsupervised home use. On three independent test sets (n=389; 188 with PD), PARK achieved strong predictive performance on classifying individuals with and without PD, with accuracy ranging from 80.

Lysosome Escape and Golgi Apparatus Accumulation Drive Robust Pyroptosis Based on Sulfhydryl-Inspired Aggregation-Induced Emission Photosensitizers.

The prolonged residence time of photosensitizers (PSs) at the subcellular compartment was proposed as a smart approach to enhance the efficiency of oxidative damage in photodynamic therapy. However, before reaching an interested organelle, small molecules during the internalization process suffered acidic conditions and hydrolases in lysosomes, which finally hindered more than 90% when arriving into targets. Herein, we synthesized a small-molecule PS (BTF-DNBS) with GSH-activatable tumoral identification, lysosome-escape, and Golgi apparatus-triggered pyroptosis.

Construction of balanced-transition AIE phototherapeutic agents based on a fluorination strategy for prolonged triplet excited state lifetime.

To solve the competitive energy decay pathways in photodynamic therapy (PDT) and photothermal therapy (PTT), herein, we proposed a fluorination strategy of AIE photosensitizers, which exhibited high ROS generation and heat release. Innovatively, femtosecond transient absorption spectroscopy has emerged to verify the extension of triplet excited state lifetime induced by C-F bonds. In order to improve its hydrophilicity and targeting ability, GSH-responsive nanogel HPCF was constructed, which presented controllable release of TPAF.

Microdroplet Surface Drives and Accelerates Proton-Controlled, Size-Dependent Nitrate Photolysis.

Particulate nitrate photolysis regenerates reactive oxidized nitrogen species (HONO and NO) in the atmosphere, influencing tropospheric ozone, atmospheric oxidation capacity, and particulate matter formation. However, reported nitrate photolysis rates vary by orders of magnitude, and the roles of protons and the air-water interface in accelerating nitrate photolysis in deliquesced aerosols (i.e.

Pregnane X receptor attenuates gold nanoparticles' toxicity through accelerating zebrafish embryo hatching.

It is well known that fish embryos are vulnerable to waterborne nanoparticles (NPs), with delayed hatching being the most common and sensitive endpoint. Up-regulation of hatching enzymes has been believed to be an important detoxification mechanism for NPs, but the inner mechanism for such phenomena has been seldom investigated. This study aimed to investigate the role of pregnane X receptor (Pxr) in maintaining the robustness of embryo hatching after treatment with gold nanoparticles (AuNPs, 4 and 82 nm).

pH-responsive carbohydrate polymer-based nanoparticles in cancer therapy.

Using the specific features of the tumor microenvironment (TME) for the development and design of novel nanomaterials can improve the capacity in tumor suppression. One of the prominent features of the TME is the mild acidic pH. Therefore, the development of pH-responsive nanoparticles can lead to the release of cargo and therapeutics at the tumor site, improving the selectivity and specificity.

Optimizing the production and efficacy of antimicrobial bioactive compounds from in combating multi-drug-resistant pathogens.

Background: The rise of antibiotic-resistant pathogens has intensified the search for novel antimicrobial agents. This study aimed to isolate from local soil samples and evaluate its antimicrobial properties, along with optimizing the production of bioactive compounds.

Methods: Soil samples were collected from local regions, processed, and analysed for Streptomyces strains isolation using morphological characteristics and molecular identification through 16S rRNA gene PCR assay.

Correction: Potentiating light-harvesting tactics through an A-D-A structure: repolarization of tumor-associated macrophages through phototherapy.

Correction for 'Potentiating light-harvesting tactics through an A-D-A structure: repolarization of tumor-associated macrophages through phototherapy' by Pai Liu , , 2024, , 7870-7878, https://doi.org/10.1039/D4TB00814F.

Cooperative Multiscale-Assembly for Directional and Hierarchical Growth of Highly Oriented Porous Organic Cage Single-Crystal Microtubes and Arrays.

The directional assembly of porous organic molecules into long-range ordered architectures, featuring controlled hierarchical porosity and oriented pore channels with defined spatial arrangements, is a fundamental challenge in chemistry and materials science. Herein, using porous organic cages as starting units, we present a cooperative multiscale-assembly strategy enabling the simultaneous alignment of pore channels and directional hierarchical growth in a single step. At the microscopic level, we employed double solvents to manipulate the intermolecular packing of microporous tetrahedral [4+6] imine cages (CC1 and CC3), resulting in pore channel orientation.

Relative burden of cancer and noncancer mortality among long-term survivors of differentiated thyroid cancer in the US.

Background: Limited information is available regarding the relative risks of cancer-specific mortality and noncancer-specific mortality among long-term survivors with differentiated thyroid cancer (DTC).

Methods: In this retrospective study, nationwide data from the Surveillance, Epidemiology, and End Results database (1992-2020) were utilized. The Accelerated Failure Time Model was applied to calculate Survival Time Ratios (TR), with the primary focus on mortality resulting from DTC.

Inverted All-Inorganic Nanorod-Based Light-Emitting Diodes via Electrophoretic Deposition.

High performance and high stability in all-inorganic solution processed nanocrystal-based light-emitting diodes (LEDs) are highly attractive for large area devices compared to organic material-based LEDs. In this work, an inverted all-inorganic LED structure is designed to have an easy integration with thin-film transistors. Adopting robust inorganic materials such as Ni O nanoparticle films as a hole transport layer (HTL) is beneficial for the performance of LED.

Genetic landscape of ESBL producing international clone ST410 of from pediatric infections in Shenzhen, China.

Background: The emergence of ESBLs producing cephalosporin-resistant isolates poses a threat to public health. This study aims to decipher the genetic landscape and gain insights into ESBL-producing strains belonging to the high-risk clone ST410 from pediatric patients.

Methods: 29 ST410 isolates were collected from young children and subjected to antimicrobial susceptibility testing, Whole-genome sequencing (WGS), serotype analysis, MLST, ESBL genes, virulence genes, and plasmid profiling.

Potentiating light-harvesting tactics through an A-D-A structure: repolarization of tumor-associated macrophages through phototherapy.

Aiming to decrease the recurrence of tumors and achieve patient satisfaction, the elicitation of immunotherapy and its integrated synergistic employment is a bright new direction in oncotherapy, yet an emergently challenging task. In particular, tumor-associated macrophage (TAM) regulation though light-induced photodynamic and photothermal therapy (PDT and PTT) is regarded as a powerful approach, which focuses on the systemic immune system instead of the tumor itself. Herein, this study reports an acceptor-donor-acceptor (A-D-A) aggregation-induced emission luminogen (AIEgen), named TPA-2CN, which was applied as a photosensitizer (PS) and photothermal agent (PTA).

A Terbium Ion-Based Dual-Ligand Fluorescent Probe for Highly Selective and Sensitive Detection of Cu Ions.

In this study, a fluorescent probe (GMP-Tb-SSA) utilizing lanthanide coordination polymer nanoparticles, GMP-Tb, as a sensing platform, and 5-sulfosalicylic acid (SSA) as a cofactor ligand was proposed for the detection of copper ions (Cu). GMP-Tb was synthesized by the self-assembly of guanine monophosphate (GMP) and terbium ion (Tb), and SSA was introduced as a sensitizer into the GMP-Tb network. Cu could efficiently inhibit the electron transfer from the ligand GMP to the central ion, Tb, leading to a significant quench of fluorescence of Tb.

A Retrospective Cohort Study on Infection: Clinical Trends and Treatment Outcomes for Congenital Syphilis in Guangxi, China (2013-2023).

Background: Syphilis, a prevalent sexually transmitted infection, poses severe risks, especially during pregnancy. This study aimed to elucidate the trends and impacts of syphilis in Guangxi, China, focusing on prevalence, clinical manifestations, and treatment outcomes in pregnant women and newborns. The objectives included understanding the demographic characteristics of affected pregnant women, analysing the clinical manifestations in newborns, and assessing the effectiveness of the treatment protocol.

Sonodynamic Therapy-Driven Immunotherapy: Constructing AIE Organic Sonosensitizers Using an Advanced Receptor-Regulated Strategy.

Benefit from the deeper penetration of mechanical wave, ultrasound (US)-based sonodynamic therapy (SDT) executes gratifying efficacy in treating deep-seated tumors. Nevertheless, the complicated mechanism of SDT undeniably hinders the exploration of ingenious sonosensitizers. Herein, a receptor engineering strategy of aggregation-induced emission (AIE) sonosensitizers (TPA-Tpy) with acceptor (A)-donor (D)-A' structure is proposed, which inspects the effect of increased cationizations on US sensitivity.

Comparative analysis of the intestinal flora of BmNPV-resistant and BmNPV-sensitive silkworm varieties.

Bombyx mori nucleopolyhedrovirus (BmNPV) is a very common and infectious virus that affects silkworms and hinders silk production. To investigate the intestinal flora of BmNPV-resistant and BmNPV-sensitive silkworm varieties, 16 S rDNA high-throughput sequencing was performed. The results of the cluster analysis showed that the intestinal flora of the resistant silkworm variety was more abundant than that of the sensitive silkworm variety.

Effect of 23‑hydroxybetulinic acid on lung adenocarcinoma and its mechanism of action.

The present study aimed to investigate the effect and mechanism of Pulsatilla compounds on lung adenocarcinoma. The representative drug chosen was the compound 23-HBA. GeneCards, Swiss target prediction, DisGeNET and TCMSP were used to screen out related genes, and MTT and flow cytometry assays were used to verify the inhibitory effect of Pulsatilla compounds on the proliferation of lung adenocarcinoma cells.

Decoupling of nitrogen allocation and energy partitioning in rice after flowering.

Estimation of energy partitioning at leaf scale, such as fluorescence yield (ΦF) and photochemical yield (ΦP), is crucial to tracking vegetation gross primary productivity (GPP) at global scale. Nitrogen is an important participant in the process of light capture, electron transfer, and carboxylation in vegetation photosynthesis. However, the quantitative relationship between leaf nitrogen allocation and leaf energy partitioning remains unexplored.