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The human microbiome, a dynamic ecosystem within the gastrointestinal tract, plays a pivotal role in shaping overall health. This review delves into six interconnected sections, unraveling the intricate relationship between diet, gut microbiota, and their profound impact on human health. The dance of nutrients in the gut orchestrates a complex symphony, influencing digestive processes and susceptibility to gastrointestinal disorders. Emphasizing the bidirectional communication between the gut and the brain, the Brain-Gut Axis section highlights the crucial role of dietary choices in physical, mental, and emotional well-being. Autoimmune diseases, particularly those manifesting in the gastrointestinal tract, reveal the delicate balance disrupted by gut microbiome imbalances. Strategies for reconciling gut microbes through diets, precision nutrition, and clinical indications showcase promising avenues for managing gastrointestinal distress and revolutionizing healthcare. From the Low-FODMAP diet to neuro-gut interventions, these strategies provide a holistic understanding of the gut's dynamic world. Precision nutrition, as a groundbreaking discipline, holds transformative potential by tailoring dietary recommendations to individual gut microbiota compositions, reshaping the landscape of gastrointestinal health. Recent advancements in clinical indications, including exact probiotics, fecal microbiota transplantation, and neuro-gut interventions, signify a new era where the gut microbiome actively participates in therapeutic strategies. As the microbiome takes center stage in healthcare, a paradigm shift toward personalized and effective treatments for gastrointestinal disorders emerges, reflecting the symbiotic relationship between the human body and its microbial companions.
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http://dx.doi.org/10.3389/fnut.2024.1395664 | DOI Listing |
PLoS One
September 2025
Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Background: Metabolic syndrome (MetS) and sarcopenia are major global public health problems, and their coexistence significantly increases the risk of death. In recent years, this trend has become increasingly prominent in younger populations, posing a major public health challenge. Numerous studies have regarded reduced muscle mass as a reliable indicator for identifying pre-sarcopenia.
View Article and Find Full Text PDFDiabetologia
September 2025
Centre Universitaire de Diabétologie et de ses Complications, AP-HP, Hôpital Lariboisière, Paris, France.
Aims/hypothesis: Severe hypoglycaemia events (SHE) remain frequent in people with type 1 diabetes despite advanced diabetes technologies. We examined whether time below range (TBR) 3.9 mmol/l (70 mg/dl; TBR70) or 3.
View Article and Find Full Text PDFFuture Oncol
September 2025
Medical Oncology Unit, Comprehensive Cancer Centre, AUSL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Background: Esophageal cancer is a rare neoplasm, with more than 0.6 million new cases and 0.54 million deaths worldwide in 2020.
View Article and Find Full Text PDFFood Res Int
November 2025
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, Jiangsu, China.
Cognitive disorders, a rapidly growing public health concern, can be prevented by a healthy diet. Several studies have shown that protein intake is a key modulator of cognitive function. The development of precision nutrition has allowed the study of specific amino acids within proteins, with many studies reporting that the level of methionine (Met) intake plays a central role in modulating cognitive function.
View Article and Find Full Text PDFFood Res Int
November 2025
College of Agriculture, Henan University, Kaifeng 475004, China; School of Food and Pharmacy, Xuchang University, Xuchang 461000, China. Electronic address:
High- and low-protein diets have long been debated for their effects on body fat accumulation, which may stem from neglecting interactions with other macronutrients. This study investigates how the dietary carbohydrate-to-protein caloric ratio (CPCR) affects hepatic fat deposition via the IGF-1/PI3K/Akt signaling pathway. Within an isocaloric dietary framework, we evaluated the effects of varying CPCR (dietary fat held constant at 10 %) on hepatic fat accumulation in Sprague-Dawley rats over 8 weeks.
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