LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer.

Background: Cuproptosis, a copper-dependent form of regulated cell death, has emerged as a redox-sensitive vulnerability in cancer. However, the molecular basis by which this process is initiated and sustained in tumors remains poorly defined.

Methods: We investigated the functional role of FDX1 in cuproptosis in colorectal cancer through a series of in vivo and in vitro assays.

Research on the electro-magnetic-thermal-mechanical characteristics of shearer cables.

Cables provide power and control signals for the shearer, playing a crucial role in ensuring the reliable operation of the shearer. Utilizing MCP0.66-1.

Downregulated NT-3 and PI3K/AKT signaling pathway mediates arsenic-induced apoptosis in hippocampal neurons in vivo and in vitro.

Arsenic is a neurotoxin associated with cognitive impairment following long-term exposure, while Neurotrophin-3 (NT-3) is essential for the survival and development of neurons. This study aims to explore the protective effects of NT-3 on arsenic-caused cognitive impairment and neuronal damage, as well as clarify the underlying mechanisms. In vivo and in vitro results indicated that sodium arsenite impaired cognitive function, reduced neuronal density, and induced apoptosis, which was accompanied by the down-regulation of NT-3 and the PI3K/AKT pathway.

OGG1S326C variant frequent in human populations facilitates inflammatory responses due to its extended interaction with DNA substrate.

8-oxoguanine (8-oxoGua) is one of the most frequent forms of oxidative DNA base lesions, repaired by 8-oxoguanine DNA glycosylase 1 (OGG1) via base excision repair (BER) pathway to maintain genome fidelity. The human allelic variant , prevalent in Caucasians and Asians, has been regarded as a susceptibility factor for various diseases, yet its pathogenic mechanism remains elusive. In this study, we demonstrate that mice exhibit increased and sustained airway inflammation compared with wild-type (WT) mice.

An inter-city input-output database distinguishing firm ownership in the Greater China area during 2002-2017.

Most multi-region input-output (MRIO) tables in China focus on provinces or urban agglomerations and ignore the tremendous geographical heterogeneities of economic activities across Chinese prefectural cities, where regional economic centres are usually located for domestic and global production. This paper constructs an inter-city input-output (IO) database with 42 sectors in the Greater China area. Compared with previous MRIO tables, it has three important features: (1) A complete coverage of Chinese cities, including 335 prefectural cities, four municipalities, and Hong Kong, Macao, and Taiwan; (2) Distinguishes three types of firm ownership for every city and sector for four benchmark years; (3) A novel data completion approach to reconcile all accessible micro-level data with city and provincial-level aggregate statistics, and effectively combining the bottom-up and top-down methods commonly used in the MRIO compilation literature.

TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis.

TAK1 is a serine/threonine protein kinase that is a key regulator in a wide variety of cellular processes. However, the functions and mechanisms involved in cancer metastasis are still not well understood. Here, we found that TAK1 knockdown promoted esophageal squamous cancer carcinoma (ESCC) migration and invasion, whereas TAK1 overexpression resulted in the opposite outcome.

Advances in environmental pollutant detection techniques: Enhancing public health monitoring and risk assessment.

Accurate detection and monitoring of environmental pollutants are of paramount importance for disease prevention and public health. In recent years, the ever-expanding human activities and industrial production have given rise to a sharp increase in the complexity and variety of these pollutants, which pose significant threats to human well - being. Environmental pollutants stem from multiple sources, such as heavy metals, persistent organic pollutants, inorganic non - metallic pollutants, emerging pollutants, and biological contaminants.

Abcb1 is involved in the efflux of trivalent inorganic arsenic from brain microvascular endothelial cells.

Arsenic (As) can penetrate brain tissue through the blood-brain barrier (BBB), and the ATP-binding cassette subfamily B member 1 (Abcb1) has been shown to facilitate the transport of inorganic arsenic (iAs) in animal liver, small intestine, and yeast. However, the relationship between Abcb1 and BBB has not been reported, and the mechanism of brain microvascular endothelial cells Abcb1 on the transport of iAs needs to be further studied. Increased arsenic levels were observed in mice exposed to 25 mg/L or 50 mg/L of sodium arsenite (NaAsO) in drinking water, and both arsenic uptake and efflux were detected in bEnd.

Preparation of novel membranes with multiple hydrogen bonding sites and π-conjugated structure for high temperature proton exchange membrane fuel cells.

A novel poly(dibenzofuran isatin) (PBFI) with π conjugated structure was synthesized. Through the facile ring-opening reaction, flexible and hydrophilic side chains with hydroxyl and quaternary ammounium groups were grafted into PBFI. Obtained PBFI-%GTA membranes with twisted polymer structure and multiple hydrogen bonding sites displayed high HT-PEMFC performance.

Coal falling trajectory and strength analysis of drum of shearer based on a bidirectional coupling method.

The cutting and crushing of coal and rock containing gangue is the result of the coupling effect of multiple factors. The geometric parameters of the working mechanism, the kinematic parameters of the shearer, and the physical and mechanical properties of the coal and rock to be cut all affect the cutting and crushing process of the shearer. To study the coal falling trajectory of cutting coal and rock using a spiral drum, optimal cutting parameters were obtained, efficient cutting using a spiral drum was achieved, and analysis of the coal falling trajectory and strength of the drum of a shearer based on bidirectional coupling technology was proposed based on particle discrete element contact theory and virtual prototype technology.

Positive Association of Urinary Dimethylarsinic Acid (DMA) with Serum 25(OH)D in Adults Living in an Area of Water-Borne Arsenicosis in Shanxi, China.

Limited studies have demonstrated that inorganic arsenic exposure is positively associated with serum vitamin D levels, although the correlation between urinary arsenic species and serum vitamin D has not been investigated in areas of water-borne arsenicosis. A cross-sectional study of 762 participants was conducted in Wenshui Country, Shanxi Province, a water-borne arsenicosis area. The results showed a positive relationship between urinary arsenic species (inorganic arsenic (iAs), methylarsonic acid (MMA), dimethylarsinic acid (DMA) and serum 25(OH)D.

The disruption of blood-brain barrier induced by long-term arsenic exposure is associated with the increase of MMP-9 and MMP-2: The characteristics are similar to those caused by senescence.

Accumulating evidence suggests that Matrix metalloproteinase-9 (MMP-9) and -2 (MMP-2) are involved in the neuropathological processes by contributing to breaking the extracellular matrix and the tight junctions that constitute the blood-brain barrier (BBB). However, the influences of arsenic (As) on these two MMPs were inconsistent. In the cross-sectional study of 500 adults, serum MMP-2 and MMP-9 positively correlated with urine arsenic.

Association between ADAMTS14_rs4747096 gene polymorphism and bone mineral density of Chinese Han population residing in fluorine exposed areas in ShanXi Province, China.

This study aimed to investigate the effects of fluorine and ADAMTS14_rs4747096 on bone mineral density (BMD). The survey was explored in a cross-sectional case-control study conducted in Shanxi, China. The BMD was measured by an ultrasonic bone mineral density instrument.

Association between arsenic (+3 oxidation state) methyltransferase gene polymorphisms and arsenic methylation capacity in rural residents of northern China: a cross-sectional study.

Arsenic is a toxic metal-like element. The toxic reaction of the body to arsenic is related to the ability of arsenic methylation metabolism. As the rate-limiting enzyme of arsenic methylation metabolism, the genetic single nucleotide polymorphisms (SNPs) of arsenic (+ 3 oxidation state) methyltransferase (AS3MT) gene are related to capacity of arsenic methylation.

Association between mtDNA haplogroups and skeletal fluorosis in Han population residing in drinking water endemic fluorosis area of northern China.

To investigate the association between mtDNA genetic information and the risk of SF, individuals were conducted in the drinking water endemic fluorosis area in northern China, sequenced the whole genome of mtDNA, identified the SNPs and SNVs, analyzed the haplogroups, and diagnosed SF, and then, the effect of mtDNA genetic information on the risk of SF was evaluated. We find that, D5 haplogroup and its specific SNPs reduced the risk, while the D4 haplogroup and its specific SNPs increased the risk of SF. The number of SNVs in coding regions of mitochondrial respiratory chain (MRC) is different between the controls and cases.

ERK/PKM2 Is Mediated in the Warburg Effect and Cell Proliferation in Arsenic-Induced Human L-02 Hepatocytes.

This study aimed to investigate the potential role of pyruvate kinase M2 (PKM2) and extracellular regulated protein kinase (ERK) in arsenic-induced cell proliferation. L-02 cells were treated with 0.2 and 0.

Enhanced adsorption and co-adsorption of heavy metals using highly hydrophilicity amine-functionalized magnetic hydrochar supported MIL-53(Fe)-NH: performance, kinetics, and mechanism studies.

It is a "kill two birds with one stone" method to convert invasive plants into hydrochar via hydrothermal carbonization as well as coinciding with 3R rules (reduction, recycling, and reuse). In this work, a series of hydrochars (pristine, modified, and composite) derived from invasive plants Alternanthera philoxeroides (AP) were prepared and applied to the adsorption and co-adsorption of heavy metals (HMs) such as Pb(II), Cr(VI), Cu(II), Cd(II), Zn(II), and Ni(II). The results show that MIL-53(Fe)-NH- magnetic hydrochar composite (M-HBAP) displayed a strong affinity for HMs, which the maximum adsorption capacities for HMs were 153.

An interprovincial input-output database distinguishing firm ownership in China from 1997 to 2017.

Input-Output (IO) data describing supply-demand relationships between buyers and sellers for goods and services within an economy have been used not only in economics but also in scientific, environmental, and interdisciplinary research. However, most conventional IO data are highly aggregated, resulting in challenges for researchers and practitioners who face complex issues in large countries such as China, where firms within the same IO sector may have significant differences in technologies across subnational regions and different ownerships. This paper is the first attempt to compile China's interprovincial IO (IPIO) tables with separate information for mainland China-, Hong Kong, Macau, Taiwan-, and foreign-owned firms inside each province/industry pair.

SIRT1/P53 pathway is involved in the Arsenic induced aerobic glycolysis in hepatocytes L-02 cells.

Arsenic is a known human carcinogen. Low doses of arsenic can induce cell proliferation, but the mechanism remains elusive. Aerobic glycolysis, also known as the Warburg effect, is one of the characteristics of tumour cells and rapidly proliferating cells.

Analysis and construction of the coal and rock cutting state identification system in coal mine intelligent mining.

The recognition of cutting state of coal-rock is the key technology to realize "unmanned" mining in coal face. In order to realized real-time perception and accurate judgment of coal-rock cutting state information, this paper combined the field test sampling, construction technology of complex coal seam, virtual prototype technology, bidirectional coupling technology, data processing theory, image fusion method, and deep learning theory to carry out multi domain deep fusion experimental research on multi-source heterogeneous data of coal and rock cutting state. The typical complex coal seam containing gangue, inclusion, and minor fault in Yangcun mine of Yanzhou mining area was taken as the engineering object.

Peptide-assembled nanoparticles targeting tumor cells and tumor microenvironment for cancer therapy.

Tumor cells and corrupt stromal cells in the tumor microenvironment usually overexpress cancer-specific markers that are absent or barely detectable in normal cells, providing available targets for inhibiting the occurrence and development of cancers. It is noticeable that therapeutic peptides are emerging in cancer therapies and playing more and more important roles. Moreover, the peptides can be self-assembled and/or incorporated with polymeric molecules to form nanoparticles non-covalent bond, which have presented appealing as well as enhanced capacities of recognizing targeted cells, responding to microenvironments, mediating internalization, and achieving therapeutic effects.

Iron oxide nanoparticles cause surface coating- and core chemistry-dependent endothelial cell ferroptosis.

Iron oxide nanoparticles (IONPs) are mostly intended to be administrated intravenously, understanding the interaction of IONPs with vascular endothelial cells is extremely crucial for developing safe application regimes of IONPs. In this work, interactions of three kinds of IONPs to endothelial cells were investigated both in human umbilical vein endothelial cells (HUVECs) and in healthy mice. Both meso-2,3-dimercaptosuccinic acid (DMSA) coated FeO NPs (DMSA-FeO NPs) and DMSA-FeO NPs induced cell growth inhibition, while polyglucose sorbitol carboxymethyether coated FeO NPs(PSC-FeO NPs) did not.

LDL receptor-related protein 5 rs648438 polymorphism is associated with the risk of skeletal fluorosis.

To investigate the potential association between LRP5 rs648438 polymorphism and the risk of skeletal fluorosis (SF) was evaluated in a cross-sectional case-control study conducted in Shanxi, China, in 2019. A total of 973 individuals were enrolled in this study, in which cases and controls were 346 and 627, respectively. SF was diagnosed according to the standard WS/192-2008 (China).

The ROS/NF-κB/HK2 axis is involved in the arsenic-induced Warburg effect in human L-02 hepatocytes.

Arsenic has been identified as a carcinogen, although the molecular mechanism underlying itscarcinogenesis has not been fully elucidated. To date, only a few studies have attempted to confirm a direct link between oxidative stress and the Warburg effect . This study demonstrated that 0.

Nanomicelles co-loading CXCR4 antagonist and doxorubicin combat the refractory acute myeloid leukemia.

Acute myeloid leukemia (AML) is featured with poor prognosis and high mortality, because chemo-resistance, nonspecific distribution and dose-limiting toxicity lead to a high rate of relapse and a very low 5-year survival percentage of less than 25%. CXCR4 is a highly expressed chemokine receptor in multiple types of AML cells and closely associated with the drug resistance and relapse. In this work, we integrate a chemically synthesized CXCR4 antagonistic peptide and doxorubicin using DSPE-mPEG2000 micelles (referred to as M-E5-Dox) that is applied to a very challenging refractory AML mouse model as well as human AML cell lines.