Tumor microenvironment modulation innovates combinative cancer therapy a versatile graphene oxide nanosystem.

The tumor microenvironment (TME) emerges as a unique challenge to oncotherapy due to its intricate ecosystem containing diverse cell types, extracellular matrix, secreted factors, and neovascularization, which furnish tumor growth, progression, invasion, and metastasis. Graphene oxide (GO)-based materials have garnered increasing attention in cancer therapy owing to their vast specific surface area, flexible lamellar structure, and electronic-photonic properties. Recently, interactions of GO with the TME have been broadly investigated, including trapping biomolecules, catalysis, cancer stem cell targeting, immunoreactions, .

An inter-city input-output database distinguishing firm ownership in the Greater China area during 2002-2017.

Most multi-region input-output (MRIO) tables in China focus on provinces or urban agglomerations and ignore the tremendous geographical heterogeneities of economic activities across Chinese prefectural cities, where regional economic centres are usually located for domestic and global production. This paper constructs an inter-city input-output (IO) database with 42 sectors in the Greater China area. Compared with previous MRIO tables, it has three important features: (1) A complete coverage of Chinese cities, including 335 prefectural cities, four municipalities, and Hong Kong, Macao, and Taiwan; (2) Distinguishes three types of firm ownership for every city and sector for four benchmark years; (3) A novel data completion approach to reconcile all accessible micro-level data with city and provincial-level aggregate statistics, and effectively combining the bottom-up and top-down methods commonly used in the MRIO compilation literature.

Effect of an auxiliary device on scanning accuracy for multiple implants: an in vitro comparative study.

Objectives: To determine the influence of a consumable auxiliary device, the O-I buckle, on the accuracy of intraoral scanning among complete arches.

Methods: A standard mandibular model with six implants was used as the master model and was scanned by a precise dental laboratory scanner to establish a reference. Three impression techniques were compared: the conventional splinted open-tray impression (CI group), the digital intraoral scanning technique (IOS group), and IOS with the auxiliary device (OI group).

Accuracy of Photogrammetry, Intraoral Scanning, and Conventional Impression for Multiple Implants: An In Vitro Study.

Objectives: This in vitro study compared the accuracy of conventional impressions (CNVs), photogrammetry (PG), and intraoral scanning (IOS) for recording implant impressions of edentulous segments, ranging from part to complete arches by different evaluation methods.

Methods: The master model for an edentulous maxillary arch was created with six implants (a-f). CNVs, PG, and IOS were used for impressions.

Maxillary sinus floor augmentation: a review of current evidence on anatomical factors and a decision tree.

Maxillary sinus floor augmentation using lateral window and crestal technique is considered as predictable methods to increase the residual bone height; however, this surgery is commonly complicated by Schneiderian membrane perforation, which is closely related to anatomical factors. This article aimed to assess anatomical factors on successful augmentation procedures. After review of the current evidence on sinus augmentation techniques, anatomical factors related to the stretching potential of Schneiderian membrane were assessed and a decision tree for the rational choice of surgical approaches was proposed.

An interprovincial input-output database distinguishing firm ownership in China from 1997 to 2017.

Input-Output (IO) data describing supply-demand relationships between buyers and sellers for goods and services within an economy have been used not only in economics but also in scientific, environmental, and interdisciplinary research. However, most conventional IO data are highly aggregated, resulting in challenges for researchers and practitioners who face complex issues in large countries such as China, where firms within the same IO sector may have significant differences in technologies across subnational regions and different ownerships. This paper is the first attempt to compile China's interprovincial IO (IPIO) tables with separate information for mainland China-, Hong Kong, Macau, Taiwan-, and foreign-owned firms inside each province/industry pair.

A multiomic study uncovers a bZIP23-PER1A-mediated detoxification pathway to enhance seed vigor in rice.

Seed vigor in crops is important in terms of improving grain quality and germplasm conservation; however, little is known about its regulatory mechanisms through the encoded proteome and gene network. Comparative analyses of transcriptome (RNA sequencing [RNA-seq]) and broadly targeted metabolic profiling of two subspecific rice cultivars with distinct seed vigor during accelerated aging revealed various biological pathways and metabolic processes as key influences explaining trait differences. RNA-seq coexpression regulatory network analyses identified several transcription factors, including bZIP23 and bZIP42, that act as nodes in the gene network.

ZmMADS69 functions as a flowering activator through the ZmRap2.7-ZCN8 regulatory module and contributes to maize flowering time adaptation.

Flowering time is a major determinant of the local adaptation of plants. Although numerous loci affecting flowering time have been mapped in maize, their underlying molecular mechanisms and roles in adaptation remain largely unknown. Here, we report the identification and characterization of MADS-box transcription factor ZmMADS69 that functions as a flowering activator through the ZmRap2.

enhances maize adaptation to higher latitudes.

From its tropical origin in southwestern Mexico, maize spread over a wide latitudinal cline in the Americas. This feat defies the rule that crops are inhibited from spreading easily across latitudes. How the widespread latitudinal adaptation of maize was accomplished is largely unknown.

Genome-wide Analysis of Transcriptional Variability in a Large Maize-Teosinte Population.

Gene expression regulation plays an important role in controlling plant phenotypes and adaptation. Here, we report a comprehensive assessment of gene expression variation through the transcriptome analyses of a large maize-teosinte experimental population. Genome-wide mapping identified 25 660 expression quantitative trait loci (eQTL) for 17 311 genes, capturing an unprecedented range of expression variation.

Complex genetic architecture underlies maize tassel domestication.

Maize (Zea mays) tassels underwent profound morphological changes during maize domestication and improvement. Although a number of genes affecting maize inflorescence development have been identified, the genetic basis of the morphological changes in maize tassels since domestication is not well understood. Here, using a large population of 866 maize-teosinte BC S recombinant inbred lines genotyped using 19 838 single nucleotide polymorphism (SNP) markers, we performed high-resolution quantitative trait locus (QTL) mapping for five tassel morphological traits.

The genetic architecture of leaf number and its genetic relationship to flowering time in maize.

The number of leaves and their distributions on plants are critical factors determining plant architecture in maize (Zea mays), and leaf number is frequently used as a measure of flowering time, a trait that is key to local environmental adaptation. Here, using a large set of 866 maize-teosinte BC2 S3 recombinant inbred lines genotyped by using 19,838 single nucleotide polymorphism markers, we conducted a comprehensive genetic dissection to assess the genetic architecture of leaf number and its genetic relationship to flowering time. We demonstrated that the two components of total leaf number, the number of leaves above (LA) and below (LB) the primary ear, were under relatively independent genetic control and might be subject to differential directional selection during maize domestication and improvement.

Identification and fine mapping of quantitative trait loci for the number of vascular bundle in maize stem.

Studies that investigated the genetic basis of source and sink related traits have been widely conducted. However, the vascular system that links source and sink received much less attention. When maize was domesticated from its wild ancestor, teosinte, the external morphology has changed dramatically; however, less is known for the internal anatomy changes.