The Economic Landscape of Global Rabies: A Scoping Review and Future Directions.

Rabies remains a significant global public health concern, causing an estimated 59,000-69,000 human fatalities annually. Despite being entirely preventable through vaccination, rabies continues to impose substantial economic burdens worldwide. This study presents a scoping review of the economic research on rabies to determine overlaps and gaps in knowledge and inform future research strategies.

Preparation of Electrodes by Molecular Imprinting Technique for Pesticide Detection.

Pesticides, vital for agricultural productivity, also present health risks due to residues in food and water. Therefore, the development of economical, efficient, reliable, and easy-to-operate pesticide detection technologies is of utmost importance. The synergistic effect of the molecular imprinting technique (MIT) and the electrochemical sensor has attracted wide attention in the field of detection.

Discovery and structural-activity relationship of N-benzyl-2-fluorobenzamides as EGFR/HDAC3 dual-target inhibitors for the treatment of triple-negative breast cancer.

Epidermal growth factor receptor (EGFR) and histone deacetylase 3 (HDAC3) synergistically drive malignant progression in triple-negative breast cancer (TNBC). In this study, a series of N-benzyl-2-fluorobenzamide derivatives (11-43) were identified as EGFR/HDAC3 dual-target inhibitors. Among them, compound 38 exhibited the most promising activity, with IC₅₀ values of 20.

Vagal nerve magnetic stimulation for post-traumatic cricopharyngeal achalasia with bilateral vocal cord paralysis: A case report.

Rationale: Post-traumatic dysphagia is a severe complication of traumatic brain injury, particularly in cases involving medullary damage. The rare combination of cricopharyngeal achalasia and bilateral vocal cord paralysis presents substantial challenges, with profound swallowing dysfunction and increased aspiration risk. Current treatments primarily target cricopharyngeal dysfunction but lack effective solutions for concurrent vocal cord paralysis, highlighting the need for innovative therapeutic strategies.

Zhutong Decoction relieves constipation by enhancing intestinal peristalsis through modulation of C-KIT/ANO1 and PDGFRα/SK3 in the SIP syncytium.

Ethnopharmacological Relevance: Slow transit constipation (STC) is a common gastrointestinal disease. Zhutong Decoction (ZTD), a traditional empirical prescription, is composed of Zhizhu Decoction and Prunus persica (L.) Batsch.

Ceftriaxone ameliorates tau phosphorylation and mislocalization in APP/PS1 AD mice by inhibiting endoplasmic reticulum stress.

Tau phosphorylation and mislocalization are hallmark pathological features of Alzheimer's disease (AD), with endoplasmic reticulum stress (ERS) contributing to tauopathy. We previously showed that ceftriaxone (Cef) improves cognition in APP/PS1 AD mice through regulating GLT-1-mediated glutamate homeostasis. Here, we examined Cef's neuroprotection against ERS-related tauopathy.

Insights into toxic elements mobilization in Karstic paddy soil of southwest China: The overlooked significance of iron-organic matter colloids.

Due to their large specific surface area, variable surface charge, and abundant reactive functional groups, soil colloids are important "carriers" for the migration of HMs (heavy metals) in the soil. This study systematically investigates the migration-transformation mechanisms of colloidal As, Cd, Tl and their driving factors in paddy soils of the Karst region in southwest China. Results show that colloidal Fe and OM are the primary environmental factors influencing the formation and distribution of these three colloidal heavy metals, with significant positive correlations (correlation coefficients r = 0.

Comprehensive characterization of the competitive endogenous RNA network revealing its immune-related functions in hepatic ischemia-reperfusion injury.

Hepatic ischemia-reperfusion injury (HIRI) is a common complication in liver surgery and transplantation. Recent studies have revealed the significant role of the competing endogenous RNA (ceRNA) network in HIRI. Herein, we comprehensively analyzed the HIRI-related ceRNA network and its correlation with immune-related pathways and immune cells in HIRI patients.

Prognostic Implications of Red Blood Cell Distribution Width to Albumin Ratio in Myelofibrosis: A 10-Year Multicenter and Retrospective Study.

Introduction: Myelofibrosis (MF) is a rare myeloproliferative neoplasm (MPN) characterized by significant mortality and limited predictive biomarkers. The red cell distribution width to albumin ratio (RAR), a novel biomarker indicative of inflammation, has emerged as a strong prognostic indicator in the general population but remains unexplored in MF.

Methods: We retrospectively enrolled 504 consecutive MF patients from 7 hematological centers over a 10-year period.

Mobilization of water-dispersible colloidal chromium and nickel in basalt-derived paddy soils: Role of Fe (hydr)oxides and organic matter.

Basalt weathering can lead to heavy metal enrichment in soils, and nickel (Ni) isotopes can served as an effective tracer for this weathering process. Water-dispersible colloids (WDCs) are ubiquitous in soil environments and can facilitate the long-range transport of sorbed pollutants. Here, we analyzed soil colloidal distribution, concentration, morphology and Ni isotopes in soil to understand the potential mobilization of WDC-bound Cr and Ni in basalt-derived paddy soils.

Cellular crosstalk mediated by Meteorin-like regulating hepatic stellate cell activation during hepatic fibrosis.

Liver fibrosis is characterized by an excessive accumulation of extracellular matrix (ECM), primarily produced by activated hepatic stellate cells (HSCs). The activation of HSCs is influenced by paracrine signaling interactions among various liver cell types, but molecular mechanisms remain to be elucidated. Secretory Meteorin-like (Metrnl) can effectively ameliorate fulminant hepatitis.

SMYD2 Promotes Renal Tubular Cell Apoptosis and Chronic Kidney Disease Following Cisplatin Nephrotoxicity.

The protein lysine methyltransferase 2 (SMYD2) can affect cell proliferation, differentiation, and survival through methylation of its histone and non-histone substrates. SMYD2 has been shown to act as an oncogene to promote disease progression in a variety of cancer diseases, but its role in chronic kidney diseases (CKD) pathogenesis has not been fully elucidated. This study aims to investigate the effect of SMYD2 on cisplatin-induced CKD and its underlying mechanisms.

Comprehensive and high-coverage glycerophospholipidomic analysis based on iterative quadrupole time-of-flight mass spectrometry and its application in cerebral ischemia-reperfusion injury.

Glycerophospholipids play important roles in iron-induced lipid peroxidation during cerebral ischemia-reperfusion, making it essential to investigate changes in their varieties and concentrations under these conditions. However, the wide range of glycerophospholipid contents, particularly the low-abundance species in actual biological samples, posed a challenge for comprehensive analysis. In this study, an iterative quadrupole time-of-flight mass spectrometry (Q-ToF-MS/MS) method was established with the aim of comprehensively detecting glycerophospholipids.

Combined effect of areca nut, cigarettes, alcohol and SNPs in glycosyltransferase family genes on lung cancer development in Hainan, China.

Background: Abnormal glycosylation modification is closely related to the development and metastasis of cancers. As a carcinogen by the International Agency for Research on Cancer (IARC) of the WHO, areca nut lacked of combined effect' study with genetic factors related to lung cancer. The aim of this study was to investigate the combined effect of polymorphisms of glycosyltransferase family genes and behavioral factors on the susceptibility of lung cancer.

Association of SNPs in nAChRs genes, areca nut chewing and smoking, and their interaction with lung cancer in Hainan, China: a case control study.

Background: Areca nut (AN) was classified as a carcinogen by the International Agency for Research on Cancer (IARC) of the WHO in 2003. AN has the same carcinogenic components as cigarettes, such as benzo[a]pyrene (B[a]P) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), but its effects on interactions with genetic factors related to lung cancer have rarely been investigated.  METHODS: Here, a propensity score-matched case‒control study was conducted in Hainan, which included 445 patients with lung cancer and 445 cancer-free controls.

Durable response to Olaparib in EGFR and somatic BRCA2-mutated lung adenocarcinoma with leptomeningeal metastases: a case report.

Mutations in breast cancer susceptibility genes 1/2 (BRCA1/2) are strongly associated with a significantly higher risk of numerous cancers, including ovarian, breast, prostate, and pancreatic cancer. PARP inhibitors have been approved for the treatment of ovarian and breast cancer. However, studies focusing on the association between the BRCA gene and NSCLC, as well as the efficacy of PARP inhibitors in NSCLC, are scarce.

A nomogram for predicting T315I-free survival in chronic phase chronic myeloid leukemia patients: a multicenter retrospective study.

The T315I mutation poses a significant threat to patients with chronic phase chronic myeloid leukemia (CP-CML). This study aimed to establish a nomogram to predict the risk of T315I mutation in CP-CML patients. The training cohort included 1,466 patients from 24 hematology centers, and the validation cohort included 820 patients from an additional 20 centers.

Impact of IL-32 gene polymorphisms on tuberculosis susceptibility in a Chinese Han population.

Objective: Interleukin (IL)-32, encoded by the IL-32 gene, is a crucial constituent of the autophagy pathway and is involved in the regulation of Mycobacterium tuberculosis (M.tb) infection, a major global health challenge. This study aimed to examine the potential association between IL-32 polymorphisms and susceptibility to Tuberculosis(TB), highlighting the significance of genetic factors in TB risk.

Efficacy and safety of low-dose TBI combined MAC regimen for HSCT in high-risk AML patients with active disease.

Background: The management of high-risk acute myeloid leukaemia (AML) remains challenging, highlighting the need for innovative conditioning strategies beyond current regimens.

Methods: In the present single-arm study, a FACT regimen comprised of low-dose total body irradiation (TBI) with fludarabine, cytarabine and cyclophosphamide was employed to treat cytogenetically high-risk AML patients exhibiting pre-transplant active disease. This clinical trial is registered in the Chinese Clinical Trial Registry with the registration number ChiCTR2000035111.

Myeloprotection effects of trilaciclib in Chinese patients with extensive stage small cell lung cancer (ES-SCLC) receiving chemotherapy-a real-world study.

Background: Trilaciclib, an intravenous short acting cyclin-dependent kinase 4/6 inhibitor, has been approved for the prevention of chemotherapy-induced myelosuppression (CIM) in patients with extensive stage small cell lung cancer (ES-SCLC) receiving platinum/etoposide (EP) or topotecan (TPT)-based therapy in United States (US) since February 2021. Trilaciclib use received the priority review and approval in a real-world setting in China. This study thus aimed to collect real-world data and evaluate the protective effect of trilaciclib on CIM in Chinese patients with ES-SCLC.

A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages.

Diabetic kidney disease (DKD) is the main cause of deaths due to diabetes mellitus (DM). Due to the complexity of its onset, it is difficult to achieve accurate prevention and treatment. The classically activated macrophage (M1) polarization is a crucial proinflammatory mechanism of DKD, while the interaction and cascade effects of oxidative stress and inflammatory response remain to be elucidated.

The effectiveness and factors influencing frequency of endoscopic bougie dilatation in treating postoperative anastomotic stenosis of congenital esophageal atresia.

Objective: This study is to evaluate the effectiveness and frequency factors of endoscopic bougie dilatation in treating postoperative anastomotic stenosis of congenital esophageal atresia (CEA).

Methods: The clinical data of patients of anastomotic stenosis with endoscopic bougie were retrospectively analyzed. According to the number of dilation times (ND), patients were divided into two groups (Group 0: ND < 3; Grooup1: ND ≥ 3), and the differences in multiple clinical data were compared.

Retrieval In Decoder benefits generative models for explainable complex question answering.

Large-scale Language Models (LLMs) utilizing the Chain-of-Thought prompting demonstrate exceptional performance in a variety of tasks. However, the persistence of factual hallucinations remains a significant challenge in practical applications. Prevailing retrieval-augmented methods treat the retriever and generator as separate components, which inadvertently restricts the generator's capabilities to those of the retriever through intensive supervised training.

Potential of Progressive and Disruptive Innovation-Driven Cost Reductions of Green Hydrogen Production.

Green hydrogen from water electrolysis is a key driver for energy and industrial decarbonization. The prediction of the future green hydrogen cost reduction is required for investment and policy-making purposes but is complicated due to a lack of data, incomplete accounting for costs, and difficulty justifying trend predictions. A new AI-assisted data-driven prediction model is developed for an in-depth analysis of the current and future levelized costs of green hydrogen, driven by both progressive and disruptive innovations.