Targeted therapy combined with immunotherapy trifluridine/tipiracil with bevacizumab as late-line therapy in metastatic colorectal cancer.

Background: Targeted therapy combined with anti-programmed cell death 1 immunotherapy (TP) and trifluridine/tipiracil (TAS-102) combined with bevacizumab (TB) are two common therapies for patients with late-line therapy in microsatellite stable (MSS) metastatic colorectal cancer (mCRC). However, it is still unclear which therapy can bring better prognosis.

Aim: To evaluate the effectiveness and safety of TP TB as the late-line regimen for MSS mCRC in the real world.

Real world effectiveness of chemotherapy plus bevacizumab with immunotherapy in colorectal cancer.

Patients diagnosed with microsatellite stable (MSS) metastatic colorectal cancer (mCRC) typically have an immunosuppressive tumor microenvironment, which leads to a low response rate when treated with immunotherapy. Some studies indicate that chemotherapy and anti-angiogenic therapy could potentially improve the responsiveness of these patients to immunotherapy. Therefore, this study is designed to assess the effectiveness and safety of combining chemotherapy with bevacizumab and anti-PD-1 immunotherapy as a second-line treatment option for MSS mCRC.

Hepatocyte uptake ratio derived from T1 mapping for quantitative assessment of liver fibrosis.

Objectives: To investigate the diagnostic potential of T1 mapping-derived parameters for liver fibrosis, offering a quantitative approach to guide treatment strategies.

Materials And Methods: In this retrospective study, patients with chronic liver disease who underwent magnetic resonance imaging and pathological evaluation of the liver between April 2018 and May 2024 were included. The pre-contrast (T1pre) and post-contrast (T1post) T1 relaxation times, the difference between T1pre and T1post (ΔT1), reduction rates of T1 relaxation times, hepatocyte uptake ratio, and hepatocyte uptake index (KHep), were derived from pre-contrast and post-contrast T1 mapping images, and the liver-to-spleen signal intensity ratio (LSR) was measured on hepatobiliary phase images.

Computed tomography and magnetic resonance imaging features of primary liver perivascular epithelioid cell tumor with renal angiomyolipoma: a case report and literature review.

Hepatic perivascular epithelioid cell tumor (PEComa) is an extremely rare mesenchymal tumor. The disease has few specific clinical symptoms and imaging manifestations, making its accurate diagnosis an intractable clinical challenge. This is a report of a female patient diagnosed with lesions and a mass in the left lobe of the liver.

Real-world comparison of chemotherapy plus bevacizumab with or without immunotherapy as first-line therapy in colorectal cancer.

Background: Microsatellite stable (MSS) metastatic colorectal cancer (mCRC) is characterized by an immunosuppressive tumor microenvironment, leading to limited efficacy of immunotherapy in these patients. Clinical trial data suggest that chemotherapy and anti-angiogenic therapy may have the potential to enhance the response to immunotherapy in these patients. However, whether these research findings can be "replicated" in clinical practice still requires further validation through real-world studies.

Chemotherapy plus bevacizumab with or without anti-programmed death 1 immunotherapy as the second-line therapy in colorectal cancer.

Background: Patients with microsatellite stable (MSS) metastatic colorectal cancer (mCRC) typically exhibit an immunosuppressive tumor microenvironment and demonstrate a low response rate to immunotherapy. Reports suggest that chemotherapy and anti-angiogenic therapy may have the potential to enhance the response to immunotherapy in these patients. This study aims to evaluate the effectiveness and safety of chemotherapy combined with bevacizumab with or without anti-programmed death 1 (PD-1) immunotherapy as the second-line regimen for MSS mCRC.

Intravoxel Incoherent Motion Improves the Accuracy of Preoperative Prediction of Vessels Encapsulating Tumor Clusters in Hepatocellular Carcinoma.

Purpose: Hepatocellular carcinoma (HCC) with vessels encapsulating tumor clusters (VETC) pattern presents a higher risk of recurrence and metastasis, and the unique vascular structure of the VETC pattern may affect the perfusion and diffusion, and the effect that can be captured by intravoxel incoherent motion (IVIM). Therefore, this study used preoperative IVIM to predict VETC pattern in HCC and performed preoperative noninvasive recurrence risk stratification.

Patients And Methods: Patients with suspicious HCC were included prospectively.

Research on a Novel AC/DC Hybrid Microgrid Based on Silicon Controlled Converters and Polarity Reversal Switches.

In order to reduce the economic costs, enhance the efficiency, and improve the structural stability of microgrids, this paper proposes a novel AC/DC hybrid microgrid structure. This structure, based on Silicon Controlled Converters (SCCs) and Polarity Reversal Switches (PRSs), enables bidirectional power flow and provides a low-cost and straightforward control solution. This paper elaborates on the overall control strategy of the microgrid under different states of the PRS and introduces the control logic of the Current Reversible Chopper (CRC) circuit.

Tocilizumab improves the efficacy of anti-PD-1 in a patient with advanced gastroesophageal junction cancer: a case report.

Background: Cancer-related inflammation contributes to the progression of malignancies and considerably affects therapeutic outcomes. IL-6 acts as a main mediator of both local and systemic inflammatory responses. Although IL-6 therapies have been successful in the treatment of inflammatory conditions, there has been little experience in patients with cancer.

Unraveling tumoral heterogeneity and angiogenesis-associated mechanisms of PD-1 and LAG-3 dual inhibition in lung cancers by single-cell RNA sequencing.

Background: Lymphocyte activation gene 3 (LAG-3) is a promising immune checkpoint for combination immunotherapy. This study aims to elucidate the exact synergistic anti-tumor mechanism of programmed death 1 (PD-1) and LAG-3 dual inhibition in lung cancer.

Methods: Multiple patient-derived xenograft (PDX) models of lung cancer were constructed and analyzed by single-cell RNA sequencing (scRNA-seq).

Automated Microfluidics for Efficient Characterization of Cyclohexanol Electrooxidation for Sustainable Chemical Production.

The electrochemical conversion of biomass-derived compounds into value-added chemicals using renewable electricity has attracted attention as a promising pathway for sustainable chemical production, with the electrooxidation of cyclohexanol being a typical example. However, optimizing and upscaling these processes have been hindered due to a limited understanding of the underlying mechanisms and limiting factors. To address this, there is a critical need for experimental tools that enable more efficient and reproducible measurements of these complex processes.

How Epistemic Curiosity Influences Digital Literacy: Evidence from International Students in China.

Digital literacy is the core competitiveness and necessary ability that international students should cultivate while studying in China in the context of education digitalization, and this paper mainly explores whether epistemic curiosity can affect the digital literacy of international students in China. Based on the Technology Acceptance Model, this paper introduces the variable of epistemic curiosity, uses questionnaire survey method and quantitative tools (SPSS and AMOS software) to construct a model of the cognition-perception-formation mechanism of international students' digital literacy in China, and obtains the following conclusions: Firstly, both interest- and deprivation-type epistemic curiosity can directly promote the digital literacy of international students in China. Secondly, this paper discusses how interest- and deprivation-type epistemic curiosity can affect digital literacy under the mediating effect of perceived usefulness.

Gibberellin promotes theanine synthesis by relieving the inhibition of CsWRKY71 on in tea plant ().

Theanine is a crucial indicator of tea quality, and its significance is closely tied to the economic value of tea. There have been many reports on the regulation mechanism of theanine synthesis and accumulation, but the mechanism by which gibberellin regulates theanine synthesis in tea plants is poorly understood. Previous studies have shown that the content of theanine experiences significant changes in the growth stages of tea shoots, displaying a strong correlation with gibberellin.

Adjuvant chemotherapy for isolated resectable colorectal lung metastasis: A retrospective study using inverse probability treatment weighting propensity analysis.

Background: The benefit of adjuvant chemotherapy (ACT) for patients with no evidence of disease after pulmonary metastasis resection (PM) from colorectal cancer (CRC) remains controversial.

Aim: To assess the efficacy of ACT in patients after PM resection for CRC.

Methods: This study included 96 patients who underwent pulmonary metastasectomy for CRC at a single institution between April 2008 and July 2023.

Imaging manifestations of cervical aggressive fibromatosis: a case report and literature review.

Cervical aggressive fibromatosis is a rare intermediate tumor characterized by invasive growth. Aggressive fibromatosis (AF), also referred to as desmoid-type fibrosarcoma or grade I fibrosarcoma, is a clonal proliferative lesion of fibroblasts located in deep soft tissues. While many cases have been reported, there are relatively few involving aggressive fibromatosis in the anterior inferior margin muscle space of the neck trapezius muscle.

A causal relationship between bone mineral density and breast cancer risk: a mendelian randomization study based on east Asian population.

Background: Breast cancer (BC) poses significant burdens on women globally. While past research suggests a potential link between bone mineral density (BMD) and BC risk, findings remain inconsistent. Our study aims to elucidate the causal relationship between BMD and BC in East Asians using bidirectional Mendelian randomization (MR).

Effect of perioperative chemotherapy on resection of isolated pulmonary metastases from colorectal cancer: A single center experience.

Background: Numerous studies have assessed surgical resection as a standard treatment option for patients with colorectal cancer (CRC) and resectable pulmonary metastases (PM). However, the role of perioperative chemotherapy after complete resection of isolated PM from patients with CRC patients remains controversial. We hypothesize that perioperative chemotherapy does not provide significant survival benefits for patients undergoing resection of PM from CRC.

Highlighting immune features of the tumor ecosystem and prognostic value of Tfh and Th17 cell infiltration in head and neck squamous cell carcinoma by single-cell RNA-seq.

Background: Head and neck squamous cell carcinoma (HNSCC) typically present with a complex anatomical distribution, often accompanied by insidious symptoms. This combination contributes to its high incidence and poor prognosis. It is now understood that the immune features of cellular components within the tumor ecosystem and their complex interactions are critical factors influencing both tumor progression and the effective immune response.

Smell cancer by machine learning-assisted peptide/MXene bioelectronic array.

Non-invasive detection of tumors is of utmost importance to save lives. Nonetheless, identifying tumors through gas analysis is a challenging task. In this work, biosensors with remarkable gas-sensing characteristics were developed using a self-assembly method consisting of peptides and MXene.

Risks of SARS-CoV-2 JN.1 Infection and COVID-19-Associated Emergency Department Visits/Hospitalizations Following Updated Boosters and Prior Infection: A Population-Based Cohort Study.

Background: Data on protection afforded by updated coronavirus disease 2019 (COVID-19) vaccines (bivalent/XBB 1.5 monovalent) against the emergent JN.1 variant remain limited.

Potential of Progressive and Disruptive Innovation-Driven Cost Reductions of Green Hydrogen Production.

Green hydrogen from water electrolysis is a key driver for energy and industrial decarbonization. The prediction of the future green hydrogen cost reduction is required for investment and policy-making purposes but is complicated due to a lack of data, incomplete accounting for costs, and difficulty justifying trend predictions. A new AI-assisted data-driven prediction model is developed for an in-depth analysis of the current and future levelized costs of green hydrogen, driven by both progressive and disruptive innovations.

YY1 mediated DCUN1D5 transcriptional activation promotes triple-negative breast cancer progression by targeting FN1/PI3K/AKT pathway.

Triple-negative breast cancer (TNBC) is more aggressive and has a higher metastasis rate compared with other subtypes of breast cancer. Due to the lack of drug-targetable receptors, chemotherapy is now the only available systemic treatment for TNBC. However, some patients might still develop drug resistance and have poor prognosis.

Additional prognostic value of polymorphisms within the 3'-untranslated region of programmed cell death pathway genes in early-stage breast cancer.

Introduction: The programmed cell death (PCD) pathway plays an important role in restricting cancer cell survival and proliferation. However, limited studies have investigated the association between genetic variants in the 3'-untranslated region of the PCD pathway genes and breast cancer outcomes.

Methods: In this study, we genotyped 28 potentially functional single nucleotide polymorphisms (SNPs) in 23 PCD pathway genes in 1,177 patients with early-stage breast cancer (EBC) from a Han Chinese population.

Unified cross-modality integration and analysis of T cell receptors and T cell transcriptomes by low-resource-aware representation learning.

Single-cell RNA sequencing (scRNA-seq) and T cell receptor sequencing (TCR-seq) are pivotal for investigating T cell heterogeneity. Integrating these modalities, which is expected to uncover profound insights in immunology that might otherwise go unnoticed with a single modality, faces computational challenges due to the low-resource characteristics of the multimodal data. Herein, we present UniTCR, a novel low-resource-aware multimodal representation learning framework designed for the unified cross-modality integration, enabling comprehensive T cell analysis.