Discrimination of isomeric dihydroflavone and chalcone by the boosting optimal collision energy-liquid chromatography-tandem mass spectrometry: A case study of pharmacokinetics in honey-fried licorice.

The occurrence of isomeric dihydroflavone and chalcone, two important subfamilies of flavonoid class, extensively happens in herbal medicines. However, identical MS/MS spectra make the identity confirmation a tough job, the complexity will be further boosted in biological samples. Inspired by that isomers possess distinct inherent physicochemical parameters, optimal collision energy (OCE), which is positively correlated with the bond dissociation energies (BDEs), was evaluated towards differentiating isomeric dihydroflavone and chalcone.

The impact of psychological nursing interventions on occupational burnout in sterilization supply center personnel: A retrospective analysis.

This study investigates the prevalence of occupational burnout among hospital sterilization supply center staff and evaluates the effectiveness of psychological interventions in mitigating burnout and associated mental health concerns, such as anxiety and depression. A retrospective analysis was conducted on 120 sterilization supply center employees, categorized into an intervention group (n = 40) receiving structured psychological support-including stress management, emotional regulation training, and mindfulness practices-and a nonintervention group (n = 80). Burnout levels were assessed using the Maslach Burnout Inventory (MBI), while the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) measured anxiety and depression, respectively.

Zhutong Decoction relieves constipation by enhancing intestinal peristalsis through modulation of C-KIT/ANO1 and PDGFRα/SK3 in the SIP syncytium.

Ethnopharmacological Relevance: Slow transit constipation (STC) is a common gastrointestinal disease. Zhutong Decoction (ZTD), a traditional empirical prescription, is composed of Zhizhu Decoction and Prunus persica (L.) Batsch.

Optimal array design of deficient coding metasurfaces for terahertz beam steering via phase-gradient approaching.

Confronted with the low reconfigurability of switches and materials with continuously tunable refractive indices, terahertz active coding metasurfaces suffer from narrow phase shift ranges and low quantization precision. To address the consequent terahertz beam-steering deterioration, an array-level optimization framework from the principle of phase-coding modulation and genetic algorithm (GA) has evolved, enabling enhanced beam steering on deficient 2-bit coding metasurfaces. Unlike traditional exhaustive iterative optimization methods, a near-optimal initial population from a phase-gradient approaching algorithm combined with objective directivity functions significantly improves the beam steering performance in fewer iterations.

Two new abietane diterpenoids from .

Two new abietane diterpenoids, massonianene A () and massonianene B (), were isolated from the extract of . Their structures were elucidated based on HR-ESI-MS, IR, UV, NMR, ECD and X-ray diffraction analysis. Compound exhibited significant inhibitory effect against LPS-induced NO production in RAW 264.

Is high IgG level associated with disease activity and organ damage in patients with Sjögren's syndrome? A 3-year follow-up cohort study.

Hypergammaglobulinemia is prevalent in primary Sjögren's syndrome (pSS) and is considered a marker of disease activity. However, limited data exist regarding its association with disease activity and organ damage. We enrolled patients with pSS from the Chinese Rheumatism Data Centre and categorized them into four groups based on the IgG levels over a 3-year follow-up: consistently high, consistently intermediate, consistently normal, and intermittent.

[Prediction of quality markers for cough-relieving and phlegm-expelling effects of Kening Granules based on plasma pharmacology combined with network pharmacology and pharmacokinetics].

This study predicts the quality markers(Q-markers) for the cough-relieving and phlegm-expelling effects of Kening Granules based on pharmacodynamics, plasma drug chemistry, network pharmacology, and pharmacokinetics. Strong ammonia solution spray and phenol red secretion assays were employed to evaluate the cough-relieving and phlegm-expelling effects of Kening Granules. Twentysix absorbed prototype components of Kening Granules were identified by ultra high performance liquid chromatography coupled with QExactive Plus quadrupole/Orbitrap high resolution mass spectrometry(UHPLC-Q-Exactive Plus Orbitrap HRMS).

A Pharmacokinetic-Pharmacodynamic Study of Protosappanoside D, a Component Derived from Extracts, for Its Anti-Inflammatory Effects.

(Roth) O. Deg. (Fabaceae), traditionally used by the Hmong people to treat rheumatoid arthritis (RA), has not been extensively studied for the correlation between its anti-inflammatory activity and its active components.

Exploring the Mechanisms of Polygonum orientale L. Against Myocardial Ischemia: An Integrated Analysis Using Ultra-High-Performance Liquid Chromatography-Quadrupole Exactive Orbitrap Mass Spectrometry, Network Pharmacology, and RNA Sequencing.

Polygonum orientale L. (PO) represents significant bioactivities in treating myocardial ischemia (MI); however, its underlying mechanisms remain unclear. This study aims to elucidate PO's potential mechanisms in MI using an integrated approach that combines UHPLC-Q-Exactive Orbitrap HRMS, network pharmacology, and RNA-sequencing (RNA-seq).

The effects and mechanisms of aqueous Persicaria capitata extract on uropathogenic Escherichia coli adhesion.

Background: Urinary tract infections (UTIs) in humans are common, with uropathogenic Escherichia coli (UPEC) being the primary pathogen. The adhesive capabilities of UPEC are a substantial pathogenicity factor. Due to limitations of first-line antibiotics, Persicaria capitata (Buch.

Mizagliflozin ameliorates diabetes induced kidney injury by inhibitor inhibit inflammation and oxidative stress.

Background: Mizagliflozin (MIZ) is a specific inhibitor of sodium-glucose cotransport protein 1 (SGLT1) originally developed as a medication for diabetes.

Aim: To explore the impact of MIZ on diabetic nephropathy (DN).

Methods: Diabetic mice were created using db/db mice.

Effects of Metabolic Factors on Left Ventricular Diastolic Function in Patients with Obstructive Sleep Apnea.

Purpose: The effect of metabolic factors on cardiovascular risk in obstructive sleep apnea (OSA) is unclear. This study aimed to investigate the effect of metabolic factors on the left ventricular diastolic function in patients with OSA.

Patients And Methods: This cross-sectional study included a total of 478 patients with OSA from September 2018 to September 2023.

Sub-terahertz transmissive reconfigurable intelligent surface for integrated beam steering and self-OOK-modulation.

Boasting superior flexibility in beam manipulation and a simpler framework than traditional phased arrays, terahertz metasurface-based phased arrays show great promise for 5G-A/6G communication networks. Compared with the reflective reconfigurable intelligent surface (reflective RIS), the transmissive RIS (TRIS) offers more feasibility for transceiver multiplexing systems to meet the growing demand for high-performance beam tracking in terahertz communication and radar systems. However, the terahertz TRIS encounters greater challenges in phase shift, beam efficiency, and complex circuitry.

Role of plasma neuropeptide Y in acute myocardial infarction: a case-control study.

Background: As neuropeptide Y is associated with endothelial dysfunction, this study explored the relationship between neuropeptide Y and acute myocardial infarction.

Methods: We included 128 acute myocardial infarction cases and 62 controls. Using the SYNTAX scoring system, the acute myocardial infarction group was sub-grouped into "SYNTAX ≤ 22," "SYNTAX = 23-32," and "SYNTAX ≥ 33.

Regulation of the SIRT3/SOD2 Signaling Pathway by a Compound Mixture from L. for Myocardial Damage.

L. (PO) has demonstrated notable efficacy in treating coronary heart disease. Previous research identified eight key active components in PO for cardiomyocyte protection, but the underlying mechanisms remained unclear; Methods: Network pharmacology and molecular docking were used to identify potential target proteins of PO's active components.

Graphene Oxide Nanosheets Toxicity in Mice Is Dependent on Protein Corona Composition and Host Immunity.

Two-dimension graphene oxide (GO) nanosheets with high and low serum protein binding profiles (high/low hard-bound protein corona/HC) are used in this study as model materials and screening tools to investigate the underlying roles of the protein corona on nanomaterial toxicities . We proposed that the biocompatibility/nanotoxicity of GO is protein corona-dependent and host immunity-dependent. The hypothesis was tested by injecting HC GO nanosheets in immunocompetent ICR/CD1 and immunodeficient NOD- mice and performed histopathological and hematological evaluation studies on days 1 and 14 post-injection.

D-CyPre: a machine learning-based tool for accurate prediction of human CYP450 enzyme metabolic sites.

The advancement of graph neural networks (GNNs) has made it possible to accurately predict metabolic sites. Despite the combination of GNNs with XGBOOST showing impressive performance, this technology has not yet been applied in the realm of metabolic site prediction. Previous metabolic site prediction tools focused on bonds and atoms, regardless of the overall molecular skeleton.

Effectiveness of probiotic- and fish oil-loaded water-in-oil-in-water (W/O/W) emulsions at alleviating ulcerative colitis.

Ulcerative colitis (UC) is a common chronic inflammatory disease that causes serious harm to human health. Probiotics have the effect of improving UC. This study evaluated the preventative potential of water-in-oil-in-water (W/O/W) emulsions containing both probiotics and fish oil on UC and associated anxiety-like behavior using a mice model.

[Comparative study on excretion of Shuganning Injection and Scutellariae Radix extract in bile, urine, and feces of rats].

Scutellariae Radix extract is one of the important components in Shuganning Injection. In this study, an ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) method was established for simultaneously determining five components in Shuganning Injection and Scutellariae Radix extract in bile, urine, and feces of rats, so as to reveal the difference in the excretion process of Shuganning Injection and Scutellariae Radix extract in rats and explore the law of the excretion process of the five components in vivo before and after the compatibility of Scutellariae Radix. Rats were injected with Shuganning Injection and Scutellariae Radix extract(4.

An enhanced cardio-protective effect of nanoparticles loaded with active components from Polygonum orientale L. against isoproterenol-induced myocardial ischemia in rats.

In this study, nanoparticles loaded with active components from Polygonum orientale L. (PO), a traditional Chinese herb known for its anti-myocardial ischemic properties, were investigated for cardio-protective properties. Specifically, OVQ-Nanoparticles (OVQ-NPs) with Orientin (Ori), Vitexin (Vit), and Quercetin (Que) was obtained by double emulsion-solvent evaporation method.