The relationship between PAEs components profile of real-world household airborne dust and total DNA demethylation potential in vitro.

Phthalate esters (PAEs) existed in household environment globally, and household airborne dust PAEs (HD-PAEs) have garnered significant attention due to their endocrine-like toxicity. In on-site study investigating PAE contamination from 60 households across three Chinese cities, we analyzed 43 dust samples for specific PAE components and conducted comprehensive total DNA demethylation potential (TDP) toxicity assays. Ten congeners were detected across all cities (130.

FSP1 reduces exogenous coenzyme Q10 and inhibits ferroptosis to alleviate intestinal ischemia-reperfusion injury.

Introduction: Intestinal ischemia-reperfusion injury (IRI) is a critical condition often requiring emergency intervention. Ferroptosis, a form of regulated cell death driven by phospholipid peroxidation, plays a central role in its pathogenesis.

Objective: This study aimed to explore whether CoQ10 could mitigate intestinal IRI by suppressing ferroptosis.

Molecular Characterization, Activation Mechanism, and Antimelanosis Implications of Polyphenol Oxidase in .

Polyphenol oxidase (PPO) plays a central role in the quality deterioration of shrimp, particularly in melanosis development. However, the mechanisms triggering melanosis in () remain poorly understood. This study purified natural PPO from and investigated its molecular characteristics and activation mechanism.

PopPK modeling supports BW band dosing of lacosamide for pediatric epilepsy.

Personalized precision dosing remains an unmet clinical need. This study used population pharmacokinetic (PopPK) modeling to evaluate transitioning lacosamide (LCM) in children with epilepsy from body weight (BW)-based (mg/kg) to simplified BW-band or fixed-dose (mg) regimens. Real-world data from 190 patients were analyzed using nonlinear mixed-effects modeling program, comparing a BW-based model (Model I) and a genotype-guided model (Model II); the latter showed superior predictive performance.

Secure wireless communication of brain-computer interface and mind control of smart devices enabled by space-time-coding metasurface.

Brain-computer interface (BCI) provides an interconnected pathway between the human brain and external devices and paves a potential route for mind manipulations. However, most existing BCI technologies are based on simple signal transmission and are independent of other interface devices, with limited consideration for the reliability and security of the human brain's information interaction in complicated wireless environments. Here, we propose a deep fusion coding scheme that combines the BCI visual stimulation coding with metasurface space-time coding at the physical layer, enabling reliable and secure information transfers between the human brain and external devices.

Contribution of Protected Area Networks to Achieving Global Biodiversity Framework Targets and Sustainable Development Goals: Evidence From Coastal Shandong, China.

The protected area network (PAN) is a vital strategy for enhancing ecological integrity and connectivity. However, its contributions to the Kunming-Montreal Global Biodiversity Framework (GBF) 2030 Targets and Sustainable Development Goals (SDGs) remain understudied due to limited indicator assessments and regional case comparisons. This study applied circuit theory to construct and optimize a PAN in China's coastal region.

Characterization of total DNA demethylation potential and its PBDE components of household airborne dust in three Chinese cities.

Household dust is a major reservoir for indoor pollutants, yet its epigenetic effects remain poorly characterized. This study investigated household airborne dust's total DNA demethylation potential (TDP) and its association with 14 priority polybrominated diphenyl ethers (PBDEs) in 43 residences across Lanzhou, Suzhou, and Harbin. The median TDP (5-AZA-CdR equivalent) was 0.

Multimodal artificial intelligence for subepithelial lesion classification and characterization: a multicenter comparative study (with video).

Background: Subepithelial lesions (SELs) present significant diagnostic challenges in gastrointestinal endoscopy, particularly in differentiating malignant types, such as gastrointestinal stromal tumors (GISTs) and neuroendocrine tumors, from benign types like leiomyomas. Misdiagnosis can lead to unnecessary interventions or delayed treatment. To address this challenge, we developed ECMAI-WME, a parallel fusion deep learning model integrating white light endoscopy (WLE) and microprobe endoscopic ultrasonography (EUS), to improve SEL classification and lesion characterization.

MDSGCN: Predicting Multiple Types of Mutation-Drug Association Through Signed Graph Convolution Network.

Cancer constitutes a significant global public health challenge, resulting in millions of fatalities annually. Gene mutations are pivotal in initiating and advancing cancer, disrupting regular cellular growth and differentiation mechanisms, thereby fostering tumor development. Consequently, comprehending the intricacies of gene mutations and their interplay with pharmaceuticals is imperative for cancer prevention, diagnosis, and treatment.

Simultaneous and ultrasensitive detection of three dihydroxybenzene isomers based on 3D chain structure-modified MOF electrochemical sensors.

To prevent phenolic compounds from threatening ecological environment safety and human health, the development of rapid and sensitive methods is vital. Herein, a novel Ketjen black (KB) and multi-walled carbon nanotubes (MWCNTs)- multifunctionalized metal-organic framework nanocomposite (ZIF-67/KB-MWCNTs) was synthesized, which was used for the modification of bare electrode (GCE), achieving simultaneous and ultrasensitive detection of hydroquinone (HQ), catechol (CC), and resorcinol (RS) in environmental water. The proposed electrochemical sensor (ECS) was constructed based on the synergistic effect of ZIF-67 with an ultra-large specific area and KB-MWCNTs with 3D chain structure and high conductivity resulted in both high electrocatalysis and fast electron transfer.

Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation.

Discrete genomic units can recombine into composite transposons that transcribe and transpose as single units, but their regulation and function are not fully understood. We report that composite transposons harbor bivalent histone marks, with activating and repressive marks in distinct regions. Genome-wide CRISPR-Cas9 screening, using a reporter driven by the hominid-specific composite transposon SVA (SINE [short interspersed nuclear element]-VNTR [variable number of tandem repeats]-Alu) in human cells, identified diverse genes that modify bivalent histone marks to regulate SVA transcription.

Global trends and sociodemographic inequalities in smoking and high-salt diet attributable to gastric cancer: a secondary analysis based on the global burden of disease 2021 study.

Background: Gastric cancer is a common malignancy worldwide. Smoking and a high-salt diet are behavioural risk factors for gastric cancer that can be easily controlled; however, comprehensive and systematic studies are lacking. This study reports the variation trend in the attribution of the burden of gastric cancer in different regions from 1990 to 2021 and suggests personalised recommendations developed for regions with different sociodemographic indices (SDI).

Sources, temporal-spatial characteristics, exposure assessment and children health risk of phthalate esters (PAEs) in household dust in China from 2000 to 2023: a review and pool analysis.

Phthalate esters (PAEs) have been extensively used in the household environment globally for decades, posing persistent hazards. There is significant attention on the characteristics of PAEs in household dust (HD-PAEs) in China, driven by an increasing awareness of their endocrine-disruptor toxicity. In this study, 876 peer-reviewed papers published between 2000 and 2023 were evaluated and screened for raw numerical data of HD-PAEs in residential households, including 27 papers available for final analysis.

Photo-Induced Catalytic Dearomative Coupling of N-Heteroarenes.

Naturally occurring dimeric products have attracted considerable attention from both chemists and pharmacologists. The construction of pseudo-dimers often requires elaborate synthetic effort with low efficiency. Dearomatization reactions represent an ideal method to transform planar aromatics into 3D skeletons, which has attracted increasing interest in medicinal chemistry and total synthesis.

Prevalence and predictive importance for short-term clinical outcomes of GLIM-defined malnutrition among adult inpatients: A nationwide cross-sectional study.

Background & Aims: Malnutrition is a significant health issue in hospital settings, with persistent diagnostic challenges. Despite the Global Leadership Initiative on Malnutrition (GLIM) criteria providing a standardised approach, nationwide validation and implementation remain limited. We aimed to estimate the national prevalence of GLIM-defined malnutrition among Chinese adult inpatients and assess the predictive value of the GLIM criteria for short-term clinical outcomes.

Time course of indirect reply comprehension in the young and older adults: an event-related potential study.

Introduction: In verbal communication, speakers often use implicit utterances that need listeners to interpret via pragmatic inference. As individuals age, their ability to make efficient and accurate pragmatic inferences may decline, leading to communication difficulties.

Objectives: This study examined the cognitive aging phenomenon of pragmatic inference and its neural mechanisms using EEG recordings.

Protein Engineering of an Inositol-1-phosphate Synthase Based on the Active-Site Redesign Facilitates the Biomanufacturing of -Inositol from Starch Synthetic Enzymatic Biosystem.

-Inositol, a water-soluble B vitamin compound, has broad applications in the food, pharmaceutical, and feed industries. Sustainable production of -inositol from starch can be achieved using an synthetic enzymatic biosystem (ivSEB) comprising four key enzymes. The NAD/NADH self-recycling hyperthermophilic inositol 1-phosphate synthase (AfIPS) from catalyzes the rate-limiting reaction.

Study on the Performance of Composite-Modified Epoxy Resin Potting Adhesive for Repairing Oblique Cracks.

Reinforced concrete structures are prone to the development of microcracks during service. In this study, a composite-modified epoxy potting adhesive was formulated using nano-TiO, carboxyl-terminated butadiene nitrile liquid rubber (CTBN), and the reactive diluent D-669. The mechanical properties and effectiveness of this composite adhesive in repairing oblique cracks were systematically evaluated and compared with those of single-component-modified epoxy adhesives.

Noninvasive Left Ventricular Pressure-Strain Loop for Assessment of Myocardial Work in Hemodialysis in Patients With Chronic Kidney Disease.

Objective: To explore the value of a novel echocardiographic measure-left ventricular pressure-strain loop (LV-PSL) for assessment of patients with chronic kidney disease by comparing the changes before and after hemodialysis (HD).

Methods: A total of 117 patients undergoing regular hemodialysis were recruited. Global longitudinal strain (GLS) combined with cuff blood pressure measurement is used to calculate the global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE).

An elusive causal link between epilepsy and vitamin D in children: More questions than answers? A narrative review.

When discussing childhood epilepsy and children's serum vitamin D status together, the matter becomes complex and intriguing. A long-standing question has been whether there is a causal link between epilepsy itself and the serum vitamin D status: does vitamin D deficiency lead to seizures, or do seizures occur alongside or result in vitamin D deficiency, or is the deficiency caused by anti-seizure medication therapy? Clarifying these questions would significantly enhance our understanding of the relationship between them and improve the treatment and management for childhood epilepsy. This narrative review summarized existing literature on vitamin D and pediatric epilepsy and collected those clinical and non-clinical researches in this field to see if sufficient evidence has accumulated to address these questions.

Chinese Expert Consensus on Standardized Outpatient Management of Sarcopenia in the Elderly (2024).

Sarcopenia is an age-related disorder that influences the daily living ability of older adults and interacts with various chronic diseases. Older adults with sarcopenia typically experience a deterioration in their quality of life and healthy lifespan. The number of Chinese persons with sarcopenia is considerable, and the burden of sarcopenia is substantial; however, the specific sarcopenia clinics available for outpatients are insufficient.

Sex differences in endocrine, metabolic and psychological disturbance in obese patients with OSA.

Background: Obstructive sleep apnea (OSA) is associated with increased risks of glucolipid metabolic disruption, endocrine disturbances and psychological distress. There is scarce research regarding the influence of sex on these associations. The current study aimed to evaluate the effects of sex on metabolic, endocrine and psychological changes in patients with OSA.

Structure-based identification of potent fibroblast growth factor receptor 4 (FGFR4) inhibitors as potential therapeutics for hepatocellular carcinoma.

Fibroblast growth factor receptor 4 (FGFR4), a member of the fibroblast growth factor receptor family, plays a crucial role in cell growth, differentiation, and tissue repair. Increased FGFR4 expression has been detected in various cancers, including lung, liver, kidney and pancreatic cancer, making it a potential drug target. In this study, we conducted a structure-based virtual screening campaign to identify potential FGFR4 inhibitors.