Analysis of the correlation between corneal and meibomian gland morphology and glycated hemoglobin levels in type 2 diabetes patients.

Purpose: To investigate the correlation between corneal nerve and meibomian gland morphological changes and glycated hemoglobin (HbA1c) levels in type 2 diabetes mellitus (T2DM) patients, and to provide an objective basis for early detection of diabetic peripheral neuropathy.

Methods: A total of 150 subjects were enrolled, including 130 T2DM patients and 20 healthy controls. T2DM patients were divided into two groups based on HbA1c levels: well-controlled group (HbA1c < 7.

Single nuclear spin detection and control in a van der Waals material.

Optically active spin defects in solids are leading candidates for quantum sensing and quantum networking. Recently, single spin defects were discovered in hexagonal boron nitride (hBN), a layered van der Waals (vdW) material. Owing to its two-dimensional structure, hBN allows spin defects to be positioned closer to target samples than in three-dimensional crystals, making it ideal for atomic-scale quantum sensing, including nuclear magnetic resonance (NMR) of single molecules.

Anomalous Hall effect from inter-superlattice scattering in a noncollinear antiferromagnet.

Superlattice formation dictates the physical properties of many materials, including the nature of the ground state in magnetic materials. Chemical composition is commonly considered to be the primary determinant of superlattice identity, especially in intercalation compounds. Nevertheless, in this work, we find that kinetic control of superlattice growth leads to the coexistence of disparate crystallographic domains within a compositionally perfect single crystal.

Exploring the spatial heterogeneity of trade-offs and synergies across ecosystem service bundles based on supply and demand relationships in the Wuhan Metropolitan Area.

Understanding the trade-offs and synergies among ecosystem services (ESs) is crucial for multi-objective management and ecosystem sustainability. However, limited research has focused on identifying ecosystem service bundles (ESBs) through ES supply-demand relationships and analyzing the internal trade-offs and synergies within each bundle. To address this gap, this study used the Wuhan Metropolitan Area (WMA) in 2021 as a case study to evaluate the supply and demand of six ESs at both the raster and county scales, using the InVEST model and multisource data including geospatial and statistical datasets.

Autophagy and exosome dynamics in Radiation-Induced pulmonary fibrosis: the critical role of TRIB3.

Objective: Dysregulated autophagy plays a critical role in the pathogenesis of pulmonary fibrosis. The stress protein TRIB3 has been correlated with abnormal autophagy, but its specific contribution to radiation-induced pulmonary fibrosis (RIPF) remains unclear. This study aimed to elucidate the role of TRIB3 in RIPF progression.

Peptide hydrogel platform encapsulating manganese ions and high-density lipoprotein nanoparticle-mimicking nanovaccines for the prevention and treatment of gastric cancer.

Background: Advanced gastric cancer remains a significant global health challenge, with limited therapeutic options available. In contrast, immunotherapy have emerged as promising alternatives, offering greater potency in treating advanced gastric cancer. However, the development of novel and efficient immunotherapeutic strategy is crucial to enhance the body's immune response against gastric cancer.

Molecular docking to investigate HLA-associated idiosyncratic drug reactions.

Idiosyncratic drug reactions (IDRs) pose severe threats to patient health. Unlike conventionally dose-dependent side effects, they are unpredictable and more frequently manifest as life-threatening conditions, such as severe cutaneous adverse reactions (SCARs) and drug-induced liver injury (DILI). Some HLA alleles, such as , , and , are known risk factors for adverse reactions induced by multiple drugs.

A functional hydrogel dressing based on glycyrrhizic acid with low-swelling and moisturizing properties for enhancing infected wound repair.

Wound healing is a challenging due to the presence of bacterial infection, excessive inflammation and angiogenesis disorders. While traditional therapies struggle, a functional hydrogel can effectively repair wounds. However, the use of hydrogels is limited due to their high swelling and excessive dehydration characteristics.

Spin Dynamics in Hybrid Halide Perovskites - Effect of Dynamical and Permanent Symmetry Breaking.

The hybrid organic-inorganic halide perovskite (HOIP), for example, MAPbBr, exhibits extended spin lifetime and apparent spin lifetime anisotropy in experiments. The underlying mechanisms of these phenomena remain illusive. By utilizing our first-principles density-matrix dynamics approach with quantum scatterings including electron-phonon and electron-electron interactions and self-consistent spin-orbit coupling, we present temperature- and magnetic field-dependent spin lifetimes in hybrid perovskites, in agreement with experimental observations.

IRF1 transcriptionally up-regulates CXCL10 which increases CD8 T cells infiltration in colorectal cancer.

Tumor-infiltrating CD8 T cell is a robust predictor of outcome and immunotherapy response in patients with CRC. However, limited introduction of intratumoral CD8 T cells remains a barrier for treatment of CRC. One of the most effective but difficult therapy for CD8 T cells entering the tumor is activating chemokine receptors.

Effect of pelvic floor muscle exercise combined with infrared physiotherapy on postpartum urinary incontinence.

Background: Scientific treatments for postpartum urinary incontinence, including pelvic floor muscle exercises (such as Kegel exercises) and infrared therapy, can effectively improve pelvic floor and urethral function, thus enhancing quality of life. However, clinical research on the combined use of these interventions for postpartum urinary incontinence is limited.

Objective: To investigate the combining efficacy of pelvic floor muscle exercises with infrared physiotherapy on postpartum urinary incontinence.

PBPK model of pegylated liposomal doxorubicin to simultaneously predict the concentration-time profile of encapsulated and free doxorubicin in tissues.

The objective of this study was to develop a physiologically based pharmacokinetic (PBPK) model to predict the concentrations of encapsulated and free doxorubicin in plasma and tissues in mice after intravenous injection of PEGylated liposomes (Doxil). The PBPK model used in this study contains liposomes and free doxorubicin disposition components. The free doxorubicin disposition component was used to simulate the disposition of free doxorubicin produced by mononuclear phagocyte system (MPS)-degrading liposomes.

Bacterial networks and enzyme genes in bacterial floccules from hydrolysis and aeration reactors in a dairy wastewater treatment system.

The dairy industry generates substantial wastewater, which is commonly treated using integrated anaerobic hydrolysis and aerated biofilm reactors. However, the bacterial composition and functional differences within the generated floccules remain unclear. In this study, we employed 16S rRNA and metagenomic sequencing to compare bacterial communities and enzyme gene profiles between suspended floccules from the hydrolysis ponds and the aeration ponds.

A review: Marine aquaculture impacts marine microbial communities.

Marine aquaculture is key for protein production but disrupts marine ecosystems by releasing excess feed and pharmaceuticals, thus affecting marine microbes. Though vital, its environmental impact often remains overlooked. This article delves into mariculture's effects on marine microbes, including bacteria, fungi, viruses, and antibiotic-resistance genes in seawater and sediments.

Progress in the study of association between hematological indicators and retinopathy of prematurity (Review).

Retinopathy of prematurity (ROP) is a retinopathy caused by abnormal proliferation of blood vessels in premature infants. It can lead to retinal detachment and, in severe cases, blindness, rendering ROP a critical condition. Advances in neonatal medicine have improved survival rates of low birth weight and low gestational age infants.

Decoding trends in mRNA vaccine research: A comprehensive bibliometric study.

Background: In recent years, infectious diseases like COVID-19 have had profound global socio-economic impacts. mRNA vaccines have gained prominence due to their rapid development, industrial adaptability, simplicity, and responsiveness to new variants. Notably, the 2023 Nobel Prize in Physiology or Medicine recognized significant contributions to mRNA vaccine research.

LncRNA SNHG3 discriminates rheumatoid arthritis from healthy individuals and regulates inflammatory response and oxidative stress via modulating miR-128-3p.

Objectives: This study evaluated the expression and significance of SNHG3 in rheumatoid arthritis (RA), aiming to explore a biomarker and regulator for RA.

Methods: The expression of SNHG3 in serum and synovial tissue was compared between RA patients and healthy individuals using polymerase chain reaction (PCR). The RA animal models were induced by the Porcine Type II collagen in Wistar rats and validated by the foot volume and arthritis index score.

The diversity of planktonic bacteria driven by environmental factors in different mariculture areas in the East China Sea.

Planktonic bacteria play a crucial role in sustaining the ecological balance of aquatic ecosystems. However, their seasonal variations in different aquaculture areas within the East China Sea, along with their correlation to environmental factors, have not been extensively explored. In this study, each area with 3 sample points were set up to represent the fish aquaculture area, shellfish aquaculture area and non-aquaculture area.

Integrated characterizations of intestinal bacteria and transcriptomics revealed the acute stress response to carbonate alkalinity in white shrimp Penaeusvannamei.

The impact of carbonate alkalinity in saline-alkaline water on aquatic organisms, particularly Penaeus vannamei, a significant species in aquaculture, remains a critical area of study. To elucidate the acute response mechanisms of P. vannamei to elevated carbonate alkalinity environments, we utilized 16S rRNA gene and transcriptome sequencing technologies to analyze intestinal bacteria and gene expressions within various tissues.

Miniaturized ascorbic acid assay platform based on point discharge atomic emission spectrometry coupling with gold filament enrichment.

Background: Miniaturized microplasma-based atomic emission spectrometry (AES) has been extensively used for element analysis in recent years due to the advantages of low power consumption, low gas consumption, relatively low manufacturing and running cost, and the potential for real-time and field analysis. However, few applications in bioassay detection have been reported based on microplasma AES systems because of their relatively low sensitivity and the absence of indirect analytical strategies. It is still a challenge to develop a simple, sensitive, and portable microplasma-based AES bioassay approach.

How spin relaxes and dephases in bulk halide perovskites.

Spintronics in halide perovskites has drawn significant attention in recent years, due to their highly tunable spin-orbit fields and intriguing interplay with lattice symmetry. Here, we perform first-principles calculations to determine the spin relaxation time (T) and ensemble spin dephasing time ([Formula: see text]) in a prototype halide perovskite, CsPbBr. To accurately capture spin dephasing in external magnetic fields we determine the Landé g-factor from first principles and take it into account in our calculations.

microRNA-622 upregulates cell cycle process by targeting FOLR2 to promote CRC proliferation.

Background: Epigenetic alterations contribute greatly to the development and progression of colorectal cancer, and effect of aberrant miR-622 expression is still controversial. This study aimed to discover miR-622 regulation in CRC proliferation.

Methods: miR-622 expression and prognosis were analyzed in clinical CRC samples from Nanfang Hospital.

Hyperthermia inhibits the progression of gastric cancer by downregulating PLEK2/PD-L1 and possibly participates in immunomodulation.

Background: Hyperthermia is used as an adjunctive treatment for gastric cancer; however, the corresponding antitumor mechanism remains unclear.

Objective: To investigate the expression of PLEK2 in gastric cancer and the mechanism by which hyperthermia inhibits gastric cancer progression and participating in immunomodulation.

Methods: PLEK2 was screened by combining microarray analysis with gene knockdown and proliferation assays.

Acute effects of the environmental probiotics Rhodobacter sphaeroides on intestinal bacteria and transcriptome in shrimp Penaeusvannamei.

In recent years, a substantial number of studies have been dedicated to exploring the potential benefits of probiotics in aquaculture. Rhodobacter sphaeroides can be used in aquaculture-related environmental bioremediation, and its protein is also used as a feed additive in Penaeus vannamei culture. To investigate the effects of releasing R.